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  1. Book ; Online: Cellular Oxidative Stress

    Marino, Angela / Dossena, Silvia

    2021  

    Keywords Medicine ; neuroinflammation ; clinical ; palmitoylethanolamide ; luteolin ; co-ultramicronization ; CNS pathology ; adaptive immune response ; cell homeostasis ; legumes ; liver ; hepatic steatosis ; lipid dyshomeostasis ; ROS ; traumatic brain injury ; palmitoylethanolamide (PEA) ; therapeutic strategies ; oxidative stress ; RNA-Seq ; RPE ; Retinitis pigmentosa ; A2E ; diabetes ; glucose exposure ; Band 3 protein ; erythrocytes ; SO42− ; 4-hydroxy-2-nonenal ; 3-glutathionyl-4-hydroxynonanal ; astrocytoma cells ; soy ; soybeans ; soy foods ; antioxidants ; reactive oxygen species ; cardiovascular diseases ; cancer ; paw edema ; cashew nuts ; antioxidant ; inflammation ; polyphenols ; analgesic ; d-Galactose ; glycation ; SO42− uptake ; anion exchange ; diseases ; immune system ; NF-κB ; cigarette smoke extract ; nasal fibroblasts ; tissue inhibitor of metalloproteinases ; matrix metalloproteinase ; steroids ; Plasmodium falciparum ; syk kinase inhibitors ; artemisinin derivatives ; hemichromes ; cellular redox state ; mitochondrial function ; cisplatin nephrotoxicity ; acute pancreatitis ; obesity ; nitrosative stress ; PGC-1α ; microparticles ; vesiculation ; band 3 ; tert-Bytyl hydroperoxide t-BOOH ; nitric oxide donor ; calcium ionophore A23187 ; age-related macular degeneration (AMD) ; diet ; Substance-P ; adipose-derived stem cells ; paracrine factors ; epilepsy ; status epilepticus ; Trolox ; HeLa ; prooxidant ; AVD ; apoptosis ; neurodegeneration ; ncRNA ; miRNA ; tRNA fragments ; lncRNA ; circRNA ; preeclampsia ; hemostasis ; platelets ; coagulation ; fish ; mucosal immunity ; nasal immunity ; peroxide ; vitamin C ; NAC ; immunosenescence ; T cells ; vaccination ; aging ; microvascular permeability ; bradykinin ; interleukin 1β ; NADPH oxidase ; simvastatin ; molecular hydrogen ; autophagy ; matrix metalloproteinases ; reactive oxygen species (ROS) ; phytochemicals ; dietary chemicals ; natural compounds ; programmed cell death ; anoikis ; ferroptosis ; pyroptosis ; n/a
    Size 1 electronic resource (529 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021290053
    ISBN 9783036516431 ; 3036516433
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: The role of pendrin in health and disease

    Dossena, Silvia / Paulmichl, Markus

    molecular and functional aspects of the SLC26A4 anion exchanger

    2017  

    Author's details Silvia Dossena, Markus Paulmichl editors
    Keywords Medicine ; Human genetics ; Molecular biology ; Endocrinology ; Otorhinolaryngology
    Subject code 611.01816
    Language English
    Size 1 Online-Ressource (X, 226 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019408296
    ISBN 978-3-319-43287-8 ; 9783319432854 ; 3-319-43287-7 ; 3319432850
    DOI 10.1007/978-3-319-43287-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Functional interplay between CFTR and pendrin: physiological and pathophysiological relevance.

    Tamma, Grazia / Dossena, Silvia

    Frontiers in bioscience (Landmark edition)

    2022  Volume 27, Issue 2, Page(s) 75

    Abstract: The transport of chloride and bicarbonate across epithelia controls the pH and volume of the intracellular and luminal fluids, as well as the systemic pH and vascular volume. The anion exchanger pendrin (SLC26A4) and the cystic fibrosis transmembrane ... ...

