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  1. Article ; Online: Brain activity patterns underlying memory confidence.

    Wynn, Syanah C / Nyhus, Erika

    The European journal of neuroscience

    2022  Volume 55, Issue 7, Page(s) 1774–1797

    Abstract: The primary aim of this review is to examine the brain activity patterns that are related to subjectively perceived memory confidence. We focus on the main brain regions involved in episodic memory: the medial temporal lobe (MTL), prefrontal cortex (PFC), ...

    Abstract The primary aim of this review is to examine the brain activity patterns that are related to subjectively perceived memory confidence. We focus on the main brain regions involved in episodic memory: the medial temporal lobe (MTL), prefrontal cortex (PFC), and posterior parietal cortex (PPC), and relate activity in their subregions to memory confidence. How this brain activity in both the encoding and retrieval phase is related to (subsequent) memory confidence ratings will be discussed. Specifically, encoding related activity in MTL regions and ventrolateral PFC mainly shows a positive linear increase with subsequent memory confidence, while dorsolateral and ventromedial PFC activity show mixed patterns. In addition, encoding-related PPC activity seems to only have indirect effects on memory confidence ratings. Activity during retrieval in both the hippocampus and parahippocampal cortex increases with memory confidence, especially during high-confident recognition. Retrieval-related activity in the PFC and PPC show mixed relationships with memory confidence, likely related to post-retrieval monitoring and attentional processes, respectively. In this review, these MTL, PFC, and PPC activity patterns are examined in detail and related to their functional roles in memory processes. This insight into brain activity that underlies memory confidence is important for our understanding of brain-behaviour relations and memory-guided decision making.
    MeSH term(s) Brain ; Brain Mapping ; Magnetic Resonance Imaging ; Memory, Episodic ; Temporal Lobe
    Language English
    Publishing date 2022-03-29
    Publishing country France
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 645180-9
    ISSN 1460-9568 ; 0953-816X
    ISSN (online) 1460-9568
    ISSN 0953-816X
    DOI 10.1111/ejn.15649
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The role of theta and gamma oscillations in item memory, source memory, and memory confidence.

    Wynn, Syanah C / Townsend, Christopher D / Nyhus, Erika

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Theta and gamma oscillations have been linked to episodic memory processes in various studies. Both oscillations seem to be vital for processes guided by the medial temporal lobe, such as the retrieval of information from memory. While theta oscillations ...

    Abstract Theta and gamma oscillations have been linked to episodic memory processes in various studies. Both oscillations seem to be vital for processes guided by the medial temporal lobe, such as the retrieval of information from memory. While theta oscillations increase with successful memory, it is unclear what the unique contribution of theta is to various subcomponents of memory. On the other hand, memory-related gamma oscillations have been mainly reported in the hippocampus, leaving the role of neocortical gamma in memory underexplored. In the current study, we explored how unique variability in memory accuracy and memory confidence contributes to fluctuations in theta and gamma power. To this end, we recorded EEG from 54 participants while they performed a source memory task. From this task we obtained their item memory accuracy, source memory accuracy, item memory confidence, and source memory confidence. These behavioral measures were put in a trial-by-trial linear mixed effects model to uncover their unique contribution to the oscillatory power in frontal and parietal regions. Our results are in line with the involvement of theta oscillations in both memory accuracy and confidence, but seem to indicate a main role for theta oscillations in memory-related confidence. In addition, we found that gamma oscillations play various roles in memory-processing, dependent of brain region.
    Language English
    Publishing date 2023-10-19
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.10.18.562880
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Brain Networks Related to Beta Oscillatory Activity during Episodic Memory Retrieval.

    Nyhus, Erika

    Journal of cognitive neuroscience

    2017  Volume 30, Issue 2, Page(s) 174–187

    Abstract: Evidence from fMRI has consistently located a widespread network of frontal, parietal, and temporal lobe regions during episodic retrieval. However, the temporal limitations of the fMRI methodology have made it difficult to assess the transient network ... ...

