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Article: Carbon neutral electrochemical conversion of carbon dioxide mediated by [Mn+(cyclam)Cln] (M = Ni2+ and Co3+) on mercury free electrodes and ionic liquids as reaction media

Honores, J / Quezada, D / García, M / Calfumán, K / Muena, J. P / Aguirre, M. J / Arévalo, M. C / Isaacs, M

Green chemistry. 2017 Feb. 21, v. 19, no. 4

2017

Abstract: In this work, the electrochemical reduction of carbon dioxide using [Mn+(cyclam)Cln] (M = Ni2+ and ... parameters, such as a heterogeneous electron transfer rate was calculated. Results indicate a faster M(ii)/M ...

Abstract	In this work, the electrochemical reduction of carbon dioxide using [Mn+(cyclam)Cln] (M = Ni2+ and Co3+) as electrocatalysts has been studied in 1-butyl-3-methylimidazolium tetrafluoroborate and 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide (BMImBF4 and BMImNTf2 respectively) ionic liquids as reaction media. Complexes were characterized electrochemically in these salts and relevant parameters, such as a heterogeneous electron transfer rate was calculated. Results indicate a faster M(ii)/M(i) redox process in BMImBF4 despite its higher viscosity compared to BMImNTF2. Cyclic voltammetry experiments demonstrated that [Ni(cyclam)Cl2] is the most active macrocycle, towards the reaction under survey. For this compound, potential controlled electrolysis was carried out at−1.4 V vs. Ag/AgCl in BMImBF4 as a solvent, yielding only CO as a reaction product, with a turnover frequency (TOF) of 0.73 h−1. NMR spectra for the ionic liquids, after electrolysis, show that the applied potential does not affect the chemical structure of the salts. FT-IR thin layer spectroelectrochemical experiments in CO2 saturated solution in BMImBF4 at −1.4 V vs. Ag/AgCl show the formation of [Ni(cyclam)CO]+ as precursor species, and also the most stable [Ni(CO)4].
Keywords	Fourier transform infrared spectroscopy ; carbon ; carbon dioxide ; carbon monoxide ; catalysts ; chemical structure ; cobalt ; electrochemistry ; electrodes ; electrolysis ; electron transfer ; green chemistry ; ionic liquids ; mercury ; nickel ; nuclear magnetic resonance spectroscopy ; silver ; silver chloride ; surveys ; viscosity
Language	English
Dates of publication	2017-0221
Size	p. 1155-1162.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2006274-6
ISSN	1463-9270 ; 1463-9262
ISSN (online)	1463-9270
ISSN	1463-9262
DOI	10.1039/c6gc02599d
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Mpox Evolution: Has the Current Outbreak Revealed a Pox on "U"?

Kohli, Rahul M / Isaacs, Stuart N

The Journal of infectious diseases

2022 Volume 227, Issue 6, Page(s) 828–830

Abstract: The recent mpox (monkeypox) outbreak has prompted genomic studies to track global spread of the disease. These studies have also revealed unexpected patterns of mutations that implicate the action of the immune defense APOBEC3 family of enzymes, which ... ...

Abstract	The recent mpox (monkeypox) outbreak has prompted genomic studies to track global spread of the disease. These studies have also revealed unexpected patterns of mutations that implicate the action of the immune defense APOBEC3 family of enzymes, which catalyze conversion of cytosine (C) to uracil (U) in DNA, in viral evolution. As poxviruses have conventionally been regarded as slow-evolving viruses, the rapid emergence of APOBEC3 mutational signatures begs a series of important and open questions regarding how host-pathogen interactions may have changed and whether these mutations are bystanders or have roles in pathogenesis.
MeSH term(s)	Humans ; Cytidine Deaminase/genetics ; Mpox (monkeypox) ; Viruses/genetics ; DNA ; Mutation
Chemical Substances	Cytidine Deaminase (EC 3.5.4.5) ; DNA (9007-49-2)
Language	English
Publishing date	2022-12-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1093/infdis/jiac471
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Article ; Online: Natural History, Treatment Outcomes and Quality of Life in Idiopathic Normal Pressure Hydrocephalus (iNPH).

