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Article: Neural Mechanisms of Vicarious Reward Processing in Adults with Autism Spectrum Disorder.

Greene, Rachel K / Damiano-Goodwin, Cara R / Walsh, Erin / Bizzell, Joshua / Dichter, Gabriel S

2020 Volume 2020, Page(s) 8014248

Abstract: Previous studies examining the neural substrates of reward processing in ASD have explored responses to rewards for oneself but not rewards earned for others (i.e., vicarious reward). This omission is notable given that vicarious reward processing is a ... ...

Abstract	Previous studies examining the neural substrates of reward processing in ASD have explored responses to rewards for oneself but not rewards earned for others (i.e., vicarious reward). This omission is notable given that vicarious reward processing is a critical component of creating and maintaining social relationships. The current study examined the neural mechanisms of vicarious reward processing in 15 adults with ASD and 15 age- and gender-matched typically developing controls. Individuals with ASD demonstrated attenuated activation of reward-related regions during vicarious reward processing. Altered connectivity was also observed in individuals with ASD during reward receipt. These findings of altered neural sensitivity to vicarious reward processing may represent a mechanism that hinders the development of social abilities in ASD.
Language	English
Publishing date	2020-03-21
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2626622-2
ISSN	2090-1933 ; 2090-1925
ISSN (online)	2090-1933
ISSN	2090-1925
DOI	10.1155/2020/8014248
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Article ; Online: Future directions for research in autism spectrum disorders.

Damiano, Cara R / Mazefsky, Carla A / White, Susan W / Dichter, Gabriel S

Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53

2014 Volume 43, Issue 5, Page(s) 828–843

Abstract: This article suggests future directions for research aimed at improving our understanding of the etiology and pathophysiology of autism spectrum disorder (ASD) as well as pharmacologic and psychosocial interventions for ASD across the lifespan. The past ... ...

Abstract	This article suggests future directions for research aimed at improving our understanding of the etiology and pathophysiology of autism spectrum disorder (ASD) as well as pharmacologic and psychosocial interventions for ASD across the lifespan. The past few years have witnessed unprecedented transformations in the understanding of ASD neurobiology, genetics, early identification, and early intervention. However, recent increases in ASD prevalence estimates highlight the urgent need for continued efforts to translate novel ASD discoveries into effective interventions for all individuals with ASD. In this article we highlight promising areas for ongoing and new research expected to quicken the pace of scientific discovery and ultimately the translation of research findings into accessible and empirically supported interventions for those with ASD. We highlight emerging research in the following domains as particularly promising and pressing: (a) preclinical models, (b) experimental therapeutics, (c) early identification and intervention, (d) psychiatric comorbidities and the Research Domain Criteria initiative, (e) ecological momentary assessment, (f) neurotechnologies, and (g) the needs of adults with ASD. Increased research emphasis in these areas has the potential to hasten the translation of knowledge on the etiological mechanisms of ASD to psychosocial and biological interventions to reduce the burden of ASD on affected individuals and their families.
MeSH term(s)	Biomedical Research/trends ; Child ; Child Development Disorders, Pervasive ; Forecasting ; Humans
Language	English
Publishing date	2014-09-10
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2073310-0
ISSN	1537-4424 ; 1537-4416
ISSN (online)	1537-4424
ISSN	1537-4416
DOI	10.1080/15374416.2014.945214
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Article ; Online: Neural Correlates of Sensory Hyporesponsiveness in Toddlers at High Risk for Autism Spectrum Disorder.

Simon, David M / Damiano, Cara R / Woynaroski, Tiffany G / Ibañez, Lisa V / Murias, Michael / Stone, Wendy L / Wallace, Mark T / Cascio, Carissa J

Journal of autism and developmental disorders

2017 Volume 47, Issue 9, Page(s) 2710–2722

Abstract: Altered patterns of sensory responsiveness are a frequently reported feature of Autism Spectrum Disorder (ASD). Younger siblings of individuals with ASD are at a greatly elevated risk of a future diagnosis of ASD, but little is known about the neural ... ...

