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Article ; Online: A narrative review of the Medtronic Hugo RAS and technical comparison with the Intuitive da Vinci robotic surgical system.

Ngu, James Chi-Yong / Lin, Charles Chung-Wei / Sia, Crystal Jin-Yang / Teo, Nan-Zun

2024 Volume 18, Issue 1, Page(s) 99

Abstract: Medtronic launched the Hugo Robotic-Assisted Surgery (RAS) System in 2021, offering a modular alternative to the incumbent market leader in surgical robotics, the Intuitive da Vinci (dV) surgical system. A detailed technical review of the Hugo RAS was ... ...

Abstract	Medtronic launched the Hugo Robotic-Assisted Surgery (RAS) System in 2021, offering a modular alternative to the incumbent market leader in surgical robotics, the Intuitive da Vinci (dV) surgical system. A detailed technical review of the Hugo RAS was conducted to explore the strengths and weaknesses of this new robotic surgical system. Each component of the system-vision tower, arm cart, and surgeon console-was compared against the existing dV systems. The docking process, instrumentation, and external arm movement trajectories were analyzed. The modular Hugo RAS provides the possibility of operating using up to four arm carts. It has certain design features that are unique to itself, and others that have been implemented to address the shortcomings of the dV Si. While Medtronic's first-generation robot offers distinct advantages over the older Intuitive systems, the true test of its mettle will be its performance compared to the latest dV Xi.
MeSH term(s)	Humans ; Robotic Surgical Procedures/methods ; Robotics ; Surgeons
Language	English
Publishing date	2024-02-28
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2268283-1
ISSN	1863-2491 ; 1863-2483
ISSN (online)	1863-2491
ISSN	1863-2483
DOI	10.1007/s11701-024-01838-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Age alters the oncogenic trajectory toward luminal mammary tumors that activate unfolded proteins responses.

Jenkins, Edmund Charles / Chattopadhyay, Mrittika / Gomez, Maria / Torre, Denis / Ma'ayan, Avi / Torres-Martin, Miguel / Sia, Daniela / Germain, Doris

Aging cell

2022 Volume 21, Issue 10, Page(s) e13665

Abstract: A major limitation in the use of mouse models in breast cancer research is that most mice develop estrogen receptor-alpha (ERα)-negative mammary tumors, while in humans, the majority of breast cancers are ERα-positive. Therefore, developing mouse models ... ...

Abstract	A major limitation in the use of mouse models in breast cancer research is that most mice develop estrogen receptor-alpha (ERα)-negative mammary tumors, while in humans, the majority of breast cancers are ERα-positive. Therefore, developing mouse models that best mimic the disease in humans is of fundamental need. Here, using an inducible MMTV-rtTA/TetO-NeuNT mouse model, we show that despite being driven by the same oncogene, mammary tumors in young mice are ERα-negative, while they are ERα-positive in aged mice. To further elucidate the mechanisms for this observation, we performed RNAseq analysis and identified genes that are uniquely expressed in aged female-derived mammary tumors. We found these genes to be involved in the activation of the ERα axis of the mitochondrial UPR and the ERα-mediated regulation of XBP-1s, a gene involved in the endoplasmic reticulum UPR. Collectively, our results indicate that aging alters the oncogenic trajectory towards the ERα-positive subtype of breast cancers, and that mammary tumors in aged mice are characterized by the upregulation of multiple UPR stress responses regulated by the ERα.
MeSH term(s)	Aged ; Animals ; Carcinogenesis/genetics ; Estrogen Receptor alpha/genetics ; Estrogen Receptor alpha/metabolism ; Female ; Humans ; Mice ; Oncogenes ; Receptors, Estrogen/metabolism ; Unfolded Protein Response/genetics
Chemical Substances	Estrogen Receptor alpha ; Receptors, Estrogen
Language	English
Publishing date	2022-09-15
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2113083-8
ISSN	1474-9726 ; 1474-9718
ISSN (online)	1474-9726
ISSN	1474-9718
DOI	10.1111/acel.13665
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Article ; Online: Local Prostate Radiation Therapy and Symptomatic Local Events in De Novo Metastatic Prostate Cancer.

