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  1. Article ; Online: Relationship Between Cognitive Abilities and Basic Auditory Processing in Young Adults.

    Maggu, Akshay R / Sharma, Bhamini

    American journal of audiology

    2024  , Page(s) 1–11

    Abstract: Purpose: The diagnosis of auditory processing disorder (APD) is controversial particularly due to the influence of higher order factors of language and cognition on the diagnostic APD testing. As a result, there might be a need for testing for other ... ...

    Abstract Purpose: The diagnosis of auditory processing disorder (APD) is controversial particularly due to the influence of higher order factors of language and cognition on the diagnostic APD testing. As a result, there might be a need for testing for other domains (e.g., cognition) along with conducting the diagnostic APD testing to rule out the influence of other domains. In order to make recommendations on whether cognitive testing is needed along with the auditory processing testing, as a starting point, the current study was conducted to examine the relationship between cognitive abilities and basic auditory processing in young adults.
    Method: A total of 38 young adults with normal audiometric thresholds between 250 and 8000 Hz participated in this study. They were tested on their executive function, language, processing speed, working memory, and episodic memory components of cognitive testing and tests for temporal fine structure and spectrotemporal sensitivity for auditory processing testing.
    Results: No significant correlation was found between the cognitive tests and the tests for basic auditory processing in young adults.
    Conclusions: These findings present contrast to the existing findings in children and older adults where a stronger correlation between cognitive abilities and auditory processing has been found. The current findings suggest that testing for cognitive abilities may not be needed when testing for basic auditory processing in young adults.
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1162315-9
    ISSN 1558-9137 ; 1059-0889
    ISSN (online) 1558-9137
    ISSN 1059-0889
    DOI 10.1044/2024_AJA-23-00261
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3807: Show issues Location:
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  2. Article: Temporal alteration in ovarian follicle fate with hormonal and hemodynamic perspectives during receptive phase of estrous cycle in endometritic cattle.

    Sharma, Akshay / Kumar, Pravesh / Sood, Pankaj / Negi, Vijender / Sharma, Pururava

    Veterinary research forum : an international quarterly journal

    2024  Volume 15, Issue 2, Page(s) 83–88

    Abstract: The present research was carried out to assess the serum progesterone ( ... ...

    Abstract The present research was carried out to assess the serum progesterone (P
    Language English
    Publishing date 2024-02-15
    Publishing country Iran
    Document type Journal Article
    ISSN 2008-8140
    ISSN 2008-8140
    DOI 10.30466/vrf.2023.2013227.4033
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  3. Article: Tension Band Wiring in Gap Non-union Patella - A Simple Technique with Profound Results: Case Report.

    Udiwal, Harshita / Sharma, Akshay / Rai, Vikramaditya / Sharma, Vipin / Sharma, Kavya

    Journal of orthopaedic case reports

    2024  Volume 14, Issue 4, Page(s) 160–164

    Abstract: Introduction: Gap non-union patellas are challenging to treat for an orthopedic surgeon. We hereby report a case of a 22-year-old person with a 3 cm gap nonunion, its surgical management, functional outcome, and implications for clinical practice.: ... ...

    Abstract Introduction: Gap non-union patellas are challenging to treat for an orthopedic surgeon. We hereby report a case of a 22-year-old person with a 3 cm gap nonunion, its surgical management, functional outcome, and implications for clinical practice.
    Case report: A 22-year-old active male presented to us with a background of comminuted fracture patella left side that he suffered 1 year ago, following which he was treated by open reduction and internal fixation (ORIF) with Tension Band Wiring (TBW). One year post-surgery, the patient had another fall, following which he had pain swelling in his left knee and difficulty in his knee extension. The patient presented 6 months later with painful ambulation and a swelling left knee. A 3 cm gap along with underlying implants could be palpated. The patient underwent surgery in the form of previous implant removal, freshening and apposition of fracture ends, and single-staged reconstruction of the extensor mechanism using TBW. The patient had full range of motion at the 1-year follow-up.
    Conclusion: The present case highlights the fact that small-gap non-union patella can be managed simply as a single-stage procedure with ORIF and TBW.
    Language English
    Publishing date 2024-04-26
    Publishing country India
    Document type Case Reports
    ZDB-ID 2658169-3
    ISSN 2250-0685
    ISSN 2250-0685
    DOI 10.13107/jocr.2024.v14.i04.4396
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  4. Article ; Online: Machine Learning Made Easy (MLme): a comprehensive toolkit for machine learning-driven data analysis.

