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  1. Article ; Online: Direct Tax Burden, Financing Constraints, and Innovation-Based Output

    Yu Lu / Yaqi Zhao / Yuhan Li / Yuhe Cao

    Sustainability, Vol 15, Iss 21, p

    2023  Volume 15275

    Abstract: Tax and fee reductions serve as pivotal instruments in the deepening of structural reforms on the supply side and constitute a significant element of China’s proactive fiscal policy. Although China’s tax regime encompasses both direct and indirect tax ... ...

    Abstract Tax and fee reductions serve as pivotal instruments in the deepening of structural reforms on the supply side and constitute a significant element of China’s proactive fiscal policy. Although China’s tax regime encompasses both direct and indirect tax burdens, the direct tax burden directly impacts the operational costs of firms and remains non-transferable. As such, it holds significant influence over corporate growth trajectories. A decrease in the direct tax burden alleviates financing constraints for firms, subsequently reducing their exposure to business risks. Focusing on the innovative output capabilities of firms, this study analyzes A-share-listed companies on the Shanghai and Shenzhen stock exchanges from 2010 to 2021. It aims to ascertain the influence of direct tax burden reductions on innovation output within the tax and fee reduction framework. The findings indicate that lessening the direct tax burden ameliorates financing constraints, thereby enhancing a firm’s innovative output capabilities. A deeper analysis reveals that non-state-owned enterprises benefit more significantly from this dynamic than their state-owned counterparts, underscoring the potential for targeted tax and fee reduction policies to bolster enterprise innovation. Furthermore, the government should recognize enterprise differentiation and drive broader economic growth through tailored strategies. Notably, the positive impact of mitigating financing constraints on innovation is more pronounced in firms with suboptimal corporate governance structures. While this mechanism notably influences non-invention patent applications, its effect on invention patent applications is comparatively muted. Post-outbreak, the interplay between tax burdens and innovative outputs has intensified, becoming more pronounced than in pre-outbreak times.
    Keywords tax and fee reduction ; direct tax burden ; enterprise innovation output ; financing constraints ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 336
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Tax Burden and Corporate Investment Efficiency

    Yu Lu / Rui Liu / Yuhe Cao / Yuhan Li

    Sustainability, Vol 15, Iss 1747, p

    2023  Volume 1747

    Abstract: Using A-share listed companies in Shanghai and Shenzhen from 2015 to 2021 as the research sample, a fixed-effects model was used to examine the effect of the reduction of corporate tax burden on investment efficiency under the tax reduction policy, as ... ...

    Abstract Using A-share listed companies in Shanghai and Shenzhen from 2015 to 2021 as the research sample, a fixed-effects model was used to examine the effect of the reduction of corporate tax burden on investment efficiency under the tax reduction policy, as well as the role of tax avoidance and financing constraints in the mechanism. The results of the study show that the reduction of tax burden can effectively improve the efficiency of corporate investment, and this positive effect is reflected in the alleviation of corporate under-investment and discouragement of over-investment. The paper also analyses the mechanism through which tax burden affects the efficiency of corporate investment, and finds that tax reduction can discourage inefficient investment by reducing corporate tax avoidance and alleviating corporate financing constraints. In further analysis, it is found that the effect of tax cuts on investment efficiency is more significant in the sample of non-state enterprises, low corporate governance and low marketisation. The findings of the study support the positive significance of the current tax reduction policy. We provide a reference of tax reduction benefits to curb tax avoidance behavior, and provide a basis for relevant policy departments to further accelerate the implementation of tax reduction policies.
    Keywords tax burden ; degree of tax avoidance ; financing constraints ; efficiency of investment ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 336
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Systematic Proteomics Study on the Embryonic Development of

    Yan, Jiahao / Ding, Yuhe / Peng, Zhao / Qin, Lu / Gu, Jingyu / Wan, Cuihong

    Journal of proteome research

    2023  Volume 22, Issue 9, Page(s) 2814–2826

    Abstract: The early development of zebrafish ( ...

    Abstract The early development of zebrafish (
    Language English
    Publishing date 2023-07-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2078618-9
    ISSN 1535-3907 ; 1535-3893
    ISSN (online) 1535-3907
    ISSN 1535-3893
    DOI 10.1021/acs.jproteome.3c00056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Dynamic changes in marker components during the stir-frying of Pharbitidis Semen, and network analysis of its potential effects on nephritis.

    Li, Yuman / Lu, Yuhe / Zhu, Yujie / Yao, Jingchun / Hua, Haibing / Shen, Jinyang / Gao, Xun / Qin, Kunming

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1123476

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-03-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1123476
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Case report: A kidney metastasis from vulvar squamous cell carcinoma.

    He, Junwei / Xiao, Yuhe / Wang, Lu / Wang, Zhaohui / Pan, Jun / Bai, Zunguang

    Frontiers in oncology

    2024  Volume 13, Page(s) 1280531

    Abstract: Introduction: Distant metastases of vulvar SCC most commonly involve the lung, liver, bone, skin, and lymph nodes. Metastasis from vulvar SCC to the kidneys is extremely rare, with only one case reported in the literature to date.: Case presentation: ...

