LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 104

Search options

  1. Article ; Online: miRNAs: new biomarkers of cardiac rehabilitation response?

    Vodovar, Nicolas / Cohen-Solal, Alain

    European journal of preventive cardiology

    2021  Volume 28, Issue 15, Page(s) 1734–1735

    MeSH term(s) Biomarkers ; Cardiac Rehabilitation ; Humans ; MicroRNAs/genetics
    Chemical Substances Biomarkers ; MicroRNAs
    Language English
    Publishing date 2021-10-06
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2626011-6
    ISSN 2047-4881 ; 2047-4873
    ISSN (online) 2047-4881
    ISSN 2047-4873
    DOI 10.1093/eurjpc/zwab174
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4686: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Could Neprilysin Be Already Inhibited by BNP in the LIFE Trial?

    Vodovar, Nicolas / Cohen-Solal, Alain / Logeart, Damien

    JAMA cardiology

    2022  Volume 7, Issue 6, Page(s) 656–657

    MeSH term(s) Clinical Trials as Topic ; Humans ; Natriuretic Peptide, Brain ; Neprilysin
    Chemical Substances Natriuretic Peptide, Brain (114471-18-0) ; Neprilysin (EC 3.4.24.11)
    Language English
    Publishing date 2022-05-04
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2380-6591
    ISSN (online) 2380-6591
    DOI 10.1001/jamacardio.2022.0784
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Impact of sacubitril/valsartan on cardiac and systemic hypoxia in chronic heart failure

    Hélène Nougué / François Picard / Alain Cohen-Solal / Damien Logeart / Jean-Marie Launay / Nicolas Vodovar

    iScience, Vol 27, Iss 1, Pp 108520- (2024)

    1481  

    Abstract: Summary: In heart failure patients with reduced ejection fraction, Sacubitril/valsartan (S/V) increased proBNP T71 glycosylation, which is regulated negatively by hypoxia via miR-30a in vitro. Using a cohort of 73 HFrEF patients who were transitioned ... ...

    Abstract Summary: In heart failure patients with reduced ejection fraction, Sacubitril/valsartan (S/V) increased proBNP T71 glycosylation, which is regulated negatively by hypoxia via miR-30a in vitro. Using a cohort of 73 HFrEF patients who were transitioned from standard HF medication to S/V, we found that the increase in proBNP T71 glycosylation after S/V was associated with a decrease in cardiac hypoxia. We further found that plasma levels of K709-acteylated HIF1α, HIF-regulated and HIF-independent biomarkers also evolved consistently with a decrease in hypoxia. We further confirmed that biomarker changes were related to hypoxia, in a rat model subjected to isobaric hypoxia. We measured them in rats subjected to isobaric hypoxia. Overall, these data strongly suggest that optimally treated HFrEF patients exhibited subclinical hypoxia that is improved by S/V. The data also posit proBNP T71 glycosylation as a biomarker of cardiac hypoxia.
    Keywords Health sciences ; Medicine ; Pharmacology ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Impact of sacubitril/valsartan on cardiac and systemic hypoxia in chronic heart failure.

    Nougué, Hélène / Picard, François / Cohen-Solal, Alain / Logeart, Damien / Launay, Jean-Marie / Vodovar, Nicolas

    iScience

    2023  Volume 27, Issue 1, Page(s) 108520

    Abstract: In heart failure patients with reduced ejection fraction, Sacubitril/valsartan (S/V) increased proBNP T71 glycosylation, which is regulated negatively by hypoxia via miR- ... ...

    Abstract In heart failure patients with reduced ejection fraction, Sacubitril/valsartan (S/V) increased proBNP T71 glycosylation, which is regulated negatively by hypoxia via miR-30a
    Language English
    Publishing date 2023-11-23
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.108520
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: Impact of IDO activation and alterations in the kynurenine pathway on hyperserotonemia, NAD

    Launay, Jean-Marie / Delorme, Richard / Pagan, Cécile / Callebert, Jacques / Leboyer, Marion / Vodovar, Nicolas

    Translational psychiatry

    2023  Volume 13, Issue 1, Page(s) 380

    Abstract: Hyperserotonemia is the most replicated biochemical anomaly associated with autism spectrum disorder (ASD) and has been reported in 35-46% of individuals with ASD. Serotonin is synthesised from the essential amino acid tryptophan (TRP). However, the main ...

