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Article ; Online: Letter in Response to the Article "Platelet-Rich Plasma Versus Platelet-Poor Plasma for Treating Facial Photoaging: A Double Blind Randomized Controlled Splitting Face Study" by Tsai and Cheng et al.

Tsai, Ya-Wen / Cheng, Chun-Yu / Huang, Yau-Li

2024

Language	English
Publishing date	2024-02-27
Publishing country	United States
Document type	Letter
ZDB-ID	532791-x
ISSN	1432-5241 ; 0364-216X
ISSN (online)	1432-5241
ISSN	0364-216X
DOI	10.1007/s00266-024-03934-1
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Article ; Online: EEG-Channel-Temporal-Spectral-Attention Correlation for Motor Imagery EEG Classification.

Hsu, Wei-Yen / Cheng, Ya-Wen

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society

2023 Volume 31, Page(s) 1659–1669

Abstract: In brain-computer interface (BCI) work, how correctly identifying various features and their corresponding actions from complex Electroencephalography (EEG) signals is a challenging technology. However, most current methods do not consider EEG feature ... ...

Abstract	In brain-computer interface (BCI) work, how correctly identifying various features and their corresponding actions from complex Electroencephalography (EEG) signals is a challenging technology. However, most current methods do not consider EEG feature information in spatial, temporal and spectral domains, and the structure of these models cannot effectively extract discriminative features, resulting in limited classification performance. To address this issue, we propose a novel text motor-imagery EEG discrimination method, namely wavelet-based temporal-spectral-attention correlation coefficient (WTS-CC), to simultaneously consider the features and their weighting in spatial, EEG-channel, temporal and spectral domains in this study. The initial Temporal Feature Extraction (iTFE) module extracts the initial important temporal features of MI EEG signals. The Deep EEG-Channel-attention (DEC) module is then proposed to automatically adjust the weight of each EEG channel according to its importance, thereby effectively enhancing more important EEG channels and suppressing less important EEG channels. Next, the Wavelet-based Temporal-Spectral-attention (WTS) module is proposed to obtain more significant discriminative features between different MI tasks by weighting features on two-dimensional time-frequency maps. Finally, a simple discrimination module is used for MI EEG discrimination. The experimental results indicate that the proposed text WTS-CC method can achieve promising discrimination performance that outperforms the state-of-the-art methods in terms of classification accuracy, Kappa coefficient, F1 score, and AUC on three public datasets.
MeSH term(s)	Humans ; Imagination ; Brain ; Electroencephalography/methods ; Brain-Computer Interfaces ; Algorithms
Language	English
Publishing date	2023-03-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1166307-8
ISSN	1558-0210 ; 1063-6528 ; 1534-4320
ISSN (online)	1558-0210
ISSN	1063-6528 ; 1534-4320
DOI	10.1109/TNSRE.2023.3255233
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Zs.A 4726: Show issues

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Article ; Online: The sonographic and histopathologic correlation study of solitary nevus lipomatosus cutaneus superficialis.

Tsai, Ya-Wen / Cheng, Chun-Yu

Indian journal of dermatology, venereology and leprology

2022 Volume 88, Issue 6, Page(s) 819–822

MeSH term(s)	Humans ; Correlation of Data ; Nevus/diagnostic imaging ; Skin Neoplasms/diagnostic imaging ; Skin Neoplasms/pathology ; Lipomatosis/diagnostic imaging
Language	English
Publishing date	2022-08-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	416068-x
ISSN	0973-3922 ; 0019-5162 ; 0378-6323
ISSN (online)	0973-3922
ISSN	0019-5162 ; 0378-6323
DOI	10.25259/IJDVL_1139_2021
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Zs.A 85: Show issues

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Article ; Online: Poor in vitro activity of ceftazidime/avibactam against carbapenem-resistant Escherichia coli and Klebsiella pneumoniae in India: Results from the Antimicrobial Testing Leadership and Surveillance (ATLAS) program, 2018 - 2021.

Hsueh, Chun-Chung / Lai, Chih-Cheng / Tsai, Ya-Wen / Ko, Wen-Chien / Wang, Jiun-Ling

International journal of antimicrobial agents

2024 Volume 63, Issue 3, Page(s) 107087

MeSH term(s)	Ceftazidime/pharmacology ; Klebsiella pneumoniae ; Leadership ; Anti-Bacterial Agents/pharmacology ; Carbapenem-Resistant Enterobacteriaceae ; Escherichia coli ; Carbapenems/pharmacology ; Azabicyclo Compounds
Chemical Substances	Ceftazidime (9M416Z9QNR) ; avibactam (7352665165) ; Anti-Bacterial Agents ; Carbapenems ; Azabicyclo Compounds
Language	English
Publishing date	2024-01-12
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2024.107087
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Zs.A 3368: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Impact of the trans-ancestry polygenic risk score on type 2 diabetes risk, onset age and progression among population in Taiwan.