Isaacs, Albert M / Hamilton, Mark

Neurology India

2022 Volume 69, Issue Supplement, Page(s) S561–S568

Abstract: Background: The natural history and treatment outcomes in adult patients with hydrocephalus is a broad and heterogeneous topic that encompasses the natural history of the various subtypes of adult hydrocephalus with or without treatment; their surgical ... ...

Abstract	Background: The natural history and treatment outcomes in adult patients with hydrocephalus is a broad and heterogeneous topic that encompasses the natural history of the various subtypes of adult hydrocephalus with or without treatment; their surgical operative results, including symptom improvements, treatment failure, short- and long-term complications, and reoperations; and morbidity, mortality, and patient-centered health-related quality of life (HRQoL). Objective, methods, and materials: The objective of this review is to present a current update on the natural history and treatment outcomes, including QoL, for adults with hydrocephalus with a focus on patients with idiopathic normal pressure hydrocephalus (iNPH). A nonsystematic review of relevant literature was summarized. Results and conclusions: The natural history for untreated patients with iNPH is poor, with both increased mortality and morbidity. It is strongly recommended that practitioners follow established guidelines to select patients with suspected iNPH while using objective measures of gait, balance, and cognition for consideration of treatment with a CSF shunt. Other factors such as patient-related medical comorbidities or frailty may need to be factored into the decision-making process before surgical treatment is offered. As a rule, failure to select patients based on the identified guidelines will result in a significantly lower positive response to treatment with a CSF shunt. Over 90% of iNPH patients who undergo CSF-shunt treatment demonstrate symptomatic relief after surgery, and long-term studies have shown that in most patients, the clinical improvements are long-lasting, with over 70% demonstrating improvement longer than 6 years after treatment. There is no evidence to support the routine use of endoscopic third ventriculostomy (ETV) to treat patients with iNPH. There is limited data regarding HRQoL in patients with iNPH. In addition to objective measures of outcomes focused on gait and cognition, it is equally important for future studies to assess patient-centered subjective measures of HRQoL.
MeSH term(s)	Adult ; Cerebrospinal Fluid Shunts ; Humans ; Hydrocephalus, Normal Pressure/surgery ; Quality of Life ; Treatment Outcome ; Ventriculostomy
Language	English
Publishing date	2022-01-28
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	415522-1
ISSN	1998-4022 ; 0028-3886
ISSN (online)	1998-4022
ISSN	0028-3886
DOI	10.4103/0028-3886.332281
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Article ; Online: Role of IFN-α in Rheumatoid Arthritis.

Lin, Chung M A / Isaacs, John D / Cooles, Faye A H

Current rheumatology reports

2023 Volume 26, Issue 2, Page(s) 37–52

Abstract: Purpose of review: Type 1 interferons (IFN-I) are of increasing interest across a wide range of autoimmune rheumatic diseases. Historically, research into their role in rheumatoid arthritis (RA) has been relatively neglected, but recent work continues ... ...

Abstract	Purpose of review: Type 1 interferons (IFN-I) are of increasing interest across a wide range of autoimmune rheumatic diseases. Historically, research into their role in rheumatoid arthritis (RA) has been relatively neglected, but recent work continues to highlight a potential contribution to RA pathophysiology. Recent findings: We emphasise the importance of disease stage when examining IFN-I in RA and provide an overview on how IFN-I may have a direct role on a variety of relevant cellular functions. We explore how clinical trajectory may be influenced by increased IFN-I signalling, and also, the limitations of scores composed of interferon response genes. Relevant environmental triggers and inheritable RA genetic risk relating to IFN-I signalling are explored with emphasis on intriguing data potentially linking IFN-I exposure, epigenetic changes, and disease relevant processes. Whilst these data cumulatively illustrate a likely role for IFN-I in RA, they also highlight the knowledge gaps, particularly in populations at risk for RA, and suggest directions for future research to both better understand IFN-I biology and inform targeted therapeutic strategies.
MeSH term(s)	Humans ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/genetics ; Interferon-alpha/therapeutic use ; Interferon Type I ; Autoimmune Diseases ; Risk Factors
Chemical Substances	Interferon-alpha ; Interferon Type I
Language	English
Publishing date	2023-12-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2057357-1
ISSN	1534-6307 ; 1523-3774
ISSN (online)	1534-6307
ISSN	1523-3774
DOI	10.1007/s11926-023-01125-6
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Article ; Online: Retrieval and savings of contextual fear memories across an extended retention interval in juvenile and adult male and female rats.

