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  1. Book ; Online ; E-Book: Performance of metals and ceramics in total hip arthroplasty

    Reyes Rojas, Armando

    (Synthesis Lectures on Biomedical Engineering,)

    2023  

    Abstract: This book offers expert guidance on materials for total hip arthroplasty (THA), providing readers with quick access to well-organized summaries on biomaterials such as metals, ceramics, polymers, and composites. It also includes in-depth coverage of ... ...

    Author's details Armando Reyes Rojas [and four others]
    Series title Synthesis Lectures on Biomedical Engineering,
    Synthesis lectures on biomedical engineering
    Collection Synthesis lectures on biomedical engineering
    Abstract This book offers expert guidance on materials for total hip arthroplasty (THA), providing readers with quick access to well-organized summaries on biomaterials such as metals, ceramics, polymers, and composites. It also includes in-depth coverage of biocompatibility and implant problems such as necrosis, ulceration, high toxicity with metals, and allergic reactions. Coverage also emphasizes the mechanical properties of the materials used for prostheses applications, immunity to corrosion, enhanced biocompatibility, complete inertness to the body environment, and the high capacity to join with the bone and other tissues. Performance of Metals and Ceramics in Total Hip Arthroplasty is an essential reference for engineers and scientists specializing in prostheses design and manufacturing and orthopedic medical professionals. The book can also be used as a study guide for materials science and orthopedics students. Provides a broad overview of the properties of biomaterials and their applications; Includes an in-depth overview of THA; Can be used as a study guide for students in materials science and orthopedics.
    Keywords Biomedical materials ; Orthopedics
    Subject code 704.943
    Language English
    Size 1 online resource (193 pages)
    Edition 1st ed. 2023.
    Publisher Springer
    Publishing place Cham, Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-031-25420-1 ; 9783031254192 ; 978-3-031-25420-8 ; 3031254198
    DOI 10.1007/978-3-031-25420-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: The RAGE Axis: A Relevant Inflammatory Hub in Human Diseases.

    Rojas, Armando / Lindner, Cristian / Schneider, Ivan / Gonzalez, Ileana / Uribarri, Jaime

    Biomolecules

    2024  Volume 14, Issue 4

    Abstract: In 1992, a transcendental report suggested that the receptor of advanced glycation end-products (RAGE) functions as a cell surface receptor for a wide and diverse group of compounds, commonly referred to as advanced glycation end-products (AGEs), ... ...

    Abstract In 1992, a transcendental report suggested that the receptor of advanced glycation end-products (RAGE) functions as a cell surface receptor for a wide and diverse group of compounds, commonly referred to as advanced glycation end-products (AGEs), resulting from the non-enzymatic glycation of lipids and proteins in response to hyperglycemia. The interaction of these compounds with RAGE represents an essential element in triggering the cellular response to proteins or lipids that become glycated. Although initially demonstrated for diabetes complications, a growing body of evidence clearly supports RAGE's role in human diseases. Moreover, the recognizing capacities of this receptor have been extended to a plethora of structurally diverse ligands. As a result, it has been acknowledged as a pattern recognition receptor (PRR) and functionally categorized as the RAGE axis. The ligation to RAGE leads the initiation of a complex signaling cascade and thus triggering crucial cellular events in the pathophysiology of many human diseases. In the present review, we intend to summarize basic features of the RAGE axis biology as well as its contribution to some relevant human diseases such as metabolic diseases, neurodegenerative, cardiovascular, autoimmune, and chronic airways diseases, and cancer as a result of exposure to AGEs, as well as many other ligands.
    MeSH term(s) Humans ; Receptor for Advanced Glycation End Products/metabolism ; Glycation End Products, Advanced/metabolism ; Inflammation/metabolism ; Signal Transduction ; Neoplasms/metabolism ; Animals ; Cardiovascular Diseases/metabolism ; Neurodegenerative Diseases/metabolism ; Metabolic Diseases/metabolism ; Autoimmune Diseases/metabolism
    Chemical Substances Receptor for Advanced Glycation End Products ; Glycation End Products, Advanced
    Language English
    Publishing date 2024-03-28
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom14040412
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Imperative Authentication of Cell Lines.

    Rojas, Armando

    Antimicrobial agents and chemotherapy

    2017  Volume 61, Issue 11

    MeSH term(s) Cell Line, Tumor
    Language English
    Publishing date 2017-10-24
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.01823-17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Emerging and multifaceted potential contributions of polyphenols in the management of type 2 diabetes mellitus.

