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  1. AU=Hashitani Hikaru
  2. AU="Löw, Martina"
  3. AU="Robertson, Leon S"
  4. AU="Wright, Aaron T"
  5. AU="Jones, T. B."
  6. AU=Shirtliff Mark E.
  7. AU="Riis, Kamilla R"
  8. AU="Xu, Leyao"
  9. AU="Udayakumar, Karthikrajan Parasuraman"
  10. AU="Fry, Brian"

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  1. Buch: Smooth muscle spontaneous activity

    Hashitani, Hikaru / Lang, Richard J.

    physiological and pathological modulation

    (Advances in experimental medicine and biology ; 1124)

    2019  

    Verfasserangabe Hikaru Hashitani, Richard J. Lang editors
    Serientitel Advances in experimental medicine and biology ; 1124
    Überordnung
    Sprache Englisch
    Umfang xix, 427 Seiten, Illustrationen
    Verlag Springer
    Erscheinungsort Singapore
    Erscheinungsland Singapur
    Dokumenttyp Buch
    HBZ-ID HT020026243
    ISBN 978-981-13-5894-4 ; 9789811358951 ; 981-13-5894-X ; 9811358958
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  2. Artikel ; Online: PTHrP attenuates spontaneous contractions in detrusor smooth muscle of the rat bladder by activating spontaneous transient outward potassium currents.

    Kudo, Wataru / Hashitani, Hikaru

    Pflugers Archiv : European journal of physiology

    2024  Band 476, Heft 5, Seite(n) 809–820

    Abstract: Parathyroid hormone-related protein (PTHrP) released from detrusor smooth muscle (DSM) cells upon bladder distension attenuates spontaneous phasic contractions (SPCs) in DSM and associated afferent firing to facilitate urine storage. Here, we investigate ...

    Abstract Parathyroid hormone-related protein (PTHrP) released from detrusor smooth muscle (DSM) cells upon bladder distension attenuates spontaneous phasic contractions (SPCs) in DSM and associated afferent firing to facilitate urine storage. Here, we investigate the mechanisms underlying PTHrP-induced inhibition of SPCs, focusing on large-conductance Ca
    Mesh-Begriff(e) Animals ; Rats ; Urinary Bladder/metabolism ; Urinary Bladder/physiology ; Urinary Bladder/drug effects ; Parathyroid Hormone-Related Protein/pharmacology ; Parathyroid Hormone-Related Protein/metabolism ; Large-Conductance Calcium-Activated Potassium Channels/metabolism ; Muscle Contraction/drug effects ; Muscle Contraction/physiology ; Muscle, Smooth/metabolism ; Muscle, Smooth/drug effects ; Muscle, Smooth/physiology ; Rats, Sprague-Dawley ; Male ; Calcium/metabolism ; Membrane Potentials/drug effects ; Membrane Potentials/physiology
    Chemische Substanzen Parathyroid Hormone-Related Protein ; Large-Conductance Calcium-Activated Potassium Channels ; Calcium (SY7Q814VUP)
    Sprache Englisch
    Erscheinungsdatum 2024-02-29
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 6380-0
    ISSN 1432-2013 ; 0031-6768
    ISSN (online) 1432-2013
    ISSN 0031-6768
    DOI 10.1007/s00424-024-02931-2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Neural targets of the enteric dopaminergic system in regulating motility of rat proximal colon.

    Nakamori, Hiroyuki / Hashitani, Hikaru

    Pflugers Archiv : European journal of physiology

    2023  Band 475, Heft 11, Seite(n) 1315–1327

    Abstract: In isolated segments of the rat proximal colon, the dopamine reuptake inhibitor GBR 12909 (GBR) causes a dilatation, while the ... ...

    Abstract In isolated segments of the rat proximal colon, the dopamine reuptake inhibitor GBR 12909 (GBR) causes a dilatation, while the D
    Mesh-Begriff(e) Rats ; Animals ; Dopamine/pharmacology ; Tetrodotoxin/pharmacology ; Neurons ; Peristalsis/physiology ; Arginine/pharmacology ; Colon ; Gastrointestinal Motility
    Chemische Substanzen Dopamine (VTD58H1Z2X) ; Tetrodotoxin (4368-28-9) ; Arginine (94ZLA3W45F)
    Sprache Englisch
    Erscheinungsdatum 2023-08-17
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 6380-0
    ISSN 1432-2013 ; 0031-6768
    ISSN (online) 1432-2013
    ISSN 0031-6768
    DOI 10.1007/s00424-023-02849-1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Involvement of ANO1 currents in pacemaking of PDGFRα-positive specialised smooth muscle cells in rat caudal epididymis.

