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  1. Book ; Thesis: Wirkung von Steroiden auf Überleben und Funktion retinaler Ganglienzellen nach Netzhautischämie

    Volz, Cornelia

    2011  

    Author's details vorgelegt von Cornelia Volz
    Language German
    Size 61 Bl. : Ill.
    Edition [Mikrofiche-Ausg.]
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Freiburg (Breisgau), Univ., Diss., 2012
    HBZ-ID HT017455940
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Baseline characteristics and progression of neovascular age-related macular degeneration in patients receiving over 60 intravitreal injections of anti-vascular endothelial growth factor.

    Prahs, Philipp / Brandl, Caroline / Helbig, Horst / Volz, Cornelia

    Romanian journal of ophthalmology

    2023  Volume 67, Issue 3, Page(s) 260–266

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Humans ; Aged ; Angiogenesis Inhibitors/therapeutic use ; Vascular Endothelial Growth Factor A ; Retrospective Studies ; Intravitreal Injections ; Ranibizumab ; Macular Degeneration/diagnosis ; Macular Degeneration/drug therapy ; Tomography, Optical Coherence/methods ; Wet Macular Degeneration/diagnosis ; Wet Macular Degeneration/drug therapy
    Chemical Substances Angiogenesis Inhibitors ; Vascular Endothelial Growth Factor A ; Ranibizumab (ZL1R02VT79)
    Language English
    Publishing date 2023-11-01
    Publishing country Romania
    Document type Journal Article
    ZDB-ID 2842202-8
    ISSN 2501-2533 ; 2457-4325
    ISSN (online) 2501-2533
    ISSN 2457-4325
    DOI 10.22336/rjo.2023.43
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: ERG Alteration Due to the rd8 Mutation of the Crb1 Gene in Cln3

    Volz, Cornelia / Mirza, Myriam / Langmann, Thomas / Jägle, Herbert

    Advances in experimental medicine and biology

    2019  Volume 1185, Page(s) 395–400

    Abstract: Mattapallil et al. described that vendor lines for C57BL/6 N mice may carry the rd8 mutation that leads to an ocular phenotype, which could be mistaken for an induced retinal degeneration. This mouse strain is widely used in ophthalmic research as a ... ...

    Abstract Mattapallil et al. described that vendor lines for C57BL/6 N mice may carry the rd8 mutation that leads to an ocular phenotype, which could be mistaken for an induced retinal degeneration. This mouse strain is widely used in ophthalmic research as a background for modeling retinal degeneration. In the process of studying Cln3
    MeSH term(s) Aging ; Animals ; Disease Models, Animal ; Electroretinography ; Gene Knock-In Techniques ; Membrane Glycoproteins/genetics ; Mice ; Mice, Inbred C57BL ; Molecular Chaperones/genetics ; Mutation ; Nerve Tissue Proteins/genetics ; Retina/physiopathology ; Retinal Degeneration/genetics
    Chemical Substances CLN3 protein, mouse ; Crb1 protein, mouse ; Membrane Glycoproteins ; Molecular Chaperones ; Nerve Tissue Proteins
    Language English
    Publishing date 2019-12-28
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-030-27378-1_65
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Perioperative Antibiotikaprophylaxe in der Dermatochirurgie - Positionspapier der Arbeitsgruppe Antibiotic Stewardship der Deutschen Gesellschaft für Dermatochirurgie (DGDC), Teil 2: Spezielle Indikationen und Situationen.

    Balakirski, Galina / Becker, Sören L / Hartmann, Daniela / Kofler, Lukas / Kunte, Christian / Müller, Cornelia S L / Volz, Thomas / Kendziora, Benjamin / Schlager, Justin Gabriel / Löser, Christoph R

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2023  Volume 21, Issue 10, Page(s) 1109–1119

    Language German
    Publishing date 2023-10-26
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.15153_g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Further Characterization of the Predominant Inner Retinal Degeneration of Aging Cln3

    Volz, Cornelia / Mirza, Myriam / Langmann, Thomas / Jägle, Herbert

    Advances in experimental medicine and biology

    2018  Volume 1074, Page(s) 403–411

    Abstract: Neuronal ceroid lipofuscinosis (NCL) is the most common group of neurogenetic storage diseases typically beginning in childhood. The juvenile form (JNCL), also known as Batten disease, is the most common form. Vision-related problems are often an early ... ...