    Abstract Evidence from fMRI has consistently located a widespread network of frontal, parietal, and temporal lobe regions during episodic retrieval. However, the temporal limitations of the fMRI methodology have made it difficult to assess the transient network dynamics by which these distributed regions coordinate activity. Recent evidence suggests that beta oscillations (17-20 Hz) are important for top-down control for memory suppression. However, the spatial limitations of the EEG methodology make it difficult to assess the relationship between these oscillatory signals and the distributed networks identified with fMRI. This study used simultaneous EEG/fMRI to identify networks related to beta oscillations during episodic retrieval. Participants studied adjectives and either imagined a scene (Place Task) or judged its pleasantness (Pleasant Task). During the recognition test, participants decided which task was performed with each word ("Old Place Task" or "Old Pleasant Task") or "New." EEG results revealed that posterior beta power was greater for new than old words. fMRI results revealed activity in a frontal, parietal network that was greater for old than new words, consistent with prior studies. Although overall beta power increases correlated with decreased activity within a predominantly parietal network, within the right dorsolateral and ventrolateral pFC, beta power correlated with BOLD activity more under conditions requiring more cognitive control and EEG/fMRI effects in the right frontal cortex correlated with BOLD activity in a frontoparietal network. Therefore, using simultaneous EEG and fMRI, the present results suggest that beta oscillations are related to postretrieval control operations in the right frontal cortex and act within a broader postretrieval control network.
    MeSH term(s) Adolescent ; Adult ; Beta Rhythm/physiology ; Brain/diagnostic imaging ; Brain/physiology ; Female ; Humans ; Imagination/physiology ; Judgment/physiology ; Magnetic Resonance Imaging ; Male ; Memory, Episodic ; Mental Recall/physiology ; Multimodal Imaging ; Neural Pathways/diagnostic imaging ; Neural Pathways/physiology ; Young Adult
    Language English
    Publishing date 2017-10-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1007410-7
    ISSN 1530-8898 ; 0898-929X ; 1096-8857
    ISSN (online) 1530-8898
    ISSN 0898-929X ; 1096-8857
    DOI 10.1162/jocn_a_01194
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Alpha modulation in younger and older adults during distracted encoding.

    Wynn, Syanah C / Nyhus, Erika / Jensen, Ole

    The European journal of neuroscience

    2021  Volume 55, Issue 11-12, Page(s) 3451–3464

    Abstract: To successfully encode information into long-term memory, we need top-down control to focus our attention on target stimuli. This attentional focus is achieved by the modulation of sensory neuronal excitability through alpha power. Failure to modulate ... ...

    Abstract To successfully encode information into long-term memory, we need top-down control to focus our attention on target stimuli. This attentional focus is achieved by the modulation of sensory neuronal excitability through alpha power. Failure to modulate alpha power and to inhibit distracting information has been reported in older adults during attention and working memory tasks. Given that alpha power during encoding can predict subsequent memory performance, aberrant oscillatory modulations might play a role in age-related memory deficits. However, it is unknown whether there are age-related differences in memory performance or alpha modulation when encoding targets with distraction. Here we show that both older and younger adults are able to encode targets paired with distractors and that the level of alpha power modulation during encoding predicted recognition success. Even though older adults showed signs of higher distractibility, this did not harm their episodic memory for target information. Also, we demonstrate that older adults only modulated alpha power during high distraction, both by enhancing target processing and inhibiting distractor processing. These results indicate that both younger and older adults are able to employ the same inhibitory control mechanisms successfully, but that older adults fail to call upon these when distraction is minimal. The findings of this study give us more insight into the mechanisms involved in memory encoding across the lifespan.
    MeSH term(s) Attention/physiology ; Longevity ; Memory, Episodic ; Memory, Short-Term/physiology
    Language English
    Publishing date 2021-01-11
    Publishing country France
    Document type Journal Article
    ZDB-ID 645180-9
    ISSN 1460-9568 ; 0953-816X
    ISSN (online) 1460-9568
    ISSN 0953-816X
    DOI 10.1111/ejn.15086
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Combining Behavior and EEG to Study the Effects of Mindfulness Meditation on Episodic Memory.

    Nyhus, Erika / Engel, William A / Pitfield, Tomas Donatelli / Vakkur, Isabella M W

    Journal of visualized experiments : JoVE

    2020  , Issue 159

    Abstract: Although there has been recent interest in how mindfulness meditation can affect episodic memory as well as brain structure and function, no study has examined the behavioral and neural effects of mindfulness meditation on episodic memory. Here we ... ...

    Abstract Although there has been recent interest in how mindfulness meditation can affect episodic memory as well as brain structure and function, no study has examined the behavioral and neural effects of mindfulness meditation on episodic memory. Here we present a protocol that combines mindfulness meditation training, an episodic memory task, and EEG to examine how mindfulness meditation changes behavioral performance and the neural correlates of episodic memory. Subjects in a mindfulness meditation experimental group were compared to a waitlist control group. Subjects in the mindfulness meditation experimental group spent four weeks training and practicing mindfulness meditation. Mindfulness was measured before and after training using the Five Facet Mindfulness Questionnaire (FFMQ). Episodic memory was measured before and after training using a source recognition task. During the retrieval phase of the source recognition task, EEG was recorded. The results showed that mindfulness, source recognition behavioral performance, and EEG theta power in right frontal and left parietal channels increased following mindfulness meditation training. In addition, increases in mindfulness correlated with increases in theta power in right frontal channels. Therefore, results obtained from combining mindfulness meditation training, an episodic memory task, and EEG reveal the behavioral and neural effects of mindfulness meditation on episodic memory.
    MeSH term(s) Adult ; Behavior ; Brain/physiology ; Electroencephalography ; Female ; Humans ; Male ; Meditation ; Memory, Episodic ; Mindfulness ; Surveys and Questionnaires ; Theta Rhythm/physiology ; Young Adult
    Language English
    Publishing date 2020-05-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Video-Audio Media
    ZDB-ID 2259946-0
    ISSN 1940-087X ; 1940-087X
    ISSN (online) 1940-087X
    ISSN 1940-087X
    DOI 10.3791/61247
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Incorporating an ERP Project into Undergraduate Instruction.