Abstract	Altered patterns of sensory responsiveness are a frequently reported feature of Autism Spectrum Disorder (ASD). Younger siblings of individuals with ASD are at a greatly elevated risk of a future diagnosis of ASD, but little is known about the neural basis of sensory responsiveness patterns in this population. Younger siblings (n = 20) of children diagnosed with ASD participated in resting electroencephalography (EEG) at an age of 18 months. Data on toddlers' sensory responsiveness were obtained using the Sensory Experiences Questionnaire. Correlations were present between hyporesponsiveness and patterns of oscillatory power, functional connectivity, and signal complexity. Our findings suggest that neural signal features hold promise for facilitating early identification and targeted remediation in young children at risk for ASD.
MeSH term(s)	Autism Spectrum Disorder/diagnosis ; Autism Spectrum Disorder/genetics ; Brain Waves ; Child, Preschool ; Female ; Humans ; Male ; Perception ; Sensation ; Siblings
Language	English
Publishing date	2017-06-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	391999-7
ISSN	1573-3432 ; 0162-3257
ISSN (online)	1573-3432
ISSN	0162-3257
DOI	10.1007/s10803-017-3191-4
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Article ; Online: Vicarious Effort-Based Decision-Making in Autism Spectrum Disorders.

Mosner, Maya G / Kinard, Jessica L / McWeeny, Sean / Shah, Jasmine S / Markiewitz, Nathan D / Damiano-Goodwin, Cara R / Burchinal, Margaret R / Rutherford, Helena J V / Greene, Rachel K / Treadway, Michael T / Dichter, Gabriel S

Journal of autism and developmental disorders

2017 Volume 47, Issue 10, Page(s) 2992–3006

Abstract: This study investigated vicarious effort-based decision-making in 50 adolescents with autism spectrum disorders (ASD) compared to 32 controls using the Effort Expenditure for Rewards Task. Participants made choices to win money for themselves or for ... ...

Abstract	This study investigated vicarious effort-based decision-making in 50 adolescents with autism spectrum disorders (ASD) compared to 32 controls using the Effort Expenditure for Rewards Task. Participants made choices to win money for themselves or for another person. When choosing for themselves, the ASD group exhibited relatively similar patterns of effort-based decision-making across reward parameters. However, when choosing for another person, the ASD group demonstrated relatively decreased sensitivity to reward magnitude, particularly in the high magnitude condition. Finally, patterns of responding in the ASD group were related to individual differences in consummatory pleasure capacity. These findings indicate atypical vicarious effort-based decision-making in ASD and more broadly add to the growing body of literature addressing social reward processing deficits in ASD.
MeSH term(s)	Adolescent ; Autism Spectrum Disorder/psychology ; Case-Control Studies ; Decision Making ; Female ; Humans ; Male ; Motivation ; Reward ; Task Performance and Analysis
Language	English
Publishing date	2017-06-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	391999-7
ISSN	1573-3432 ; 0162-3257
ISSN (online)	1573-3432
ISSN	0162-3257
DOI	10.1007/s10803-017-3220-3
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Article ; Online: Developmental sequelae and neurophysiologic substrates of sensory seeking in infant siblings of children with autism spectrum disorder.

Damiano-Goodwin, Cara R / Woynaroski, Tiffany G / Simon, David M / Ibañez, Lisa V / Murias, Michael / Kirby, Anne / Newsom, Cassandra R / Wallace, Mark T / Stone, Wendy L / Cascio, Carissa J

Developmental cognitive neuroscience

2017 Volume 29, Page(s) 41–53

Abstract: It has been proposed that early differences in sensory responsiveness arise from atypical neural function and produce cascading effects on development across domains. This longitudinal study prospectively followed infants at heightened risk for autism ... ...