    Abstract Neuronal ceroid lipofuscinosis (NCL) is the most common group of neurogenetic storage diseases typically beginning in childhood. The juvenile form (JNCL), also known as Batten disease, is the most common form. Vision-related problems are often an early sign, appearing prior to motor and mental deficits. We have previously investigated disease progression with age in the Cln3
    MeSH term(s) Aging ; Animals ; Disease Models, Animal ; Electroretinography ; Eye Proteins/genetics ; Eye Proteins/physiology ; Gap Junctions/physiology ; Gene Knock-In Techniques ; Membrane Glycoproteins/genetics ; Membrane Glycoproteins/physiology ; Mice ; Mice, Inbred C57BL ; Molecular Chaperones/genetics ; Molecular Chaperones/physiology ; Neuronal Ceroid-Lipofuscinoses/genetics ; Neuronal Ceroid-Lipofuscinoses/physiopathology ; Night Vision ; Retinal Degeneration/genetics ; Retinal Degeneration/physiopathology ; Retinal Rod Photoreceptor Cells/physiology ; Visual Pathways/physiology
    Chemical Substances CLN3 protein, mouse ; Eye Proteins ; Membrane Glycoproteins ; Molecular Chaperones
    Language English
    Publishing date 2018-05-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-319-75402-4_50
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Perioperative antibiotic prophylaxis in skin surgery - Position paper of the Antibiotic Stewardship working group of the German Society for Dermatologic Surgery (DGDC), Part 2: Special indications and situations.

    Balakirski, Galina / Becker, Sören L / Hartmann, Daniela / Kofler, Lukas / Kunte, Christian / Müller, Cornelia S L / Volz, Thomas / Kendziora, Benjamin / Schlager, Justin Gabriel / Löser, Christoph R

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2023  Volume 21, Issue 10, Page(s) 1109–1117

    Abstract: In addition to prevention of surgical site infections after skin surgery, perioperative antibiotic prophylaxis (PAP) aims to prevent the occurrence of other postoperative infectious complications, especially bacterial endocarditis and hematogenous joint ... ...

    Abstract In addition to prevention of surgical site infections after skin surgery, perioperative antibiotic prophylaxis (PAP) aims to prevent the occurrence of other postoperative infectious complications, especially bacterial endocarditis and hematogenous joint prosthesis infections. This article discusses specific indications for the use of PAP. For example, patients who have undergone any type of heart valve replacement, including transcatheter valve replacement or use of prosthetic material to correct the heart valve, or patients who have experienced bacterial endocarditis, require PAP during skin surgery on mucosal membranes or ulcerated tumors. The use of PAP in special situations such as secondary wound healing, septic dermatosurgery or ulcer surgery is also presented and discussed in detail in this paper based on the current scientific literature. This paper represents the second part of the position paper of the Antibiotic Stewardship Working Group of the German Society for Dermatologic Surgery (DGDC) and summarizes evidence-based recommendations for the administration of PAP during skin surgery for special indications and situations. This is particularly important because, as detailed in Part 1 of this position paper, PAP can and usually should be avoided in skin surgery.
    MeSH term(s) Humans ; Antibiotic Prophylaxis ; Antimicrobial Stewardship ; Surgical Wound Infection/prevention & control ; Surgical Wound Infection/drug therapy ; Endocarditis, Bacterial/drug therapy ; Endocarditis, Bacterial/prevention & control ; Dermatologic Surgical Procedures/adverse effects ; Anti-Bacterial Agents/therapeutic use
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-07-27
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.15153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Antibody therapies and their challenges in the treatment of age-related macular degeneration.

    Volz, Cornelia / Pauly, Diana

    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

    2015  Volume 95, Issue Pt B, Page(s) 158–172

    Abstract: Age-related macular degeneration (AMD) is the leading cause of vision loss in the western world. This multifactorial disease results from the combined contributions of age, environment and genetic predisposition. Antibody-based treatment of late-stage ... ...

