Article ; Online: Ancient genome of the Chinese Emperor Wu of Northern Zhou.
2024 Volume 34, Issue 7, Page(s) 1587–1595.e5
Abstract: Emperor Wu (, Wudi) of the Xianbei-led Northern Zhou dynasty, named Yuwen Yong (, 543-578 CE), was ...
Abstract | Emperor Wu (, Wudi) of the Xianbei-led Northern Zhou dynasty, named Yuwen Yong (, 543-578 CE), was a highly influential emperor who reformed the system of regional troops, pacified the Turks, and unified the northern part of the country. His genetic profile and physical characteristics, including his appearance and potential diseases, have garnered significant interest from the academic community and the public. In this study, we have successfully generated a 0.343×-coverage genome of Wudi with 1,011,419 single-nucleotide polymorphisms (SNPs) on the 1240k panel. By analyzing pigmentation-relevant SNPs and conducting cranial CT-based facial reconstruction, we have determined that Wudi possessed a typical East or Northeast Asian appearance. Furthermore, pathogenic SNPs suggest Wudi faced an increased susceptibility to certain diseases, such as stroke. Wudi shared the closest genetic relationship with ancient Khitan and Heishui Mohe samples and modern Daur and Mongolian populations but also showed additional affinity with Yellow River (YR) farmers. We estimated that Wudi derived 61% of his ancestry from ancient Northeast Asians (ANAs) and nearly one-third from YR farmer-related groups. This can likely be attributed to continuous intermarriage between Xianbei royal families, and local Han aristocrats. |
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MeSH term(s) | Humans ; DNA, Mitochondrial/genetics ; Asian People/genetics ; Genome ; Polymorphism, Single Nucleotide ; China ; Genetics, Population |
Chemical Substances | DNA, Mitochondrial |
Language | English |
Publishing date | 2024-03-28 |
Publishing country | England |
Document type | Journal Article |
ZDB-ID | 1071731-6 |
ISSN | 1879-0445 ; 0960-9822 |
ISSN (online) | 1879-0445 |
ISSN | 0960-9822 |
DOI | 10.1016/j.cub.2024.02.059 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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