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Article ; Online: Isotopic evidence of long-lived volcanism on Io.

de Kleer, Katherine / Hughes, Ery C / Nimmo, Francis / Eiler, John / Hofmann, Amy E / Luszcz-Cook, Statia / Mandt, Kathy

Science (New York, N.Y.)

2024 , Page(s) eadj0625

Abstract: Jupiter's moon Io hosts extensive volcanism, driven by tidal heating. The isotopic composition of Io's inventory of volatile chemical elements, including sulfur and chlorine, reflects its outgassing and mass loss history, and thus records information ... ...

Abstract	Jupiter's moon Io hosts extensive volcanism, driven by tidal heating. The isotopic composition of Io's inventory of volatile chemical elements, including sulfur and chlorine, reflects its outgassing and mass loss history, and thus records information about its evolution. We used millimeter observations of Io's atmosphere to measure sulfur isotopes in gaseous SO
Language	English
Publishing date	2024-04-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.adj0625
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Article ; Online: Who to Enroll in Parkinson Disease Prevention Trials? The Case for Composite Prodromal Cohorts.

Molsberry, Samantha A / Hughes, Katherine C / Schwarzschild, Michael A / Ascherio, Alberto

Neurology

2022 Volume 99, Issue 7 Suppl 1, Page(s) 26–33

Abstract: Significant progress has been made in expanding our understanding of prodromal Parkinson disease (PD), particularly for recognition of early motor and nonmotor signs and symptoms. Although identification of these prodromal features may improve our ... ...

Abstract	Significant progress has been made in expanding our understanding of prodromal Parkinson disease (PD), particularly for recognition of early motor and nonmotor signs and symptoms. Although identification of these prodromal features may improve our understanding of the earliest stages of PD, they are individually insufficient for early disease detection and enrollment of participants in prevention trials in most cases because of low sensitivity, specificity, and positive predictive value. Composite cohorts, composed of individuals with multiple co-occurring prodromal features, are an important resource for conducting prodromal PD research and eventual prevention trials because they are more representative of the population at risk for PD, allow investigators to evaluate the efficacy of an intervention across individuals with varying prodromal feature patterns, are able to produce larger sample sizes, and capture individuals at different stages of prodromal PD. A key challenge in identifying individuals with prodromal disease for composite cohorts and prevention trial participation is that we know little about the natural history of prodromal PD. To move toward prevention trials, it is critical that we better understand common prodromal feature patterns and be able to predict the probability of progression and phenoconversion. Ongoing research in cohort studies and administrative databases is beginning to address these questions, but further longitudinal analyses in a large population-based sample are necessary to provide a convincing and definitive strategy for identifying individuals to be enrolled in a prevention trial.
MeSH term(s)	Cohort Studies ; Early Diagnosis ; Humans ; Longitudinal Studies ; Parkinson Disease/diagnosis ; Parkinson Disease/epidemiology ; Parkinson Disease/prevention & control ; Prodromal Symptoms
Language	English
Publishing date	2022-05-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0000000000200788
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Article ; Online: Author Reply to Letter by Topkan et al Regarding Delays in Starting Postoperative Radiotherapy.

Duckett, Kelsey A / Lee, Byung Joo / Chera, Bhisham S / Puram, Sidharth V / Sandulache, Vlad C / Kahmke, Russel / Nguyen, Shaun A / Nussenbaum, Brian / Alberg, Anthony J / Halbert, Chanita Hughes / Sterba, Katherine R / Graboyes, Evan M

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

2024

Language	English
Publishing date	2024-04-24
Publishing country	England
Document type	Letter
ZDB-ID	392085-9
ISSN	1097-6817 ; 0161-6439 ; 0194-5998
ISSN (online)	1097-6817
ISSN	0161-6439 ; 0194-5998
DOI	10.1002/ohn.769
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Article ; Online: Subgroup Analyses: Subpar or Sublime?