Abstract	It has been proposed that early differences in sensory responsiveness arise from atypical neural function and produce cascading effects on development across domains. This longitudinal study prospectively followed infants at heightened risk for autism spectrum disorder (ASD) based on their status as younger siblings of children diagnosed with ASD (Sibs-ASD) and infants at relatively lower risk for ASD (siblings of typically developing children; Sibs-TD) to examine the developmental sequelae and possible neurophysiological substrates of a specific sensory response pattern: unusually intense interest in nonsocial sensory stimuli or "sensory seeking." At 18 months, sensory seeking and social orienting were measured with the Sensory Processing Assessment, and a potential neural signature for sensory seeking (i.e., frontal alpha asymmetry) was measured via resting state electroencephalography. At 36 months, infants' social symptomatology was assessed in a comprehensive diagnostic evaluation. Sibs-ASD showed elevated sensory seeking relative to Sibs-TD, and increased sensory seeking was concurrently associated with reduced social orienting across groups and resting frontal asymmetry in Sibs-ASD. Sensory seeking also predicted later social symptomatology. Findings suggest that sensory seeking may produce cascading effects on social development in infants at risk for ASD and that atypical frontal asymmetry may underlie this atypical pattern of sensory responsiveness.
MeSH term(s)	Autism Spectrum Disorder/physiopathology ; Autism Spectrum Disorder/psychology ; Child ; Child Development ; Child, Preschool ; Electroencephalography ; Female ; Humans ; Infant ; Longitudinal Studies ; Male ; Prospective Studies ; Risk ; Sensation/physiology ; Siblings/psychology
Language	English
Publishing date	2017-08-14
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	1878-9307
ISSN (online)	1878-9307
DOI	10.1016/j.dcn.2017.08.005
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Article ; Online: What do repetitive and stereotyped movements mean for infant siblings of children with autism spectrum disorders?

Damiano, Cara R / Nahmias, Allison / Hogan-Brown, Abigail L / Stone, Wendy L

Journal of autism and developmental disorders

2012 Volume 43, Issue 6, Page(s) 1326–1335

Abstract: Repetitive and stereotyped movements (RSMs) in infancy are associated with later diagnoses of autism spectrum disorder (ASD), yet this relationship has not been fully explored in high-risk populations. The current study investigated how RSMs involving ... ...

Abstract	Repetitive and stereotyped movements (RSMs) in infancy are associated with later diagnoses of autism spectrum disorder (ASD), yet this relationship has not been fully explored in high-risk populations. The current study investigated how RSMs involving object and body use are related to diagnostic outcomes in infant siblings of children with ASD (Sibs-ASD) and typically developing children (Sibs-TD). The rate and number of different types of RSMs were measured at an average of 15 months with follow-up diagnostic evaluations approximately 18 months later. While Sibs-ASD displayed higher rates of RSMs relative to Sibs-TD, rates did not differ according to diagnostic outcome in Sibs-ASD. However preliminary evidence suggests that qualitative differences in RSM type warrant further investigation as early diagnostic markers.
MeSH term(s)	Child Development Disorders, Pervasive/diagnosis ; Child Development Disorders, Pervasive/genetics ; Child, Preschool ; Female ; Follow-Up Studies ; Genetic Predisposition to Disease/genetics ; Humans ; Infant ; Infant, Newborn ; Male ; Siblings/psychology ; Stereotyped Behavior ; Stereotypic Movement Disorder/diagnosis
Language	English
Publishing date	2012-10-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	391999-7
ISSN	1573-3432 ; 0162-3257
ISSN (online)	1573-3432
ISSN	0162-3257
DOI	10.1007/s10803-012-1681-y
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Article: Intact Hedonic Responses to Sweet Tastes in Autism Spectrum Disorder.