Kwok, Jaime Kirsten / Martell, Kevin / Sia, Michael / Bhindi, Bimal / Abedin, Tasnima / Lu, Shuang / Quon, Harvey Charles

Practical radiation oncology

2022 Volume 13, Issue 1, Page(s) e61–e67

Abstract: Purpose: Local prostate radiation therapy (LPRT) for low-burden metastatic prostate cancer (mPCa) improves overall survival and is the standard of care. The role of LPRT in reducing symptomatic local events (SLE) remains unclear. We aimed to identify ... ...

Abstract	Purpose: Local prostate radiation therapy (LPRT) for low-burden metastatic prostate cancer (mPCa) improves overall survival and is the standard of care. The role of LPRT in reducing symptomatic local events (SLE) remains unclear. We aimed to identify SLE risk factors and to evaluate the association between LPRT and SLE in mPCa. Methods and materials: We conducted a retrospective, population-based cohort study of patients initially diagnosed with mPCa between 2005 and 2016 in a cancer registry. Patient, tumor, and treatment characteristics were obtained from chart review and the cancer registry. The coprimary endpoints were genitourinary (GU) and gastrointestinal (GI) SLE, identified by physician billing claims between 2004 and 2017 for diagnostic or therapeutic procedures potentially related to GU and GI SLE. The effect of LPRT on SLE was evaluated using both recurrent event (Andersen-Gill model) and time-to-first-event sequential landmark analyses. Risk factors for SLE were assessed by multivariable Cox regression. LPRT was defined as ≥40 Gy within 1 year of diagnosis. Metastatic burden was defined per the STAMPEDE trial. Results: Of 1363 patients, 46 (3.4%) received LPRT. Median follow-up was 27.3 and 28.9 months in the control and LPRT groups, respectively. LPRT was associated with less recurrent GU SLE (hazard ratio [HR], 0.34; 95% confidence interval [CI], 0.17-0.67; P = .002), upper tract obstruction (HR, 0.20; 95% CI, 0.05-0.84; P = .03), and cystoscopy (HR, 0.38; 95% CI, 0.15-0.96; P = .04). Metastatic burden was not associated with SLE. Conclusions: LPRT in mPCa was associated with less recurrent GU SLE, specifically for upper tract obstruction and cystoscopy.
MeSH term(s)	Humans ; Male ; Cohort Studies ; Prostate/pathology ; Prostatic Neoplasms/pathology ; Retrospective Studies
Language	English
Publishing date	2022-09-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2655748-4
ISSN	1879-8519 ; 1879-8500
ISSN (online)	1879-8519
ISSN	1879-8500
DOI	10.1016/j.prro.2022.08.005
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Article: Corrigendum to: Epidemiological and Clinical Characteristics of Melioidosis Caused by Gentamicin-Susceptible

Sia, Tonnii L L / Mohan, Anand / Ooi, Mong-How / Chien, Su-Lin / Tan, Lee-See / Goh, Charles / Pang, Daniel C L / Currie, Bart J / Wong, Jin-Shyan / Podin, Yuwana

Open forum infectious diseases

2022 Volume 9, Issue 2, Page(s) ofab653

Abstract: This corrects the article DOI: 10.1093/ofid/ofab460.]. ...

Abstract	[This corrects the article DOI: 10.1093/ofid/ofab460.].
Language	English
Publishing date	2022-01-27
Publishing country	United States
Document type	Published Erratum
ZDB-ID	2757767-3
ISSN	2328-8957
ISSN	2328-8957
DOI	10.1093/ofid/ofab653
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Article ; Online: Influence of vegetation type and climatological conditions on evapotranspiration from extensive green roofs

O'Carroll, Denis M. / Eloisa Sia, Maria / Staniec, Maja / Voogt, James A. / Lundholm, Jeremy T. / Smart, Charles C. / Robinson, Clare E.

Journal of Hydrology. 2023 Feb., v. 617 p.128951-

2023

Abstract: Evapotranspiration (ET) is the key hydrologic process governing the capacity of a green roof to retain rainfall as it regenerates available water storage space in the green roof substrate (soil) between rainfall events. In this field study, the impact of ...

