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Article ; Online: Synaptojanin 1 Modulates Functional Recovery After Incomplete Spinal Cord Injury in Male Apolipoprotein E Epsilon 4 Mice.

Toro, Carlos A / Hansen, Jens / Siddiq, Mustafa M / Johnson, Kaitlin / Cao, Jiqing / Pero, Adriana / Iyengar, Ravi / Cai, Dongming / Cardozo, Christopher P

Neurotrauma reports

2023 Volume 4, Issue 1, Page(s) 464–477

Abstract: Apolipoprotein E epsilon 4 (ApoE4) is the second most common variant of ApoE, being present in ∼14% of the population. Clinical reports identify ApoE4 as a genetic risk factor for poor outcomes after traumatic spinal cord injury (SCI) and spinal cord ... ...

Abstract	Apolipoprotein E epsilon 4 (ApoE4) is the second most common variant of ApoE, being present in ∼14% of the population. Clinical reports identify ApoE4 as a genetic risk factor for poor outcomes after traumatic spinal cord injury (SCI) and spinal cord diseases such as cervical myelopathy. To date, there is no intervention to promote recovery of function after SCI/spinal cord diseases that is specifically targeted at ApoE4-associated impairment. Studies in the human and mouse brain link ApoE4 to elevated levels of synaptojanin 1 (synj1), a lipid phosphatase that degrades phosphoinositol 4,5-bisphosphate (PIP
Language	English
Publishing date	2023-07-27
Publishing country	United States
Document type	Journal Article
ISSN	2689-288X
ISSN (online)	2689-288X
DOI	10.1089/neur.2023.0023
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: First-World Care at Third-World Rates: Pakistan, an Attractive Destination for Bariatric Tourism.

Bashir, Umar / Siddiq, Ghulam / Saleem, Nitasha / Farooq, Humza / Awais, Muhammad / Ussama, Muhammad / Iqbal, Hania / Shabbir, Hassan / Rafiq, Talha / Banoori, Mustafa

Cureus

2023 Volume 15, Issue 11, Page(s) e48572

Abstract: ... greater than 30 kg/m². When the BMI exceeds 40 kg/m², it is classified as morbid obesity. This condition ...

Abstract	Introduction Obesity, a complex and multifactorial disease, is defined by a body mass index (BMI) greater than 30 kg/m². When the BMI exceeds 40 kg/m², it is classified as morbid obesity. This condition leads to excessive fat accumulation, which impairs normal body function and metabolism. For individuals grappling with morbid obesity and those who have faced significant hurdles in their quest for substantial weight loss, bariatric surgery emerges as a vital option. Purpose The study aims to explore the dynamics of bariatric surgical tourism in Pakistan, shedding light on factors influencing the choice of Pakistan as a destination for bariatric tourism. Materials and methods A retrospective cross-sectional study design was adopted. Data were gathered from the medical records database, including all patients who had undergone bariatric surgery from 2018 until 2022. The data collection process involved comprehensive patient outreach, where investigators conducted phone interviews and collected patient satisfaction assessments. During these phone interviews, valuable information was gathered by posing questions. These inquiries encompassed various aspects, including the patient's overall satisfaction with the surgical experience, their countries of origin, the specific bariatric procedures they underwent, the motivating factors behind their decision to travel abroad for surgery, their postoperative follow-up routines, and any complications they may have encountered. Results One hundred and nine patients traveled to Pakistan for bariatric surgery from 2018 to 2022. Out of 109 patients, 78 responded to the questionnaire by phone or email. The proforma was filled by 41 (52.5%) males and 37 (47.5%) females. Forty-seven (60.2%) of these patients underwent Roux-en-Y gastric bypass and 31 (39.8%) patients underwent sleeve gastrectomy. Out of 78 bariatric patients, 72 (92.3%) were satisfied with their surgery, five patients (6.4%) were neutral in their response and one patient (1.3%) was dissatisfied with the surgery. Most of the patients (26, 33.3%) declared money as the main driving force for traveling, with long waiting times being the close second reason (19, 24.36%) patients. Conclusion At least 2% of worldwide bariatric procedures are provided for medical tourists. Countries such as Mexico, India, Lebanon, and Romania dominate as providers for patients mainly from the USA, UK, and Germany. The lack of affordable bariatric healthcare and long waiting lists are some of the reasons for patients choosing bariatric tourism. The 92.3% satisfaction rate of patients with the surgery and its outcomes is a significant finding, as it suggests that bariatric surgery services provided in Pakistan are meeting or exceeding the expectations of international patients. The exceptionally high level of patient satisfaction speaks to the quality of care provided by the medical institutions in Pakistan. The data and analysis presented in this study shed light on the motivations and experiences of international patients traveling to Pakistan for bariatric surgery. These insights are invaluable for healthcare providers, policymakers, and the medical tourism industry as they seek to enhance the accessibility, affordability, and quality of healthcare services for domestic and international patients.
Language	English
Publishing date	2023-11-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.48572
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Boldine modulates glial transcription and functional recovery in a murine model of contusion spinal cord injury.