Damiano, Cara R / Aloi, Joseph / Burrus, Caley / Garbutt, James C / Kampov-Polevoy, Alexei B / Dichter, Gabriel S

Research in autism spectrum disorders

2014 Volume 8, Issue 3, Page(s) 230–236

Abstract: The Sweet Taste Test (STT) is a standardized measure designed to index the ability to detect differences in sweet tastes (sweet taste sensitivity) and hedonic responses to sweet tastes (sweet taste liking). Profiles of response on the STT suggest ... ...

Abstract	The Sweet Taste Test (STT) is a standardized measure designed to index the ability to detect differences in sweet tastes (sweet taste sensitivity) and hedonic responses to sweet tastes (sweet taste liking). Profiles of response on the STT suggest enhanced hedonic responses to sweet tastes in psychiatric disorders characterized by dysfunctional reward processing systems, including binge-eating disorders and substance use disorders, and a putative mechanism governing STT responses is the brain opioid system. The present study examined STT responses in 20 adults with autism spectrum disorder (ASD) and 38 healthy control adults. There were no differences in sweet taste sensitivity or hedonic response to sweet tastes between the ASD and control groups. Within the ASD sample, ASD symptom severity was associated with sweet taste sensitivity, but not hedonic response to sweet taste. Results may ultimately shed light on brain opioid system functioning in ASD.
Language	English
Publishing date	2014-01-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2260224-0
ISSN	1878-0237 ; 1750-9467
ISSN (online)	1878-0237
ISSN	1750-9467
DOI	10.1016/j.rasd.2013.12.003
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Article ; Online: Adults with autism spectrum disorders exhibit decreased sensitivity to reward parameters when making effort-based decisions.

Damiano, Cara R / Aloi, Joseph / Treadway, Michael / Bodfish, James W / Dichter, Gabriel S

Journal of neurodevelopmental disorders

2012 Volume 4, Issue 1, Page(s) 13

Abstract: Background: Efficient effort expenditure to obtain rewards is critical for optimal goal-directed behavior and learning. Clinical observation suggests that individuals with autism spectrum disorders (ASD) may show dysregulated reward-based effort ... ...

Abstract	Background: Efficient effort expenditure to obtain rewards is critical for optimal goal-directed behavior and learning. Clinical observation suggests that individuals with autism spectrum disorders (ASD) may show dysregulated reward-based effort expenditure, but no behavioral study to date has assessed effort-based decision-making in ASD. Methods: The current study compared a group of adults with ASD to a group of typically developing adults on the Effort Expenditure for Rewards Task (EEfRT), a behavioral measure of effort-based decision-making. In this task, participants were provided with the probability of receiving a monetary reward on a particular trial and asked to choose between either an "easy task" (less motoric effort) for a small, stable reward or a "hard task" (greater motoric effort) for a variable but consistently larger reward. Results: Participants with ASD chose the hard task more frequently than did the control group, yet were less influenced by differences in reward value and probability than the control group. Additionally, effort-based decision-making was related to repetitive behavior symptoms across both groups. Conclusions: These results suggest that individuals with ASD may be more willing to expend effort to obtain a monetary reward regardless of the reward contingencies. More broadly, results suggest that behavioral choices may be less influenced by information about reward contingencies in individuals with ASD. This atypical pattern of effort-based decision-making may be relevant for understanding the heightened reward motivation for circumscribed interests in ASD.
Language	English
Publishing date	2012-05-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2487174-6
ISSN	1866-1955 ; 1866-1947
ISSN (online)	1866-1955
ISSN	1866-1947
DOI	10.1186/1866-1955-4-13
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Article ; Online: Adults with autism spectrum disorders exhibit decreased sensitivity to reward parameters when making effort-based decisions

Damiano Cara R / Aloi Joseph / Treadway Michael / Bodfish James W / Dichter Gabriel S

Journal of Neurodevelopmental Disorders, Vol 4, Iss 1, p

2012 Volume 13

Abstract: Abstract Background Efficient effort expenditure to obtain rewards is critical for optimal goal-directed behavior and learning. Clinical observation suggests that individuals with autism spectrum disorders (ASD) may show dysregulated reward-based effort ... ...

