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  1. Article ; Online: Target genes used for biosensor development in COVID-19 diagnosis.

    Zandi, Milad / Fani, Mona

    Biosensors & bioelectronics

    2021  Volume 200, Page(s) 113924

    Abstract: In a published review entitled "COVID-19 diagnosis -A review of current methods", the authors considered hemagglutinin esterase as one of the structural proteins of SARS-CoV-2 and also they did not represent ORF3b, ORF9b, and ORF9c in SARS-CoV-2 genome ... ...

    Abstract In a published review entitled "COVID-19 diagnosis -A review of current methods", the authors considered hemagglutinin esterase as one of the structural proteins of SARS-CoV-2 and also they did not represent ORF3b, ORF9b, and ORF9c in SARS-CoV-2 genome structure. However, according to the scientific evidence, among coronaviruses only some betacoronaviruses (Embecovirus subgenera) contain HE, and the genome of most of the coronaviruses such as SARS-CoV-2, SARS-CoV, and MERS-CoV lack the HE gene. In addition, the genome of SARS-CoV-2 contains several accessory proteins ORFs including ORF3a, ORF3b, ORF6, ORF7a, ORF7b, ORF8, ORF9b, ORF9c, and ORF10.
    MeSH term(s) Biosensing Techniques ; COVID-19 ; COVID-19 Testing ; Humans ; Open Reading Frames ; SARS-CoV-2
    Language English
    Publishing date 2021-12-30
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1011023-9
    ISSN 1873-4235 ; 0956-5663
    ISSN (online) 1873-4235
    ISSN 0956-5663
    DOI 10.1016/j.bios.2021.113924
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  2. Article: Target genes used for biosensor development in COVID-19 diagnosis

    Zandi, Milad / Fani, Mona

    Biosensors & bioelectronics. 2022 Mar. 15, v. 200

    2022  

    Abstract: In a published review entitled “COVID-19 diagnosis —A review of current methods”, the authors considered hemagglutinin esterase as one of the structural proteins of SARS-CoV-2 and also they did not represent ORF3b, ORF9b, and ORF9c in SARS-CoV-2 genome ... ...

    Abstract In a published review entitled “COVID-19 diagnosis —A review of current methods”, the authors considered hemagglutinin esterase as one of the structural proteins of SARS-CoV-2 and also they did not represent ORF3b, ORF9b, and ORF9c in SARS-CoV-2 genome structure. However, according to the scientific evidence, among coronaviruses only some betacoronaviruses (Embecovirus subgenera) contain HE, and the genome of most of the coronaviruses such as SARS-CoV-2, SARS-CoV, and MERS-CoV lack the HE gene. In addition, the genome of SARS-CoV-2 contains several accessory proteins ORFs including ORF3a, ORF3b, ORF6, ORF7a, ORF7b, ORF8, ORF9b, ORF9c, and ORF10.
    Keywords COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; biosensors ; esterases ; genes ; hemagglutinins
    Language English
    Dates of publication 2022-0315
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1011023-9
    ISSN 1873-4235 ; 0956-5663
    ISSN (online) 1873-4235
    ISSN 0956-5663
    DOI 10.1016/j.bios.2021.113924
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  3. Article: Targeting host calcium channels and viroporins: a promising strategy for SARS-CoV-2 therapy.

    Fani, Mona / Moossavi, Maryam / Bakhshi, Hasan / Jahrodi, Abozar Nasiri / Khazdair, Mohammad Reza / Zardast, Amir Hossein / Ghafari, Shokouh

    Future virology

    2023  

    Abstract: Despite passing the pandemic phase of the COVID-19, researchers are still investigating various drugs. Previous evidence suggests that blocking the calcium channels may be a suitable treatment option. ... ...

    Abstract Despite passing the pandemic phase of the COVID-19, researchers are still investigating various drugs. Previous evidence suggests that blocking the calcium channels may be a suitable treatment option. Ca
    Language English
    Publishing date 2023-09-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2254606-6
    ISSN 1746-0808 ; 1746-0794
    ISSN (online) 1746-0808
    ISSN 1746-0794
    DOI 10.2217/fvl-2022-0203
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  4. Article ; Online: Comparison between various biosensor methods for human T-lymphotropic virus-1 (HTLV-1) detection.

    Kamali, Peyman / Zandi, Milad / Ghasemzadeh-Moghaddam, Hamed / Fani, Mona

    Molecular biology reports

    2021  Volume 49, Issue 2, Page(s) 1513–1517

    Abstract: Due to the drawback of traditional and current diagnostic methods including serological and molecular assays, the development of the rapid and free-PCR techniques can be an alternative technique for the human T-cell lymphotropic virus (HTLV-1) DNA ... ...

