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  1. Article ; Online: Response by Tsukamoto and Takashima to Letter Regarding Article, "Restoration of Cardiac Myosin Light Chain Kinase Ameliorates Systolic Dysfunction by Reducing Super-Relaxed Myosin".

    Tsukamoto, Osamu / Takashima, Seiji

    Circulation

    2023  Volume 148, Issue 25, Page(s) 2074–2075

    MeSH term(s) Humans ; Myosin-Light-Chain Kinase ; Myosins ; Cardiomyopathies ; Heart
    Chemical Substances Myosin-Light-Chain Kinase (EC 2.7.11.18) ; Myosins (EC 3.6.4.1)
    Language English
    Publishing date 2023-12-18
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.123.066938
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  2. Article ; Online: Direct Sarcomere Modulators Are Promising New Treatments for Cardiomyopathies.

    Tsukamoto, Osamu

    International journal of molecular sciences

    2019  Volume 21, Issue 1

    Abstract: Mutations in sarcomere genes can cause both hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM). However, the complex genotype-phenotype relationships in pathophysiology of cardiomyopathies by gene or mutation location are not fully ... ...

    Abstract Mutations in sarcomere genes can cause both hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM). However, the complex genotype-phenotype relationships in pathophysiology of cardiomyopathies by gene or mutation location are not fully understood. In addition, it is still unclear how mutations within same molecule result in different clinical phenotypes such as HCM and DCM. To clarify how the initial functional insult caused by a subtle change in one protein component of the sarcomere with a given mutation is critical for the development of proper effective treatments for cardiomyopathies. Fortunately, recent technological advances and the development of direct sarcomere modulators have provided a more detailed understanding of the molecular mechanisms that govern the effects of specific mutations. The direct inhibition of sarcomere contractility may be able to suppress the development and progression of HCM with hypercontractile mutations and improve clinical parameters in patients with HCM. On the other hand, direct activation of sarcomere contractility appears to exert unexpected beneficial effects such as reverse remodeling and lower heart rate without increasing adverse cardiovascular events in patients with systolic heart failure due to DCM. Direct sarcomere modulators that can positively influence the natural history of cardiomyopathies represent promising treatment options.
    MeSH term(s) Animals ; Cardiomyopathy, Dilated/drug therapy ; Cardiomyopathy, Dilated/metabolism ; Cardiomyopathy, Hypertrophic/drug therapy ; Cardiomyopathy, Hypertrophic/metabolism ; Cardiovascular Agents/pharmacology ; Cardiovascular Agents/therapeutic use ; Humans ; Myocardial Contraction ; Myosins/metabolism ; Sarcomeres/drug effects ; Sarcomeres/metabolism ; Sarcomeres/physiology
    Chemical Substances Cardiovascular Agents ; Myosins (EC 3.6.4.1)
    Language English
    Publishing date 2019-12-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21010226
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  3. Article ; Online: Direct Sarcomere Modulators Are Promising New Treatments for Cardiomyopathies

    Osamu Tsukamoto

    International Journal of Molecular Sciences, Vol 21, Iss 1, p

    2019  Volume 226

    Abstract: Mutations in sarcomere genes can cause both hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM). However, the complex genotype-phenotype relationships in pathophysiology of cardiomyopathies by gene or mutation location are not fully ... ...

    Abstract Mutations in sarcomere genes can cause both hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM). However, the complex genotype-phenotype relationships in pathophysiology of cardiomyopathies by gene or mutation location are not fully understood. In addition, it is still unclear how mutations within same molecule result in different clinical phenotypes such as HCM and DCM. To clarify how the initial functional insult caused by a subtle change in one protein component of the sarcomere with a given mutation is critical for the development of proper effective treatments for cardiomyopathies. Fortunately, recent technological advances and the development of direct sarcomere modulators have provided a more detailed understanding of the molecular mechanisms that govern the effects of specific mutations. The direct inhibition of sarcomere contractility may be able to suppress the development and progression of HCM with hypercontractile mutations and improve clinical parameters in patients with HCM. On the other hand, direct activation of sarcomere contractility appears to exert unexpected beneficial effects such as reverse remodeling and lower heart rate without increasing adverse cardiovascular events in patients with systolic heart failure due to DCM. Direct sarcomere modulators that can positively influence the natural history of cardiomyopathies represent promising treatment options.
    Keywords sarcomere ; direct sarcomere modulators ; hypertrophic cardiomyopathy ; dilated cardiomyopathy ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2019-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Association Between B-Type Natriuretic Peptide Deficiency and Left Ventricular Concentric Hypertrophy in Subclinical Individuals.