Abstract	Abstract Background Efficient effort expenditure to obtain rewards is critical for optimal goal-directed behavior and learning. Clinical observation suggests that individuals with autism spectrum disorders (ASD) may show dysregulated reward-based effort expenditure, but no behavioral study to date has assessed effort-based decision-making in ASD. Methods The current study compared a group of adults with ASD to a group of typically developing adults on the Effort Expenditure for Rewards Task (EEfRT), a behavioral measure of effort-based decision-making. In this task, participants were provided with the probability of receiving a monetary reward on a particular trial and asked to choose between either an “easy task” (less motoric effort) for a small, stable reward or a “hard task” (greater motoric effort) for a variable but consistently larger reward. Results Participants with ASD chose the hard task more frequently than did the control group, yet were less influenced by differences in reward value and probability than the control group. Additionally, effort-based decision-making was related to repetitive behavior symptoms across both groups. Conclusions These results suggest that individuals with ASD may be more willing to expend effort to obtain a monetary reward regardless of the reward contingencies. More broadly, results suggest that behavioral choices may be less influenced by information about reward contingencies in individuals with ASD. This atypical pattern of effort-based decision-making may be relevant for understanding the heightened reward motivation for circumscribed interests in ASD.
Keywords	Reward ; Motivation ; Decision-making ; Autism spectrum disorders ; Dopamine ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Neurology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	150
Language	English
Publishing date	2012-05-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Accurate COP Trajectory Estimation in Healthy and Pathological Gait Using Multimodal Instrumented Insoles and Deep Learning Models.

Duong, Ton T H / Uher, David / Young, Sally Dunaway / Farooquee, Rabia / Druffner, Abigail / Pasternak, Amy / Kanner, Cara / Fragala-Pinkham, Maria / Montes, Jacqueline / Zanotto, Damiano

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society

2023 Volume 31, Page(s) 4801–4811

Abstract: Measuring center-of-pressure (COP) trajectories in out-of-the-lab environments may provide valuable information about changes in gait and balance function related to natural disease progression or treatment in neurological disorders. Traditional ... ...

Abstract	Measuring center-of-pressure (COP) trajectories in out-of-the-lab environments may provide valuable information about changes in gait and balance function related to natural disease progression or treatment in neurological disorders. Traditional equipment to acquire COP trajectories includes stationary force plates, instrumented treadmills, electronic walkways, and insoles featuring high-density force sensing arrays, all of which are expensive and not widely accessible. This study introduces novel deep recurrent neural networks that can accurately estimate dynamic COP trajectories by fusing data from affordable and heterogeneous insole-embedded sensors (namely, an eight-cell array of force sensitive resistors (FSRs) and an inertial measurement unit (IMU)). The method was validated against gold-standard equipment during out-of-the-lab ambulatory tasks that simulated real-world walking. Root-mean-square errors (RMSE) in the mediolateral (ML) and anteroposterior (AP) directions obtained from healthy individuals (ML: 0.51 cm, AP: 1.44 cm) and individuals with neuromuscular conditions (ML: 0.59 cm, AP: 1.53 cm) indicated technical validity. In individuals with neuromuscular conditions, COP-derived metrics showed significant correlations with validated clinical measures of ambulatory function and lower-extremity muscle strength, providing proof-of-concept evidence of the convergent validity of the proposed method for clinical applications.
MeSH term(s)	Humans ; Deep Learning ; Gait/physiology ; Walking ; Neural Networks, Computer ; Foot/physiology ; Biomechanical Phenomena
Language	English
Publishing date	2023-12-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1166307-8
ISSN	1558-0210 ; 1063-6528 ; 1534-4320
ISSN (online)	1558-0210
ISSN	1063-6528 ; 1534-4320
DOI	10.1109/TNSRE.2023.3338519
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