Toro, Carlos A / Johnson, Kaitlin / Hansen, Jens / Siddiq, Mustafa M / Vásquez, Walter / Zhao, Wei / Graham, Zachary A / Sáez, Juan C / Iyengar, Ravi / Cardozo, Christopher P

bioRxiv : the preprint server for biology

2023

Abstract: Membrane channels such as connexins (Cx), pannexins (Panx) and ... ...

Abstract	Membrane channels such as connexins (Cx), pannexins (Panx) and P2X
Language	English
Publishing date	2023-02-15
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.02.15.528337
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Article: Boldine modulates glial transcription and functional recovery in a murine model of contusion spinal cord injury.

Toro, Carlos A / Johnson, Kaitlin / Hansen, Jens / Siddiq, Mustafa M / Vásquez, Walter / Zhao, Wei / Graham, Zachary A / Sáez, Juan C / Iyengar, Ravi / Cardozo, Christopher P

Frontiers in cellular neuroscience

2023 Volume 17, Page(s) 1163436

Abstract: Membrane channels such as those formed by connexins (Cx) and ... ...

Abstract	Membrane channels such as those formed by connexins (Cx) and P2X
Language	English
Publishing date	2023-06-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2452963-1
ISSN	1662-5102
ISSN	1662-5102
DOI	10.3389/fncel.2023.1163436
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Article: Macrophage activation syndrome in a Sudanese child: a case report from Sudan.

Yahia Elhassan, Maha Abdalla / Hussain Idres, Roua Mohammedali / Mohamed Elhassan, Baraa Mohamed Salaheldin / Banaga Siddiq, Naema Siddiq / Osman Mohammed, Rayan Abdelwahab / Mahmmoud Fadelallah Eljack, Mohammed / Mustafa, Ghassan E / Hemmeda, Lina / Abbasher Hussien Mohamed Ahmed, Khabab

Annals of medicine and surgery (2012)

2024 Volume 86, Issue 5, Page(s) 3047–3051

Abstract: Introduction and importance: Macrophage activation syndrome (MAS) is a severe form of hemophagocytic lymphohistiocytosis that is frequently associated with either a flare-up of rheumatologic diseases, or infection and is characterized by intermittent ... ...

Abstract	Introduction and importance: Macrophage activation syndrome (MAS) is a severe form of hemophagocytic lymphohistiocytosis that is frequently associated with either a flare-up of rheumatologic diseases, or infection and is characterized by intermittent fever, organomegaly, and multisystem dysfunction. Early diagnosis and treatment are crucial for outcome improvement. Case presentation: The authors present a 9-year-old male with systemic onset juvenile idiopathic arthritis who presented with fever, vomiting, and nose bleeding, as well as being jaundiced, and having hepatomegaly and ascites. Pancytopenia, hepatic dysfunction, and elevated ferritin levels were discovered, along with negative virological and immunological tests. He was given broad-spectrum antibiotics, and a high-dose steroid showed a good response, and he was discharged about a week later. Clinical discussion: It is hypothesized that decreased natural killer cells' function could lead to the inability to clear the infection, and subsequent lymphocytes-induced macrophages activation. Despite being beneficial in this case, steroids led to no improvement in other similar cases. Conclusion: MAS is a real life-threatening complication for patients with systemic Juvenile idiopathic arthritis (sJIA), and early diagnosis and prompt initial treatment can both offer a favourable result against such syndrome.
Language	English
Publishing date	2024-03-06
Publishing country	England
Document type	Case Reports
ZDB-ID	2745440-X
ISSN	2049-0801
ISSN	2049-0801
DOI	10.1097/MS9.0000000000001900
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Article: Muscle-restricted Nox4 knockout partially corrects muscle contractility following spinal cord injury in mice.