    González, Ileana / Lindner, Cristian / Schneider, Ivan / Diaz, Erik / Morales, Miguel Angel / Rojas, Armando

    World journal of diabetes

    2024  Volume 15, Issue 2, Page(s) 154–169

    Abstract: Type 2 diabetes mellitus (T2DM) is recognized as a serious public health concern with a considerable impact on human life, long-term health expenditures, and substantial health losses. In this context, the use of dietary polyphenols to prevent and manage ...

    Abstract Type 2 diabetes mellitus (T2DM) is recognized as a serious public health concern with a considerable impact on human life, long-term health expenditures, and substantial health losses. In this context, the use of dietary polyphenols to prevent and manage T2DM is widely documented. These dietary compounds exert their beneficial effects through several actions, including the protection of pancreatic islet β-cell, the antioxidant capacities of these molecules, their effects on insulin secretion and actions, the regulation of intestinal microbiota, and their contribution to ameliorate diabetic complications, particularly those of vascular origin. In the present review, we intend to highlight these multifaceted actions and the molecular mechanisms by which these plant-derived secondary metabolites exert their beneficial effects on type 2 diabetes patients.
    Language English
    Publishing date 2024-02-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2583471-X
    ISSN 1948-9358
    ISSN 1948-9358
    DOI 10.4239/wjd.v15.i2.154
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Exploring the Interplay between Polyphenols and Lysyl Oxidase Enzymes for Maintaining Extracellular Matrix Homeostasis.

    Añazco, Carolina / Riedelsberger, Janin / Vega-Montoto, Lorenzo / Rojas, Armando

    International journal of molecular sciences

    2023  Volume 24, Issue 13

    Abstract: Collagen, the most abundant structural protein found in mammals, plays a vital role as a constituent of the extracellular matrix (ECM) that surrounds cells. Collagen fibrils are strengthened through the formation of covalent cross-links, which involve ... ...

    Abstract Collagen, the most abundant structural protein found in mammals, plays a vital role as a constituent of the extracellular matrix (ECM) that surrounds cells. Collagen fibrils are strengthened through the formation of covalent cross-links, which involve complex enzymatic and non-enzymatic reactions. Lysyl oxidase (LOX) is responsible for catalyzing the oxidative deamination of lysine and hydroxylysine residues, resulting in the production of aldehydes, allysine, and hydroxyallysine. These intermediates undergo spontaneous condensation reactions, leading to the formation of immature cross-links, which are the initial step in the development of mature covalent cross-links. Additionally, non-enzymatic glycation contributes to the formation of abnormal cross-linking in collagen fibrils. During glycation, specific lysine and arginine residues in collagen are modified by reducing sugars, leading to the creation of Advanced Glycation End-products (AGEs). These AGEs have been associated with changes in the mechanical properties of collagen fibers. Interestingly, various studies have reported that plant polyphenols possess amine oxidase-like activity and can act as potent inhibitors of protein glycation. This review article focuses on compiling the literature describing polyphenols with amine oxidase-like activity and antiglycation properties. Specifically, we explore the molecular mechanisms by which specific flavonoids impact or protect the normal collagen cross-linking process. Furthermore, we discuss how these dual activities can be harnessed to generate properly cross-linked collagen molecules, thereby promoting the stabilization of highly organized collagen fibrils.
    MeSH term(s) Animals ; Protein-Lysine 6-Oxidase/metabolism ; Lysine/metabolism ; Polyphenols/metabolism ; Extracellular Matrix/metabolism ; Collagen/metabolism ; Glycation End Products, Advanced/metabolism ; Homeostasis ; Amines/metabolism ; Mammals/metabolism
    Chemical Substances Protein-Lysine 6-Oxidase (EC 1.4.3.13) ; Lysine (K3Z4F929H6) ; Polyphenols ; Collagen (9007-34-5) ; Glycation End Products, Advanced ; Amines
    Language English
    Publishing date 2023-07-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241310985
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Exploring the Interplay between Polyphenols and Lysyl Oxidase Enzymes for Maintaining Extracellular Matrix Homeostasis

    Carolina Añazco / Janin Riedelsberger / Lorenzo Vega-Montoto / Armando Rojas

    International Journal of Molecular Sciences, Vol 24, Iss 10985, p

    2023  Volume 10985

    Abstract: Collagen, the most abundant structural protein found in mammals, plays a vital role as a constituent of the extracellular matrix (ECM) that surrounds cells. Collagen fibrils are strengthened through the formation of covalent cross-links, which involve ... ...