    Abstract Introduction: Distant metastases of vulvar SCC most commonly involve the lung, liver, bone, skin, and lymph nodes. Metastasis from vulvar SCC to the kidneys is extremely rare, with only one case reported in the literature to date.
    Case presentation: We report the case of a 53-year-old postmenopausal female patient was diagnosed with vulvar squamous cell carcinoma in an external hospital and following the diagnosis, she had been performed a vulvectomy for squamous cell carcinoma of the vulva, at that time, the patient had not undergone inguinal lymphadenectomy. In July 2019, she was admitted to our hospital due to upper right quadrant pain. An enhanced whole-body CT scan showed a mixed-density tumor of the right kidney with invasion into the right renal portal vein and multiple enlarged retroperitoneal lymph nodes. Positron emission tomography-computed tomography (PET - CT) scan showed a significantly increased radioactivity uptake in the tumor and enlarged lymph nodes, but PET-CT did not show abnormal enlargement of bilateral inguinal lymph nodes and no abnormal increase in radioactivity uptake. PET-CT examination did not show recurrence in terms of local of vulvar. These results led us to be gravely worried about possible renal carcinoma, so it was agreed upon to perform laparoscopic nephrectomy of the right kidney in the same month. Histology of the resected tumor confirmed it to be poorly differentiated squamous cell carcinoma with invasion consistent with metastatic vulvar carcinoma. Based on clinical history, radiological and histological facts, the patient was diagnosed with kidney metastasis from vulvar squamous cell carcinoma. Recovery from surgery went well and the patient was transferred to the oncology department and underwent a chemotherapy regimen consisting of paclitaxel and nedaplatin for further treatment. After 6 courses of chemotherapy. For a year after treatment, the patient had lived progression-free. Unfortunately, she died of tumor progression in July 2022.
    Conclusion: Although renal metastasis from vulvar SCC is rare, renal metastasis should be considered for the patient with a history of vulvar cancer, whenever a mass is identified in the kidney. Timely surgical removal of renal metastasis may prolong the survival time.
    Language English
    Publishing date 2024-01-16
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1280531
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Advances of MnO

    Zhang, Tangxin / Hu, Chunmiao / Zhang, Wenting / Ruan, Yongdui / Ma, Yuhe / Chen, Dongsheng / Huang, Yuhe / Fan, Shuhao / Lin, Wensen / Huang, Yifan / Liao, Kangsheng / Lu, Hongemi / Xu, Jun-Fa / Pi, Jiang / Guo, Xinrong

    Frontiers in immunology

    2023  Volume 14, Page(s) 1156239

    Abstract: As an essential micronutrient, manganese plays an important role in the physiological process and immune process. In recent decades, cGAS-STING pathway, which can congenitally recognize exogenous and endogenous DNA for activation, has been widely ... ...

    Abstract As an essential micronutrient, manganese plays an important role in the physiological process and immune process. In recent decades, cGAS-STING pathway, which can congenitally recognize exogenous and endogenous DNA for activation, has been widely reported to play critical roles in the innate immunity against some important diseases, such as infections and tumor. Manganese ion (Mn
    MeSH term(s) Humans ; Signal Transduction ; Manganese ; Manganese Compounds/pharmacology ; Oxides/therapeutic use ; Nucleotidyltransferases/metabolism ; Neoplasms/drug therapy
    Chemical Substances Manganese (42Z2K6ZL8P) ; Manganese Compounds ; Oxides ; Nucleotidyltransferases (EC 2.7.7.-)
    Language English
    Publishing date 2023-04-19
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1156239
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Immunomodulatory activity of manganese dioxide nanoparticles: Promising for novel vaccines and immunotherapeutics.

    Huang, Yuhe / Ruan, Yongdui / Ma, Yuhe / Chen, Dongsheng / Zhang, Tangxin / Fan, Shuhao / Lin, Wensen / Huang, Yifan / Lu, Hongmei / Xu, Jun-Fa / Pi, Jiang / Zheng, Biying

    Frontiers in immunology

    2023  Volume 14, Page(s) 1128840

    Abstract: Manganese (Mn), a nutrient inorganic trace element, is necessary for a variety of physiological processes of animal body due to their important roles in oxidative regulation effects and other aspects of activities. Moreover, manganese ion ( ... ...

    Abstract Manganese (Mn), a nutrient inorganic trace element, is necessary for a variety of physiological processes of animal body due to their important roles in oxidative regulation effects and other aspects of activities. Moreover, manganese ion (Mn
    MeSH term(s) Animals ; Manganese Compounds/pharmacology ; Manganese Compounds/metabolism ; Manganese ; Oxides/pharmacology ; Hydrogen Peroxide/metabolism ; Nanoparticles/metabolism ; Oxygen ; Vaccines ; Immunotherapy
    Chemical Substances manganese dioxide (TF219GU161) ; Manganese Compounds ; Manganese (42Z2K6ZL8P) ; Oxides ; Hydrogen Peroxide (BBX060AN9V) ; Oxygen (S88TT14065) ; Vaccines
    Language English
    Publishing date 2023-02-28
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1128840
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Photocatalytic Conversion of Diluted CO

    Lu, Kang-Qiang / Hao, Jin-Ge / Wei, Yu / Weng, Bo / Ge, Shiyi / Yang, Kai / Lu, Suwei / Yang, Min-Quan / Liao, Yuhe

    Inorganic chemistry

    2023  Volume 63, Issue 1, Page(s) 795–802

    Abstract: The conversion of diluted ... ...