Toro, Carlos A / De Gasperi, Rita / Aslan, Abdurrahman / Johnson, Nicholas / Siddiq, Mustafa M / Chow, Christine / Zhao, Wei / Harlow, Lauren / Graham, Zachary / Liu, Xin-Hua / Sadoshima, Junichi / Iyengar, Ravi / Cardozo, Christopher P

bioRxiv : the preprint server for biology

2023

Abstract: Spinal cord injury (SCI) results in severe atrophy of skeletal muscle in paralyzed regions, and a decrease in the force generated by muscle per unit of cross-sectional area. Oxidation of skeletal muscle ryanodine 1 receptors (RyR1) reduces contractile ... ...

Abstract	Spinal cord injury (SCI) results in severe atrophy of skeletal muscle in paralyzed regions, and a decrease in the force generated by muscle per unit of cross-sectional area. Oxidation of skeletal muscle ryanodine 1 receptors (RyR1) reduces contractile force due to reduced binding of calstabin 1 to RyR1 together with altered gating of RyR1. One cause of RyR1 oxidation is NADPH oxidase 4 (Nox4). We have previously shown that in rats, RyR1 was oxidized and bound less calstabin 1 at 56 days after spinal cord injury (SCI) by transection. Here, we used a conditional knock-out mouse model of Nox4 in muscle to investigate the role of Nox4 in reduced muscle specific force after SCI. Peak twitch force in control mice after SCI was reduced by 42% compared to sham-operated controls but was increased by approximately 43% in SCI Nox4 conditional KO mice compared to SCI controls although it remained less than that for sham-operated controls. Unlike what observed in rats, after SCI the expression of Nox4 was not increased in gastrocnemius muscle and binding of calstabin 1 to RyR1 was not reduced in this muscle. The results suggest a link between Nox4 expression in muscle tissue and reduction in muscle twitch force, however further studies are needed to understand the mechanistic basis for this linkage.
Language	English
Publishing date	2023-08-04
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.08.04.551985
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Looking downstream: the role of cyclic AMP-regulated genes in axonal regeneration.

Siddiq, Mustafa M / Hannila, Sari S

Frontiers in molecular neuroscience

2015 Volume 8, Page(s) 26

Abstract: Elevation of intracellular cyclic AMP (cAMP) levels has proven to be one of the most effective means of overcoming inhibition of axonal regeneration by myelin-associated inhibitors such as myelin-associated glycoprotein (MAG), Nogo, and oligodendrocyte ... ...

Abstract	Elevation of intracellular cyclic AMP (cAMP) levels has proven to be one of the most effective means of overcoming inhibition of axonal regeneration by myelin-associated inhibitors such as myelin-associated glycoprotein (MAG), Nogo, and oligodendrocyte myelin glycoprotein. Pharmacological manipulation of cAMP through the administration of dibutyryl cAMP or rolipram leads to enhanced axonal growth both in vivo and in vitro, and importantly, upregulation of cAMP within dorsal root ganglion neurons is responsible for the conditioning lesion effect, which indicates that cAMP plays a significant role in the endogenous mechanisms that promote axonal regeneration. The effects of cAMP are transcription-dependent and are mediated through the activation of protein kinase A (PKA) and the transcription factor cyclic AMP response element binding protein (CREB). This leads to the induction of a variety of genes, several of which have been shown to overcome myelin-mediated inhibition in their own right. In this review, we will highlight the pro-regenerative effects of arginase I (ArgI), interleukin (IL)-6, secretory leukocyte protease inhibitor (SLPI), and metallothionein (MT)-I/II, and discuss their potential for therapeutic use in spinal cord injury.
Language	English
Publishing date	2015-06-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2452967-9
ISSN	1662-5099
ISSN	1662-5099
DOI	10.3389/fnmol.2015.00026
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Article: Postpartum Depression: Role of Therapy and Associated Stigmas in Developing Countries.

Edhi, Maliha / Abid, Mishal / Khemane, Zoya / Asif, Maham / Mustafa, Muhammad Saqlain / Rangwala, Hussain Sohail / Siddiq, Mohammad Arham

Annals of neurosciences

2023 Volume 31, Issue 1, Page(s) 10–11

Language	English
Publishing date	2023-10-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2576191-2
ISSN	0976-3260 ; 0972-7531
ISSN (online)	0976-3260
ISSN	0972-7531
DOI	10.1177/09727531231203453
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Article ; Online: Trapped temporal horn: From theory to practice, a systematic review of current understanding and future perspectives.