Odynocki, Natalie / Isaacs, Zerah / Poulos, Andrew M

Behavioral neuroscience

2023 Volume 137, Issue 6, Page(s) 339–346

Abstract: Adult rodents exhibit an exceptional ability to retrieve context fear memories across lengthy retention intervals. In contrast, these memories established in younger rodents are susceptible to significant forgetting. The present study aimed to examine ... ...

Abstract	Adult rodents exhibit an exceptional ability to retrieve context fear memories across lengthy retention intervals. In contrast, these memories established in younger rodents are susceptible to significant forgetting. The present study aimed to examine the persistence of contextual fear memories established in juvenile and adult Long-Evans male and female rats. Testing 1-day after conditioning, adult males exhibited evidence for greater conditioning than juvenile males, while in females, conditioning did not differ between juvenile and adult rats. In adults, males displayed greater conditioning than females, while in juveniles, males and females reached similar conditioning levels. At the 60-day retention interval, adult sex differences were maintained; however, juvenile rats failed to retrieve this remote contextual fear memory. Next, we examined whether a savings test procedure could recover these remotely established juvenile memories. Following a 60-day retention test, the now adult rats were presented with an additional context-shock pairing to assess the level of savings. While this procedure produced greater conditioning in males than females, the relative savings of this early life memory were similar in males and females. The results of these experiments indicate that adult sex differences in contextual fear memory are maintained across an extended retention interval, while in juveniles, there were no significant sex differences. A novel finding in the present study was that both male and female rats failed to retrieve an initial juvenile memory following an extended retention interval. However, these memories were recovered with a single reminder of the original juvenile experience. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
MeSH term(s)	Rats ; Female ; Male ; Animals ; Rats, Long-Evans ; Fear ; Memory, Long-Term
Language	English
Publishing date	2023-10-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	230159-3
ISSN	1939-0084 ; 0735-7044
ISSN (online)	1939-0084
ISSN	0735-7044
DOI	10.1037/bne0000569
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Article ; Online: Adherence to hormonal therapy after surgery among older women with ductal carcinoma in situ: Implications for breast cancer-related adverse health events.

Mitchell, Jean M / DeLeire, Thomas / Isaacs, Claudine

Cancer

2023 Volume 130, Issue 1, Page(s) 107–116

Abstract: Background: Evidence from randomized clinical trials (RCTs) shows that receipt of hormonal therapy after surgery for estrogen receptor-positive ductal carcinoma in situ (DCIS) reduces the risk of DCIS and contralateral invasive breast cancer (IBC) but ... ...