    Abstract Hyperserotonemia is the most replicated biochemical anomaly associated with autism spectrum disorder (ASD) and has been reported in 35-46% of individuals with ASD. Serotonin is synthesised from the essential amino acid tryptophan (TRP). However, the main catabolic route of TRP is the kynurenine pathway (KP), which competes with serotonin synthesis when indoleamine dioxygenase (IDO) is activated. Using the same cohort of individuals with ASD, we used to report extensive studies of the serotonin/melatonin pathway, and found increased kynurenine (KYN), suggesting IDO activation in 58.7% of individuals with ASD (159/271), supported by a strong negative correlation between KYN/TRP ratio and miR-153-3p plasma levels, which negatively regulates IDO. IDO activation was associated with normoserotonemia, suggesting that IDO activation could mask hyperserotonemia which meant that hyperserotonemia, if not masked by IDO activation, could be present in ~94% of individuals with ASD. We also identified several KP alterations, independent of IDO status. We observed a decrease in the activity of 3-hydroxyanthranilate dioxygenase which translated into the accumulation of the aryl hydrocarbon receptor (AhR) selective ligand cinnabarinic acid, itself strongly positively correlated with the AhR target stanniocalcin 2. We also found a deficit in NAD
    MeSH term(s) Humans ; Kynurenine ; NAD ; Serotonin ; Receptors, Aryl Hydrocarbon ; Autism Spectrum Disorder ; Tryptophan/metabolism ; Dioxygenases ; Neuropeptides ; MicroRNAs
    Chemical Substances Kynurenine (343-65-7) ; NAD (0U46U6E8UK) ; Serotonin (333DO1RDJY) ; Receptors, Aryl Hydrocarbon ; Tryptophan (8DUH1N11BX) ; Dioxygenases (EC 1.13.11.-) ; Neuropeptides ; MIRN153 microRNA, human ; MicroRNAs
    Language English
    Publishing date 2023-12-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2609311-X
    ISSN 2158-3188 ; 2158-3188
    ISSN (online) 2158-3188
    ISSN 2158-3188
    DOI 10.1038/s41398-023-02687-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Similar BNP and Mortality Association in Patients With and Without Heart Failure: Any Increase Matters.

    Vodovar, Nicolas / Logeart, Damien

    Journal of the American College of Cardiology

    2018  Volume 71, Issue 19, Page(s) 2089–2091

    MeSH term(s) Heart Failure ; Humans ; Natriuretic Peptide, Brain ; Peptide Fragments
    Chemical Substances Peptide Fragments ; Natriuretic Peptide, Brain (114471-18-0)
    Language English
    Publishing date 2018-05-10
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2018.03.454
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1846: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 196: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Ventilatory depression following oral buprenorphine exposure: insight into the involved mechanisms.

    Vodovar, Dominique / Tournier, Nicolas / Mégarbane, Bruno

    Clinical toxicology (Philadelphia, Pa.)

    2020  Volume 59, Issue 7, Page(s) 677–679

    MeSH term(s) Blood-Brain Barrier ; Buprenorphine/adverse effects ; Humans ; Naloxone/therapeutic use ; Respiratory Insufficiency/chemically induced
    Chemical Substances Naloxone (36B82AMQ7N) ; Buprenorphine (40D3SCR4GZ)
    Language English
    Publishing date 2020-11-02
    Publishing country England
    Document type Letter
    ZDB-ID 204476-6
    ISSN 1556-9519 ; 0009-9309 ; 0731-3810 ; 1556-3650
    ISSN (online) 1556-9519
    ISSN 0009-9309 ; 0731-3810 ; 1556-3650
    DOI 10.1080/15563650.2020.1837858
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 419: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Brain PET imaging using

    Auvity, Sylvain / Vodovar, Dominique / Goutal, Sébastien / Cisternino, Salvatore / Chevillard, Lucie / Soyer, Amélie / Bottlaender, Michel / Caillé, Fabien / Mégarbane, Bruno / Tournier, Nicolas

    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

    2023  Volume 44, Issue 3, Page(s) 449–458

    Abstract: Among opioids, buprenorphine presents a favorable safety profile with a limited risk of respiratory depression. However, fatalities have been reported when buprenorphine is combined to a benzodiazepine. Potentiation of buprenorphine interaction with ... ...