    Abstract Age-related macular degeneration (AMD) is the leading cause of vision loss in the western world. This multifactorial disease results from the combined contributions of age, environment and genetic predisposition. Antibody-based treatment of late-stage neovascular AMD with inhibitors of vascular endothelial growth factor has had great success, which is now the goal for currently untreatable AMD manifestations. The existence of an immune-privileged environment in the eye supports the feasibility of localized antibody therapy. Many different antibodies against various targets are being developed for the treatment of AMD, which reflects the etiological complexity of the disease. This review provides an overview of 19 potential therapeutic antibodies targeting angiogenesis, the complement system, inflammation or amyloid beta deposition in the eye. It summarizes the immunoglobulin structure, the specific target and study outcomes for each approach. The latter include beneficial results or adverse effects in AMD models and patients. Finally, this article discusses the challenges in the development of antibody-based drugs to treat degenerative processes in the posterior eye. In spite of these difficulties, to date, the following four antibodies have overcome the technical and preclinical hurdles and are being tested in active clinical studies: Lampalizumab, Sonepcizumab, GSK933776 and LFG316. We conclude that, while there are some antibody-based drugs that have made it into clinical practice, a successful transfer from bench to beside is still pending for many promising approaches.
    MeSH term(s) Angiogenesis Inhibitors/administration & dosage ; Angiogenesis Inhibitors/pharmacology ; Animals ; Antibodies, Monoclonal/administration & dosage ; Antibodies, Monoclonal/pharmacology ; Complement System Proteins/immunology ; Drug Design ; Humans ; Inflammation/drug therapy ; Inflammation/immunology ; Macular Degeneration/drug therapy ; Macular Degeneration/immunology ; Macular Degeneration/physiopathology ; Neovascularization, Pathologic/drug therapy ; Neovascularization, Pathologic/immunology ; Neovascularization, Pathologic/physiopathology ; Vascular Endothelial Growth Factor A/antagonists & inhibitors
    Chemical Substances Angiogenesis Inhibitors ; Antibodies, Monoclonal ; Vascular Endothelial Growth Factor A ; Complement System Proteins (9007-36-7)
    Language English
    Publishing date 2015-09
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1065368-5
    ISSN 1873-3441 ; 0939-6411
    ISSN (online) 1873-3441
    ISSN 0939-6411
    DOI 10.1016/j.ejpb.2015.02.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Prognostic relevance of programmed death-ligand 1 expression and microsatellite status in small bowel adenocarcinoma.

    Klose, Johannes / Lasitschka, Felix / Horsch, Cornelia / Strowitzki, Moritz J / Bruckner, Thomas / Volz, Claudia / Schmidt, Thomas / Schneider, Martin

    Scandinavian journal of gastroenterology

    2020  Volume 55, Issue 3, Page(s) 321–329

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Adenocarcinoma/genetics ; Adenocarcinoma/mortality ; Adenocarcinoma/pathology ; Adult ; Aged ; B7-H1 Antigen/genetics ; Biomarkers, Tumor/genetics ; Duodenal Neoplasms/genetics ; Duodenal Neoplasms/mortality ; Duodenal Neoplasms/pathology ; Female ; Humans ; Ileal Neoplasms/genetics ; Ileal Neoplasms/mortality ; Ileal Neoplasms/pathology ; Immunohistochemistry ; Jejunal Neoplasms/genetics ; Jejunal Neoplasms/mortality ; Jejunal Neoplasms/pathology ; Male ; Microsatellite Instability ; Middle Aged ; Multivariate Analysis ; Prognosis ; Retrospective Studies ; Survival Analysis
    Chemical Substances B7-H1 Antigen ; Biomarkers, Tumor ; CD274 protein, human
    Language English
    Publishing date 2020-03-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 82042-8
    ISSN 1502-7708 ; 0036-5521
    ISSN (online) 1502-7708
    ISSN 0036-5521
    DOI 10.1080/00365521.2020.1734073
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Magnetic Macroporous Hydrogels as a Novel Approach for Perfused Stem Cell Culture in 3D Scaffolds via Contactless Motion Control.