    Akshay, Akshay / Katoch, Mitali / Shekarchizadeh, Navid / Abedi, Masoud / Sharma, Ankush / Burkhard, Fiona C / Adam, Rosalyn M / Monastyrskaya, Katia / Gheinani, Ali Hashemi

    GigaScience

    2024  Volume 13

    Abstract: Background: Machine learning (ML) has emerged as a vital asset for researchers to analyze and extract valuable information from complex datasets. However, developing an effective and robust ML pipeline can present a real challenge, demanding ... ...

    Abstract Background: Machine learning (ML) has emerged as a vital asset for researchers to analyze and extract valuable information from complex datasets. However, developing an effective and robust ML pipeline can present a real challenge, demanding considerable time and effort, thereby impeding research progress. Existing tools in this landscape require a profound understanding of ML principles and programming skills. Furthermore, users are required to engage in the comprehensive configuration of their ML pipeline to obtain optimal performance.
    Results: To address these challenges, we have developed a novel tool called Machine Learning Made Easy (MLme) that streamlines the use of ML in research, specifically focusing on classification problems at present. By integrating 4 essential functionalities-namely, Data Exploration, AutoML, CustomML, and Visualization-MLme fulfills the diverse requirements of researchers while eliminating the need for extensive coding efforts. To demonstrate the applicability of MLme, we conducted rigorous testing on 6 distinct datasets, each presenting unique characteristics and challenges. Our results consistently showed promising performance across different datasets, reaffirming the versatility and effectiveness of the tool. Additionally, by utilizing MLme's feature selection functionality, we successfully identified significant markers for CD8+ naive (BACH2), CD16+ (CD16), and CD14+ (VCAN) cell populations.
    Conclusion: MLme serves as a valuable resource for leveraging ML to facilitate insightful data analysis and enhance research outcomes, while alleviating concerns related to complex coding scripts. The source code and a detailed tutorial for MLme are available at https://github.com/FunctionalUrology/MLme.
    MeSH term(s) Humans ; Data Analysis ; Machine Learning ; Research Personnel ; Software
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2708999-X
    ISSN 2047-217X ; 2047-217X
    ISSN (online) 2047-217X
    ISSN 2047-217X
    DOI 10.1093/gigascience/giad111
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  5. Article ; Online: ShinyArchR.UiO: user-friendly,integrative and open-source tool for visualization of single-cell ATAC-seq data using ArchR.

    Sharma, Ankush / Akshay, Akshay / Rogne, Marie / Eskeland, Ragnhild

    Bioinformatics (Oxford, England)

    2021  Volume 38, Issue 3, Page(s) 834–836

    Abstract: Motivation: Mapping of chromatin accessibility landscapes in single-cells and the integration with gene expression enables a better understanding of gene regulatory mechanisms defining cell identities and cell-fate determination in development and ... ...

