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  1. Article ; Online: Furin Protease: From SARS CoV-2 to Anthrax, Diabetes, and Hypertension.

    Fitzgerald, Kara

    The Permanente journal

    2021  Volume 24

    Abstract: Furin is a protease that is ubiquitous in mammalian metabolism. One of the innovations that make sudden acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) more infectious than its ancestor viruses is the addition of a furin cleavage site. Conditions ... ...

    Abstract Furin is a protease that is ubiquitous in mammalian metabolism. One of the innovations that make sudden acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) more infectious than its ancestor viruses is the addition of a furin cleavage site. Conditions associated with elevated furin levels, including diabetes, obesity, and hypertension, overlap greatly with vulnerability to the severe form of coronavirus disease 2019 (COVID-19). We suggest that diet and lifestyle modifications that reduce the associated comorbidities may prevent the development of severe COVID-19 by, in part, lowering circulating furin levels. Likewise, natural and pharmaceutical inhibitors of furin may be candidate prophylactic interventions or, if used early in the COVID-19, may prevent the development of critical symptoms.
    MeSH term(s) Anthrax/blood ; Anthrax/enzymology ; COVID-19/blood ; COVID-19/enzymology ; Diabetes Mellitus/blood ; Diabetes Mellitus/enzymology ; Furin/blood ; Humans ; Hypertension/blood ; Hypertension/enzymology ; SARS Virus/enzymology ; SARS Virus/metabolism
    Chemical Substances Furin (EC 3.4.21.75)
    Keywords covid19
    Language English
    Publishing date 2021-01-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2062823-7
    ISSN 1552-5775 ; 1552-5775
    ISSN (online) 1552-5775
    ISSN 1552-5775
    DOI 10.7812/TPP/20.187
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Enhancing your practice: debriefing in interventional radiology.

    Fitzgerald, Kara / Knight, Jesse / Valji, Karim

    CVIR endovascular

    2024  Volume 7, Issue 1, Page(s) 12

    Abstract: Learning objectives: Review the history of debriefing and provide an Interventional Radiologist (IR) specific framework for leading an effective debrief.: Background: A debrief is often regarded as a meeting with persons who were involved in a ... ...

    Abstract Learning objectives: Review the history of debriefing and provide an Interventional Radiologist (IR) specific framework for leading an effective debrief.
    Background: A debrief is often regarded as a meeting with persons who were involved in a stressful, traumatic and/or emotionally challenging situation to review processes, communicate concerns or gather feedback. The goals of these sessions can be for learning/quality improvement (QI) or psychological/emotional support, or a mix of both. Debriefing after tough situations has become a standard tool of many medical specialties, such as surgery, critical care and emergency medicine, with specialty specific literature available. However, there is a paucity of Interventional Radiology specific literature available for debriefing techniques.
    Clinical findings/procedure details: We will review the history and types of debriefing and why a debrief could be considered. We will provide a framework for leading a successful debrief in Interventional Radiology.
    Conclusion: Debriefing can be a useful tool for learning and QI as well as psychological or emotional support after a challenging or tough situation. Debriefing can address multiple variables and can stylistically be tailored to suit specific needs. IRs have an opportunity to take a leadership role in debriefing, providing comfort and quality improvement through communication and support.
    Language English
    Publishing date 2024-01-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2520-8934
    ISSN (online) 2520-8934
    DOI 10.1186/s42155-023-00412-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Furin Protease

    Fitzgerald, Kara

    SSRN Electronic Journal ; ISSN 1556-5068

    From SARS CoV‐2 to Anthrax, Diabetes and Hypertension

    2020  

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.2139/ssrn.3612934
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Furin Protease: From SARS CoV-2 to Anthrax, Diabetes, and Hypertension

    Fitzgerald, Kara

    Abstract: Furin is a protease that is ubiquitous in mammalian metabolism. One of the innovations that make sudden acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) more infectious than its ancestor viruses is the addition of a furin cleavage site. Conditions ... ...

    Abstract Furin is a protease that is ubiquitous in mammalian metabolism. One of the innovations that make sudden acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) more infectious than its ancestor viruses is the addition of a furin cleavage site. Conditions associated with elevated furin levels, including diabetes, obesity, and hypertension, overlap greatly with vulnerability to the severe form of coronavirus disease 2019 (COVID-19). We suggest that diet and lifestyle modifications that reduce the associated comorbidities may prevent the development of severe COVID-19 by, in part, lowering circulating furin levels. Likewise, natural and pharmaceutical inhibitors of furin may be candidate prophylactic interventions or, if used early in the COVID-19, may prevent the development of critical symptoms.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #931342
    Database COVID19

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  5. Article ; Online: Potential reversal of biological age in women following an 8-week methylation-supportive diet and lifestyle program: a case series.