    Abstract Among opioids, buprenorphine presents a favorable safety profile with a limited risk of respiratory depression. However, fatalities have been reported when buprenorphine is combined to a benzodiazepine. Potentiation of buprenorphine interaction with opioid receptors (ORs) with benzodiazepines, and/or vice versa, is hypothesized to explain this drug-drug interaction (DDI). The mutual DDI between buprenorphine and benzodiazepines was investigated at the neuroreceptor level in nonhuman primates (n = 4 individuals) using brain PET imaging and kinetic modelling. The binding potential (BP
    MeSH term(s) Animals ; Benzodiazepines/metabolism ; Flumazenil/pharmacokinetics ; Buprenorphine/metabolism ; Positron-Emission Tomography/methods ; Diazepam/metabolism ; Receptors, GABA-A/metabolism ; Brain/diagnostic imaging ; Brain/metabolism
    Chemical Substances Benzodiazepines (12794-10-4) ; Flumazenil (40P7XK9392) ; Buprenorphine (40D3SCR4GZ) ; Diazepam (Q3JTX2Q7TU) ; Receptors, GABA-A
    Language English
    Publishing date 2023-12-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604628-9
    ISSN 1559-7016 ; 0271-678X
    ISSN (online) 1559-7016
    ISSN 0271-678X
    DOI 10.1177/0271678X231221040
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1663: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Patterns of left ventricular remodeling post-myocardial infarction, determinants, and outcome.

    Logeart, Damien / Taille, Yoann / Derumeaux, Geneviève / Gellen, Barnabas / Sirol, Marc / Galinier, Michel / Roubille, François / Georges, Jean-Louis / Trochu, Jean-Noël / Launay, Jean-Marie / Vodovar, Nicolas / Bauters, Christophe / Vicaut, Eric / Mercadier, Jean-Jacques

    Clinical research in cardiology : official journal of the German Cardiac Society

    2024  

    Abstract: Aim: Left ventricular remodeling (LVR) after myocardial infarction (MI) can lead to heart failure, arrhythmia, and death. We aim to describe adverse LVR patterns at 6 months post-MI and their relationships with subsequent outcomes and to determine ... ...

    Abstract Aim: Left ventricular remodeling (LVR) after myocardial infarction (MI) can lead to heart failure, arrhythmia, and death. We aim to describe adverse LVR patterns at 6 months post-MI and their relationships with subsequent outcomes and to determine baseline.
    Methods and results: A multicenter cohort of 410 patients (median age 57 years, 87% male) with reperfused MI and at least 3 akinetic LV segments on admission was analyzed. All patients had transthoracic echocardiography performed 4 days and 6 months post-MI, and 214 also had cardiac magnetic resonance imaging performed on day 4. To predict LVR, machine learning methods were employed in order to handle many variables, some of which may have complex interactions. Six months post-MI, echocardiographic increases in LV end-diastolic volume (LVEDV), LV end-systolic volume (LVESV), and LV ejection fraction (LVEF) were 14.1% [interquartile range 0.0, 32.0], 5.0% [- 14.0, 25.8], and 8.7% [0.0, 19.4], respectively. At 6 months, ≥ 15% or 20% increases in LVEDV were observed in 49% and 42% of patients, respectively, and 37% had an LVEF < 50%. The rate of death or new-onset HF at the end of 5-year follow-up was 8.8%. Baseline variables associated with adverse LVR were determined best by random forest analysis and included stroke volume, stroke work, necrosis size, LVEDV, LVEF, and LV afterload, the latter assessed by Ea or Ea/Ees. In contrast, baseline clinical and biological characteristics were poorly predictive of LVR. After adjustment for predictive baseline variables, LV dilation > 20% and 6-month LVEF < 50% were significantly associated with the risk of death and/or heart failure: hazard ratio (HR) 2.12 (95% confidence interval (CI) 1.05-4.43; p = 0.04) and HR 2.68 (95% CI 1.20-6.00; p = 0.016) respectively.
    Conclusion: Despite early reperfusion and cardioprotective therapy, adverse LVR remains frequent after acute MI and is associated with a risk of death and HF. A machine learning approach identified and prioritized early variables that are associated with adverse LVR and which were mainly hemodynamic, combining LV volumes, estimates of systolic function, and afterload.
    Language English
    Publishing date 2024-01-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2213295-8
    ISSN 1861-0692 ; 1861-0684
    ISSN (online) 1861-0692
    ISSN 1861-0684
    DOI 10.1007/s00392-023-02331-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui IV Zs 10: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: A pharmacological imaging challenge based on

    Leroy, Claire / Goutal, Sébastien / Breuil, Louise / Gervais, Philippe / Cherkaoui, Hamza / Ciuciu, Philippe / Auvity, Sylvain / Vodovar, Dominique / Comtat, Claude / Lebon, Vincent / Bottlaender, Michel / Tournier, Nicolas

    European journal of nuclear medicine and molecular imaging

    2023  Volume 50, Issue 10, Page(s) 3153–3154

    MeSH term(s) Humans ; Analgesics, Opioid/pharmacology ; Buprenorphine/pharmacology ; Magnetic Resonance Imaging ; Positron-Emission Tomography
    Chemical Substances Analgesics, Opioid ; Buprenorphine (40D3SCR4GZ)
    Language English
    Publishing date 2023-05-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-023-06253-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1227: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top