Abstract	Evapotranspiration (ET) is the key hydrologic process governing the capacity of a green roof to retain rainfall as it regenerates available water storage space in the green roof substrate (soil) between rainfall events. In this field study, the impact of climatological conditions, vegetation type, and substrate depth on ET rates were evaluated from experimental, modular extensive green roofs installed in three climate regions in Canada: Calgary AB (Prairies), London ON (Great Lakes/St. Lawrence), and Halifax NS (Atlantic/ Maritime). Daily ET rates and cumulative ET over two field seasons were quantified for two substrate depths (10 and 15 cm), substrate only treatments (no vegetation), and four vegetation treatments (monoculture treatments of Sedum spurium, Sporobolus heterolepis, and Aquilegia canadensis, and a mixed species treatment consisting of the three aforementioned species). 73 %, 67 % and 33 % of the cumulative rainfall was returned to the atmosphere via ET over the two field seasons in Calgary, London and Halifax, respectively. Importantly, ET rates were shown to be a strong function of substrate moisture content as well as atmospheric forcing with the relative importance of each varying between the different cities. ET rates were typically greater in the mixed species treatment in comparison to the three monoculture treatments (Sedum spurium, Sporobolus heterolepis, and Aquilegia canadensis) and for deeper substrate depths, although ET rate enhancement with substrate depth was comparatively small. This study provides valuable insights on the impact of climatological conditions and green roof design parameters (i.e., vegetation type and substrate depth) on ET rates.
Keywords	Aquilegia canadensis ; Sedum ; Sporobolus heterolepis ; climate ; evapotranspiration ; green roofs ; rain ; soil ; vegetation types ; water content ; water storage ; Canada ; Green roof ; Stormwater management ; Low impact development systems ; Vegetation ; Substrate
Language	English
Dates of publication	2023-02
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	1473173-3
ISSN	1879-2707 ; 0022-1694
ISSN (online)	1879-2707
ISSN	0022-1694
DOI	10.1016/j.jhydrol.2022.128951
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Replenishing Peripheral CD4(+) Regulatory T Cells: A Possible Immune-Intervention Strategy in Type 1 Diabetes?

Sia, Charles

The review of diabetic studies : RDS

2006 Volume 3, Issue 3, Page(s) 102–107

Abstract: Controlling the diabetogenic activity of peripheral islet antigen-specific T cells is essential to halt the progression of autoimmunity that leads to the development of type 1 diabetes mellitus (T1DM). Over the past years, evidence has been gathered to ... ...

Abstract	Controlling the diabetogenic activity of peripheral islet antigen-specific T cells is essential to halt the progression of autoimmunity that leads to the development of type 1 diabetes mellitus (T1DM). Over the past years, evidence has been gathered to suggest that the dysfunction of CD4(+)CD25(+) regulatory T (Treg) cells, and the interleukin-10 (IL10) -secreting type 1 regulatory T (Tr1) cells are associated with disease onset in diabetic patients. Although CD4(+)CD25(+) Treg cells develop as a distinct lineage of T cells in the thymus, results from recent studies have shown that they can also arise independently from the peripheral pool of conventional CD4(+) lymphocytes. These observations have led to the development of various methods to convert peripheral CD4(+) T cells into CD4(+)CD25(+) Treg and Tr1 cells in vitro or to induce the development and expansion of Treg cell subsets in vivo. This article reviews the progress made in Treg cell recruitment in vivo that involves the potential for the prevention or even reversal of T1DM.
Language	English
Publishing date	2006-11-10
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2168938-6
ISSN	1614-0575 ; 1613-6071
ISSN (online)	1614-0575
ISSN	1613-6071
DOI	10.1900/RDS.2006.3.102
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Article ; Online: Imbalance in Th cell polarization and its relevance in type 1 diabetes mellitus.

