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  1. Article ; Online: Molecular mechanisms and targets of right ventricular fibrosis in pulmonary hypertension.

    Bekedam, F T / Goumans, M J / Bogaard, H J / de Man, F S / Llucià-Valldeperas, A

    Pharmacology & therapeutics

    2023  Volume 244, Page(s) 108389

    Abstract: Right ventricular fibrosis is a stress response, predominantly mediated by cardiac fibroblasts. This cell population is sensitive to increased levels of pro-inflammatory cytokines, pro-fibrotic growth factors and mechanical stimulation. Activation of ... ...

    Abstract Right ventricular fibrosis is a stress response, predominantly mediated by cardiac fibroblasts. This cell population is sensitive to increased levels of pro-inflammatory cytokines, pro-fibrotic growth factors and mechanical stimulation. Activation of fibroblasts results in the induction of various molecular signaling pathways, most notably the mitogen-activated protein kinase cassettes, leading to increased synthesis and remodeling of the extracellular matrix. While fibrosis confers structural protection in response to damage induced by ischemia or (pressure and volume) overload, it simultaneously contributes to increased myocardial stiffness and right ventricular dysfunction. Here, we review state-of-the-art knowledge of the development of right ventricular fibrosis in response to pressure overload and provide an overview of all published preclinical and clinical studies in which right ventricular fibrosis was targeted to improve cardiac function.
    MeSH term(s) Humans ; Animals ; Hypertension, Pulmonary/etiology ; Myocardium/metabolism ; Fibrosis ; Heart Failure ; Heart Ventricles/metabolism ; Heart Ventricles/pathology ; Fibroblasts/metabolism ; Ventricular Remodeling ; Disease Models, Animal
    Language English
    Publishing date 2023-03-20
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 194735-7
    ISSN 1879-016X ; 0163-7258
    ISSN (online) 1879-016X
    ISSN 0163-7258
    DOI 10.1016/j.pharmthera.2023.108389
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1183: Show issues Location:
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  2. Article ; Online: Corrigendum to "Defining vulnerability in European pregnant women, a Delphi study" [Midwifery 86 (2020) 102708].

    Scheele, J / Harmsen van der Vliet-Torij, H W / Wingelaar-Loomans, E M / Goumans, M J B M

    Midwifery

    2023  Volume 128, Page(s) 103872

    Language English
    Publishing date 2023-11-11
    Publishing country Scotland
    Document type Published Erratum
    ZDB-ID 1036567-9
    ISSN 1532-3099 ; 0266-6138
    ISSN (online) 1532-3099
    ISSN 0266-6138
    DOI 10.1016/j.midw.2023.103872
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2662: Show issues Location:
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  3. Article ; Online: Angiogenesis in Chronic Thromboembolic Pulmonary Hypertension: A Janus-Faced Player?

    Willems, Lynn / Kurakula, Kondababu / Verhaegen, Janne / Klok, Frederikus A / Delcroix, Marion / Goumans, Marie-José / Quarck, Rozenn

    Arteriosclerosis, thrombosis, and vascular biology

    2024  Volume 44, Issue 4, Page(s) 794–806

    Abstract: Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare form of pulmonary hypertension characterized by the presence of organized thrombi that obstruct pulmonary arteries, ultimately leading to right heart failure and death. Among others, ... ...