Wang, Shi-Heng / Huang, Yu-Chuen / Cheng, Chun-Wen / Chang, Ya-Wen / Liao, Wen-Ling

American journal of physiology. Endocrinology and metabolism

2024 Volume 326, Issue 5, Page(s) E547–E554

Abstract: Type 2 diabetes (T2D) prevalence in adults at a younger age has increased but the disease status may go unnoticed. This study aimed to determine whether the onset age and subsequent diabetic complications can be attributed to the polygenic architecture ... ...

Abstract	Type 2 diabetes (T2D) prevalence in adults at a younger age has increased but the disease status may go unnoticed. This study aimed to determine whether the onset age and subsequent diabetic complications can be attributed to the polygenic architecture of T2D in the Taiwan Han population. A total of 9,627 cases with T2D and 85,606 controls from the Taiwan Biobank were enrolled. Three diabetic polygenic risk scores (PRSs), PRS_EAS and PRS_EUR, and a trans-ancestry PRS (PRS_META), calculated using summary statistic from East Asian and European populations. The onset age was identified by linking to the National Taiwan Insurance Research Database, and the incidence of different diabetic complications during follow-up was recorded. PRS_META (7.4%) explained a higher variation for T2D status. And the higher percentile of PRS is also correlated with higher percentage of T2D family history and prediabetes status. More, the PRS was negatively associated with onset age (β = -0.91 yr), and this was more evident among males (β = -1.11 vs. -0.76 for males and females, respectively). The hazard ratio of diabetic retinopathy (DR) and diabetic foot were significantly associated with PRS_EAS and PRS_META, respectively. However, the PRS was not associated with other diabetic complications, including diabetic nephropathy, cardiovascular disease, and hypertension. Our findings indicated that diabetic PRS which combined susceptibility variants from cross-population could be used as a tool for early screening of T2D, especially for high-risk populations, such as individuals with high genetic risk, and may be associated with the risk of complications in subjects with T2D.
MeSH term(s)	Male ; Adult ; Female ; Humans ; Diabetes Mellitus, Type 2/genetics ; Genetic Risk Score ; Taiwan ; Genetic Predisposition to Disease ; Age of Onset ; Polymorphism, Single Nucleotide ; Genome-Wide Association Study ; Risk Factors ; Diabetic Retinopathy
Language	English
Publishing date	2024-02-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	603841-4
ISSN	1522-1555 ; 0193-1849
ISSN (online)	1522-1555
ISSN	0193-1849
DOI	10.1152/ajpendo.00252.2023
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Uc I Zs.89: Show issues

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Article ; Online: The small heat shock protein Hsp20.8 imparts tolerance to high temperatures in the leafminer fly,

Zhang, Yue / Chang, Ya-Wen / Wang, Yu-Cheng / Yan, Yu-Qing / Du, Yu-Zhou

Bulletin of entomological research

2024 , Page(s) 1–7

Abstract: As an environmental factor, temperature impacts the distribution of species and influences interspecific competition. The molecular chaperones encoded by small heat shock proteins (sHsps) are essential for rapid, appropriate responses to environmental ... ...

Abstract	As an environmental factor, temperature impacts the distribution of species and influences interspecific competition. The molecular chaperones encoded by small heat shock proteins (sHsps) are essential for rapid, appropriate responses to environmental stress. This study focuses on
Language	English
Publishing date	2024-03-13
Publishing country	England
Document type	Journal Article
ZDB-ID	280516-9
ISSN	1475-2670 ; 0007-4853
ISSN (online)	1475-2670
ISSN	0007-4853
DOI	10.1017/S0007485324000026
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Zs.B 514: Show issues

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Article ; Online: High ceftazidime-avibactam resistance among carbapenem-resistant Enterobacter species: Data from the Antimicrobial Testing Leadership and Surveillance (ATLAS) programme, 2014-2021.

Wang, Jiun-Ling / Lai, Chih-Cheng / Tsai, Ya-Wen / Ko, Wen-Chien / Hsueh, Po-Ren

International journal of antimicrobial agents

2024 Volume 63, Issue 4, Page(s) 107105

Abstract: Objectives: Trends in the susceptibility to ceftazidime-avibactam (CZA) and tigecycline (TGC) among Enterobacter species from different geographic areas are unknown.This study aimed to analyse the trends in CZA and TGC susceptibility changes across ... ...