Abstract	Background: Evidence from randomized clinical trials (RCTs) shows that receipt of hormonal therapy after surgery for estrogen receptor-positive ductal carcinoma in situ (DCIS) reduces the risk of DCIS and contralateral invasive breast cancer (IBC) but not death from breast cancer. RCTs examined homogeneous samples, and therefore whether this evidence can be generalized to diverse populations is unclear. Methods: Population-based data from four state cancer registries (California, New Jersey, New York, and Texas) were analyzed on women aged 65 years and older newly diagnosed with DCIS who underwent surgery with or without radiation during the years 2006-2013. Registry records were merged with Medicare enrollment in Parts A and/or B and D (prescription drugs) and associated claims. Whether adherence to hormonal therapy was associated with adverse breast cancer-related health events was analyzed. Results: Achieving excellent adherence did not affect death from breast cancer. In contrast, the risk of developing a subsequent breast tumor was 6.24 percentage points (breast-conserving surgery [BCS] with radiation therapy [RT]) and 10.54 percentage points (BCS alone) lower for women with excellent versus low adherence (p < .00001). For excellent versus good adherence, the reduced risk among women who had BCS with and without RT was approximately 3 and 5 percentage points, respectively. A similar pattern emerged for the risk of IBC among women who achieved excellent versus good or low adherence, whereas good versus low adherence comparisons were not significant. Conclusions: This analysis of a diverse population-based cohort of women with DCIS demonstrates that achieving excellent adherence to hormonal therapy is critical to minimizing the occurrence of developing subsequent breast tumors. Plain language summary: Our analysis of a diverse population-based cohort of women with ductal carcinoma in situ demonstrates that achieving excellent adherence to hormonal therapy is critical to minimizing the occurrence of developing subsequent breast tumors.
MeSH term(s)	Female ; Humans ; Aged ; Carcinoma, Intraductal, Noninfiltrating/drug therapy ; Carcinoma, Intraductal, Noninfiltrating/surgery ; Carcinoma, Intraductal, Noninfiltrating/pathology ; Carcinoma, Ductal, Breast/pathology ; Breast Neoplasms/pathology ; Mastectomy, Segmental ; Registries
Language	English
Publishing date	2023-09-26
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1429-1
ISSN	1097-0142 ; 0008-543X ; 1934-662X
ISSN (online)	1097-0142
ISSN	0008-543X ; 1934-662X
DOI	10.1002/cncr.35009
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Article: Perspectives from Adults with Tourette Syndrome on Research Priorities and Registry Development: A Focus Group Study.

Isaacs, David A / Bonnet, Kemberlee / Eckland, Michelle R / Markowitz, Kimberly / Pena, Maria / Schlundt, David G

Neuropsychiatric disease and treatment

2024 Volume 20, Page(s) 257–269

Abstract: Purpose: Adults with Tourette syndrome (TS) have worse mental health, physical health, and quality of life than the general population. The factors contributing to negative outcomes across multiple health domains in adults with TS remain uncertain, in ... ...

Abstract	Purpose: Adults with Tourette syndrome (TS) have worse mental health, physical health, and quality of life than the general population. The factors contributing to negative outcomes across multiple health domains in adults with TS remain uncertain, in part due to a lack of longitudinal studies in this population. In attempt to address these knowledge gaps, our center has initiated development of a regional registry for adults with TS. During the goal-setting and design phase of registry development, we conducted focus groups with adults with TS to identify research issues of greatest importance to this population and to obtain feedback on design and implementation of an adult TS registry. Patients and methods: Participants were recruited from a tertiary care adult TS clinic and from institutional research registries. Focus groups were conducted online and were moderated by a qualitative research expert. Qualitative data analysis was performed using an iterative inductive/deductive approach. Results: Across four focus groups, adult TS participants (n=22) expressed a variety of research priorities, including developing more effective treatments for tics, identifying risk factors for tic persistence into adulthood, clarifying the interaction between TS symptoms and women's health, clarifying the relationships between TS and other mental and physical health disorders, and addressing day-to-day living issues. Focus group participants were generally enthusiastic about creation of an adult TS registry. They indicated that adults with TS are more likely to engage with a registry that logistically accommodates participants (eg, by offering a wide range of visit times, by providing telehealth options) and that fosters bidirectional interaction (eg, by disseminating results regularly, by involving participants in registry design and implementation, by notifying participants of support resources). Conclusion: Focus group input clarifies the research priorities of adults with TS and will inform the ongoing development of an adult TS registry.
Language	English
Publishing date	2024-02-09
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2186503-6
ISSN	1178-2021 ; 1176-6328
ISSN (online)	1178-2021
ISSN	1176-6328
DOI	10.2147/NDT.S442131
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Article ; Online: Using the GRADE evidence to decision framework to reach recommendations together with ethnic minority community organizations: the example of COVID-19 vaccine uptake in the United Kingdom.

