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  1. Book ; Online ; Thesis: Carbon nanomaterials as antibacterial and antiviral alternatives

    Łoczechin, Aleksandra [Verfasser] / Metzler-Nolte, Nils [Gutachter] / Rosenhahn, Axel [Gutachter] / Szunerits, Sabine [Gutachter]

    2023  

    Author's details Aleksandra Łoczechin ; Gutachter: Nils Metzler-Nolte, Axel Rosenhahn, Sabine Szunerits ; Fakultät für Chemie und Biochemie
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Ruhr-Universität Bochum
    Publishing place Bochum
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  2. Article ; Online: Correction to "Functional Carbon Quantum Dots as Medical Countermeasures to Human Coronavirus".

    Łoczechin, Aleksandra / Séron, Karin / Barras, Alexandre / Giovanelli, Emerson / Belouzard, Sandrine / Chen, Yen-Ting / Metzler-Nolte, Nils / Boukherroub, Rabah / Dubuisson, Jean / Szunerits, Sabine

    ACS applied materials & interfaces

    2023  Volume 16, Issue 1, Page(s) 1950–1952

    Language English
    Publishing date 2023-12-27
    Publishing country United States
    Document type Published Erratum
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c15036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Functional Carbon Quantum Dots as Medical Countermeasures to Human Coronavirus

    Łoczechin, Aleksandra / Séron, Karin / Barras, Alexandre / Giovanelli, Emerson / Belouzard, Sandrine / Chen, Yen-Ting / Metzler-Nolte, Nils / Boukherroub, Rabah / Dubuisson, Jean / Szunerits, Sabine

    ACS applied materials & interfaces. 2019 Oct. 21, v. 11, no. 46

    2019  

    Abstract: Therapeutic options for the highly pathogenic human coronavirus (HCoV) infections are urgently needed. Anticoronavirus therapy is however challenging, as coronaviruses are biologically diverse and rapidly mutating. In this work, the antiviral activity of ...

    Abstract Therapeutic options for the highly pathogenic human coronavirus (HCoV) infections are urgently needed. Anticoronavirus therapy is however challenging, as coronaviruses are biologically diverse and rapidly mutating. In this work, the antiviral activity of seven different carbon quantum dots (CQDs) for the treatment of human coronavirus HCoV-229E infections was investigated. The first generation of antiviral CQDs was derived from hydrothermal carbonization of ethylenediamine/citric acid as carbon precursors and postmodified with boronic acid ligands. These nanostructures showed a concentration-dependent virus inactivation with an estimated EC50 of 52 ± 8 μg mL–1. CQDs derived from 4-aminophenylboronic acid without any further modification resulted in the second-generation of anti-HCoV nanomaterials with an EC50 lowered to 5.2 ± 0.7 μg mL–1. The underlying mechanism of action of these CQDs was revealed to be inhibition of HCoV-229E entry that could be due to interaction of the functional groups of the CQDs with HCoV-229E entry receptors; surprisingly, an equally large inhibition activity was observed at the viral replication step.
    Keywords Coronavirinae ; animal viruses ; antiviral properties ; boronic acids ; carbon quantum dots ; citric acid ; ethylenediamines ; hydrothermal carbonization ; ligands ; mechanism of action ; median effective concentration ; moieties ; receptors ; therapeutics ; virus replication ; viruses ; covid19
    Language English
    Dates of publication 2019-1021
    Size p. 42964-42974.
    Publishing place American Chemical Society
    Document type Article
    ISSN 1944-8252
    DOI 10.1021/acsami.9b15032
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Functional Carbon Quantum Dots as Medical Countermeasures to Human Coronavirus.

    Łoczechin, Aleksandra / Séron, Karin / Barras, Alexandre / Giovanelli, Emerson / Belouzard, Sandrine / Chen, Yen-Ting / Metzler-Nolte, Nils / Boukherroub, Rabah / Dubuisson, Jean / Szunerits, Sabine

    ACS applied materials & interfaces

    2019  Volume 11, Issue 46, Page(s) 42964–42974

    Abstract: Therapeutic options for the highly pathogenic human coronavirus (HCoV) infections are urgently needed. Anticoronavirus therapy is however challenging, as coronaviruses are biologically diverse and rapidly mutating. In this work, the antiviral activity of ...