    Abstract The transport of chloride and bicarbonate across epithelia controls the pH and volume of the intracellular and luminal fluids, as well as the systemic pH and vascular volume. The anion exchanger pendrin (SLC26A4) and the cystic fibrosis transmembrane conductance regulator (CFTR) channel are expressed in the apical membrane of epithelial cells of various organs and tissues, including the airways, kidney, thyroid, and inner ear. While pendrin drives chloride reabsorption and bicarbonate, thiocyanate or iodide secretion within the apical compartment, CFTR represents a pathway for the apical efflux of chloride, bicarbonate, and possibly iodide. In the airways, pendrin and CFTR seems to be involved in alkalinization of the apical fluid via bicarbonate secretion, especially during inflammation, while CFTR also controls the volume of the apical fluid via a cAMP-dependent chloride secretion, which is stimulated by pendrin. In the kidney, pendrin is expressed in the cortical collecting duct and connecting tubule and co-localizes with CFTR in the apical membrane of β intercalated cells. Bicarbonate secretion occurs via pendrin, which also drives chloride reabsorption. A functional CFTR is required for pendrin activity. Whether CFTR stimulates pendrin via a direct molecular interaction or other mechanisms, or simply provides a pathway for chloride recycling across the apical membrane remains to be established. In the thyroid, CFTR and pendrin might have overlapping functions in driving the apical flux of iodide within the follicular lumen. In other organs, including the inner ear, the possible functional interplay between pendrin and CFTR needs to be explored.
    MeSH term(s) Bicarbonates/metabolism ; Chlorides/metabolism ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Cystic Fibrosis Transmembrane Conductance Regulator/metabolism ; Iodides/metabolism ; Sulfate Transporters/genetics ; Sulfate Transporters/metabolism
    Chemical Substances Bicarbonates ; Chlorides ; Iodides ; Sulfate Transporters ; Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
    Language English
    Publishing date 2022-03-09
    Publishing country Singapore
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2704569-9
    ISSN 2768-6698 ; 2768-6698
    ISSN (online) 2768-6698
    ISSN 2768-6698
    DOI 10.31083/j.fbl2702075
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Clinical and Molecular Aspects Associated with Defects in the Transcription Factor POU3F4: A Review.

    Bernardinelli, Emanuele / Huber, Florian / Roesch, Sebastian / Dossena, Silvia

    Biomedicines

    2023  Volume 11, Issue 6

    Abstract: X-linked deafness (DFNX) is estimated to account for up to 2% of cases of hereditary hearing loss and occurs in both syndromic and non-syndromic forms. ...

    Abstract X-linked deafness (DFNX) is estimated to account for up to 2% of cases of hereditary hearing loss and occurs in both syndromic and non-syndromic forms.
    Language English
    Publishing date 2023-06-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11061695
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Cellular Oxidative Stress.

    Dossena, Silvia / Marino, Angela

    Antioxidants (Basel, Switzerland)

    2021  Volume 10, Issue 3

    Abstract: Oxidative stress on a cellular level affects the function of tissues and organs and eventually of the whole body [ ... ]. ...

    Abstract Oxidative stress on a cellular level affects the function of tissues and organs and eventually of the whole body [...].
    Language English
    Publishing date 2021-03-06
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox10030399
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Editorial: Non-invasive brain stimulation techniques in neurological and neuropsychiatric disorders: Physiological and molecular evidence.

    Cambiaghi, Marco / Cordaro, Marika / Dossena, Silvia / Cuzzocrea, Salvatore / Buffelli, Mario

    Frontiers in systems neuroscience

    2023  Volume 17, Page(s) 1128205

    Language English
    Publishing date 2023-02-06
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2453005-0
    ISSN 1662-5137
    ISSN 1662-5137
    DOI 10.3389/fnsys.2023.1128205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Editorial: Ion transporters and channels in cellular pathophysiology.

    Remigante, Alessia / Gavazzo, Paola / Morabito, Rossana / Dossena, Silvia

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 1049433

    Language English
    Publishing date 2022-10-17
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.1049433
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Functional interplay between CFTR and pendrin

    Grazia Tamma / Silvia Dossena

    Frontiers in Bioscience-Landmark, Vol 27, Iss 2, p

    physiological and pathophysiological relevance

    2022  Volume 075

    Abstract: The transport of chloride and bicarbonate across epithelia controls the pH and volume of the intracellular and luminal fluids, as well as the systemic pH and vascular volume. The anion exchanger pendrin (SLC26A4) and the cystic fibrosis transmembrane ... ...