    Kudo, Wataru / Mitsui, Retsu / Hashitani, Hikaru

    Cell and tissue research

    2024  

    Abstract: The epididymal duct exhibits spontaneous phasic contractions (SPCs) to store and transport sperm. Here, we explored molecular identification of pacemaker cells driving SPCs in the caudal epididymal duct and also investigated properties of pacemaker ... ...

    Abstract The epididymal duct exhibits spontaneous phasic contractions (SPCs) to store and transport sperm. Here, we explored molecular identification of pacemaker cells driving SPCs in the caudal epididymal duct and also investigated properties of pacemaker currents underlying SPCs focusing on ANO1 Ca
    Sprache Englisch
    Erscheinungsdatum 2024-04-08
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 125067-x
    ISSN 1432-0878 ; 0302-766X
    ISSN (online) 1432-0878
    ISSN 0302-766X
    DOI 10.1007/s00441-024-03890-x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Commonality and heterogeneity of pacemaker mechanisms in the male reproductive organs.

    Hashitani, Hikaru / Takeya, Mitsue / van Helden, Dirk F

    The Journal of physiology

    2024  

    Abstract: During emission, the first phase of ejaculation, smooth muscle in organs of the male reproductive tract (MRT) vigorously contract upon sympathetic nerve excitation to expel semen consisting of sperm and seminal plasma. During inter-ejaculation phases, ... ...

    Abstract During emission, the first phase of ejaculation, smooth muscle in organs of the male reproductive tract (MRT) vigorously contract upon sympathetic nerve excitation to expel semen consisting of sperm and seminal plasma. During inter-ejaculation phases, the epididymis, seminal vesicles and prostate undergo spontaneous phasic contractions (SPCs), this transporting and maintaining the quality of sperm and seminal plasma. Recent studies have revealed platelet-derived growth factor receptor α-expressing (PDGFRα
    Sprache Englisch
    Erscheinungsdatum 2024-04-12
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP284756
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Roles of endothelial prostaglandin I

    Mitsui, Retsu / Miwa-Nishimura, Kyoko / Hashitani, Hikaru

    The Journal of physiology

    2023  Band 601, Heft 23, Seite(n) 5213–5240

    Abstract: In hollow visceral organs, capillary pericytes appear to drive spontaneous ... ...

    Abstract In hollow visceral organs, capillary pericytes appear to drive spontaneous Ca
    Mesh-Begriff(e) Mice ; Animals ; Pericytes ; Capillaries ; Epoprostenol ; Cromakalim ; Chloride Channels ; Adenosine Triphosphate
    Chemische Substanzen Epoprostenol (DCR9Z582X0) ; Cromakalim (0G4X367WA3) ; Chloride Channels ; Adenosine Triphosphate (8L70Q75FXE)
    Sprache Englisch
    Erscheinungsdatum 2023-10-11
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP284284
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Nitrergic inhibition of sympathetic arteriolar constrictions in the female rodent urethra.

    Hashitani, Hikaru / Mitsui, Retsu / Hirai, Yuuna / Tanaka, Hidekazu / Miwa-Nishimura, Kyoko

    The Journal of physiology

    2024  Band 602, Heft 10, Seite(n) 2199–2226

    Abstract: During the urine storage phase, tonically contracting urethral musculature would have a higher energy consumption than bladder muscle that develops phasic contractions. However, ischaemic dysfunction is less prevalent in the urethra than in the bladder, ... ...

    Abstract During the urine storage phase, tonically contracting urethral musculature would have a higher energy consumption than bladder muscle that develops phasic contractions. However, ischaemic dysfunction is less prevalent in the urethra than in the bladder, suggesting that urethral vasculature has intrinsic properties ensuring an adequate blood supply. Diameter changes in rat or mouse urethral arterioles were measured using a video-tracking system. Intercellular Ca
    Mesh-Begriff(e) Animals ; Female ; Urethra/innervation ; Urethra/physiology ; Urethra/drug effects ; Vasoconstriction/drug effects ; Mice ; Arterioles/drug effects ; Arterioles/physiology ; Arterioles/metabolism ; Rats ; Mice, Inbred C57BL ; Rats, Sprague-Dawley ; Sympathetic Nervous System/physiology ; Sympathetic Nervous System/drug effects
    Sprache Englisch
    Erscheinungsdatum 2024-04-24
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP285583
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: ATYPICAL or INTERSTITIAL, take your PIC.

    Hashitani, Hikaru / Lang, Richard J

    The Journal of physiology

    2020  Band 598, Heft 15, Seite(n) 3061–3062

    Mesh-Begriff(e) Animals ; Interstitial Cells of Cajal ; Kidney Pelvis ; Mice ; Muscle, Smooth
    Sprache Englisch
    Erscheinungsdatum 2020-06-11
    Erscheinungsland England
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP280080
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Inhibition of PDE-4 isoenzyme attenuates frequency and overall contractility of agonist-evoked ureteral phasic contractions.