    Okamoto, Chisato / Tsukamoto, Osamu / Hasegawa, Takuya / Matsuoka, Ken / Amaki, Makoto / Kanzaki, Hideaki / Izumi, Chisato / Takashima, Seiji / Ito, Shin / Kitakaze, Masafumi

    JACC. Asia

    2024  Volume 4, Issue 1, Page(s) 87–88

    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Journal Article
    ISSN 2772-3747
    ISSN (online) 2772-3747
    DOI 10.1016/j.jacasi.2023.10.002
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  5. Article ; Online: Analysis of Thoracoscopic Enucleation Combined with Esophagoscopy in the Prone Position for Esophageal Submucosal Tumor.

    Mikami, Shinya / Hisatsune, Yasuhito / Hiwatari, Masaki / Tsukamoto, Yoshitsugu / Kimura, Sae / Shimada, Jin / Enomoto, Takeharu / Saji, Osamu / Otsubo, Takehito

    Journal of laparoendoscopic & advanced surgical techniques. Part A

    2024  Volume 34, Issue 4, Page(s) 354–358

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Humans ; Esophagoscopy/methods ; Prone Position ; Retrospective Studies ; Esophageal Neoplasms/surgery ; Esophageal Neoplasms/pathology ; Thoracoscopy/methods ; Treatment Outcome
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1381909-4
    ISSN 1557-9034 ; 1092-6429
    ISSN (online) 1557-9034
    ISSN 1092-6429
    DOI 10.1089/lap.2023.0466
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  6. Article ; Online: Radiation-induced HFpEF model as a potential tool for the exploration of novel therapeutic targets.

    Tsukamoto, Osamu / Kitakaze, Masafumi

    American journal of physiology. Heart and circulatory physiology

    2017  Volume 313, Issue 2, Page(s) H323–H325

    MeSH term(s) Diastole ; Heart Failure ; Humans ; Radiation Exposure ; Stroke Volume ; Ventricular Dysfunction
    Language English
    Publishing date 2017-06-16
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 603838-4
    ISSN 1522-1539 ; 0363-6135
    ISSN (online) 1522-1539
    ISSN 0363-6135
    DOI 10.1152/ajpheart.00307.2017
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    Uc I Zs.89: Show issues Location:
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  7. Article ; Online: PATIENT DOSIMETRY SURVEY OF PEDIATRIC DIAGNOSTIC AND THERAPEUTIC CARDIAC CATHETERISATION IN JAPAN.

    Ishibashi, Toru / Takei, Yasutaka / Kato, Mamoru / Yamashita, Yukari / Tsukamoto, Atsuko / Matsumoto, Kazuma / Sakamoto, Hajime / Masuda, Takanori / Miyazaki, Osamu

    Radiation protection dosimetry

    2023  Volume 199, Issue 10, Page(s) 1082–1089

    Abstract: To propose reference values for air-kerma at the reference point (Ka,r), air-kerma area product (PKA), fluoroscopy time (FT) and number of cine images (CI) for four age groups in Japan, a nationwide questionnaire was posted to 132 pediatric ... ...

    Abstract To propose reference values for air-kerma at the reference point (Ka,r), air-kerma area product (PKA), fluoroscopy time (FT) and number of cine images (CI) for four age groups in Japan, a nationwide questionnaire was posted to 132 pediatric catheterisation of certified facility in Japan, using the conventional post system, to which 43 facilities responded. For diagnostic cardiac angiography, reference values were as follows: Ka,r: 86, 102, 165 and 264 mGy; PKA: 9.3, 9.5, 16 and 34 Gy.cm2; FT: 33, 29, 26 and 30 min and CI: 1904, 1966, 2405 and 1871 images. For therapeutic cardiac angiography, reference values were as follows: Ka,r: 107, 163, 103 and 202 mGy; PKA: 7.5, 18, 7 and 24 Gy.cm2; FT: 56, 52, 42 and 30 min and CI: 3886, 3232, 2212 and 4316 images for less than 1, 1-5, 6-10 and 11-15 y, respectively. To optimal patient exposure from diagnostic and therapeutic cardiac catheterisation, it is therefore necessary to establish reference values for pediatric cardiac catheterisation examinations for four age groups.
    MeSH term(s) Humans ; Child ; Radiation Dosage ; Japan ; Radiography, Interventional ; Cardiac Catheterization ; Surveys and Questionnaires ; Fluoroscopy
    Language English
    Publishing date 2023-04-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 225912-6
    ISSN 1742-3406 ; 0144-8420
    ISSN (online) 1742-3406
    ISSN 0144-8420
    DOI 10.1093/rpd/ncad139
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    Zs.A 2009: Show issues Location:
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  8. Article ; Online: Assessment of mediastinal shift angles in congenital pulmonary airway malformation: a new fetal magnetic resonance imaging indicator of congenital lung disease.