    Abstract Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare form of pulmonary hypertension characterized by the presence of organized thrombi that obstruct pulmonary arteries, ultimately leading to right heart failure and death. Among others, impaired angiogenesis and inflammatory thrombosis have been shown to contribute to the progression of CTEPH. In this review, we summarize the 2-faced nature of angiogenesis in both thrombus formation and resolution in the context of CTEPH and highlight the dual role of angiogenesis and neovascularization in resolving venous thrombi. Furthermore, we discuss relevant in vitro and in vivo models that support the benefits or drawbacks of angiogenesis in CTEPH progression. We discuss the key pathways involved in modulating angiogenesis, particularly the underexplored role of TGFβ (transforming growth factor-beta) signaling in driving fibrosis as an integral element of CTEPH pathogenesis. We finally explore innovative treatment strategies that target angiogenic pathways. These strategies have the potential to pioneer preventive, inventive, or alternative therapeutic options for patients with CTEPH who may not qualify for surgical interventions. Moreover, they could be used synergistically with established treatments such as pulmonary endarterectomy or balloon pulmonary angioplasty. In summary, this review emphasizes the crucial role of angiogenesis in the development of in fibrothrombotic tissue, a major pathological characteristic of CTEPH.
    MeSH term(s) Humans ; Hypertension, Pulmonary/etiology ; Pulmonary Embolism/therapy ; Angiogenesis ; Pulmonary Artery/pathology ; Thrombosis/pathology ; Chronic Disease ; Endarterectomy/adverse effects
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.123.319852
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1705: Show issues Location:
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  4. Article ; Online: Single-cell analysis of human fetal epicardium reveals its cellular composition and identifies CRIP1 as a modulator of EMT.

    Streef, Thomas J / Groeneveld, Esmee J / van Herwaarden, Tessa / Hjortnaes, Jesper / Goumans, Marie José / Smits, Anke M

    Stem cell reports

    2023  Volume 18, Issue 7, Page(s) 1421–1435

    Abstract: The epicardium plays an essential role in cardiogenesis by providing cardiac cell types and paracrine cues to the developing myocardium. The human adult epicardium is quiescent, but recapitulation of developmental features may contribute to adult cardiac ...

    Abstract The epicardium plays an essential role in cardiogenesis by providing cardiac cell types and paracrine cues to the developing myocardium. The human adult epicardium is quiescent, but recapitulation of developmental features may contribute to adult cardiac repair. The cell fate of epicardial cells is proposed to be determined by the developmental persistence of specific subpopulations. Reports on this epicardial heterogeneity have been inconsistent, and data regarding the human developing epicardium are scarce. Here we specifically isolated human fetal epicardium and used single-cell RNA sequencing to define its composition and to identify regulators of developmental processes. Few specific subpopulations were observed, but a clear distinction between epithelial and mesenchymal cells was present, resulting in novel population-specific markers. Additionally, we identified CRIP1 as a previously unknown regulator involved in epicardial epithelial-to-mesenchymal transition. Overall, our human fetal epicardial cell-enriched dataset provides an excellent platform to study the developing epicardium in great detail.
    MeSH term(s) Adult ; Humans ; Pericardium/metabolism ; Myocardium/metabolism ; Epithelial-Mesenchymal Transition ; Fetus/metabolism ; Single-Cell Analysis ; Carrier Proteins/metabolism ; LIM Domain Proteins/metabolism
    Chemical Substances CRIP1 protein, human ; Carrier Proteins ; LIM Domain Proteins
    Language English
    Publishing date 2023-06-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2720528-9
    ISSN 2213-6711 ; 2213-6711
    ISSN (online) 2213-6711
    ISSN 2213-6711
    DOI 10.1016/j.stemcr.2023.06.002
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  5. Book ; Conference proceedings: Waste materials in construction

    Goumans, J. J. J. M.

    putting theory into practice ; proceedings of the International Conference on the Environmental and Technical Implications of Construction with Alternative Materials, WASCON '97, Houthem St. Gerlach, the Netherlands, 4 - 6 June 1997

    (Studies in environmental science ; 71)

    1997  

    Institution WASCON
    Author's details ed. by J. J. J. M. Goumans
    Series title Studies in environmental science ; 71
    Collection
    Keywords Abfallwirtschaft
    Size XVIII, 886 S. : Ill., graph. Darst., Kt.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book ; Conference proceedings
    HBZ-ID HT008060186
    ISBN 0-444-82771-4 ; 978-0-444-82771-5
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    988/117 available for loan (reading room) Freihandmagazin (U1)

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  6. Book ; Conference proceedings: Environmental aspects of construction with waste materials

    Goumans, J. J. J. M.

    proceeding of the [Second] International Conference on Environmental Implications of Construction Materials and Technology Developments, Maastricht, the Netherlands, 1 - 3 June 1994