    Lim, Iris / Masutani, Taishi / Hashitani, Hikaru / Chess-Williams, Russ / Sellers, Donna

    Pharmacology research & perspectives

    2024  Band 12, Heft 1, Seite(n) e1175

    Abstract: The aim of this study was to investigate the functional role of phosphodiesterase enzymes (PDE) in the isolated porcine ureter. Distal ureteral strips were mounted in organ baths and pre-contracted with 5-HT (100 μM). Upon generation of stable phasic ... ...

    Abstract The aim of this study was to investigate the functional role of phosphodiesterase enzymes (PDE) in the isolated porcine ureter. Distal ureteral strips were mounted in organ baths and pre-contracted with 5-HT (100 μM). Upon generation of stable phasic contractions, PDE-4 and PDE-5 inhibitors were added cumulatively to separate tissues. PDE-4 inhibitors, such as rolipram (10 nM and greater) and roflumilast (100 nM and greater), resulted in significant attenuation of ureteral contractile responses, while a higher concentration of piclamilast (1 μM and greater) was required to induce a significant depressant effect. The attenuation effect by rolipram was abolished by SQ22536 (100 μM). PDE-5 inhibitors, such as sildenafil and tadalafil, were not nearly as effective and were only able to suppress the 5-HT-induced contractions at higher concentrations of 1 μM. Rolipram significantly enhanced the depressant effect of forskolin, while sodium nitroprusside-induced attenuation of contractile responses remained unchanged in the presence of tadalafil. In summary, our study demonstrates that PDE-4 inhibitors are effective in attenuating 5-HT-induced contractility in porcine distal ureteral tissues, while PDE-5 inhibitors are less effective. These findings suggest that PDE-4 inhibitors, such as rolipram, may hold promise as potential therapeutic agents for the treatment of ureteral disorders attributable to increased intra-ureteral pressure.
    Mesh-Begriff(e) Animals ; Swine ; Rolipram/pharmacology ; Cyclic Nucleotide Phosphodiesterases, Type 4 ; Isoenzymes ; Phosphodiesterase 5 Inhibitors/pharmacology ; Phosphodiesterase 4 Inhibitors/pharmacology ; Ureter/physiology ; Serotonin/pharmacology ; Tadalafil
    Chemische Substanzen Rolipram (K676NL63N7) ; Cyclic Nucleotide Phosphodiesterases, Type 4 (EC 3.1.4.17) ; Isoenzymes ; Phosphodiesterase 5 Inhibitors ; Phosphodiesterase 4 Inhibitors ; Serotonin (333DO1RDJY) ; Tadalafil (742SXX0ICT)
    Sprache Englisch
    Erscheinungsdatum 2024-02-09
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2740389-0
    ISSN 2052-1707 ; 2052-1707
    ISSN (online) 2052-1707
    ISSN 2052-1707
    DOI 10.1002/prp2.1175
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Mechanosensitive modulation of peristaltic contractions in the mouse renal pelvis.

    Yoshikawa, Mikako / Mitsui, Retsu / Takano, Hiromichi / Hashitani, Hikaru

    European journal of pharmacology

    2022  Band 920, Seite(n) 174834

    Abstract: The renal pelvis develops spontaneous phasic contractions (SPCs) that underlie pyeloureteric peristalsis. Increased urine flow into the renal pelvis mechanically stimulates the contractile machinery within the renal pelvis to facilitate the propagation ... ...

    Abstract The renal pelvis develops spontaneous phasic contractions (SPCs) that underlie pyeloureteric peristalsis. Increased urine flow into the renal pelvis mechanically stimulates the contractile machinery within the renal pelvis to facilitate the propagation of peristalsis. Here, the effects of mechanostimulation of the pelvicalyceal junction (PCJ), where SPCs originate from, on the properties of SPCs were investigated. Using the wire myograph, isometric tension changes in tubular preparations of mouse renal pelvis with calyces were circumferentially measured, while mechanostimuli were applied to the PCJ. Immunohistochemistry and intracellular Ca
    Mesh-Begriff(e) Animals ; Calcitonin Gene-Related Peptide/pharmacology ; Capsaicin/pharmacology ; Kidney Pelvis/physiology ; Mice ; Muscle Contraction ; Myocytes, Smooth Muscle ; Peristalsis ; TRPV Cation Channels
    Chemische Substanzen TRPV Cation Channels ; Trpv4 protein, mouse ; Calcitonin Gene-Related Peptide (JHB2QIZ69Z) ; Capsaicin (S07O44R1ZM)
    Sprache Englisch
    Erscheinungsdatum 2022-02-17
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 80121-5
    ISSN 1879-0712 ; 0014-2999
    ISSN (online) 1879-0712
    ISSN 0014-2999
    DOI 10.1016/j.ejphar.2022.174834
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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