    Tsukamoto, Jun / Miyazaki, Osamu / Saito, Yuki / Irahara, Saho / Okamoto, Reiko / Miyasaka, Mikiko / Tsutsumi, Yoshiyuki / Itoh, Yushi / Sago, Haruhiko / Kanamori, Yutaka / Mikami, Masashi / Hayashida, Yoshiko / Aoki, Takatoshi / Nosaka, Shunsuke

    Pediatric radiology

    2024  Volume 54, Issue 5, Page(s) 715–724

    Abstract: Background: The mediastinal shift angle is a new fetal magnetic resonance imaging (MRI) index that is reportedly correlated with postnatal survival in fetuses with congenital diaphragmatic hernia. However, its correlation in patients with congenital ... ...

    Abstract Background: The mediastinal shift angle is a new fetal magnetic resonance imaging (MRI) index that is reportedly correlated with postnatal survival in fetuses with congenital diaphragmatic hernia. However, its correlation in patients with congenital pulmonary airway malformation (CPAM) has not been assessed.
    Objective: This study aimed to establish a normal range for the right/left mediastinal shift angles, to evaluate the mediastinal shift angle in fetuses with CPAM, to compare the mediastinal shift angle with the CPAM volume ratio, and to evaluate the predictive value of the mediastinal shift angle measurements.
    Materials and methods: To establish the normal range, we measured the mediastinal shift angle bilaterally in 124 fetuses without any lung abnormality (the control group). Subsequently, the mediastinal shift angle was measured in 32 fetuses pathologically diagnosed with CPAM. Moreover, the mediastinal shift angle and CPAM volume ratio were compared using fetal MRI.
    Results: The mean values for the right/left mediastinal shift angles were 18.6°/26.3° and 39.2°/35.9° for control fetuses and fetuses with CPAM, respectively. The mediastinal shift angle and the CPAM volume ratio showed a positive statistical correlation. The area under the curve demonstrated high discriminatory accuracy for the mediastinal shift angle (0.76).
    Conclusion: The mediastinal shift angle has potential to replace the CPAM volume ratio for evaluating the severity of CPAM in fetal MRI.
    MeSH term(s) Humans ; Female ; Magnetic Resonance Imaging/methods ; Prenatal Diagnosis/methods ; Pregnancy ; Mediastinum/diagnostic imaging ; Lung/diagnostic imaging ; Lung/abnormalities ; Lung/embryology ; Cystic Adenomatoid Malformation of Lung, Congenital/diagnostic imaging ; Reference Values ; Retrospective Studies
    Language English
    Publishing date 2024-01-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 124459-0
    ISSN 1432-1998 ; 0301-0449
    ISSN (online) 1432-1998
    ISSN 0301-0449
    DOI 10.1007/s00247-024-05852-5
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    Zs.A 927: Show issues Location:
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  9. Article ; Online: Mycosis fungoides responded to dasatinib for acute lymphoblastic leukemia.

    Yasuda, Masahito / Shang, Cong / Yamanaka, Masayoshi / Amano, Hiroo / Tsukamoto, Norifumi / Ishikawa, Osamu / Motegi, Sei-Ichiro

    The Journal of dermatology

    2022  Volume 50, Issue 3, Page(s) e106–e107

    MeSH term(s) Humans ; Dasatinib/therapeutic use ; Mycosis Fungoides/drug therapy ; Skin Neoplasms/diagnosis ; Skin Neoplasms/drug therapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy
    Chemical Substances Dasatinib (RBZ1571X5H)
    Language English
    Publishing date 2022-11-09
    Publishing country England
    Document type Letter
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.16632
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    Zs.B 1950: Show issues Location:
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  10. Article ; Online: Wnt5a-YAP signaling axis mediates mechanotransduction in cardiac myocytes and contributes to contractile dysfunction induced by pressure overload.

    Kishimoto, Hiroshi / Iwasaki, Masayoshi / Wada, Kensaku / Horitani, Keita / Tsukamoto, Osamu / Kamikubo, Kenta / Nomura, Seitaro / Matsumoto, Shinji / Harada, Takeshi / Motooka, Daisuke / Okuzaki, Daisuke / Takashima, Seiji / Komuro, Issei / Kikuchi, Akira / Shiojima, Ichiro

    iScience

    2023  Volume 26, Issue 7, Page(s) 107146

    Abstract: Non-canonical Wnt signaling activated by Wnt5a/Wnt11 is required for the second heart field development in mice. However, the pathophysiological role of non-canonical Wnt signaling in the adult heart has not been fully elucidated. Here we show that ... ...

    Abstract Non-canonical Wnt signaling activated by Wnt5a/Wnt11 is required for the second heart field development in mice. However, the pathophysiological role of non-canonical Wnt signaling in the adult heart has not been fully elucidated. Here we show that cardiomyocyte-specific
    Language English
    Publishing date 2023-06-15
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.107146
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