    Abstract The conversion of diluted CO
    Language English
    Publishing date 2023-12-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.3c03802
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Trends and recent progresses of selenium nanoparticles as novel autophagy regulators for therapeutic development.

    Chen, Dongsheng / Lu, Hongmei / Ma, Yuhe / Huang, Yuhe / Zhang, Tangxin / Fan, Shuhao / Lin, Wensen / Huang, Yifan / Jin, Hua / Ruan, Yongdui / Xu, Jun-Fa / Pi, Jiang

    Frontiers in nutrition

    2023  Volume 10, Page(s) 1116051

    Abstract: Autophagy, one of the major intracellular degradation systems, plays an important role in maintaining normal cellular physiological functions and protecting organisms from different diseases. Selenium (Se), an essential trace element, is involved in many ...

    Abstract Autophagy, one of the major intracellular degradation systems, plays an important role in maintaining normal cellular physiological functions and protecting organisms from different diseases. Selenium (Se), an essential trace element, is involved in many metabolic regulatory signaling events and plays a key role in human health. In recent years, selenium nanoparticles (Se NPs) have attracted increasing attentions in biomedical field due to their low toxicity, high bioavailability and high bioactivity. Taking the advantage of their advanced biological activities, Se NPs can be used alone as potential therapeutic agents, or combine with other agents and served as carriers for the development of novel therapeutics. More interestingly, Se NPs have been widely reported to affect autophagy signaling, which therefor allow Se NPs to be used as potential therapeutic agents against different diseases. Here, this review suggested the relationships between Se and autophagy, followed by the trends and recent progresses of Se NPs for autophagy regulation in different diseased conditions. More importantly, this work discussed the roles and potential mechanisms of Se NPs in autophagy regulating, which might enhance our understanding about how Se NPs regulate autophagy for potential disease treatment. This work is expected to promote the potential application of Se NPs as novel autophagy regulators, which might benefit the development of novel autophagy associated therapeutics.
    Language English
    Publishing date 2023-02-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2023.1116051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Liquid crystal monomers in ventilation and air conditioning dust: Indoor characteristics, sources analysis and toxicity assessment.

    Jin, Qianqian / Fan, Yinzheng / Lu, Yichun / Zhan, Yuting / Sun, Jiaji / Tao, Danyang / He, Yuhe

    Environment international

    2023  Volume 180, Page(s) 108212

    Abstract: Indoor dust contaminated with liquid crystal monomers (LCMs) released from various commercial liquid crystal display (LCD) screens may pose environmental health risks to humans. This study aimed to investigate the occurrence of 64 LCMs in ventilation and ...

    Abstract Indoor dust contaminated with liquid crystal monomers (LCMs) released from various commercial liquid crystal display (LCD) screens may pose environmental health risks to humans. This study aimed to investigate the occurrence of 64 LCMs in ventilation and air conditioning filters (VACF) dust, characterize their composition profiles, potential sources, and associations with indoor characteristics, and assess their in vitro toxicity using the human lung bronchial epithelial cells (BEAS-2B). A total of 31 LCMs with concentrations (ΣLCMs) ranging from 43.7 ng/g to 448 ng/g were detected in the collected VACF dust. Additional analysis revealed the potential interactions between indoor environmental conditions and human exposure risks associated with the detected LCMs in VACF dust. The service area and working time of the ventilation and air conditioning system, and the number of indoor LCD screens were positively correlated with the fluorinated ΣLCMs in VACF dust (r = 0.355 ∼ 0.511, p < 0.05), while the associations with the non-fluorinated ΣLCMs were not found (p > 0.05), suggesting different environmental behavior and fates of fluorinated and non-fluorinated LCMs in the indoor environment. Four main indoor sources of LCMs (i.e., computer (37.1%), television (28.3%), Brand A smartphone (21.2%) and Brand S smartphone (13.4%)) were identified by positive matrix factorization-multiple linear regression (PMF-MLR). Exposure to 14 relatively frequently detected LCMs, individually and in the mixture, induced significant oxidative stress in BEAS-2B cells. Among them, non-fluorinated LCMs, specifically 3cH2B and MeP3bcH, caused dominant decreased cell viability. This study provides new insights into the indoor LCMs pollution and the associated potential health risks due to the daily use of electronic devices.
    Language English
    Publishing date 2023-09-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 554791-x
    ISSN 1873-6750 ; 0160-4120
    ISSN (online) 1873-6750
    ISSN 0160-4120
    DOI 10.1016/j.envint.2023.108212
    Database MEDical Literature Analysis and Retrieval System OnLINE

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