    Abstract Motivation: Mapping of chromatin accessibility landscapes in single-cells and the integration with gene expression enables a better understanding of gene regulatory mechanisms defining cell identities and cell-fate determination in development and disease. Generally, raw data generated from single-cell Assay for Transposase-Accessible Chromatin sequencing (scATAC-seq) are deposited in repositories that are generally inaccessible due to lack of in-depth knowledge of computational programming.
    Results: We have developed ShinyArchR.UiO, an R-based shiny app, that facilitates scATAC-seq data accessibility and visualization in a user-friendly, interactive and open-source web interface. ShinyArchR.UiO is an application that can streamline collaborative efforts for interpretation of massive chromatin accessibility datasets and allow for open access data sharing for wider audiences.
    Availability and implementation: https://Github.com/EskelandLab/ShinyArchRUiO and a demo server with a hematopoietic tutorial dataset https://cancell.medisin.uio.no/ShinyArchR.UiO.
    Supplementary information: Supplementary data are available at Bioinformatics online.
    MeSH term(s) Chromatin Immunoprecipitation Sequencing ; Chromatin ; Single-Cell Analysis
    Chemical Substances Chromatin
    Language English
    Publishing date 2021-09-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1422668-6
    ISSN 1367-4811 ; 1367-4803
    ISSN (online) 1367-4811
    ISSN 1367-4803
    DOI 10.1093/bioinformatics/btab680
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2374: Show issues Location:
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  6. Article ; Online: Exploring the antioxidant potential of fermented turmeric pulp: effect of extraction methods and microencapsulation.

    Sharma, Poorva / Kashyap, Piyush / Dhakane, Akshay

    Preparative biochemistry & biotechnology

    2023  Volume 53, Issue 8, Page(s) 968–977

    Abstract: Curcumin is one of the major constituents of turmeric which possess multifarious therapeutic properties. However, owing of its limited solubility in water its bioavailability is poor. Thus, attempts have been made to increase the solubility of curcumin ... ...

    Abstract Curcumin is one of the major constituents of turmeric which possess multifarious therapeutic properties. However, owing of its limited solubility in water its bioavailability is poor. Thus, attempts have been made to increase the solubility of curcumin by fermenting turmeric followed by extraction and encapsulation.
    MeSH term(s) Antioxidants ; Curcuma ; Plant Extracts ; Curcumin ; Phenols
    Chemical Substances Antioxidants ; Plant Extracts ; Curcumin (IT942ZTH98) ; Phenols
    Language English
    Publishing date 2023-01-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1322522-4
    ISSN 1532-2297 ; 1082-6068
    ISSN (online) 1532-2297
    ISSN 1082-6068
    DOI 10.1080/10826068.2022.2163256
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    Zs.A 821: Show issues Location:
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  7. Article: Carrier transport and photoconductivity properties of BN

    Kaur, Manjot / Singh, Kulwinder / Sharma, Ram K / Sharma, Nandni / Thakur, Anup / Kumar, Akshay

    Heliyon

    2023  Volume 9, Issue 3, Page(s) e13865

    Abstract: ... ...

    Abstract BN
    Language English
    Publishing date 2023-02-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e13865
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  8. Article ; Online: Retrieval of broken intra-medullary guide wire in femoral shaft fracture: A case report and surgical technique.

    Thakur, Kamparsh / Sharma, Akshay / Prasad, Manish / Jindal, Imroz

    Trauma case reports

    2023  Volume 46, Page(s) 100865

    Abstract: Intramedullary Nailing is a standard procedure for fixation of various fractures in orthopedic practice. With the procedure also important is being aware of the complications and methods of managing them. A broken or stuck hardware can result in these ... ...

    Abstract Intramedullary Nailing is a standard procedure for fixation of various fractures in orthopedic practice. With the procedure also important is being aware of the complications and methods of managing them. A broken or stuck hardware can result in these procedures. We present a case with broken guide wire in a case of femoral shaft fracture in a young individual and the technique we used to retrieve it retrogradely from the fracture site. This technique shall be a useful technique to all the orthopedic surgeons if such a situation arises.
    Language English
    Publishing date 2023-06-04
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2835433-3
    ISSN 2352-6440 ; 2352-6440
    ISSN (online) 2352-6440
    ISSN 2352-6440
    DOI 10.1016/j.tcr.2023.100865
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  9. Article: 3-D assessment of skeletal and dentoalveolar bilateral dimensions in unilateral impacted palatal canine cases - A CBCT study.