Treweek, Shaun / Brazzelli, Miriam / Crosse, Annette / Daga, Sunil / Isaacs, Talia / Sunga, Ria

Journal of clinical epidemiology

2024 Volume 168, Page(s) 111268

Abstract: Objectives: To make recommendations regarding factors that affect COVID-19 vaccine uptake by ethnic minority individuals in the United Kingdom, together with strategies that could be used to increase uptake.: Study design and setting: The results of ... ...

Abstract	Objectives: To make recommendations regarding factors that affect COVID-19 vaccine uptake by ethnic minority individuals in the United Kingdom, together with strategies that could be used to increase uptake. Study design and setting: The results of two rapid systematic reviews-one identifying factors that affect respiratory vaccine uptake in ethnic minority adults and the other identifying experimental evaluations of strategies to increase vaccine uptake in ethnic minority adults-were put into Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) Evidence to Decision frameworks to support discussion with a panel of ethnic minority community organizations, community-focused small companies, and academics of the relevance of the review findings to the UK COVID context. Aided by the frameworks, the panel made recommendations for factors that need to be addressed to increase vaccine uptake, and for which strategies might be used to increase uptake. Results: Our two reviews contained 31 relevant research studies published in English between 2016 and 2021, all of which were from the United Kingdom (8/31), the United States (20), and Australia (3). We identified six factors-two linked to trust, three linked to information, and one on accessibility-that affected uptake. Strategies that had been evaluated fell into three categories: using trusted messengers, tailoring the message, and increasing convenience. These were put into GRADE Evidence to Decision frameworks and discussed over a series of meetings with individuals from nine ethnic minority community organizations and two community-focused small companies and academics. Community partners provided insight into why ethnic minority individuals in the United Kingdom had lower vaccine uptake, particularly with regard to the impact of nonhealth-related UK Government policy on individuals' heath decision-making. Recommendations included recognizing that trust will be low among some ethnic groups, thinking more broadly as to who messengers should be in a low-trust environment, ensuring that information is tailored to the information needs of specific ethnic groups and working to increase convenience. Our results are at https://www.collaborationforchange.co.uk. Conclusion: GRADE Evidence to Decision frameworks could be used more widely to structure discussions of research evidence between researchers, community organizations, and other nonresearch partners.
MeSH term(s)	Adult ; Humans ; COVID-19 Vaccines/therapeutic use ; Ethnicity ; Ethnic and Racial Minorities ; COVID-19/prevention & control ; Minority Groups ; United Kingdom
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2024-02-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	639306-8
ISSN	1878-5921 ; 0895-4356
ISSN (online)	1878-5921
ISSN	0895-4356
DOI	10.1016/j.jclinepi.2024.111268
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Article ; Online: Acyclic Cucurbit[n]uril Receptors Function as Solid State Sequestrants for Organic Micropollutants.

Perera, Suvenika / Shaurya, Alok / Baptiste, Michael / Zavalij, Peter Y / Isaacs, Lyle

Angewandte Chemie (International ed. in English)

2024 , Page(s) e202407169

Abstract: The accumulation of organic micropollutants (OMP) in aquatic systems is a major societal problem that can be addressed by approaches including nanofiltration, flocculation, reverse osmosis and adsorptive methods using insoluble materials (e.g. activated ... ...

Abstract	The accumulation of organic micropollutants (OMP) in aquatic systems is a major societal problem that can be addressed by approaches including nanofiltration, flocculation, reverse osmosis and adsorptive methods using insoluble materials (e.g. activated carbon, MOFs, nanocomposites). More recently, polymeric versions of supramolecular hosts (e.g. cyclodextrins, calixarenes, pillararenes) have been investigated as OMP sequestrants. Herein, we report our study of the use of water insoluble dimethylcatechol walled acyclic cucurbit[n]uril (CB[n]) hosts as solid state sequestrants for a panel of five OMPs. A series of hosts (H1 - H4) were synthesized by reaction of glycoluril oligomer (monomer - tetramer) with 3,6-dimethylcatechol and fully characterized by spectroscopic means and x-ray crystallography. The solid hosts sequester OMPs from water with removal efficiencies exceeding 90% in some cases. The removal efficiencies of the new hosts parallel the known molecular recognition properties of analogous water soluble acyclic CB[n]. OMP uptake by solid host occurs rapidly (≈120 seconds). Head-to-head comparison with CB[6] in batch-mode separation and DARCO activated carbon in flow-through separation mode show that tetramer derived host (H4) performs very well under identical conditions. The work establishes insoluble acyclic CB[n]-type receptors as a promising new platform for OMP sequestration.
Language	English
Publishing date	2024-04-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202407169
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Article ; Online: Surgical treatment of craniovertebral junction instability in children with Down syndrome: a systematic review.