Hughes, Emily / Takvorian, Katherine S / Dodd, Lori E / Koscal, Natalie / Muller, Daniel / Vining, Tim / Hardin, Charles C / Sacks, Chana A

NEJM evidence

2022 Volume 1, Issue 9, Page(s) EVIDstat2200228

Abstract: Subgroup Analyses: Subpar or Sublime?This animated video explores some of the potential pitfalls of performing subgroup analyses in randomized controlled trials and explains how to approach potential findings with caution. ...

Abstract	Subgroup Analyses: Subpar or Sublime?This animated video explores some of the potential pitfalls of performing subgroup analyses in randomized controlled trials and explains how to approach potential findings with caution.
Language	English
Publishing date	2022-08-23
Publishing country	United States
Document type	Video-Audio Media
ISSN	2766-5526
ISSN (online)	2766-5526
DOI	10.1056/EVIDstat2200228
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Article ; Online: Repeated Genetic and Adaptive Phenotypic Divergence across Tidal Elevation in a Foundation Plant Species.

Zerebecki, Robyn A / Sotka, Erik E / Hanley, Torrance C / Bell, Katherine L / Gehring, Catherine / Nice, Chris C / Richards, Christina L / Hughes, A Randall

The American naturalist

2021 Volume 198, Issue 5, Page(s) E152–E169

Abstract: AbstractMicrogeographic genetic divergence can create fine-scale trait variation. When such divergence occurs within foundation species, then it might impact community structure and ecosystem function and cause other cascading ecological effects. We ... ...

Abstract	AbstractMicrogeographic genetic divergence can create fine-scale trait variation. When such divergence occurs within foundation species, then it might impact community structure and ecosystem function and cause other cascading ecological effects. We tested for parallel microgeographic trait and genetic divergence in
MeSH term(s)	Biomass ; Ecosystem ; Plants ; Poaceae ; Wetlands
Language	English
Publishing date	2021-09-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	207092-3
ISSN	1537-5323 ; 0003-0147
ISSN (online)	1537-5323
ISSN	0003-0147
DOI	10.1086/716512
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Article: Human EGFRvIII chimeric antigen receptor T cells demonstrate favorable safety profile and curative responses in orthotopic glioblastoma.

Abbott, Rebecca C / Iliopoulos, Melinda / Watson, Katherine A / Arcucci, Valeria / Go, Margareta / Hughes-Parry, Hannah E / Smith, Pete / Call, Melissa J / Cross, Ryan S / Jenkins, Misty R

Clinical & translational immunology

2023 Volume 12, Issue 3, Page(s) e1440

Abstract: Objectives: Glioblastoma is a highly aggressive and fatal brain malignancy, and effective targeted therapies are required. The combination of standard treatments including surgery, chemotherapy and radiotherapy is not curative. Chimeric antigen receptor ...

Abstract	Objectives: Glioblastoma is a highly aggressive and fatal brain malignancy, and effective targeted therapies are required. The combination of standard treatments including surgery, chemotherapy and radiotherapy is not curative. Chimeric antigen receptor (CAR) T cells are known to cross the blood-brain barrier, mediating antitumor responses. A tumor-expressed deletion mutant of the epidermal growth factor receptor (EGFRvIII) is a robust CAR T cell target in glioblastoma. Here, we show our Methods: The GCT02 binding epitope was predicted using Deep Mutational Scanning (DMS). GCT02 CAR T cell cytotoxicity was investigated in three glioblastoma models Results: The GCT02 binding location was predicted to be located at a shared region of EGFR and EGFRvIII; however, the Conclusion: This study demonstrates the preclinical functionality of a highly specific CAR targeting EGFRvIII on human cells. This CAR could be an effective treatment for glioblastoma and warrants future clinical investigation.
Language	English
Publishing date	2023-03-05
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2694482-0
ISSN	2050-0068
ISSN	2050-0068
DOI	10.1002/cti2.1440
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Article ; Online: New and emerging therapies for the treatment of relapsed/refractory diffuse large B-cell lymphoma.

Moore, Donald C / Peery, Matthew R / Tobon, Katherine A / Raheem, Farah / Hwang, Grace S / Alhennawi, Lin / Hughes, Mitchell E

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

2022 Volume 28, Issue 8, Page(s) 1848–1858

Abstract: Diffuse large B-cell lymphoma (DLBCL) is the most common form of aggressive non-Hodgkin lymphoma. Approximately 40% of patients with DLBCL will experience disease relapse or will be refractory to first line chemoimmunotherapy, necessitating second-line ... ...

