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  1. Book ; Online: F.A.Q. Thesis

    Gudera, Andy / Stehr, Heiko

    "konkrete" Hinweise für die Erstellung von Abschlussarbeiten : ein unkonventioneller Ratgeber für Studenten, Professoren und Betreuer

    2014  

    Title variant Frequently asked questions
    Author's details Andy Gudera; Heiko Stehr
    Language German
    Size Online-Ressource (180 S.), Ill., graph. Darst.
    Edition 13. April 2012
    Publisher tredition
    Publishing place Hamburg
    Document type Book ; Online
    Note Literaturverz. S. 178 - 180
    ISBN 9783849591151 ; 3849591158
    Database Former special subject collection: coastal and deep sea fishing

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  2. Article ; Conference proceedings: Eine Kurzskala zur emotionalen sozialen Unterstützung auf Basis des F-SozU-K14: Vergleichende Analysen mittels klassischer und probabilistischer Testtheorie

    Stehr, M / Hardt, J / Lengerke, T von

    Das Gesundheitswesen

    2010  

    Abstract: ... Vor diesem Hintergrund prüft diese Studie drei Kurzskalen auf Basis des F-SozU-K14 (Kurzform des Fragebogens ...

    Event/congress Individualisierte Prävention und Epidemiologie: Die Moderne Medizin, Berlin, 2010
    Abstract Hintergrund: Emotionale Unterstützung gilt als die Komponente sozialer Unterstützung mit den stärksten Assoziationen zu gesundheitlichen Endpunkten. Für klinische und epidemiologische Studien sind daher ökonomische Instrumente zur reliablen und validen Erfassung des Konstrukts wünschenswert. Vor diesem Hintergrund prüft diese Studie drei Kurzskalen auf Basis des F-SozU-K14 (Kurzform des Fragebogens zur Sozialen Unterstützung) durch vergleichende Analysen mit Methoden der klassischen (KTT) und probabilistischen Testtheorie (PTT).
    Methoden: Für die Konstruktion der Kurzskalen lagen Daten der 2758 Teilnehmer des KORA-Surveys 2004/2005 vor (Region Augsburg, Alter: 35–74 Jahre). Die Itemauswahl erfolgte anhand inhaltlicher Überlegungen, testtheoretischer Gütekriterien sowie Kriterien faktoren- und regressionsanalytischer Modelle. Die Analysen auf Grundlage der KTT prüften Trennschärfen, Schwierigkeitsindizes, Cronbach's alphas, Split-Half-Reliabilitäten und mittlere Item-Interkorrelationen für drei Versionen einer Kurzskala mit 8, 4 und 3 Items. In ordinalen Rasch-Modellen mit Winsteps® (PTT) wurden Reliabilität, Korrelationen, Kategorie-Funktionen sowie Item- und Modell-Fit-Parameter geprüft.
    Ergebnisse: Die Kurzskala mit 4 Items weist bei guter interner Konsistenz (Cronbach's alpha=0,87) den besten Trade-off zwischen testtheoretischen Gütekriterien und ökonomischer Durchführung auf. Die Items weisen hohe Trennschärfen (r[it]=0,65–0,79) und relativ geringe Schwierigkeiten (p[m]=0,80–0,82) auf. Die Rasch-Analysen zeigen für diese Kurzskala eine angemessene Reliabilität (PR=0,78) und eine hohe Korrelation der Summenskala und des latenten Personenparameters (r=0,94). Die Gütekriterien der Model-Fit-Parameter (Infit und Outfit Mnsq/Range=0,75–1,27) waren für das ordinale (partial credit) Rasch-Modell erfüllt.
    Diskussion: Die Reliabilität und Validität einer 4-Item-Kurzskala zur emotionalen Unterstützung konnte auf Basis testtheoretischer Analysen (KTT und PTT) gezeigt werden. Die PTT-Analysen ergaben zusätzliche Erkenntnisse zu den Gütekriterien der Skala. Inhaltlich zeigt ein Vergleich der Kurzskala mit dem ENRICHD-Social-Support-Instrument (ESSI, fünf Items) trotz unterschiedlicher und unabhängiger Konstruktion der Instrumente hohe Ähnlichkeiten der Items. Dies unterstreicht ihre Relevanz, wirft jedoch auch die Frage auf, ob nicht beide Instrumente „nur“ emotionale Unterstützung erfassen, und ob weitere Kurzskalen andere Komponenten sozialer Unterstützung (instrumentelle Unterstützung, soziale Integration) berücksichtigen sollten.
    Language German
    Publishing date 2010-09-02
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 1101426-x
    ISSN 1439-4421 ; 0941-3790 ; 0949-7013
    ISSN (online) 1439-4421
    ISSN 0941-3790 ; 0949-7013
    DOI 10.1055/s-0030-1266259
    Database Thieme publisher's database

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  3. Book ; Online ; Thesis: Sekretierte Lipasen des humanpathogenen Pilzes Candida albicans und ihre Bedeutung als Virulenzfaktoren

    Stehr, Frank

    2003  

    Author's details vorgelegt von Frank Stehr
    Language German
    Publishing country Germany
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Hamburg, Univ., Diss., 2003
    Note Open Access
    HBZ-ID HT013953349
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: The parent and family impact of CLN3 disease: an observational survey-based study.

