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  1. Article ; Online: Catatonia: a review.

    Weder, Natalie D / Muralee, Sunanda / Penland, Heath / Tampi, Rajesh R

    Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists

    2008  Volume 20, Issue 2, Page(s) 97–107

    Abstract: Background: To write an up-to-date review paper on catatonia using published literature.: Methods: This review involved a search using the terms "catatonia," "stupor," "catatonic schizophrenia" and "catalepsy" in the Cochrane Database of Systematic ... ...

    Abstract Background: To write an up-to-date review paper on catatonia using published literature.
    Methods: This review involved a search using the terms "catatonia," "stupor," "catatonic schizophrenia" and "catalepsy" in the Cochrane Database of Systematic Reviews, the Medline database and EMBASE and PsychINFO. Additional use was made of these databases in searching for randomized controlled trials, meta-analyses, cohort studies, case-control studies, case series, case reports and reviews.
    Results: Available evidence indicates that catatonia is a common neuropsychiatric syndrome characterized by the presence of various motor signs and symptoms. The underlying pathophysiologic-mechanisms points to a heterogeneous group of etiologies. Current classifications are based on the type of presentation and the duration of symptoms; agitated versus retarded and acute versus chronic. Available data supports the efficacy of benzodiazepines and electroconvulsive therapy (ECT) in the treatment of this condition, but the treatment response is limited by the chronicity of symptoms.
    Conclusions: Catatonia is a common disorder that occurs in a wide variety of psychiatric, neurological and medical conditions. At the current time, there is sufficient evidence to consider it as a specific nosologic syndrome with different subtypes and treatment responses.
    MeSH term(s) Catatonia/classification ; Catatonia/diagnosis ; Catatonia/drug therapy ; Catatonia/etiology ; Humans
    Language English
    Publishing date 2008-04
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 1025337-3
    ISSN 1547-3325 ; 1040-1237
    ISSN (online) 1547-3325
    ISSN 1040-1237
    DOI 10.1080/10401230802017092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2779: Show issues Location:
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  2. Article ; Online: Frontotemporal dementias: a review.

    Weder, Natalie D / Aziz, Rehan / Wilkins, Kirsten / Tampi, Rajesh R

    Annals of general psychiatry

    2007  Volume 6, Page(s) 15

    Abstract: Dementia is a clinical state characterized by loss of function in multiple cognitive domains. It is a costly disease in terms of both personal suffering and economic loss. Frontotemporal dementia (FTD) is the term now preferred over Picks disease to ... ...

    Abstract Dementia is a clinical state characterized by loss of function in multiple cognitive domains. It is a costly disease in terms of both personal suffering and economic loss. Frontotemporal dementia (FTD) is the term now preferred over Picks disease to describe the spectrum of non-Alzheimers dementias characterized by focal atrophy of the frontal and anterior temporal regions of the brain. The prevalence of FTD is considerable, though specific figures vary among different studies. It occurs usually in an age range of 35-75 and it is more common in individuals with a positive family history of dementia. The risk factors associated with this disorder include head injury and family history of FTD. Although there is some controversy regarding the further syndromatic subdivision of the different types of FTD, the three major clinical presentations of FTD include: 1) a frontal or behavioral variant (FvFTD), 2) a temporal, aphasic variant, also called Semantic dementia (SD), and 3) a progressive aphasia (PA). These different variants differ in their clinical presentation, cognitive deficits, and affected brain regions. Patients with FTD should have a neuropsychiatric assessment, neuropsychological testing and neuroimaging studies to confirm and clarify the diagnosis. Treatment for this entity consists of behavioral and pharmacological approaches. Medications such as serotonin reuptake inhibitors, antipsychotics, mood stabilizer and other novel treatments have been used in FTD with different rates of success. Further research should be directed at understanding and developing new diagnostic and therapeutic modalities to improve the patients' prognosis and quality of life.
    Language English
    Publishing date 2007-06-12
    Publishing country England
    Document type Journal Article
    ISSN 1744-859X
    ISSN (online) 1744-859X
    DOI 10.1186/1744-859X-6-15
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Safe return to homeland of an illegal immigrant with psychosis.

    Vesga-López, Oriana / Weder, Natalie D / Jean-Baptiste, Michel / Dominguez, Lourdes

    Journal of psychiatric practice

    2009  Volume 15, Issue 1, Page(s) 64–69

    Abstract: The disposition of illegal immigrants who lack social support and wish to return to their homeland is a frequent and difficult challenge for many mental health facilities in the United States. This case involved an undocumented Mexican patient with ... ...