    (Studies in environmental science ; 60)

    1994  

    Event/congress WASCON (2, 1994, Maastricht)
    Author's details ed. by J. J. J. M. Goumans
    Series title Studies in environmental science ; 60
    Collection
    Keywords Baustoff ; Recycling ; Umweltbelastung ; Gesundheitsgefährdung
    Subject Baumaterial ; Baubedarf ; Baustoffe ; Baumaterialien ; Ökologische Belastung ; Umweltbeeinträchtigung ; Umweltproblem ; Umwelt ; Gesundheitsgefahr ; Gesundheitsrisiko ; Gesundheitsbelastung ; Gesundheitliches Risiko ; Abfall ; Abfallverwertung ; Wiederaufbereitung ; Wiederverwendung ; Rückgewinnung ; Müllverwertung ; Wiedergewinnung ; Abfallrecycling ; Rohstoffkreislauf ; Abfallnutzung ; Recyclingverfahren
    Size XV, 988 S. : Ill., graph. Darst.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book ; Conference proceedings
    HBZ-ID HT006296320
    ISBN 0-444-81853-7 ; 978-0-444-81853-9
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    948/1810 available for loan (reading room) Freihandmagazin (U1)

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  7. Article ; Online: Cyclic strain has antifibrotic effects on the human cardiac fibroblast transcriptome in a human cardiac fibrosis-on-a-chip platform.

    Bracco Gartner, Tom C L / Wang, Ye / Leiteris, Laurynas / van Adrichem, Iris / Marsman, Judith / Goumans, Marie José / Bouten, Carlijn V C / Sluijter, Joost P G / den Toonder, Jaap M J / Suyker, Willem J L / Hjortnaes, Jesper

    Journal of the mechanical behavior of biomedical materials

    2023  Volume 144, Page(s) 105980

    Abstract: In cardiac fibrosis, in response to stress or injury, cardiac fibroblasts deposit excessive amounts of collagens which contribute to the development of heart failure. The biochemical stimuli in this process have been extensively studied, but the ... ...

    Abstract In cardiac fibrosis, in response to stress or injury, cardiac fibroblasts deposit excessive amounts of collagens which contribute to the development of heart failure. The biochemical stimuli in this process have been extensively studied, but the influence of cyclic deformation on the fibrogenic behavior of cardiac fibroblasts in the ever-beating heart is not fully understood. In fact, most investigated mechanotransduction pathways in cardiac fibroblasts seem to ultimately have profibrotic effects, which leaves an important question in cardiac fibrosis research unanswered: how do cardiac fibroblasts stay quiescent in the ever-beating human heart? In this study, we developed a human cardiac fibrosis-on-a-chip platform and utilized it to investigate if and how cyclic strain affects fibrogenic signaling. The pneumatically actuated platform can expose engineered tissues to controlled strain magnitudes of 0-25% - which covers the entire physiological and pathological strain range in the human heart - and to biochemical stimuli and enables high-throughput screening of multiple samples. Microtissues of human fetal cardiac fibroblasts (hfCF) embedded in gelatin methacryloyl (GelMA) were 3D-cultured on this platform and exposed to strain conditions which mimic the healthy human heart. The results provide evidence of an antifibrotic effect of the applied strain conditions on cardiac fibroblast behavior, emphasizing the influence of biomechanical stimuli on the fibrogenic process and giving a detailed overview of the mechanosensitive pathways and genes involved, which can be used in the development of novel therapies against cardiac fibrosis.
    MeSH term(s) Humans ; Myocardium/pathology ; Transcriptome ; Mechanotransduction, Cellular ; Fibroblasts ; Fibrosis ; Lab-On-A-Chip Devices
    Language English
    Publishing date 2023-06-28
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2378381-3
    ISSN 1878-0180 ; 1751-6161
    ISSN (online) 1878-0180
    ISSN 1751-6161
    DOI 10.1016/j.jmbbm.2023.105980
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  8. Article ; Online: Preservation of human heart valves for replacement in children with heart valve disease: past, present and future.