Abstract	Objectives: Trends in the susceptibility to ceftazidime-avibactam (CZA) and tigecycline (TGC) among Enterobacter species from different geographic areas are unknown.This study aimed to analyse the trends in CZA and TGC susceptibility changes across different continents from 2014 to 2021 utilizing Antimicrobial Testing Leadership and Surveillance (ATLAS) data. Methods: A total of 23 669 isolates of Enterobacter species were collected over an 8-y period. Results: The overall non-susceptibility rate of Enterobacter isolates to both CZA and TGC was 3.2%. India (16.5%), Guatemala (15.4%), and the Philippines (13.1%) exhibited the highest resistance to CZA. The increase in CZA resistance rates was particularly evident in Asia, with an increase from 4.0% to 8.3%, and in Latin America, from 1.5% to 5%. The non-susceptibility rate for TGC mildly increased in Africa/Middle East but decreased in other continents during the study period. The overall rate of carbapenem resistance increased from 2.9% in 2014-2017 to 4.3% in 2018-2021. Among carbapenem-resistant Enterobacter isolates, the CZA resistance rate was highest in Asia (87.4%), followed by Europe (69.2%) and Africa/Middle East (60.8%). Among the 380 Enterobacter isolates resistant to CZA and carbapenem, the most common genotype of carbapenemase genes was bla Conclusions: The heterogeneous distribution of CZA resistance rates among different geographical regions highlights the divergent therapeutic options for drug-resistant Enterobacter species.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Carbapenems/pharmacology ; Enterobacter/genetics ; Leadership ; Ceftazidime/pharmacology ; Ceftazidime/therapeutic use ; Azabicyclo Compounds/pharmacology ; Azabicyclo Compounds/therapeutic use ; Anti-Infective Agents ; Drug Combinations ; Tigecycline ; beta-Lactamases/genetics ; Microbial Sensitivity Tests
Chemical Substances	avibactam, ceftazidime drug combination ; Anti-Bacterial Agents ; Carbapenems ; Ceftazidime (9M416Z9QNR) ; Azabicyclo Compounds ; Anti-Infective Agents ; Drug Combinations ; Tigecycline (70JE2N95KR) ; beta-Lactamases (EC 3.5.2.6)
Language	English
Publishing date	2024-02-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2024.107105
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Zs.A 3368: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Can Live-Actor Patients in a Mass Casualty Incident Exercise Benefit as Exercise Players?

Chou, Wei-Kuo / Chiang, Wen-Chu / Chen, Ya-Wen / Cheng, Ming-Tai

Disaster medicine and public health preparedness

2023 Volume 17, Page(s) e439

Abstract: Objectives: In a mass casualty incident (MCI) exercise, live-actor patients (LAPs) simulated different scenarios in the exercise. This study compared the benefit to LAPs with that to exercise players (EPs) and nonparticipants (NPs).: Methods: An MCI ... ...

Abstract	Objectives: In a mass casualty incident (MCI) exercise, live-actor patients (LAPs) simulated different scenarios in the exercise. This study compared the benefit to LAPs with that to exercise players (EPs) and nonparticipants (NPs). Methods: An MCI exercise was conducted in 2018. Emergency department (ED) nurses were assigned as EPs, LAPs, or NPs and asked to attend a pre-exercise lecture. A pre-exercise survey evaluated all ED nurses' background, confidence level, and knowledge of MCI management. Knowledge assessment included disaster medicine knowledge (DMK) and on emergency operation plan familiarity (EOPF). The same survey was conducted again after the exercise. A paired t-test was used to analyze the difference before and after the exercise in the 3 groups. Results: Twenty-nine ED nurses completed both surveys. Confidence improved significantly for both the EP and LAP groups. The DMK of the LAP group improved significantly. EOPF also improved significantly for all 3 groups. A comparison of the improvement levels showed no significant difference between the EP and LAP groups for confidence, DMK, and EOPF. Conclusions: ED nurses can benefit from participating as LAPs in full-scale MCI exercises. Having ED nurses act as LAPs makes it possible to train more staff in 1 exercise.
MeSH term(s)	Humans ; Mass Casualty Incidents ; Disaster Planning ; Emergency Service, Hospital ; Exercise
Language	English
Publishing date	2023-07-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2375268-3
ISSN	1938-744X ; 1935-7893
ISSN (online)	1938-744X
ISSN	1935-7893
DOI	10.1017/dmp.2023.97
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Article ; Online: Recurrent hemichorea in an adolescent with systemic lupus erythematosus and previous ipsilateral cerebral infarction.