    Abstract The disposition of illegal immigrants who lack social support and wish to return to their homeland is a frequent and difficult challenge for many mental health facilities in the United States. This case involved an undocumented Mexican patient with severe psychosis who was safely transferred to his hometown according to his and his family's wishes through the use of specific services provided by the Mexican Consulate. We hope that publication of this case will make the medical community more aware of the availability of these underused services, which can make a major difference in the prognosis of some undocumented patients who would otherwise be left without resources or appropriate care.
    MeSH term(s) Humans ; Male ; Mental Health Services/utilization ; Mexico/ethnology ; Psychotic Disorders/epidemiology ; Psychotic Disorders/ethnology ; Psychotic Disorders/therapy ; Safety ; Transients and Migrants/psychology ; Transients and Migrants/statistics & numerical data ; United States/epidemiology ; Young Adult
    Language English
    Publishing date 2009-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2022726-7
    ISSN 1538-1145 ; 1527-4160
    ISSN (online) 1538-1145
    ISSN 1527-4160
    DOI 10.1097/01.pra.0000344922.74274.c0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4753: Show issues Location:
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  4. Article ; Online: Frontotemporal Dementias

    Wilkins Kirsten / Aziz Rehan / Weder Natalie D / Tampi Rajesh R

    Annals of General Psychiatry, Vol 6, Iss 1, p

    A Review

    2007  Volume 15

    Abstract: Abstract Dementia is a clinical state characterized by loss of function in multiple cognitive domains. It is a costly disease in terms of both personal suffering and economic loss. Frontotemporal dementia (FTD) is the term now preferred over Picks ... ...

    Abstract Abstract Dementia is a clinical state characterized by loss of function in multiple cognitive domains. It is a costly disease in terms of both personal suffering and economic loss. Frontotemporal dementia (FTD) is the term now preferred over Picks disease to describe the spectrum of non-Alzheimers dementias characterized by focal atrophy of the frontal and anterior temporal regions of the brain. The prevalence of FTD is considerable, though specific figures vary among different studies. It occurs usually in an age range of 35–75 and it is more common in individuals with a positive family history of dementia. The risk factors associated with this disorder include head injury and family history of FTD. Although there is some controversy regarding the further syndromatic subdivision of the different types of FTD, the three major clinical presentations of FTD include: 1) a frontal or behavioral variant (FvFTD), 2) a temporal, aphasic variant, also called Semantic dementia (SD), and 3) a progressive aphasia (PA). These different variants differ in their clinical presentation, cognitive deficits, and affected brain regions. Patients with FTD should have a neuropsychiatric assessment, neuropsychological testing and neuroimaging studies to confirm and clarify the diagnosis. Treatment for this entity consists of behavioral and pharmacological approaches. Medications such as serotonin reuptake inhibitors, antipsychotics, mood stabilizer and other novel treatments have been used in FTD with different rates of success. Further research should be directed at understanding and developing new diagnostic and therapeutic modalities to improve the patients' prognosis and quality of life.
    Keywords Psychiatry ; RC435-571 ; Neurology. Diseases of the nervous system ; RC346-429 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Psychiatry ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Subject code 610
    Language English
    Publishing date 2007-06-01T00:00:00Z
    Publisher BioMed Central
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Child abuse, depression, and methylation in genes involved with stress, neural plasticity, and brain circuitry.

    Weder, Natalie / Zhang, Huiping / Jensen, Kevin / Yang, Bao Zhu / Simen, Arthur / Jackowski, Andrea / Lipschitz, Deborah / Douglas-Palumberi, Heather / Ge, Margrat / Perepletchikova, Francheska / O'Loughlin, Kerry / Hudziak, James J / Gelernter, Joel / Kaufman, Joan

    Journal of the American Academy of Child and Adolescent Psychiatry

    2014  Volume 53, Issue 4, Page(s) 417–24.e5

    Abstract: ... DNA-Binding Protein Inhibitor ID-3 (ID3); Glutamate Receptor, Ionotropic N-methyl-D-aspartate (NMDA) 1 (GRIN1); and ...

