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  1. Article ; Online: The association between adverse childhood experiences and metabolic syndrome in severe mental illness: A literature review.

    Balaji, Shoba / Sankaranarayanan, Anoop

    Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists

    2023  Volume 31, Issue 3, Page(s) 381–388

    Abstract: Objective: A history of adverse childhood experiences (ACE) is common among people with severe mental illness (SMI), and they are also associated with physical health problems, including metabolic syndrome (MetS) in general adult populations. We aimed ... ...

    Abstract Objective: A history of adverse childhood experiences (ACE) is common among people with severe mental illness (SMI), and they are also associated with physical health problems, including metabolic syndrome (MetS) in general adult populations. We aimed to evaluate and synthesise the evidence relating to the association between ACE and MetS and/or its components in patients with SMI.
    Methods: We systematically searched multiple databases (MEDLINE, PubMed, PsycINFO, EMBASE, Emcare, Cochrane Library, Health Technology Assessments, Joanna Briggs Institute, and Maternity and Infant Care database) and reviewed studies that described an association between ACE and MetS or its components in SMI adult patients.
    Results: Twenty studies were reviewed. Most studies described a significant association between ACE and at least one to three components of MetS, with obesity being the most studied and, therefore, showing a more consistent association compared to the other MetS components. ACE and the components of MetS did not remain significant, in most of the studies, after adjusting for confounders. None of the studies showed an association with MetS as a whole entity.
    Conclusion: Adults with SMI with a history of ACE are more likely to demonstrate health problems such as MetS and cardiovascular disease-related risk factors.
    MeSH term(s) Adult ; Humans ; Female ; Pregnancy ; Metabolic Syndrome/epidemiology ; Adverse Childhood Experiences ; Mental Disorders/epidemiology ; Mental Disorders/complications ; Obesity/complications ; Mentally Ill Persons
    Language English
    Publishing date 2023-04-08
    Publishing country England
    Document type Systematic Review ; Journal Article
    ZDB-ID 2213198-X
    ISSN 1440-1665 ; 1039-8562
    ISSN (online) 1440-1665
    ISSN 1039-8562
    DOI 10.1177/10398562231167782
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Chitosan-based nano-formulation enhances the anticancer efficacy of hesperetin.

    Mary Lazer, Lizha / Sadhasivam, Balaji / Palaniyandi, Kanagaraj / Muthuswamy, Thangavel / Ramachandran, Ilangovan / Balakrishnan, Anandan / Pathak, Surajit / Narayan, Shoba / Ramalingam, Satish

    International journal of biological macromolecules

    2018  Volume 107, Issue Pt B, Page(s) 1988–1998

    Abstract: Cancer is one of the major causes of increased morbidity and mortality in modern society. Colorectal cancer is the third leading cause for cancer related death worldwide. Current chemotherapeutics are not very effective and have severe side effects. ... ...

    Abstract Cancer is one of the major causes of increased morbidity and mortality in modern society. Colorectal cancer is the third leading cause for cancer related death worldwide. Current chemotherapeutics are not very effective and have severe side effects. Hesperetin is a bioflavonoid from citrus fruits and its clinical use is restricted because of the poor water solubility. Folate receptor is overexpressed in various cancer cells. Therefore, we synthesized the chitosan folate hesperetin nanoparticle (CFH) by covalently conjugating folic acid with chitosan molecules. The size of the CFH nanoparticles is around 450nm, which is advantageous for passively targeting the cancer cell specifically due to the leaky vasculature of the tumour. Particle surface and size were observed using SEM and TEM studies. The results show that hesperetin has an IC50 value of 190μM and it induces apoptosis in HCT15 cells, however, CFH is very potent in inhibiting the proliferation with the IC50 value of 28μM. In addition, CFH inhibited colony formation and induced apoptosis by regulating the expression of proapoptotic genes expression. Therefore, the chitosan - folic acid conjugation appears to be the suitable carrier for colorectal cancer cell-specific delivery of hesperetin.
    MeSH term(s) Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Apoptosis/genetics ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Cell Survival/drug effects ; Cell Survival/genetics ; Chitosan/chemistry ; Drug Delivery Systems ; Drug Liberation ; Gene Expression Regulation, Neoplastic/drug effects ; Hesperidin/chemistry ; Hesperidin/pharmacology ; Humans ; Nanoparticles/chemistry ; Particle Size ; Powders ; Spectroscopy, Fourier Transform Infrared ; Static Electricity ; X-Ray Diffraction
    Chemical Substances Antineoplastic Agents ; Powders ; Chitosan (9012-76-4) ; Hesperidin (E750O06Y6O) ; hesperetin (Q9Q3D557F1)
    Language English
    Publishing date 2018-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2017.10.064
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Chitosan-Based Nano-Formulation Enhanced the Anticancer Efficacy of Hesperetin

    Mary, Lizha / Anandhan Balakrishnan / Balaji Sadhasivam / Ilangovan Ramachandran / Kanagaraj Palaniyandi / Satish Ramalingam / Shoba Narayan / Surajit Pathak / Thangavel Muthuswamy

    International journal of biological macromolecules. 2017,

    2017  

    Abstract: Cancer is one of the major causes of increased morbidity and mortality in modern society. Colorectal cancer is the third leading cause for cancer related death worldwide. Current chemotherapeutics are not very effective and have severe side effects. ... ...