Isaacs, Albert M / Narapareddy, Ashruta / Nam, Andrew / Hutcheson, Kasey / Stone, Michelle / Bonfield, Christopher M

Journal of neurosurgery. Pediatrics

2023 Volume 32, Issue 2, Page(s) 163–172

Abstract: Objective: Down syndrome (DS) affects 1 in 700 live births and approximately one-third of patients develop craniovertebral junction (CVJ) instability, diagnosed by clinical examination and radiological measures such as the atlantodens interval (ADI) and ...

Abstract	Objective: Down syndrome (DS) affects 1 in 700 live births and approximately one-third of patients develop craniovertebral junction (CVJ) instability, diagnosed by clinical examination and radiological measures such as the atlantodens interval (ADI) and space available for the cord (SAC). Patients with symptomatic CVJ instability are at increased risk for spinal cord injury. There are no guidelines for surgical management of CVJ instability in DS, the existing literature is sparse, and there is a lack of consistent pediatric data. This systematic review aimed to synthesize practice patterns of the surgical management of CVJ stability in pediatric DS patients to facilitate future standardization of care. Methods: Peer-reviewed studies reporting surgical management of CVJ instability in pediatric DS patients were systematically reviewed. Inclusion criteria were studies reporting primary data on patients younger than 18 years with DS, who had CVJ instability evaluation and underwent surgical treatment. Bias risk was assessed. Descriptive statistics of the independent patient data were presented. Interval variables were analyzed using the Wilcoxon rank-sum test. Results: Of 1056 records, 38 studies were included. Of the included patients, 169 (6%) underwent surgery. The surgical indication was symptomatic, radiologically confirmed CVJ instability in 81% of the patients, presenting with myelopathy (30%), weakness (25%), abnormal gait (24%), torticollis (15%), and neck pain (14%). A cutoff of ADI ≥ 4 mm or SAC ≤ 14 mm, cord compression, cord signal change, and anomalous bony anatomy were used in diagnosing CVJ instability. Surgical approaches focused on internal fixation with posterior occipitocervical or atlantoaxial instrumented fusion in 57% and 44% of patients, respectively. Autograft, wiring, and allograft constructs were used in 48%, 45%, and 9% of patients. Anterior cervical approaches were performed in 6% of patients. Preoperative and postoperative external orthoses were used in approximately 50% of patients. The surgical mortality rate was 3%, and the complication rate was 36%. Conclusions: Assessment of CVJ instability in DS is based on radiographic and clinical factors. Surgery is recommended if symptoms are present, and the procedure type depends on patient factors, degree of instability, anomalous bony anatomy, and reduction results to relieve cord compression. Most commonly, posterior instrumented fusion is used. However, further research is required to determine the strength of evaluation methods, create standardized guidelines for evaluation and surgical treatment, and investigate the long-term results of different surgical techniques.
MeSH term(s)	Humans ; Child ; Down Syndrome/complications ; Spinal Cord Injuries ; Decompression, Surgical/methods ; Spinal Fusion/methods ; Atlanto-Axial Joint/diagnostic imaging ; Atlanto-Axial Joint/surgery
Language	English
Publishing date	2023-04-28
Publishing country	United States
Document type	Systematic Review ; Journal Article
ZDB-ID	2403985-8
ISSN	1933-0715 ; 1933-0707
ISSN (online)	1933-0715
ISSN	1933-0707
DOI	10.3171/2023.3.PEDS22353
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