    Abstract Objectives: To determine whether epigenetic markers predict dimensional ratings of depression in maltreated children.
    Method: A genome-wide methylation study was completed using the Illumina 450K BeadChip array in 94 maltreated and 96 healthy nontraumatized children with saliva-derived DNA. The 450K BeadChip does not include any methylation sites in the exact location as sites in candidate genes previously examined in the literature, so a test for replication of prior research findings was not feasible.
    Results: Methylation in 3 genes emerged as genome-wide-significant predictors of depression: DNA-Binding Protein Inhibitor ID-3 (ID3); Glutamate Receptor, Ionotropic N-methyl-D-aspartate (NMDA) 1 (GRIN1); and Tubulin Polymerization Promoting Protein (TPPP) (p < 5.0 × 10(-7), all analyses). These genes are all biologically relevant with ID3 involved in the stress response, GRIN1 involved in neural plasticity, and TPPP involved in neural circuitry development. Methylation in CpG sites in candidate genes were not predictors of depression at significance levels corrected for whole genome testing, but maltreated and control children did have significantly different β values after Bonferroni correction at multiple methylation sites in these candidate genes (e.g., BDNF, NR3C1, FKBP5).
    Conclusions: This study suggests that epigenetic changes in ID3, GRIN1, and TPPP genes, in combination with experiences of maltreatment, may confer risk for depression in children. The study adds to a growing body of literature supporting a role for epigenetic mechanisms in the pathophysiology of stress-related psychiatric disorders. Although epigenetic changes are frequently long lasting, they are not necessarily permanent. Consequently, interventions to reverse the negative biological and behavioral sequelae associated with child maltreatment are briefly discussed.
    MeSH term(s) Adolescent ; Child ; Child Abuse ; Child, Preschool ; DNA Methylation/genetics ; Depression/genetics ; Epigenesis, Genetic/genetics ; Female ; Genome-Wide Association Study ; Humans ; Inhibitor of Differentiation Proteins/genetics ; Male ; Neoplasm Proteins/genetics ; Nerve Net/metabolism ; Nerve Tissue Proteins/genetics ; Neuronal Plasticity/genetics ; Receptors, N-Methyl-D-Aspartate/genetics ; Stress, Psychological/genetics ; Stress, Psychological/metabolism
    Chemical Substances GRIN1 protein, human ; Inhibitor of Differentiation Proteins ; Neoplasm Proteins ; Nerve Tissue Proteins ; Receptors, N-Methyl-D-Aspartate ; TPPP protein, human ; ID3 protein, human (147785-34-0)
    Language English
    Publishing date 2014-01-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 392535-3
    ISSN 1527-5418 ; 0890-8567
    ISSN (online) 1527-5418
    ISSN 0890-8567
    DOI 10.1016/j.jaac.2013.12.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Um IV Zs.163: Show issues Location:
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  6. Article: Observation of fluctuation-mediated picosecond nucleation of a topological phase.

    Büttner, Felix / Pfau, Bastian / Böttcher, Marie / Schneider, Michael / Mercurio, Giuseppe / Günther, Christian M / Hessing, Piet / Klose, Christopher / Wittmann, Angela / Gerlinger, Kathinka / Kern, Lisa-Marie / Strüber, Christian / von Korff Schmising, Clemens / Fuchs, Josefin / Engel, Dieter / Churikova, Alexandra / Huang, Siying / Suzuki, Daniel / Lemesh, Ivan /
    Huang, Mantao / Caretta, Lucas / Weder, David / Gaida, John H / Möller, Marcel / Harvey, Tyler R / Zayko, Sergey / Bagschik, Kai / Carley, Robert / Mercadier, Laurent / Schlappa, Justine / Yaroslavtsev, Alexander / Le Guyarder, Loïc / Gerasimova, Natalia / Scherz, Andreas / Deiter, Carsten / Gort, Rafael / Hickin, David / Zhu, Jun / Turcato, Monica / Lomidze, David / Erdinger, Florian / Castoldi, Andrea / Maffessanti, Stefano / Porro, Matteo / Samartsev, Andrey / Sinova, Jairo / Ropers, Claus / Mentink, Johan H / Dupé, Bertrand / Beach, Geoffrey S D / Eisebitt, Stefan

    Nature materials

    2020  Volume 20, Issue 1, Page(s) 30–37

    Abstract: Topological states of matter exhibit fascinating physics combined with an intrinsic stability. A key challenge is the fast creation of topological phases, which requires massive reorientation of charge or spin degrees of freedom. Here we report the ... ...

    Abstract Topological states of matter exhibit fascinating physics combined with an intrinsic stability. A key challenge is the fast creation of topological phases, which requires massive reorientation of charge or spin degrees of freedom. Here we report the picosecond emergence of an extended topological phase that comprises many magnetic skyrmions. The nucleation of this phase, followed in real time via single-shot soft X-ray scattering after infrared laser excitation, is mediated by a transient topological fluctuation state. This state is enabled by the presence of a time-reversal symmetry-breaking perpendicular magnetic field and exists for less than 300 ps. Atomistic simulations indicate that the fluctuation state largely reduces the topological energy barrier and thereby enables the observed rapid and homogeneous nucleation of the skyrmion phase. These observations provide fundamental insights into the nature of topological phase transitions, and suggest a path towards ultrafast topological switching in a wide variety of materials through intermediate fluctuating states.
    Language English
    Publishing date 2020-10-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2088679-2
    ISSN 1476-4660 ; 1476-1122
    ISSN (online) 1476-4660
    ISSN 1476-1122
    DOI 10.1038/s41563-020-00807-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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