Sia, Charles

The review of diabetic studies : RDS

2006 Volume 2, Issue 4, Page(s) 182–186

Abstract: Functional polarization of T helper (Th) subsets of lymphocytes has been implicated in promoting or conferring risk to Type 1 diabetes mellitus (T1DM) development in human and diabetic animal models. It is assumed that an immoderate preponderance of type ...

Abstract	Functional polarization of T helper (Th) subsets of lymphocytes has been implicated in promoting or conferring risk to Type 1 diabetes mellitus (T1DM) development in human and diabetic animal models. It is assumed that an immoderate preponderance of type 1 immunity establishes the prerequisite for this development. Over the past years, various immune-intervention strategies have been tested to protect diabetic animals from developing overt diabetes. These protocols implicate a protective mechanism that is attributed to a change in the set of autoreactive Th cells from their Th1 to the Th2 phenotype. The studies were aimed at improving the effectiveness of Th2 cells to secrete the principal cytokines, IL-4 and IL-10, in order to mediate protection from diabetes in NOD mice. In contrast, some immune-modulation protocols utilizing non-specific reagents report that diabetes protection is apparently attributed to preferential survival of both Th1 and Th2 cells, rather than via a shift from their Th1 to Th2 phenotypes. Even though we know that excessive immune responses against self antigens are also controlled and terminated by regulatory T cells, this article focuses on the polarization of Th effector cells and discusses the controversial findings regarding the Th1/Th2 hypothesis to draw a conclusion on its relevance in T1DM from the existing knowledge.
Language	English
Publishing date	2006-02-10
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2168938-6
ISSN	1614-0575 ; 1613-6071
ISSN (online)	1614-0575
ISSN	1613-6071
DOI	10.1900/RDS.2005.2.182
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Article ; Online: Is a new immune response mediator in the NF-kappaB pathway--SUMO-4--related to type 1 diabetes?

Sia, Charles

The review of diabetic studies : RDS

2005 Volume 2, Issue 2, Page(s) 58–60

Language	English
Publishing date	2005-08-10
Publishing country	Singapore
Document type	Editorial
ZDB-ID	2168938-6
ISSN	1614-0575 ; 1613-6071
ISSN (online)	1614-0575
ISSN	1613-6071
DOI	10.1900/RDS.2005.2.58
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Article ; Online: The portrait of liver cancer is shaped by mitochondrial genetics.

Chattopadhyay, Mrittika / Jenkins, Edmund Charles / Lechuga-Vieco, Ana Victoria / Nie, Kai / Fiel, Maria Isabel / Rialdi, Alexander / Guccione, Ernesto / Enriquez, Jose Antonio / Sia, Daniela / Lujambio, Amaia / Germain, Doris

Cell reports

2022 Volume 38, Issue 3, Page(s) 110254

Abstract: Cancer heterogeneity and evolution are not fully understood. Here, we show that mitochondrial DNA of the normal liver shapes tumor progression, histology, and immune environment prior to the acquisition of oncogenic mutation. Using conplastic mice, we ... ...

Abstract	Cancer heterogeneity and evolution are not fully understood. Here, we show that mitochondrial DNA of the normal liver shapes tumor progression, histology, and immune environment prior to the acquisition of oncogenic mutation. Using conplastic mice, we show that mtDNA dictates the expression of the mitochondrial unfolded protein response (UPR
MeSH term(s)	Animals ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; DNA, Mitochondrial/genetics ; Female ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Pregnancy-Associated Plasma Protein-A/metabolism ; Transcriptome ; Unfolded Protein Response/genetics
Chemical Substances	DNA, Mitochondrial ; Pregnancy-Associated Plasma Protein-A (EC 3.4.24.-)
Language	English
Publishing date	2022-01-19
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2021.110254
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Article ; Online: Spotlight on ethnomedicine: usability of Sutherlandia frutescens in the treatment of diabetes.

Sia, Charles

The review of diabetic studies : RDS

2004 Volume 1, Issue 3, Page(s) 145–149

Language	English
Publishing date	2004-11-10
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2168938-6
ISSN	1614-0575 ; 1613-6071
ISSN (online)	1614-0575
ISSN	1613-6071
DOI	10.1900/RDS.2004.1.145
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