    Fitzgerald, Kara N / Campbell, Tish / Makarem, Suzanne / Hodges, Romilly

    Aging

    2023  Volume 15, Issue 6, Page(s) 1833–1839

    Abstract: Here we report on a case series of six women who completed a methylation-supportive diet and lifestyle program designed to impact DNA methylation and measures of biological aging. The intervention consisted of an 8-week program that included diet, sleep, ...

    Abstract Here we report on a case series of six women who completed a methylation-supportive diet and lifestyle program designed to impact DNA methylation and measures of biological aging. The intervention consisted of an 8-week program that included diet, sleep, exercise and relaxation guidance, supplemental probiotics and phytonutrients and nutritional coaching. DNA methylation and biological age analysis (Horvath DNAmAge clock (2013), normalized using the SeSAMe pipeline [a]) was conducted on blood samples at baseline and at the end of the 8-week period. Five of the six participants exhibited a biological age reduction of between 1.22 and 11.01 years from their baseline biological age. There was a statistically significant (p=.039) difference in the participants' mean biological age before (55.83 years) and after (51.23 years) the 8-week diet and lifestyle intervention, with an average decrease of 4.60 years. The average chronological age at the start of the program was 57.9 years and all but one participant had a biological age younger than their chronological age at the start of the program, suggesting that biological age changes were unrelated to disease improvement and instead might be attributed to underlying aging mechanisms.
    MeSH term(s) Humans ; Female ; Epigenesis, Genetic ; DNA Methylation ; Aging/genetics ; Life Style ; Diet
    Language English
    Publishing date 2023-03-22
    Publishing country United States
    Document type Journal Article
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.204602
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Sixteen-year-old Female With Acute Abdominal Pain: A Case Report.

    Fitzgerald, Kara

    Integrative medicine (Encinitas, Calif.)

    2015  Volume 14, Issue 6, Page(s) 26–29

    Abstract: A 16-y-old girl presented with abdominal pain in the lower right quadrant, ranging in intensity from 2 to 10 on a visual analog scale (VAS) that prevented her from attending school. The pain was not associated with reflux, a fever, or blood in her stools. ...

    Abstract A 16-y-old girl presented with abdominal pain in the lower right quadrant, ranging in intensity from 2 to 10 on a visual analog scale (VAS) that prevented her from attending school. The pain was not associated with reflux, a fever, or blood in her stools. Eosinophilic esophagitis (EE) had been previously diagnosed, but treatment with a proton pump inhibitor (PPI) was not successful. The patient's medical history was significant for allergies to fruit; trees, including birch; weeds; and pollen. She had also suffered an anaphylactic reaction to a raw apple. The treatment approach commonly used for EE is suppression of inflammation with steroid therapy with short-term removal of offending foods. However, an attempt to reduce allergic bias and inflammation and treat intestinal permeability is not a part of the standard approach and may explain the high rate of relapse with the condition. Treatment included an elimination diet paired with a supplement regimen designed to reduce inflammation, support healing of the gut and reduce type 2 helper T (Th2) bias of her allergic response. As a result of treatment, the patient's severe pain episodes abated and she was thereafter able to resume attendance at school.
    Language English
    Publishing date 2015-10-06
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2100529-1
    ISSN 1945-7081 ; 1546-993X
    ISSN (online) 1945-7081
    ISSN 1546-993X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5748: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: We're all in this together ….

    Fitzgerald, Kara

    Alternative therapies in health and medicine

    2013  Volume 19, Issue 2, Page(s) 16–18

    MeSH term(s) Asian Continental Ancestry Group ; China/epidemiology ; Humans ; Metabolic Syndrome/epidemiology ; Obesity/epidemiology
    Language English
    Publishing date 2013-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1225073-9
    ISSN 1078-6791
    ISSN 1078-6791
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4504: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Correction: Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial.

    Fitzgerald, Kara N / Hodges, Romilly / Hanes, Douglas / Stack, Emily / Cheishvili, David / Szyf, Moshe / Henkel, Janine / Twedt, Melissa W / Giannopoulou, Despina / Herdell, Josette / Logan, Sally / Bradley, Ryan

    Aging

    2024  Volume 16, Issue 5, Page(s) 4943–4945

    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.205700
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Association between body mass index and chronic hypertension in patients with hypertension disorders of pregnancy one-year postpartum.