Abstract	Diffuse large B-cell lymphoma (DLBCL) is the most common form of aggressive non-Hodgkin lymphoma. Approximately 40% of patients with DLBCL will experience disease relapse or will be refractory to first line chemoimmunotherapy, necessitating second-line salvage therapy. This has historically consisted of platinum-based chemotherapy regimens followed by autologous hematopoietic stem cell transplantation with curative intent for transplant-eligible patients or palliative chemotherapy for transplant-ineligible patients. In recent years there have been several new therapeutic agents approved for the treatment of relapsed/refractory DLBCL, thereby expanding the therapeutic landscape. These agents include polatuzumab vedotin, tafasitamab, loncastuximab tesirine, selinexor, and anti-CD19 chimeric antigen receptor T-cell therapies such as axicabtagene ciloleucel, tisagenlecleucel, and lisocabtagene maraleucel. This review summarizes the pharmacology, efficacy, safety, dosing, and administration of new agents recently approved for the treatment of relapsed/refractory DLBCL.
MeSH term(s)	Humans ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Lymphoma, Non-Hodgkin/drug therapy ; Antigens, CD19/adverse effects ; Immunotherapy, Adoptive/adverse effects ; Salvage Therapy
Chemical Substances	Antigens, CD19
Language	English
Publishing date	2022-04-26
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1330764-2
ISSN	1477-092X ; 1078-1552
ISSN (online)	1477-092X
ISSN	1078-1552
DOI	10.1177/10781552221096165
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Zs.A 4488: Show issues

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Article ; Online: Correction: Characteristics of eating behavior profiles among preschoolers with low-income backgrounds: a person-centered analysis.

Fisher, Jennifer Orlet / Hughes, Sheryl O / Miller, Alison L / Horodynski, Mildred A / Brophy-Herb, Holly E / Contreras, Dawn A / Kaciroti, Niko / Peterson, Karen E / Rosenblum, Katherine L / Appugliese, Danielle / Lumeng, Julie C

The international journal of behavioral nutrition and physical activity

2022 Volume 19, Issue 1, Page(s) 103

Language	English
Publishing date	2022-08-08
Publishing country	England
Document type	Published Erratum
ZDB-ID	2134691-4
ISSN	1479-5868 ; 1479-5868
ISSN (online)	1479-5868
ISSN	1479-5868
DOI	10.1186/s12966-022-01341-w
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Article ; Online: Cervical High-Grade Squamous Intraepithelial Lesion Burden and Standard of Care Treatment Effectiveness and Safety in the United States, 2008-2018: The EACH-WOMAN Project.

Hughes, Katherine C / Herring, Timothy A / Song, Jennifer N / Gately, Robert V / Przybyl, Lindsey M / Ogilvie, Rachel P / Simon, Keiko / Bhuyan, Prakash K / Kyrgiou, Maria / Seeger, John D

Journal of lower genital tract disease

2023 Volume 27, Issue 2, Page(s) 105–112

Abstract: Objective: Management of cervical high-grade squamous intraepithelial lesions (HSILs), the immediate precursor of cervical cancer, consists largely of surgical treatment for women at higher risk for progression to cancer. The authors' objective was to ... ...