    Abstract Collagen, the most abundant structural protein found in mammals, plays a vital role as a constituent of the extracellular matrix (ECM) that surrounds cells. Collagen fibrils are strengthened through the formation of covalent cross-links, which involve complex enzymatic and non-enzymatic reactions. Lysyl oxidase (LOX) is responsible for catalyzing the oxidative deamination of lysine and hydroxylysine residues, resulting in the production of aldehydes, allysine, and hydroxyallysine. These intermediates undergo spontaneous condensation reactions, leading to the formation of immature cross-links, which are the initial step in the development of mature covalent cross-links. Additionally, non-enzymatic glycation contributes to the formation of abnormal cross-linking in collagen fibrils. During glycation, specific lysine and arginine residues in collagen are modified by reducing sugars, leading to the creation of Advanced Glycation End-products (AGEs). These AGEs have been associated with changes in the mechanical properties of collagen fibers. Interestingly, various studies have reported that plant polyphenols possess amine oxidase-like activity and can act as potent inhibitors of protein glycation. This review article focuses on compiling the literature describing polyphenols with amine oxidase-like activity and antiglycation properties. Specifically, we explore the molecular mechanisms by which specific flavonoids impact or protect the normal collagen cross-linking process. Furthermore, we discuss how these dual activities can be harnessed to generate properly cross-linked collagen molecules, thereby promoting the stabilization of highly organized collagen fibrils.
    Keywords collagen cross-linking ; extracellular matrix ; fibrosis ; glycation ; lysyl oxidase ; polyphenols ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 571
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Heart and Sports Detraining in Water Polo Athletes

    Armando Marín Rojas / Jorge Luis Abreus Mora

    Revista Finlay, Vol 12, Iss 2, Pp 228-

    2022  Volume 231

    Abstract: The balance of the heart in athletes favors morphological and functional stability that favors cardiovascular function parameters within normal ranges, manifested in adequate values of: systolic and diastolic blood pressure, heart rate, respiratory rate ... ...

    Abstract The balance of the heart in athletes favors morphological and functional stability that favors cardiovascular function parameters within normal ranges, manifested in adequate values of: systolic and diastolic blood pressure, heart rate, respiratory rate and physical fitness for training and daily activities. Due to the biological sacrifices that this implies, retired water polo athletes suffer from cardiovascular morphofunctional adaptations that must be addressed when they accept retirement and move on to sports detraining, which constitutes a prophylactic and therapeutic strategy for the health care of athletes. Early interventions are proposed, with aerobic work schedules, to balance cardiovascular morphofunctional adaptations in retired high-performance athletes.
    Keywords corazón ; anomalías cardiovasculares ; deportes acuáticos ; estrategias de salud ; Internal medicine ; RC31-1245 ; Special situations and conditions ; RC952-1245
    Language Spanish
    Publishing date 2022-03-01T00:00:00Z
    Publisher Universidad de las Ciencias Médicas de Cienfuegos
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: A Tomato-Free Period Delays and Reduces Begomovirus Disease in Processing Tomato Fields in a Complex Agroecosystem in Central Brazil.

    de Macedo, Mônica Alves / Gilbertson, Robert L / Rojas, Maria R / Filho, Armando Bergamin / Pereira, José Luiz / Costa, Thiago Marques / Inoue-Nagata, Alice Kazuko

    Plant disease

    2024  , Page(s) PDIS06231154RE

    Abstract: A mandatory tomato-free period (TFP) was implemented in the state of Goiás, Brazil, in 2007 to help manage diseases caused by whitefly-transmitted begomoviruses. The impact of the TFP was examined in five locations across three states in Central Brazil ... ...