    Abstract Cancer is one of the major causes of increased morbidity and mortality in modern society. Colorectal cancer is the third leading cause for cancer related death worldwide. Current chemotherapeutics are not very effective and have severe side effects. Hesperetin is a bioflavonoid from citrus fruits and its clinical use is restricted because of the poor water solubility. Folate receptor is over expressed in various cancer cells. In this regard, we have synthesized the Chitosan Folate Hesperetin nanoparticle (CFH) by covalently conjugating folic acid with chitosan molecules. The size of the CFH nanoparticles is around 450nm, which is advantageous for passively targeting the cancer cell specifically due to the leaky vasculature of the tumour. Particle surface and size were observed using SEM and TEM studies. The results show that Hesperetin has an IC50 value of 190μM and it induces apoptosis in HCT15 cells, however, CFH is very potent in inhibiting the proliferation with the IC50 value of 28μM. In addition, CFH inhibited colony formation and induced apoptosis by regulating the expression of proapoptotic genes expression. Therefore, the chitosan − folic acid conjugation appears to be the suitable carrier for colorectal cancer cell-specific delivery of Hesperetin.
    Keywords adverse effects ; apoptosis ; chemical bonding ; chitosan ; citrus fruits ; colorectal neoplasms ; death ; folate receptors ; folic acid ; hesperetin ; inhibitory concentration 50 ; morbidity ; mortality ; nanoparticles ; neoplasm cells ; scanning electron microscopy ; transmission electron microscopy ; water solubility
    Language English
    Size p. .
    Publishing place Elsevier B.V.
    Document type Article
    Note Pre-press version
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2017.10.064
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: Chitosan-based nano-formulation enhances the anticancer efficacy of hesperetin

    Mary Lazer, Lizha / Anandan Balakrishnan / Balaji Sadhasivam / Ilangovan Ramachandran / Kanagaraj Palaniyandi / Satish Ramalingam / Shoba Narayan / Surajit Pathak / Thangavel Muthuswamy

    International journal of biological macromolecules. 2018 Feb., v. 107

    2018  

    Abstract: Cancer is one of the major causes of increased morbidity and mortality in modern society. Colorectal cancer is the third leading cause for cancer related death worldwide. Current chemotherapeutics are not very effective and have severe side effects. ... ...

    Abstract Cancer is one of the major causes of increased morbidity and mortality in modern society. Colorectal cancer is the third leading cause for cancer related death worldwide. Current chemotherapeutics are not very effective and have severe side effects. Hesperetin is a bioflavonoid from citrus fruits and its clinical use is restricted because of the poor water solubility. Folate receptor is overexpressed in various cancer cells. Therefore, we synthesized the chitosan folate hesperetin nanoparticle (CFH) by covalently conjugating folic acid with chitosan molecules. The size of the CFH nanoparticles is around 450nm, which is advantageous for passively targeting the cancer cell specifically due to the leaky vasculature of the tumour. Particle surface and size were observed using SEM and TEM studies. The results show that hesperetin has an IC50 value of 190μM and it induces apoptosis in HCT15 cells, however, CFH is very potent in inhibiting the proliferation with the IC50 value of 28μM. In addition, CFH inhibited colony formation and induced apoptosis by regulating the expression of proapoptotic genes expression. Therefore, the chitosan − folic acid conjugation appears to be the suitable carrier for colorectal cancer cell-specific delivery of hesperetin.
    Keywords adverse effects ; apoptosis ; chemical bonding ; chitosan ; citrus fruits ; colorectal neoplasms ; drug therapy ; folate receptors ; folic acid ; hesperetin ; inhibitory concentration 50 ; morbidity ; mortality ; nanoparticles ; neoplasm cells ; scanning electron microscopy ; transmission electron microscopy ; water solubility
    Language English
    Dates of publication 2018-02
    Size p. 1988-1998.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2017.10.064
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

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  5. Article: Toxigenicity testing of clinical isolates of non-typhoidal salmonellae in Vero cell culture & Caenorhabditis elegans model.

    Jesudason, Mary V / V Balaji, V / Densibai, Shoba

    The Indian journal of medical research

    2006  Volume 123, Issue 6, Page(s) 821–824

    Abstract: The non-typhoidal salmonellae (NTS) are recognized agents of gastroenteritis worldwide. Some of the NTS do not produces cytotoxic changes in tissue culture and not much is known about the endotoxicity of the clinical isolates of NTS (mostly Salmonella ... ...