    Nyhus, Erika / Curtis, Nancy

    Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience

    2016  Volume 14, Issue 2, Page(s) A91–6

    Abstract: Electroencephalogram (EEG) is a relatively non-invasive, simple technique, and recent advances in open source analysis tools make it feasible to implement EEG as a component in undergraduate neuroscience curriculum. We have successfully led students to ... ...

    Abstract Electroencephalogram (EEG) is a relatively non-invasive, simple technique, and recent advances in open source analysis tools make it feasible to implement EEG as a component in undergraduate neuroscience curriculum. We have successfully led students to design novel experiments, record EEG data, and analyze event-related potentials (ERPs) during a one-semester laboratory course for undergraduates in cognitive neuroscience. First, students learned how to set up an EEG recording and completed an analysis tutorial. Students then learned how to set up a novel EEG experiment; briefly, they formed groups of four and designed an EEG experiment on a topic of their choice. Over the course of two weeks students collected behavioral and EEG data. Each group then analyzed their behavioral and ERP data and presented their results both as a presentation and as a final paper. Upon completion of the group project students reported a deeper understanding of cognitive neuroscience methods and a greater appreciation for the strengths and weaknesses of the EEG technique. Although recent advances in open source software made this project possible, it also required access to EEG recording equipment and proprietary software. Future efforts should be directed at making publicly available datasets to learn ERP analysis techniques and making publicly available EEG recording and analysis software to increase the accessibility of hands-on research experience in undergraduate cognitive neuroscience laboratory courses.
    Language English
    Publishing date 2016-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2577251-X
    ISSN 1544-2896
    ISSN 1544-2896
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Theta oscillations support active exploration in human spatial navigation.

    Chrastil, Elizabeth R / Rice, Caroline / Goncalves, Mathias / Moore, Kylie N / Wynn, Syanah C / Stern, Chantal E / Nyhus, Erika

    NeuroImage

    2022  Volume 262, Page(s) 119581

    Abstract: Active navigation seems to yield better spatial knowledge than passive navigation, but it is unclear how active decision-making influences learning and memory. Here, we examined the contributions of theta oscillations to memory-related exploration while ... ...

    Abstract Active navigation seems to yield better spatial knowledge than passive navigation, but it is unclear how active decision-making influences learning and memory. Here, we examined the contributions of theta oscillations to memory-related exploration while testing theories about how they contribute to active learning. Using electroencephalography (EEG), we tested individuals on a maze-learning task in which they made discrete decisions about where to explore at each choice point in the maze. Half the participants were free to make active decisions at each choice point, and the other half passively explored by selecting a marked choice (matched to active exploration) at each intersection. Critically, all decisions were made when stationary, decoupling the active decision-making process from movement and speed factors, which is another prominent potential role for theta oscillations. Participants were then tested on their knowledge of the maze by traveling from object A to object B within the maze. Results show an advantage for active decision-making during learning and indicate that the active group had greater theta power during choice points in exploration, particularly in midfrontal channels. These findings demonstrate that active exploration is associated with theta oscillations during human spatial navigation, and that these oscillations are not exclusively related to movement or speed. Results demonstrating increased theta oscillations in prefrontal regions suggest communication with the hippocampus and integration of new information into memory. We also found evidence for alpha oscillations during active navigation, suggesting a role for attention as well. This study finds support for a general mnemonic role for theta oscillations during navigational learning.
    MeSH term(s) Hippocampus ; Humans ; Maze Learning ; Memory ; Spatial Navigation ; Theta Rhythm
    Language English
    Publishing date 2022-08-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1147767-2
    ISSN 1095-9572 ; 1053-8119
    ISSN (online) 1095-9572
    ISSN 1053-8119
    DOI 10.1016/j.neuroimage.2022.119581
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Increases in Theta Oscillatory Activity During Episodic Memory Retrieval Following Mindfulness Meditation Training.