    Abstract A mandatory tomato-free period (TFP) was implemented in the state of Goiás, Brazil, in 2007 to help manage diseases caused by whitefly-transmitted begomoviruses. The impact of the TFP was examined in five locations across three states in Central Brazil from 2013 to 2016. Surveys revealed significant differences in begomovirus disease incidence among locations, i.e., low in Guaíra-TFP and Patos de Minas-TFP; moderate-high in Itaberaí-TFP and Morrinhos-TFP; and high in the non-TFP (NTFP) control, Cristalina-NTFP. PCR tests and DNA sequencing were used to validate the symptoms and showed that all collected symptomatic plant samples were infected with tomato severe rugose virus (ToSRV), a common indigenous bipartite begomovirus. Early season surveys (20 to 40 days after transplants [DAT]) in Itaberaí-TFP and Morrinhos-TFP revealed significantly less begomovirus disease in fields established sooner after the TFP (0 to 2 months) compared with incidences in (i) equivalent early planted fields in the Cristalina-NTFP control and (ii) fields established longer after the end of the TFP (>2 to 5 months). Whitefly infestation of crops was detected year-round in all locations and years, and all tested adults were classified in the
    Language English
    Publishing date 2024-04-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 754182-x
    ISSN 0191-2917
    ISSN 0191-2917
    DOI 10.1094/PDIS-06-23-1154-RE
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Polymorphisms -374 T/A and -429 T/C of the Receptor for Advanced Glycation End-Products (RAGE) and Serum Levels of RAGE (sRAGE) Are Not Associated with Metabolic Syndrome.

    González-Guerrero, Diana Elizabeth / Lazo-de-la-Vega-Monroy, Maria-Luisa / Gómez-Ojeda, Armando / Luévano-Contreras, Claudia / Rojas-Rubio, Armando / Garay-Sevilla, Ma Eugenia

    Metabolites

    2023  Volume 13, Issue 4

    Abstract: RAGE is a multi-ligand transmembrane glycoprotein that promotes biological signals associated with inflammatory responses and degenerative diseases. sRAGE is a soluble variant, proposed as an inhibitor of RAGE activity. -374 T/A and -429 T/C ... ...

    Abstract RAGE is a multi-ligand transmembrane glycoprotein that promotes biological signals associated with inflammatory responses and degenerative diseases. sRAGE is a soluble variant, proposed as an inhibitor of RAGE activity. -374 T/A and -429 T/C polymorphisms of the advanced glycation end products receptor
    Language English
    Publishing date 2023-04-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo13040521
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Distribución espacial de los Genotipos de Echinococcus granulosus sensu lato por hospedero en el continente americano. Revisión sistemática.

    Rojas-Pincheira, Claudio / Manterola, Carlos / García-Méndez, Nayely / Totomoch-Serra, Armando

    Revista medica de Chile

    2023  Volume 150, Issue 7, Page(s) 944–957

    Abstract: Background: Knowledge of the distribution cystic is required for its territorial control.: Aim: To describe the spatial distribution of Echinococcus granulosus sensu lato genotypes by host in the American continent.: Material and methods: A ... ...

    Title translation Spatial distribution of Echinococcus granulosus sensu lato genotypes in the american continent.
    Abstract Background: Knowledge of the distribution cystic is required for its territorial control.
    Aim: To describe the spatial distribution of Echinococcus granulosus sensu lato genotypes by host in the American continent.
    Material and methods: A systematic review of studies from the American continent, related to genotypes of the E. granulosus s.l complex were included, including any host species, without restriction of language or year of publication. Sensitive searches were performed based on sensitive searches from PubMed, EMBASE, ScienceDirect, SCOPUS and WoS; SciELO and BIREME-BVS and Trip Database. MeSH and free terms were used, including articles up to December 2020. Cartography was carried out with the Arc Map 10® program, using a world geodetic system. Result variables sought were genotype, host, geographic location, year of publication, number of samples, genes used for genotyping.
    Results: From 1123 retrieved studies retrieved, 53 met the inclusion and exclusion criteria. The studies analyzed represent 3,397 samples from humans and animals. Thirty six percent of articles were published in the five-year period 2016-2020. Reports were mainly from Argentina (27.9%), Brazil (20.6%) and Chile (13.2%). The most reported genotypes globally were G1-G3 (47.3%), G7 (15.3%), G5 (14.6%) and G6 (13.3%). A predominance of G1-G3 and G6 genotypes was verified in South America, G8 and G10 in North America, and "epidemiological silence" in Central America and the Caribbean.
    Conclusions: Spatial analysis allows defining the relationship of territories and cases with their own characteristics, which can help to plan control interventions.
    MeSH term(s) Animals ; Humans ; Echinococcus granulosus/genetics ; Echinococcosis ; Argentina/epidemiology ; Brazil ; Genotype
    Language Spanish
    Publishing date 2023-10-25
    Publishing country Chile
    Document type Systematic Review ; English Abstract ; Journal Article
    ZDB-ID 732136-3
    ISSN 0717-6163 ; 0034-9887
    ISSN (online) 0717-6163
    ISSN 0034-9887
    DOI 10.4067/s0034-98872022000700944
    Database MEDical Literature Analysis and Retrieval System OnLINE

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