    Sharma, Swati / Sharma, Payal / Rathore, Akshay / Raza, Monis

    Journal of clinical and experimental dentistry

    2023  Volume 15, Issue 12, Page(s) e1007–e1015

    Abstract: Background: The aim of this study was to compare skeletal and dentoalveolar dimensions in subjects with maxillary unilateral impacted palatal canines versus the unaffected contralateral side using CBCT.: Material and methods: Skeletal and ... ...

    Abstract Background: The aim of this study was to compare skeletal and dentoalveolar dimensions in subjects with maxillary unilateral impacted palatal canines versus the unaffected contralateral side using CBCT.
    Material and methods: Skeletal and dentoalveolar variables (Anterior alveolar ridge height, Anterior dentoalveolar height , nasal cavity width, basal nasal width, Lateral angulation of long axis of the incisors and canines with respect to the nasal horizontal plane, premolar to median raphe width, dimensions of lateral incisor and canine, root resorption of lateral incisors, crown-root angulation of lateral incisor, and sector classification of canine) were compared between the impacted and the contralateral sides. As the data had normal distribution, means were compared using students t test. The significance was set at
    Results: Lateral angulation of long axis of canines, nasal cavity width, basal lateral width, and premolar to median raphe width were found to be significantly different. Maximum number fell in sector 4 (n = 23, 38.3%) in sector classification. Root resorption of lateral incisor on impacted side was insignificant.
    Conclusions: Skeletal and dento-alveolar dimensions vary between the impacted and non-impacted sides in unilateral palatal canine impaction cases. Canines on the impacted side were more mesially angulated compared to the non-impacted side. The nasal cavity width, basal lateral width and premolar to median raphe width were significantly less on the impacted side compared to the non- impacted side.
    Language English
    Publishing date 2023-12-01
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 2586647-3
    ISSN 1989-5488
    ISSN 1989-5488
    DOI 10.4317/jced.60982
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  10. Article ; Online: A novel gain of function mutation in TPC2 reiterates pH-pigmentation interplay: Emerging role of ionic homeostasis as a master pigmentation regulator.

    Sharma, Nutan / Sharma, Akshay / Motiani, Rajender K

    Cell calcium

    2023  Volume 111, Page(s) 102705

    Abstract: Pigmentation is a complex physiological phenomenon that protects from UV induced damage. Perturbations in pigmentation pathways lead to pigmentary disorders such as vitiligo, albinism and Darier ... s disease. Emerging literature implicates a critical role ...

    Abstract Pigmentation is a complex physiological phenomenon that protects from UV induced damage. Perturbations in pigmentation pathways lead to pigmentary disorders such as vitiligo, albinism and Darier...s disease. Emerging literature implicates a critical role of ionic homeostasis and pH in regulating pigmentation. In a recent study, Wang et al. identified a novel gain of function mutation in a non-selective cation channel "Two Pore Channel 2" (TPC2) that is responsible for albinism in a human patient. The authors demonstrate that this mutation leads to constitutive activation of TPC2 thereby modulating cellular calcium dynamics and inducing changes in the lysosomal pH. Further, authors generated a knock in mice with homologous TPC2 mutation and corroborated a causative role for this mutation in albinism. It is an exciting study that reports a novel TPC2 mutation, which is responsible for albinism in an autosomal dominant inheritance fashion. Since TPC2 is localized on melanosomes as well, going forward it would be interesting to investigate the role of this mutation on melanosomal calcium dynamics and alterations in melanosomal pH.
    MeSH term(s) Humans ; Animals ; Mice ; Gain of Function Mutation ; Calcium/metabolism ; Pigmentation/genetics ; Homeostasis ; Hydrogen-Ion Concentration
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2023-02-18
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 757687-0
    ISSN 1532-1991 ; 0143-4160
    ISSN (online) 1532-1991
    ISSN 0143-4160
    DOI 10.1016/j.ceca.2023.102705
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