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  1. Article ; Online: Longitudinally extensive posterolateral myelitis revealing invasive CNS aspergillosis in an immunocompetent patient.

    Jeantin, Lina / Leclercq, Delphine / Tran, Suzanne / Maillart, Elisabeth / Reina, Vincent / Fekkar, Arnaud / Lanternier, Fanny / Marois, Clémence / Celier, Adam

    Multiple sclerosis (Houndmills, Basingstoke, England)

    2024  , Page(s) 13524585231221680

    Abstract: Background: Fungal infections of the central nervous system usually affect immunocompromised patients. Primary : Report: A 45-year-old immunocompetent male with subacute paraplegia was treated for inflammatory myelitis before clinical deterioration ... ...

    Abstract Background: Fungal infections of the central nervous system usually affect immunocompromised patients. Primary
    Report: A 45-year-old immunocompetent male with subacute paraplegia was treated for inflammatory myelitis before clinical deterioration requiring mechanical ventilation. Purulent meningitis preceded the formation of a paraspinal nodule biopsied by neurosurgery. Histopathological analysis revealed the presence of fungal hyphae, and polymerase chain reaction was positive for
    Discussion: Primary
    Language English
    Publishing date 2024-01-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 1290669-4
    ISSN 1477-0970 ; 1352-4585
    ISSN (online) 1477-0970
    ISSN 1352-4585
    DOI 10.1177/13524585231221680
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    Zs.A 4428: Show issues Location:
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  2. Article ; Online: Earliest case of Candida auris infection imported in 2007 in Europe from India prior to the 2009 description in Japan.

    Desnos-Ollivier, Marie / Fekkar, Arnaud / Bretagne, Stéphane

    Journal de mycologie medicale

    2021  Volume 31, Issue 3, Page(s) 101139

    Abstract: Candida auris is an emerging pathogen frequently associated with multidrug resistance and involved in many worldwide outbreaks. We here report the first European imported case in France due to isolate belonging of the South Indian clade I and the ... ...

    Abstract Candida auris is an emerging pathogen frequently associated with multidrug resistance and involved in many worldwide outbreaks. We here report the first European imported case in France due to isolate belonging of the South Indian clade I and the importance of prevention measure to avoid fungal spreading.
    MeSH term(s) Antifungal Agents/therapeutic use ; Candida ; Candida auris ; Candidiasis, Invasive/drug therapy ; Europe ; Humans ; India ; Japan
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2021-04-08
    Publishing country France
    Document type Case Reports
    ZDB-ID 1067006-3
    ISSN 1773-0449 ; 1156-5233
    ISSN (online) 1773-0449
    ISSN 1156-5233
    DOI 10.1016/j.mycmed.2021.101139
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  3. Article ; Online: Fungal Infection during COVID-19: Does

    Fekkar, Arnaud / Poignon, Corentin / Blaize, Marion / Lampros, Alexandre

    American journal of respiratory and critical care medicine

    2020  Volume 202, Issue 6, Page(s) 902–903

    MeSH term(s) Aspergillosis ; Aspergillus ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; Pulmonary Aspergillosis ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-17
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202005-1945LE
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  4. Article ; Online: Hospital Clonal Outbreak of Fluconazole-Resistant Candida parapsilosis Harboring the Y132F ERG11p Substitution in a French Intensive Care Unit.

    Presente, Simona / Bonnal, Christine / Normand, Anne-Cécile / Gaudonnet, Yannick / Fekkar, Arnaud / Timsit, Jean-François / Kernéis, Solen

    Antimicrobial agents and chemotherapy

    2023  Volume 67, Issue 3, Page(s) e0113022

    Abstract: We report the first identification of a fluconazole-resistant Candida parapsilosis (FR- ...

    Abstract We report the first identification of a fluconazole-resistant Candida parapsilosis (FR-
    MeSH term(s) Humans ; Fluconazole/pharmacology ; Fluconazole/therapeutic use ; Candida parapsilosis/genetics ; Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Drug Resistance, Fungal/genetics ; Microbial Sensitivity Tests ; Intensive Care Units ; Disease Outbreaks ; Hospitals
    Chemical Substances Fluconazole (8VZV102JFY) ; Antifungal Agents
    Language English
    Publishing date 2023-02-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/aac.01130-22
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  5. Article ; Online: Invasive Aspergillosis with impaired neutrophil responses against Aspergillus fumigatus in patients treated with Acalabrutinib-findings from three cases.

    Blaize, Marion / Thizy, Guillaume / Boissonnas, Alexandre / Portalier, Anaïs / Lanternier, Fanny / de La Porte des Vaux, Clémentine / Suarez, Felipe / Bougnoux, Marie-Elisabeth / Guitard, Juliette / Jabet, Arnaud / Stocker, Nicolas / Aoudjhane, Abdelmalek / Roos-Weil, Damien / Fekkar, Arnaud

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2024  Volume 142, Page(s) 107000

    Abstract: Objectives: Ibrutinib, a first-generation covalent Bruton's tyrosine kinase inhibitor (BTKi) was found to be a risk factor for the occurrence of invasive fungal complications. Acalabrutinib is a second-generation covalent BTKi used to treat B-cell ... ...