    Abstract Therapeutic options for the highly pathogenic human coronavirus (HCoV) infections are urgently needed. Anticoronavirus therapy is however challenging, as coronaviruses are biologically diverse and rapidly mutating. In this work, the antiviral activity of seven different carbon quantum dots (CQDs) for the treatment of human coronavirus HCoV-229E infections was investigated. The first generation of antiviral CQDs was derived from hydrothermal carbonization of ethylenediamine/citric acid as carbon precursors and postmodified with boronic acid ligands. These nanostructures showed a concentration-dependent virus inactivation with an estimated EC
    MeSH term(s) Antiviral Agents/pharmacology ; Carbon/chemistry ; Carbon/pharmacology ; Cell Line, Tumor ; Coronavirus 229E, Human/physiology ; Coronavirus Infections/drug therapy ; Coronavirus Infections/metabolism ; Coronavirus Infections/pathology ; Humans ; Quantum Dots/chemistry ; Quantum Dots/therapeutic use ; Virus Replication/drug effects
    Chemical Substances Antiviral Agents ; Carbon (7440-44-0)
    Keywords covid19
    Language English
    Publishing date 2019-11-06
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.9b15032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Photothermally Active Cryogel Devices for Effective Release of Antimicrobial Peptides: On-Demand Treatment of Infections.

    Chambre, Laura / Rosselle, Léa / Barras, Alexandre / Aydin, Duygu / Loczechin, Aleksandra / Gunbay, Suzan / Sanyal, Rana / Skandrani, Nadia / Metzler-Nolte, Nils / Bandow, Julia Elisabeth / Boukherroub, Rabah / Szunerits, Sabine / Sanyal, Amitav

    ACS applied materials & interfaces

    2020  Volume 12, Issue 51, Page(s) 56805–56814

    Abstract: There has been significant interest in the use of peptides as antimicrobial agents, and peptide containing hydrogels have been proposed as biological scaffolds for various applications. Limited stability and rapid clearance of small molecular weight ... ...

    Abstract There has been significant interest in the use of peptides as antimicrobial agents, and peptide containing hydrogels have been proposed as biological scaffolds for various applications. Limited stability and rapid clearance of small molecular weight peptides pose challenges to their widespread implementation. As a common approach, antibacterial peptides are physically loaded into hydrogel scaffolds, which leads to continuous release through the passive mode with spatial control but provides limited control over drug dosage. Although utilization of peptide covalent linkage onto hydrogels addresses partially this problem, the peptide release is commonly too slow. To alleviate these challenges, in this work, maleimide-modified antimicrobial peptides are covalently conjugated onto furan-based cryogel (CG) scaffolds
    MeSH term(s) Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Antimicrobial Cationic Peptides/chemistry ; Antimicrobial Cationic Peptides/pharmacology ; Cryogels/chemical synthesis ; Cryogels/chemistry ; Cryogels/radiation effects ; Cycloaddition Reaction ; Drug Liberation ; Escherichia coli/drug effects ; Furans/chemical synthesis ; Furans/chemistry ; Furans/radiation effects ; HeLa Cells ; Heating ; Humans ; Infrared Rays ; Methacrylates/chemical synthesis ; Methacrylates/chemistry ; Methacrylates/radiation effects ; Microbial Sensitivity Tests ; Polyethylene Glycols/chemical synthesis ; Polyethylene Glycols/chemistry ; Polyethylene Glycols/radiation effects ; Staphylococcal Infections/drug therapy ; Staphylococcus aureus/drug effects
    Chemical Substances Anti-Bacterial Agents ; Antimicrobial Cationic Peptides ; Cryogels ; Furans ; Methacrylates ; polyethylene glycol methacrylate ; Polyethylene Glycols (3WJQ0SDW1A)
    Language English
    Publishing date 2020-12-08
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.0c17633
    Database MEDical Literature Analysis and Retrieval System OnLINE

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