    Anguzu, Ronald / Livergood, Christine M / Hoppe, Kara K / Kulinski, Jacquelyn / Fitzgerald, Garrett D / Palatnik, Anna

    Pregnancy hypertension

    2023  Volume 35, Page(s) 32–36

    Abstract: Objectives: To determine the association between body mass index (BMI) and chronic hypertension (CHTN) one-year postpartum following pregnancies complicated by hypertensive disorders of pregnancy (HDP).: Study design: A retrospective cohort study of ... ...

    Abstract Objectives: To determine the association between body mass index (BMI) and chronic hypertension (CHTN) one-year postpartum following pregnancies complicated by hypertensive disorders of pregnancy (HDP).
    Study design: A retrospective cohort study of patients with HDP (gestational hypertension or preeclampsia) in a single Midwestern academic center from 2014 to 2018. The primary outcome was CHTN at one-year postpartum, defined as systolic blood pressure ≥ 130 mmHg or diastolic blood pressure ≥ 80 mmHg or taking antihypertensive medication at one-year postpartum. The primary exposure variable was BMI at one-year postpartum, categorized as underweight (<18.5 kg/m
    Results: Out of 596 patients with HDP included in this analysis, 275 (46.1 %) had CHTN one-year postpartum. Mean one-year postpartum BMI was 27.9 ± 5.2 kg/m
    Conclusions: Obesity at one-year postpartum following HDP was associated with a higher risk of CHTN compared with normal BMI. Weight is a modifiable risk factor that should be targeted in postpartum interventions to reduce cardiovascular disease following HDP.
    MeSH term(s) Pregnancy ; Female ; Humans ; Pre-Eclampsia ; Overweight ; Body Mass Index ; Retrospective Studies ; Hypertension, Pregnancy-Induced ; Obesity/complications ; Obesity/epidemiology ; Postpartum Period ; Risk Factors
    Language English
    Publishing date 2023-12-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2584464-7
    ISSN 2210-7797 ; 2210-7789
    ISSN (online) 2210-7797
    ISSN 2210-7789
    DOI 10.1016/j.preghy.2023.12.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: A case report of a 53-year-old female with rheumatoid arthritis and osteoporosis: focus on lab testing and CAM therapies.

    Fitzgerald, Kara

    Alternative medicine review : a journal of clinical therapeutic

    2011  Volume 16, Issue 3, Page(s) 250–262

    Abstract: A 53-year-old female presented with rheumatoid arthritis and osteoporosis. Additional conditions and symptoms included Raynaud syndrome, fatigue, irritable bowel syndrome associated constipation (IBS-C), gastroesophageal reflux (GERD), menopausal ... ...

    Abstract A 53-year-old female presented with rheumatoid arthritis and osteoporosis. Additional conditions and symptoms included Raynaud syndrome, fatigue, irritable bowel syndrome associated constipation (IBS-C), gastroesophageal reflux (GERD), menopausal symptoms, chronic urinary tract and upper respiratory infections, and weight gain. She was taking Arthrotec (a combination of diclofenac and misoprostol - for pain and inflammation), Fosamax Plus D (alendronate with vitamin D3 - recently prescribed because of low bone density), and Catapres (clonidine - for menopausal symptoms). Against the advice of her rheumatologist, she had recently discontinued taking Plaquenil (hydroxychloroquine), methotrexate, and prednisone due to significant side effects. Lab tests to identify underlying imbalances and to direct treatment were ordered. Treatment included dietary, nutritional, hormonal, and mind/body support. After one year of therapy, the patient experienced improvement with all of her presenting conditions and symptoms, which enabled her to discontinue several medications. She became versed in identifying and avoiding the environmental triggers of her disease, including foods (dairy, wheat, eggs, and soy), molds, and emotional stress. Antinuclear antibodies were normalized. She experienced a 7.5-percent improvement in left trochanteric bone density - comparable to bisphosphonate therapy. Mild improvements were also noted in the spine and bilateral femoral neck.
    MeSH term(s) Arthritis, Rheumatoid/blood ; Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/drug therapy ; Bone Density/drug effects ; Comorbidity ; Complementary Therapies/methods ; Dietary Supplements ; Female ; Humans ; Middle Aged ; Osteoporosis/blood ; Osteoporosis/complications ; Osteoporosis/drug therapy ; Treatment Outcome
    Language English
    Publishing date 2011-09
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1465535-4
    ISSN 1089-5159
    ISSN 1089-5159
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4997: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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