    Schulz, Angela / Patel, Nita / Brudvig, Jon J / Stehr, Frank / Weimer, Jill M / Augustine, Erika F

    Orphanet journal of rare diseases

    2024  Volume 19, Issue 1, Page(s) 125

    Abstract: Background: CLN3 disease (also known as CLN3 Batten disease or Juvenile Neuronal Ceroid Lipofuscinosis) is a rare pediatric neurodegenerative disorder caused by biallelic mutations in CLN3. While extensive efforts have been undertaken to understand CLN3 ...

    Abstract Background: CLN3 disease (also known as CLN3 Batten disease or Juvenile Neuronal Ceroid Lipofuscinosis) is a rare pediatric neurodegenerative disorder caused by biallelic mutations in CLN3. While extensive efforts have been undertaken to understand CLN3 disease etiology, pathology, and clinical progression, little is known about the impact of CLN3 disease on parents and caregivers. Here, we investigated CLN3 disease progression, clinical care, and family experiences using semi-structured interviews with 39 parents of individuals with CLN3 disease. Analysis included response categorization by independent observers and quantitative methods.
    Results: Parents reported patterns of disease progression that aligned with previous reports. Insomnia and thought- and mood-related concerns were reported frequently. "Decline in visual acuity" was the first sign/symptom noticed by n = 28 parents (70%). A minority of parents reported "behavioral issues" (n = 5, 12.5%), "communication issues" (n = 3, 7.5%), "cognitive decline" (n = 1, 2.5%), or "seizures" (n = 1, 2.5%) as the first sign/symptom. The mean time from the first signs or symptoms to a diagnosis of CLN3 disease was 2.8 years (SD = 4.1). Misdiagnosis was common, being reported by n = 24 participants (55.8%). Diagnostic tests and treatments were closely aligned with observed symptoms. Desires for improved or stabilized vision (top therapeutic treatment concern for n = 14, 32.6%), cognition (n = 8, 18.6%), and mobility (n = 3, 7%) dominated parental concerns and wishes for therapeutic correction. Family impacts were common, with n = 34 (81%) of respondents reporting a financial impact on the family and n = 20 (46.5%) reporting marital strain related to the disease.
    Conclusions: Collectively, responses demonstrated clear patterns of disease progression, a strong desire for therapies to treat symptoms related to vision and cognition, and a powerful family impact driven by the unrelenting nature of disease progression.
    MeSH term(s) Humans ; Child ; Neuronal Ceroid-Lipofuscinoses/genetics ; Molecular Chaperones/genetics ; Molecular Chaperones/therapeutic use ; Membrane Glycoproteins/genetics ; Parents ; Disease Progression ; Surveys and Questionnaires
    Chemical Substances Molecular Chaperones ; Membrane Glycoproteins ; CLN3 protein, human
    Language English
    Publishing date 2024-03-18
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 2225857-7
    ISSN 1750-1172 ; 1750-1172
    ISSN (online) 1750-1172
    ISSN 1750-1172
    DOI 10.1186/s13023-024-03119-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Genomic landscape of T-large granular lymphocyte leukemia and chronic lymphoproliferative disorder of NK cells: a single institution experience.

    Fei, Fei / Stehr, Henning / Zehnder, James L

    Leukemia & lymphoma

    2023  Volume 64, Issue 9, Page(s) 1536–1544

    Abstract: LGLL is a rare and chronic lymphoproliferative disorder including T-LGLL and CLPD-NK. Here, we investigated the genomic profiles of LGLL with a focus on STAT3 and STAT5B mutations in a cohort of 49 patients (41 T-LGLL, 8 CLPD-NK). Our study indicated ... ...