Abstract	Objective: Management of cervical high-grade squamous intraepithelial lesions (HSILs), the immediate precursor of cervical cancer, consists largely of surgical treatment for women at higher risk for progression to cancer. The authors' objective was to describe the occurrence of cervical HSIL in the United States and various outcomes for women who received surgical treatment. Methods: From a US commercial health insurer, a cohort of adult women with cervical HSIL diagnoses receiving surgical treatment within 3 months of diagnosis between January 2008 and September 2018 was identified. This cohort was followed for several outcomes, including cervical HSIL recurrence, human papillomavirus clearance, preterm birth, infection, and bleeding. Results: The incidence rate of cervical HSIL declined from 2.34 (95% CI = 2.30-2.39) cases per 1,000 person-years in 2008 to 1.39 (95% CI = 1.35-1.43) cases per 1,000 person-years in 2014, remaining near that level through 2018. Among 65,527 women with cervical HSIL, 47,067 (72%) received surgical treatment within 3 months of diagnosis. Among the women receiving surgical treatment, cervical HSIL recurred in 6% of surgically treated women, whereas 45% of surgically treated women underwent subsequent virological testing that indicated human papillomavirus clearance. Preterm birth was observed in 5.9% by 5 years follow-up and bleeding and infection each at 2.2% by 7 days follow-up. Conclusions: From 2008 through 2018, the incidence of diagnosed cervical HSIL decreased for several years before stabilizing. Surgical treatment of HSIL may be beneficial in removing the precancerous lesion, but cervical HSIL may recur, and the surgery is associated with complications including preterm birth, infection, and bleeding.
MeSH term(s)	Infant, Newborn ; Adult ; Female ; Humans ; United States/epidemiology ; Uterine Cervical Dysplasia/pathology ; Vaginal Smears ; Premature Birth ; Standard of Care ; Uterine Cervical Neoplasms/epidemiology ; Uterine Cervical Neoplasms/surgery ; Uterine Cervical Neoplasms/diagnosis ; Squamous Intraepithelial Lesions/epidemiology ; Squamous Intraepithelial Lesions/complications ; Carcinoma, Squamous Cell/pathology ; Treatment Outcome ; Carcinoma in Situ ; Papillomavirus Infections/complications ; Papillomavirus Infections/epidemiology ; Papillomavirus Infections/diagnosis ; Papillomaviridae
Language	English
Publishing date	2023-02-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2041332-4
ISSN	1526-0976 ; 1089-2591
ISSN (online)	1526-0976
ISSN	1089-2591
DOI	10.1097/LGT.0000000000000719
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Zs.A 5466: Show issues

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Article ; Online: Diet pattern and prodromal features of Parkinson disease.

Molsberry, Samantha / Bjornevik, Kjetil / Hughes, Katherine C / Healy, Brian / Schwarzschild, Michael / Ascherio, Alberto

Neurology

2020 Volume 95, Issue 15, Page(s) e2095–e2108

Abstract: Objective: To assess the relationship between diet pattern and prodromal Parkinson disease (PD) features.: Methods: These analyses include 47,679 participants from the Nurses' Health Study and the Health Professionals Follow-up Study. Since 1986, ... ...

Abstract	Objective: To assess the relationship between diet pattern and prodromal Parkinson disease (PD) features. Methods: These analyses include 47,679 participants from the Nurses' Health Study and the Health Professionals Follow-up Study. Since 1986, both cohorts have collected dietary information every 4 years and calculated scores for adherence to different diet patterns, including the alternate Mediterranean diet (aMED) and the Alternative Healthy Eating Index (AHEI). In 2012, participants responded to questions regarding constipation and probable REM sleep behavior disorder. For a subset of 17,400 respondents to the 2012 questionnaire, 5 additional prodromal features of PD were assessed in 2014 to 2015. We used multinomial logistic regression to estimate the association between baseline (1986) diet pattern score quintiles and number of prodromal features (0, 1, 2, or ≥3) in 2012 to 2015. Additional analyses investigated the association between long-term adherence to these dietary patterns over 20 years and prodromal features suggestive of PD. Results: In a comparison of extreme aMED diet quintiles, the odds ratio for ≥3 vs 0 features was 0.82 (95% confidence interval [CI] 0.68-1.00, false discovery rate [FDR]-adjusted Conclusions: The inverse association between these diet patterns and prodromal PD features is consistent with previous findings and suggests that adherence to a healthy diet may reduce the occurrence of nonmotor symptoms that often precede PD diagnosis.
MeSH term(s)	Adult ; Aged ; Constipation/complications ; Feeding Behavior/psychology ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Parkinson Disease/complications ; Parkinson Disease/diagnosis ; Parkinson Disease/psychology ; Prodromal Symptoms ; REM Sleep Behavior Disorder/complications
Language	English
Publishing date	2020-08-19
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0000000000010523
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