    Abstract Objectives: Ibrutinib, a first-generation covalent Bruton's tyrosine kinase inhibitor (BTKi) was found to be a risk factor for the occurrence of invasive fungal complications. Acalabrutinib is a second-generation covalent BTKi used to treat B-cell malignancies. Healthy donor neutrophils incubated ex vivo with acalabrutinib lose ability to control Aspergillus conidia germination. In patients receiving acalabrutinib, the potential effect on neutrophil antifungal activity is unknown. Furthermore, only two cases of invasive aspergillosis have been reported during treatment with acalabrutinib, outside of a few cases in a clinical trial.
    Methods: We describe three new cases of invasive aspergillosis occurring within the first months of acalabrutinib therapy in patients with chronic lymphocytic leukemia. We used videomicroscopy and flow cytometry approaches to investigate the basic functional responses against Aspergillus of neutrophils from acalabrutinib-treated patients.
    Results: We showed an alteration in the anti-Aspergillus response after 1 month of acalabrutinb therapy: neutrophils lost their capacities of killing Aspergillus fumigatus germinating conidia and decreased their reactive oxygen species production when stimulated by Aspergillus.
    Conclusions: It is important to follow-up patients treated with acalabrutinib for the risk of aspergillosis as well as those treated with ibrutinib.
    MeSH term(s) Humans ; Agammaglobulinaemia Tyrosine Kinase ; Aspergillus fumigatus ; Neutrophils ; Aspergillosis/drug therapy ; Protein Kinase Inhibitors/therapeutic use ; Benzamides ; Pyrazines
    Chemical Substances Agammaglobulinaemia Tyrosine Kinase (EC 2.7.10.2) ; acalabrutinib (I42748ELQW) ; Protein Kinase Inhibitors ; Benzamides ; Pyrazines
    Language English
    Publishing date 2024-03-08
    Publishing country Canada
    Document type Case Reports
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2024.107000
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    Zs.A 4516: Show issues Location:
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  6. Article ; Online: COVID-19-associated pulmonary aspergillosis (CAPA): how big a problem is it?

    Fekkar, Arnaud / Neofytos, Dionysios / Nguyen, Minh-Hong / Clancy, Cornelius J / Kontoyiannis, Dimitrios P / Lamoth, Frederic

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2021  Volume 27, Issue 9, Page(s) 1376–1378

    MeSH term(s) COVID-19/complications ; Coinfection/diagnosis ; Coinfection/epidemiology ; Humans ; Invasive Pulmonary Aspergillosis/diagnosis ; Invasive Pulmonary Aspergillosis/epidemiology ; Invasive Pulmonary Aspergillosis/virology ; SARS-CoV-2
    Language English
    Publishing date 2021-06-27
    Publishing country England
    Document type Letter
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2021.06.025
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    Zs.A 4541: Show issues Location:
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  7. Article: Fungal Infection during COVID-19: Does Aspergillus Mean Secondary Invasive Aspergillosis?

    Fekkar, Arnaud / Poignon, Corentin / Blaize, Marion / Lampros, Alexandre

    Am J Respir Crit Care Med

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #656344
    Database COVID19

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  8. Article: Improving the Detection of Epidemic Clones in

    Mohammad, Noshine / Normand, Anne-Cécile / Nabet, Cécile / Godmer, Alexandre / Brossas, Jean-Yves / Blaize, Marion / Bonnal, Christine / Fekkar, Arnaud / Imbert, Sébastien / Tannier, Xavier / Piarroux, Renaud

    Microorganisms

    2023  Volume 11, Issue 4

    Abstract: Identifying fungal clones propagated during outbreaks in hospital settings is a problem that increasingly confronts biologists. Current tools based on DNA sequencing or microsatellite analysis require specific manipulations that are difficult to ... ...

    Abstract Identifying fungal clones propagated during outbreaks in hospital settings is a problem that increasingly confronts biologists. Current tools based on DNA sequencing or microsatellite analysis require specific manipulations that are difficult to implement in the context of routine diagnosis. Using deep learning to classify the mass spectra obtained during the routine identification of fungi by MALDI-TOF mass spectrometry could be of interest to differentiate isolates belonging to epidemic clones from others. As part of the management of a nosocomial outbreak due to
    Language English
    Publishing date 2023-04-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11041071
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  9. Article ; Online: COVID-19-related Respiratory Failure and Lymphopenia Do Not Seem Associated with Pneumocystosis.

    Blaize, Marion / Mayaux, Julien / Luyt, Charles-Edouard / Lampros, Alexandre / Fekkar, Arnaud

    American journal of respiratory and critical care medicine

    2020  Volume 202, Issue 12, Page(s) 1734–1736

    MeSH term(s) COVID-19 ; Coinfection ; Humans ; Lymphopenia ; Pneumocystis carinii ; Pneumonia, Pneumocystis ; Respiratory Insufficiency/etiology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-09-17
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202007-2938LE
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  10. Article ; Online: Hospital outbreak of fluconazole-resistant

    Fekkar, Arnaud / Blaize, Marion / Bouglé, Adrien / Normand, Anne-Cécile / Raoelina, Audrey / Kornblum, Dimitri / Kamus, Laure / Piarroux, Renaud / Imbert, Sébastien

    Antimicrobial agents and chemotherapy

    2021  Volume 95, Issue 5

    Abstract: The worldwide emergence of multidrug-resistant pathogenic fungi is a threat to human health. At this very moment, an emergence ... ...

    Abstract The worldwide emergence of multidrug-resistant pathogenic fungi is a threat to human health. At this very moment, an emergence of
    Language English
    Publishing date 2021-02-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.02036-20
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