    Abstract LGLL is a rare and chronic lymphoproliferative disorder including T-LGLL and CLPD-NK. Here, we investigated the genomic profiles of LGLL with a focus on STAT3 and STAT5B mutations in a cohort of 49 patients (41 T-LGLL, 8 CLPD-NK). Our study indicated that STAT3 was identified in 38.8% (19/49) of all patients, while STAT5B occurred in only 8.2% (4/49) of patients. We found that STAT3 mutations were associated with lower ANC in T-LGLL patients. The average number of pathogenic/likely pathogenic mutations in STAT3/STAT5B-mutated patients was significantly higher than that in WT patients (1.78 ± 1.17 vs 0.65 ± 1.36,
    MeSH term(s) Humans ; Leukemia, Large Granular Lymphocytic/diagnosis ; Leukemia, Large Granular Lymphocytic/genetics ; Leukemia, Large Granular Lymphocytic/pathology ; Killer Cells, Natural/pathology ; Mutation ; Genomics
    Language English
    Publishing date 2023-06-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2023.2220450
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Die NCL-Stiftung setzt sich für eine Zukunft ohne Kinderdemenz ein. The NCL Foundation is committed to a future without child dementia

    Stehr, F.

    Medizinische Genetik

    2018  Volume 30, Issue 2, Page(s) 274

    Language German
    Document type Article
    ZDB-ID 1083376-6
    ISSN 0936-5931
    Database Current Contents Medicine

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  7. Article ; Conference proceedings: Die Kinderdemenz NCL – Nicht nur eine Erkrankung des Auges

    Stehr, F

    Klinische Monatsblätter für Augenheilkunde

    2017  Volume 234, Issue 10

    Event/congress 20. Tagung der Bielschowsky-Gesellschaft für Strabologie, Neuroophthalmologie und Pädiatrische Ophthalmologie, Justus-Liebig Universität Gießen, 2017-06-30
    Language German
    Publishing date 2017-10-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 80175-6
    ISSN 1439-3999 ; 0023-2165 ; 0344-6360 ; 0344-6387
    ISSN (online) 1439-3999
    ISSN 0023-2165 ; 0344-6360 ; 0344-6387
    DOI 10.1055/s-0037-1604694
    Database Thieme publisher's database

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  8. Article ; Online: Calibration-free counting of low molecular copy numbers in single DNA-PAINT localization clusters.

    Stein, Johannes / Stehr, Florian / Jungmann, Ralf / Schwille, Petra

    Biophysical reports

    2021  Volume 1, Issue 2, Page(s) 100032

    Abstract: Single-molecule localization microscopy (SMLM) has revolutionized light microscopy by enabling optical resolution down to a few nanometer. Yet, localization precision commonly does not suffice to visually resolve single subunits in molecular assemblies ... ...

    Abstract Single-molecule localization microscopy (SMLM) has revolutionized light microscopy by enabling optical resolution down to a few nanometer. Yet, localization precision commonly does not suffice to visually resolve single subunits in molecular assemblies or multimeric complexes. Because each targeted molecule contributes localizations during image acquisition, molecular counting approaches to reveal the target copy numbers within localization clusters have been persistently proposed since the early days of SMLM, most of which rely on preliminary knowledge of the dye photophysics or on a calibration to a reference. Previously, we developed localization-based fluorescence correlation spectroscopy (lbFCS) as an absolute ensemble counting approach for the SMLM-variant DNA-PAINT (points accumulation for imaging in nanoscale topography), for the first time, to our knowledge, circumventing the necessity for reference calibrations. Here, we present an extended concept termed lbFCS+, which allows absolute counting of copy numbers for individual localization clusters in a single DNA-PAINT image. In lbFCS+, absolute counting of fluorescent loci contained in individual nanoscopic volumes is achieved via precise measurement of the local hybridization rates of the fluorescently labeled oligonucleotides ("imagers") employed in DNA-PAINT imaging. In proof-of-principle experiments on DNA origami nanostructures, we demonstrate the ability of lbFCS+ to truthfully determine molecular copy numbers and imager association and dissociation rates in well-separated localization clusters containing up to 10 docking strands. For
    Language English
    Publishing date 2021-11-10
    Publishing country United States
    Document type Journal Article
    ISSN 2667-0747
    ISSN (online) 2667-0747
    DOI 10.1016/j.bpr.2021.100032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Demenzerkrankung im Kindesalter - Allein unter Millionen

    Stehr, Frank

    Hospiz-Dialog Nordrhein-Westfalen

    2016  Volume 66, Issue -, Page(s) 17

    Language German
    Document type Article
    ZDB-ID 2257959-X
    Database Current Contents Medicine

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  10. Article ; Online: [No title information]

    Stehr, F

    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft

    2010  

    Title translation Neuronale Zeroidlipofuszinose - nicht nur eine Erkrankung der Netzhaut.
    Language German
    Publishing date 2010-04-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1105167-x
    ISSN 1433-0423 ; 0941-293X
    ISSN (online) 1433-0423
    ISSN 0941-293X
    DOI 10.1007/s00347-009-2105-z
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    Full text online

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