    Abstract The non-typhoidal salmonellae (NTS) are recognized agents of gastroenteritis worldwide. Some of the NTS do not produces cytotoxic changes in tissue culture and not much is known about the endotoxicity of the clinical isolates of NTS (mostly Salmonella enterica serotype Typhimurium and Salmonella enterica serotype Enteritidis). We examined the exotoxic (cytotoxin) and endotoxic activity of clinical isolates of NTS in two assay models namely Vero cell culture and the nematode, Caenorhabditis elegans. Bacteria-free culture supernatants of 40 isolates NTS were tested in 96 well microtitre plate containing confluent monolayers of Vero cells. For the effects on C. elegans, the worms were exposed to bacteria free culture supernatants in 24 well microtitre plate for 24 h and then transferred to OP50 Escherichia coli lawn culture. The endotoxic activity of the live bacterium was studied by feeding the worms in the lawn culture of NTS separately. No cytopathic effect was observed with NTS tested in Vero cell culture assay. Likewise, the worms exposed to the bacteria-free culture supernatants were found active up to 7 days. In the co-culture killing assay, worms were found dead with characteristic stiff and straight appearance by 16(th) day. The worms were alive up to 21 days in OP50 E. coli. Bacteria-free culture supernatants did not have any deleterious effect on worms or in Vero cell culture, suggesting that there is no soluble toxic factor (diffusible toxin) in the culture supernatants. However, live NTS were found to be lethal to the worms; indicating that direct interaction between viable NTS and C. elegans is necessary for killing.
    MeSH term(s) Animals ; Bacterial Toxins/toxicity ; Caenorhabditis elegans/drug effects ; Caenorhabditis elegans/microbiology ; Cercopithecus aethiops ; Endotoxins/toxicity ; Salmonella typhimurium/chemistry ; Salmonella typhimurium/pathogenicity ; Survival Analysis ; Toxicity Tests ; Vero Cells
    Chemical Substances Bacterial Toxins ; Endotoxins ; salmonella toxin
    Language English
    Publishing date 2006-06
    Publishing country India
    Document type Comparative Study ; Journal Article
    ZDB-ID 390883-5
    ISSN 0971-5916 ; 0019-5340
    ISSN 0971-5916 ; 0019-5340
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.143: Show issues Location:
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  6. Article ; Online: Function of sirtuins in biological tissues.

    Shoba, Balaji / Lwin, Zin Mar / Ling, Lo Soo / Bay, Boon-Huat / Yip, George W / Kumar, Srinivasan Dinesh

    Anatomical record (Hoboken, N.J. : 2007)

    2009  Volume 292, Issue 4, Page(s) 536–543

    Abstract: Sirtuins are protein deacetylases, which are dependent on nicotine adenine dinucleotide. They are phylogenetically conserved from bacteria to humans. Seven sirtuin proteins localized in a wide variety of subcellular locations have been identified in the ... ...

    Abstract Sirtuins are protein deacetylases, which are dependent on nicotine adenine dinucleotide. They are phylogenetically conserved from bacteria to humans. Seven sirtuin proteins localized in a wide variety of subcellular locations have been identified in the human genome. The most important known function of sirtuins is their regulation of transcriptional repression, mediated through binding of a complex containing sirtuins and other proteins. Studies have shown that sirtuins have pathophysiological relevance to neurodegeneration, muscle differentiation, inflammation, obesity, and cancer. In addition, sirtuin activity extends the lifespan of several organisms. In this review, we discuss the mode(s) of action of sirtuins, and their biological role(s) in health and disease.
    MeSH term(s) Acetylation ; Animals ; Cell Nucleus/genetics ; Cell Nucleus/metabolism ; Cell Nucleus/ultrastructure ; Histone Deacetylases/genetics ; Histone Deacetylases/metabolism ; Humans ; Isoenzymes/genetics ; Isoenzymes/metabolism ; Mitochondria/genetics ; Mitochondria/metabolism ; Mitochondria/ultrastructure ; NAD/metabolism ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Protein Transport/physiology ; Sirtuins/genetics ; Sirtuins/metabolism
    Chemical Substances Isoenzymes ; Nuclear Proteins ; NAD (0U46U6E8UK) ; Sirtuins (EC 3.5.1.-) ; Histone Deacetylases (EC 3.5.1.98)
    Language English
    Publishing date 2009-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2269667-2
    ISSN 1932-8494 ; 1932-8486
    ISSN (online) 1932-8494
    ISSN 1932-8486
    DOI 10.1002/ar.20875
    Database MEDical Literature Analysis and Retrieval System OnLINE

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