Ashir Shafique, Muhammad / Saqlain Mustafa, Muhammad / Haseeb, Abdul / Mussarat, Abdullah / Arham Siddiq, Muhammad / Faheem Iqbal, Muhammad / Iqbal, Javed / Kuruba, Venkataramana / Patel, Tirath

World neurosurgery: X

2024 Volume 23, Page(s) 100345

Abstract: Background: The Entrapped Temporal Horn (ETH) is characterized by localized enlargement of the temporal horn of the lateral ventricle of the brain. This study aimed to investigate the factors, development, prognosis, and effective treatment.: Methods!# ...

Abstract	Background: The Entrapped Temporal Horn (ETH) is characterized by localized enlargement of the temporal horn of the lateral ventricle of the brain. This study aimed to investigate the factors, development, prognosis, and effective treatment. Methods: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines, a systematic search was conducted in major research databases. The inclusion criteria included patients of all ages with TTH diagnosis in cohort studies, case series, and case reports. Results: Our study included 160 patients and 49 studies. The major causes of TTH were neoplastic lesions (42.3%), infections (22.3%), and cystic disease (13.08%). Of these cases, 71 were unrelated to cranial surgery, while 89 were unrelated to prior surgeries. Headache was the most common symptom (41.91%), followed by seizures (13.20%), drowsiness (12.50%) and memory loss (11.00%). Surgery was not required in 17 patients. Fenestration of the trapped temporal horn was performed in 24 patients, while VP/VA shunt surgeries were performed in the majority (57 patients) owing to favorable outcomes, lower revision rates, and extensive experience. However, TTH recurred in six of the 21 patients who underwent endoscopic ventriculocisternostomy. Tumors were the main cause, and isolated headache was the most frequent symptom. Ventriculoperitoneal shunts (VPS) are preferred because of their positive outcomes, lower revision rates, and wider expertise. Tumors near the trigonal area pose a higher risk. Conclusion: Although TTH remains a rare condition, VPS continues to be the most widely preferred procedure among surgeons.
Language	English
Publishing date	2024-03-07
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2590-1397
ISSN (online)	2590-1397
DOI	10.1016/j.wnsx.2024.100345
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Article: A spatially specified systems pharmacology therapy for axonal recovery after injury.

Siddiq, Mustafa M / Johnson, Nicholas P / Zorina, Yana / Yadaw, Arjun Singh / Toro, Carlos A / Hansen, Jens / Rabinovich, Vera / Gregorich, Sarah M / Xiong, Yuguang / Tolentino, Rosa E / Hannila, Sari S / Kaplan, Ehud / Blitzer, Robert D / Filbin, Marie T / Cardozo, Christopher P / Passaglia, Christopher L / Iyengar, Ravi

Frontiers in pharmacology

2023 Volume 14, Page(s) 1225759

Abstract: There are no known drugs or drug combinations that promote substantial central nervous system axonal regeneration after injury. We used systems pharmacology approaches to model pathways underlying axonal growth and identify a four-drug combination that ... ...

Abstract	There are no known drugs or drug combinations that promote substantial central nervous system axonal regeneration after injury. We used systems pharmacology approaches to model pathways underlying axonal growth and identify a four-drug combination that regulates multiple subcellular processes in the cell body and axons using the optic nerve crush model in rats. We intravitreally injected agonists HU-210 (cannabinoid receptor-1) and IL-6 (interleukin 6 receptor) to stimulate retinal ganglion cells for axonal growth. We applied, in gel foam at the site of nerve injury, Taxol to stabilize growing microtubules, and activated protein C to clear the debris field since computational models predicted that this drug combination regulating two subcellular processes at the growth cone produces synergistic growth. Physiologically, drug treatment restored or preserved pattern electroretinograms and some of the animals had detectable visual evoked potentials in the brain and behavioral optokinetic responses. Morphology experiments show that the four-drug combination protects axons or promotes axonal regrowth to the optic chiasm and beyond. We conclude that spatially targeted drug treatment is therapeutically relevant and can restore limited functional recovery.
Language	English
Publishing date	2023-09-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1225759
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