Yu, Ya-Wen / Chung, Cheng-Yu / Chiou, Yee-Hsuan / Fang, Nai-Wen

International journal of rheumatic diseases

2023 Volume 27, Issue 1, Page(s) e14886

Abstract: Systemic lupus erythematosus (SLE) can present with movement disorders, among which chorea is closely associated with antiphospholipid (aPL) antibodies. Brain imaging results obtained in patients with chorea are generally inconsistent with the clinical ... ...

Abstract	Systemic lupus erythematosus (SLE) can present with movement disorders, among which chorea is closely associated with antiphospholipid (aPL) antibodies. Brain imaging results obtained in patients with chorea are generally inconsistent with the clinical manifestation of chorea; moreover, medical tests for hemichorea, which are expected to reveal distinct localization, may show negative findings. Herein, we present a case of a 15-year-old girl with SLE who had a history of left cerebral infarction; tests revealed elevated aPL levels, and she developed recurrent left hemichorea 2 years later. Brain magnetic resonance imaging (MRI) results revealed no acute lesions during each episode of involuntary movements, and an MRI perfusion scan failed to provide an explanation for the asymmetric presentation. Although various hypotheses have been proposed regarding the mechanism underlying the occurrence of chorea, some scenarios still remain unexplained. Further investigation on the pathophysiology of chorea in SLE may be warranted to clarify its prognosis.
MeSH term(s)	Female ; Humans ; Adolescent ; Chorea/diagnosis ; Chorea/drug therapy ; Chorea/etiology ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/drug therapy ; Cerebral Infarction/etiology ; Cerebral Infarction/complications ; Antibodies, Antiphospholipid ; Brain
Chemical Substances	Antibodies, Antiphospholipid
Language	English
Publishing date	2023-08-22
Publishing country	England
Document type	Case Reports
ZDB-ID	2426924-4
ISSN	1756-185X ; 1756-1841
ISSN (online)	1756-185X
ISSN	1756-1841
DOI	10.1111/1756-185X.14886
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Zs.A 6098: Show issues

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Article ; Online: Structure-based development of a canine TNF-α-specific antibody using adalimumab as a template.

Lee, Cheng-Chung / Kuo, Wen-Chih / Chang, Ya-Wen / Hsu, Shu-Fang / Wu, Chia-Hung / Chen, Ya-Wen / Chang, Jui-Jen / Wang, Andrew H-J

Protein science : a publication of the Protein Society

2024 Volume 33, Issue 2, Page(s) e4873

Abstract: The canine anti-tumor necrosis factor-alpha (TNF-α) monoclonal antibody is a potential therapeutic option for treating canine arthritis. The current treatments for arthritis in dogs have limitations due to side effects, emphasizing the need for safer and ...

Abstract	The canine anti-tumor necrosis factor-alpha (TNF-α) monoclonal antibody is a potential therapeutic option for treating canine arthritis. The current treatments for arthritis in dogs have limitations due to side effects, emphasizing the need for safer and more effective therapies. The crystal structure of canine TNF-α (cTNF-α) was successfully determined at a resolution of 1.85 Å, and the protein was shown to assemble as a trimer, with high similarity to the functional quaternary structure of human TNF-α (hTNF-α). Adalimumab (Humira), a known TNF-α inhibitor, effectively targets and neutralizes TNF-α to reduce inflammation and has been used to manage autoimmune conditions such as rheumatoid arthritis. By comparing the structure of cTNF-α with the complex structure of hTNF-α and adalimumab-Fab, the epitope of adalimumab on cTNF-α was identified. The significant structural similarities of epitopes in cTNF-α and hTNF-α indicate the potential of using adalimumab to target cTNF-α. Therefore, a canine/human chimeric antibody, Humivet-R1, was created by grafting the variable domain of adalimumab onto a canine antibody framework derived from ranevetmab. Humivet-R1 exhibits potent neutralizing ability (IC
MeSH term(s)	Dogs ; Animals ; Humans ; Adalimumab/pharmacology ; Adalimumab/therapeutic use ; Tumor Necrosis Factor-alpha ; Antibodies, Monoclonal ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/pathology
Chemical Substances	Adalimumab (FYS6T7F842) ; Tumor Necrosis Factor-alpha ; Antibodies, Monoclonal
Language	English
Publishing date	2024-01-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	1106283-6
ISSN	1469-896X ; 0961-8368
ISSN (online)	1469-896X
ISSN	0961-8368
DOI	10.1002/pro.4873
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