    Rödling, Lisa / Volz, Esther Magano / Raic, Annamarija / Brändle, Katharina / Franzreb, Matthias / Lee-Thedieck, Cornelia

    Advanced healthcare materials

    2018  Volume 7, Issue 9, Page(s) e1701403

    Abstract: There is an urgent need for 3D cell culture systems that avoid the oversimplifications and artifacts of conventional culture in 2D. However, 3D culture within the cavities of porous biomaterials or large 3D structures harboring high cell numbers is ... ...

    Abstract There is an urgent need for 3D cell culture systems that avoid the oversimplifications and artifacts of conventional culture in 2D. However, 3D culture within the cavities of porous biomaterials or large 3D structures harboring high cell numbers is limited by the needs to nurture cells and to remove growth-limiting metabolites. To overcome the diffusion-limited transport of such soluble factors in 3D culture, mixing can be improved by pumping, stirring or shaking, but this in turn can lead to other problems. Using pumps typically requires custom-made accessories that are not compatible with conventional cell culture disposables, thus interfering with cell production processes. Stirring or shaking allows little control over movement of scaffolds in media. To overcome these limitations, magnetic, macroporous hydrogels that can be moved or positioned within media in conventional cell culture tubes in a contactless manner are presented. The cytocompatibility of the developed biomaterial and the applied magnetic fields are verified for human hematopoietic stem and progenitor cells (HSPCs). The potential of this technique for perfusing 3D cultures is demonstrated in a proof-of-principle study that shows that controlled contactless movement of cell-laden magnetic hydrogels in culture media can mimic the natural influence of differently perfused environments on HSPCs.
    MeSH term(s) Cell Culture Techniques/methods ; Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/metabolism ; Humans ; Hydrogels/chemistry ; Magnetic Fields ; Porosity ; Tissue Scaffolds/chemistry
    Chemical Substances Hydrogels
    Language English
    Publishing date 2018-01-19
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649576-4
    ISSN 2192-2659 ; 2192-2640
    ISSN (online) 2192-2659
    ISSN 2192-2640
    DOI 10.1002/adhm.201701403
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  10. Article ; Online: Determination of nanostructures and drug distribution in lipid nanoparticles by single molecule microscopy.

    Boreham, Alexander / Volz, Pierre / Peters, Daniel / Keck, Cornelia M / Alexiev, Ulrike

    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

    2017  Volume 110, Page(s) 31–38

    Abstract: Drug loading capacity in nanostructured lipid carriers (NLC) depends on the formation of nanostructures within the lipid matrix. However, investigation of these nanostructures with sizes below the diffraction limit of visible light is quite challenging. ... ...

    Abstract Drug loading capacity in nanostructured lipid carriers (NLC) depends on the formation of nanostructures within the lipid matrix. However, investigation of these nanostructures with sizes below the diffraction limit of visible light is quite challenging. Thus, until now the determination of structures and drug distribution within NLCs was not possible. Therefore, we aimed at developing a method to visualize the nanostructures within the lipid carriers. Model NLCs loaded with a lipophilic fluorescent drug mimetic, ATTO-Oxa12, were produced and investigated by single-molecule tracking and localization-based superresolution microscopy. Results revealed spherical ATTO-Oxa12-filled nanostructures with diameters of ∼70nm and 120-130nm, both smaller than the NLC size (∼160nm). The ATTO-Oxa12 diffusion constant was calculated from the single-molecule traces (D⩾1μm
    MeSH term(s) Biomimetics ; Diffusion ; Drug Carriers/chemistry ; Drug Delivery Systems ; Fluorescent Dyes/chemistry ; Lasers ; Light ; Lipids/chemistry ; Microscopy, Fluorescence ; Nanoparticles/chemistry ; Nanostructures/chemistry ; Oils ; Particle Size ; Scattering, Radiation ; Single Molecule Imaging/methods ; Software ; Temperature
    Chemical Substances Drug Carriers ; Fluorescent Dyes ; Lipids ; Oils
    Language English
    Publishing date 2017-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1065368-5
    ISSN 1873-3441 ; 0939-6411
    ISSN (online) 1873-3441
    ISSN 0939-6411
    DOI 10.1016/j.ejpb.2016.10.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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