    Abstract The transport of chloride and bicarbonate across epithelia controls the pH and volume of the intracellular and luminal fluids, as well as the systemic pH and vascular volume. The anion exchanger pendrin (SLC26A4) and the cystic fibrosis transmembrane conductance regulator (CFTR) channel are expressed in the apical membrane of epithelial cells of various organs and tissues, including the airways, kidney, thyroid, and inner ear. While pendrin drives chloride reabsorption and bicarbonate, thiocyanate or iodide secretion within the apical compartment, CFTR represents a pathway for the apical efflux of chloride, bicarbonate, and possibly iodide. In the airways, pendrin and CFTR seems to be involved in alkalinization of the apical fluid via bicarbonate secretion, especially during inflammation, while CFTR also controls the volume of the apical fluid via a cAMP-dependent chloride secretion, which is stimulated by pendrin. In the kidney, pendrin is expressed in the cortical collecting duct and connecting tubule and co-localizes with CFTR in the apical membrane of β intercalated cells. Bicarbonate secretion occurs via pendrin, which also drives chloride reabsorption. A functional CFTR is required for pendrin activity. Whether CFTR stimulates pendrin via a direct molecular interaction or other mechanisms, or simply provides a pathway for chloride recycling across the apical membrane remains to be established. In the thyroid, CFTR and pendrin might have overlapping functions in driving the apical flux of iodide within the follicular lumen. In other organs, including the inner ear, the possible functional interplay between pendrin and CFTR needs to be explored.
    Keywords cftr ; pendrin/slc26a4 ; lung ; kidney ; thyroid ; inner ear ; review ; Biochemistry ; QD415-436 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher IMR Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Cellular Oxidative Stress

    Dossena, Silvia / Marino, Angela

    Antioxidants. 2021 Mar. 06, v. 10, no. 3

    2021  

    Abstract: Oxidative stress on a cellular level affects the function of tissues and organs and eventually of the whole body [ ... ] ...

    Abstract Oxidative stress on a cellular level affects the function of tissues and organs and eventually of the whole body [...]
    Keywords antioxidants ; oxidative stress ; tissues
    Language English
    Dates of publication 2021-0306
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox10030399
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Clinical and Molecular Aspects Associated with Defects in the Transcription Factor POU3F4

    Emanuele Bernardinelli / Florian Huber / Sebastian Roesch / Silvia Dossena

    Biomedicines, Vol 11, Iss 1695, p

    A Review

    2023  Volume 1695

    Abstract: X-linked deafness (DFNX) is estimated to account for up to 2% of cases of hereditary hearing loss and occurs in both syndromic and non-syndromic forms. POU3F4 is the gene most commonly associated with X-linked deafness (DFNX2, DFN3) and accounts for ... ...

    Abstract X-linked deafness (DFNX) is estimated to account for up to 2% of cases of hereditary hearing loss and occurs in both syndromic and non-syndromic forms. POU3F4 is the gene most commonly associated with X-linked deafness (DFNX2, DFN3) and accounts for about 50% of the cases of X-linked non-syndromic hearing loss. This gene codes for a transcription factor of the POU family that plays a major role in the development of the middle and inner ear. The clinical features of POU3F4-related hearing loss include a pathognomonic malformation of the inner ear defined as incomplete partition of the cochlea type 3 (IP-III). Often, a perilymphatic gusher is observed upon stapedectomy during surgery, possibly as a consequence of an incomplete separation of the cochlea from the internal auditory canal. Here we present an overview of the pathogenic gene variants of POU3F4 reported in the literature and discuss the associated clinical features, including hearing loss combined with additional phenotypes such as cognitive and motor developmental delays. Research on the transcriptional targets of POU3F4 in the ear and brain is in its early stages and is expected to greatly advance our understanding of the pathophysiology of POU3F4-linked hearing loss.
    Keywords POU3F4 ; X-linked deafness ; transcription factor ; hearing loss ; gene variants ; Biology (General) ; QH301-705.5
    Subject code 390
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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