    Nyhus, Erika / Engel, William Andrew / Pitfield, Tomas Donatelli / Vakkur, Isabella Marie Wang

    Frontiers in human neuroscience

    2019  Volume 13, Page(s) 311

    Abstract: Mindfulness meditation has been shown to improve episodic memory and increase theta oscillations which are known to play a role in episodic memory retrieval. The present study examined the effect of mindfulness meditation on episodic memory retrieval and ...

    Abstract Mindfulness meditation has been shown to improve episodic memory and increase theta oscillations which are known to play a role in episodic memory retrieval. The present study examined the effect of mindfulness meditation on episodic memory retrieval and theta oscillations. Using a longitudinal design, subjects in the mindfulness meditation experimental group who underwent 4 weeks of mindfulness meditation training and practice were compared to a waitlist control group. During the pre-training and post-training experimental sessions, subjects completed the Five Facet Mindfulness Questionnaire (FFMQ) and studied adjectives and either imagined a scene (Place Task) or judged its pleasantness (Pleasant Task). During the recognition test, subjects decided which task was performed with each word ("Old Place Task" or "Old Pleasant Task") or "New." FFMQ scores and source discrimination were greater post-training than pre-training in the mindfulness meditation experimental group. Electroencephalography (EEG) results revealed that for the mindfulness meditation experimental group theta power was greater post-training than pre-training in right frontal and left parietal channels and changes in FFMQ scores correlated with changes in theta oscillations in right frontal channels (
    Language English
    Publishing date 2019-09-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2425477-0
    ISSN 1662-5161
    ISSN 1662-5161
    DOI 10.3389/fnhum.2019.00311
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: MAO-A Phenotype Effects Response Sensitivity and the Parietal Old/New Effect during Recognition Memory.

    Ross, Robert S / Smolen, Andrew / Curran, Tim / Nyhus, Erika

    Frontiers in human neuroscience

    2018  Volume 12, Page(s) 53

    Abstract: A critical problem for developing personalized treatment plans for cognitive disruptions is the lack of understanding how individual differences influence cognition. Recognition memory is one cognitive ability that varies from person to person and that ... ...

    Abstract A critical problem for developing personalized treatment plans for cognitive disruptions is the lack of understanding how individual differences influence cognition. Recognition memory is one cognitive ability that varies from person to person and that variation may be related to different genetic phenotypes. One gene that may impact recognition memory is the monoamine oxidase A gene (
    Language English
    Publishing date 2018-02-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2425477-0
    ISSN 1662-5161
    ISSN 1662-5161
    DOI 10.3389/fnhum.2018.00053
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Midazolam-induced amnesia reduces memory for details and affects the ERP correlates of recollection and familiarity.

    Nyhus, Erika / Curran, Tim

    Journal of cognitive neuroscience

    2012  Volume 24, Issue 2, Page(s) 416–427

    Abstract: Dual process models suggest that recognition memory is supported by familiarity and recollection processes. Previous research administering amnesic drugs and measuring ERPs during recognition memory have provided evidence for separable neural correlates ... ...

    Abstract Dual process models suggest that recognition memory is supported by familiarity and recollection processes. Previous research administering amnesic drugs and measuring ERPs during recognition memory have provided evidence for separable neural correlates of familiarity and recollection. This study examined the effect of midazolam-induced amnesia on memory for details and the proposed ERP correlates of recognition. Midazolam or saline was administered while subjects studied oriented pictures of common objects. ERPs were recorded during a recognition test 1 day later. Subjects' discrimination of old and new pictures as well as orientation discrimination was worse when they were given midazolam instead of saline. As predicted, the parietal old/new effect was decreased with the administration of midazolam. However, weaker effects on FN400 old/new effects were also observed. These results provide converging pharmacological and electrophysiological evidence that midazolam primarily affects recollection as indexed by parietal ERP old/new effects and memory for orientation, while also exerting some weaker effects on familiarity as indexed by FN400 old/new effects.
    MeSH term(s) Adolescent ; Adult ; Amnesia/chemically induced ; Amnesia/physiopathology ; Cerebral Cortex/drug effects ; Cerebral Cortex/physiopathology ; Electroencephalography ; Evoked Potentials/drug effects ; Female ; Humans ; Male ; Mental Recall/drug effects ; Midazolam/pharmacology ; Reaction Time/drug effects ; Recognition (Psychology)/drug effects
    Chemical Substances Midazolam (R60L0SM5BC)
    Language English
    Publishing date 2012-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1007410-7
    ISSN 1530-8898 ; 0898-929X ; 1096-8857
    ISSN (online) 1530-8898
    ISSN 0898-929X ; 1096-8857
    DOI 10.1162/jocn_a_00154
    Database MEDical Literature Analysis and Retrieval System OnLINE

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