    Peters, M C / Kruithof, B P T / Bouten, C V C / Voets, I K / van den Bogaerdt, A / Goumans, M J / van Wijk, A

    Cell and tissue banking

    2023  Volume 25, Issue 1, Page(s) 67–85

    Abstract: Valvular heart disease affects 30% of the new-borns with congenital heart disease. Valve replacement of semilunar valves by mechanical, bioprosthetic or donor allograft valves is the main treatment approach. However, none of the replacements provides a ... ...

    Abstract Valvular heart disease affects 30% of the new-borns with congenital heart disease. Valve replacement of semilunar valves by mechanical, bioprosthetic or donor allograft valves is the main treatment approach. However, none of the replacements provides a viable valve that can grow and/or adapt with the growth of the child leading to re-operation throughout life. In this study, we review the impact of donor valve preservation on moving towards a more viable valve alternative for valve replacements in children or young adults.
    MeSH term(s) Child ; Young Adult ; Humans ; Heart Valve Prosthesis ; Heart Valve Diseases/surgery ; Aortic Valve/surgery ; Preservation, Biological
    Language English
    Publishing date 2023-02-01
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2170897-6
    ISSN 1573-6814 ; 1389-9333
    ISSN (online) 1573-6814
    ISSN 1389-9333
    DOI 10.1007/s10561-023-10076-2
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5972: Show issues Location:
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  9. Book ; Conference proceedings: Waste materials in construction

    Goumans, J. J. J. M.

    proceedings of the International Conference on Environmental Implications of Construction with Waste Materials ; Maastricht, The Netherlands, 10 - 14 November 1991

    (Studies in environmental science ; 48)

    1991  

    Event/congress International Conference on Environmental Implications of Construction with Waste Materials (1991, Maastricht)
    Author's details ed. by J. J. J. M. Goumans
    Series title Studies in environmental science ; 48
    Collection
    Keywords Baustoff ; Abfall ; Toxizität ; Umweltverschmutzung ; Pflanzenschutzmittel ; Rückstand
    Subject Umweltverunreinigung ; Pollution ; Umweltkontamination ; Giftigkeit ; Toxische Wirkung ; Waste ; Müll ; Abfallstoff ; Abfälle ; Baumaterial ; Baubedarf ; Baustoffe ; Baumaterialien
    Size XIV, 672 S.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT004343484
    ISBN 0-444-89089-0 ; 978-0-444-89089-4
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    928/986 available for loan (reading room) Freihandmagazin (U1)

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  10. Article: Cardiac Progenitor-Cell Derived Exosomes as Cell-Free Therapeutic for Cardiac Repair.

    Mol, E A / Goumans, M J / Sluijter, J P G

    Advances in experimental medicine and biology

    2017  Volume 998, Page(s) 207–219

    Abstract: Cardiac progenitor cells (CPCs) have emerged as potential therapy to improve cardiac repair and prevent damage in cardiac diseases. CPCs are a promising cell source for cardiac therapy as they can generate all cardiovascular lineages in vitro and in vivo. ...

    Abstract Cardiac progenitor cells (CPCs) have emerged as potential therapy to improve cardiac repair and prevent damage in cardiac diseases. CPCs are a promising cell source for cardiac therapy as they can generate all cardiovascular lineages in vitro and in vivo. Originating from the heart itself, CPCs may be destined to activate endogenous repair mechanisms. These CPCs release paracrine molecules that are able to stimulate cardiac repair mechanisms, including stimulation of vessel formation and inhibition of cardiomyocyte apoptosis. In addition to proteins and growth factors, CPCs release extracellular membrane vesicles, such as exosomes, which have gained increasing interest in recent years. Exosomal-derived miRNAs have been indicated to play an important role in these processes. Hereby, CPC exosomes can be considered as potential off-the-shelf therapeutics, as they are able to stimulate the regenerative capacity of the heart by increasing vessel density and lowering apoptosis of cardiomyocytes.
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-981-10-4397-0_14
    Database MEDical Literature Analysis and Retrieval System OnLINE

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