    Abstract Due to the drawback of traditional and current diagnostic methods including serological and molecular assays, the development of the rapid and free-PCR techniques can be an alternative technique for the human T-cell lymphotropic virus (HTLV-1) DNA detection sequences. On the other hand, early detection of HTLV-1 prevents two dangerous diseases including Adult T-cell leukemia/lymphoma and HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis. The biosensor-based methods are sensitive techniques that can provide new opportunities to detect infectious diseases, particularly in the early stage. This study provides a comparative view among recently designed biosensors for the detection of HTLV-1.
    MeSH term(s) Base Sequence/genetics ; Biosensing Techniques/methods ; HTLV-I Infections/diagnosis ; HTLV-I Infections/genetics ; Human T-lymphotropic virus 1/genetics ; Human T-lymphotropic virus 1/pathogenicity ; Humans ; Leukemia-Lymphoma, Adult T-Cell/genetics ; Leukemia-Lymphoma, Adult T-Cell/pathology ; Leukemia-Lymphoma, Adult T-Cell/virology ; Paraparesis, Tropical Spastic/virology ; Polymerase Chain Reaction/methods
    Language English
    Publishing date 2021-11-19
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-021-06959-w
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    Zs.A 1140: Show issues Location:
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  5. Article ; Online: Future developments in biosensors for field-ready SARS-CoV-2 virus diagnostics.

    Fani, Mona / Zandi, Milad / Soltani, Saber / Abbasi, Samaneh

    Biotechnology and applied biochemistry

    2020  Volume 68, Issue 4, Page(s) 695–699

    Abstract: According to the evidence, the coronavirus disease 19 (COVID-19) is caused by a zoonotic pathogen named respiratory syndrome coronavirus 2 (SARS-CoV-2). This virus can spread through personal contact, respiratory droplets, and also through airborne ... ...

    Abstract According to the evidence, the coronavirus disease 19 (COVID-19) is caused by a zoonotic pathogen named respiratory syndrome coronavirus 2 (SARS-CoV-2). This virus can spread through personal contact, respiratory droplets, and also through airborne transmission. A rapid, low-cost, and effective biosensor platform is essential to diagnose patients with COVID-19 infection, predominantly the asymptomatic individuals, and prevent the spread of the SARS-CoV-2 via transmission routes. The objective of this review is to provide a comparative view among current diagnostic methods, focusing on recently suggested biosensors for the detection of SARS-CoV2 in clinical samples. A capable SARS-CoV-2 biosensor can be designed by the holistic insights of various biosensor studies.
    MeSH term(s) Biosensing Techniques/methods ; COVID-19 ; COVID-19 Testing ; Humans ; SARS-CoV-2/isolation & purification ; SARS-CoV-2/physiology
    Keywords covid19
    Language English
    Publishing date 2020-10-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 883433-7
    ISSN 1470-8744 ; 0885-4513
    ISSN (online) 1470-8744
    ISSN 0885-4513
    DOI 10.1002/bab.2033
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  6. Article: CRISPR-Cas System: A Promising Diagnostic Tool for Covid-19.

    Ebrahimi, Saeedeh / Khanbabaei, Hashem / Abbasi, Samaneh / Fani, Mona / Soltani, Saber / Zandi, Milad / Najafimemar, Zahra

    Avicenna journal of medical biotechnology

    2021  Volume 14, Issue 1, Page(s) 3–9

    Abstract: More than a year has passed since the beginning of the 2019 novel coronavirus diseases (COVID-19) pandemic which has created massive problems globally affecting all aspects of people's life. Due to the emergence of new strains of the SARS-CoV-2, pandemic ...

    Abstract More than a year has passed since the beginning of the 2019 novel coronavirus diseases (COVID-19) pandemic which has created massive problems globally affecting all aspects of people's life. Due to the emergence of new strains of the SARS-CoV-2, pandemic risk still remains, despite the start of vaccination. Therefore, rapid diagnostic tests are essential to control infection, improve clinical care and stop the spread of the disease. Recently CRISPR-based diagnostic tools have facilitated rapid diagnostic. Here, we review the diagnostic applications of CRISPR-Cas system in COVID-19.
    Language English
    Publishing date 2021-10-14
    Publishing country Iran
    Document type Journal Article ; Review
    ZDB-ID 2520683-7
    ISSN 2008-4625 ; 2008-2835
    ISSN (online) 2008-4625
    ISSN 2008-2835
    DOI 10.18502/ajmb.v14i1.8165
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  7. Article: Severe acute respiratory syndrome coronavirus 2 and respiratory syncytial virus coinfection in children.

    Zandi, Milad / Soltani, Saber / Fani, Mona / Abbasi, Samaneh / Ebrahimi, Saeedeh / Ramezani, Ali

    Osong public health and research perspectives

    2021  Volume 12, Issue 5, Page(s) 286–292

    Abstract: Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has infected many people around the world. Children are considered an important target group for SARS-CoV-2, as well as other viral ... ...

    Abstract Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has infected many people around the world. Children are considered an important target group for SARS-CoV-2, as well as other viral infections such as respiratory syncytial virus infection. Both SARS-CoV-2 and respiratory syncytial virus can affect the respiratory tract. Coinfection of SARS-CoV-2 and respiratory syncytial virus can pose significant challenges in terms of diagnosis and treatment in children. This review compares the symptoms, diagnostic methods, and treatment of COVID-19 and respiratory syncytial virus infection in children.
    Language English
    Publishing date 2021-10-01
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2656431-2
    ISSN 2233-6052 ; 2210-9099
    ISSN (online) 2233-6052
    ISSN 2210-9099
    DOI 10.24171/j.phrp.2021.0140
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  8. Article: Comparison between various biosensor methods for human T-lymphotropic virus-1 (HTLV-1) detection

    Kamali, Peyman / Zandi, Milad / Ghasemzadeh-Moghaddam, Hamed / Fani, Mona

    Molecular biology reports. 2022 Feb., v. 49, no. 2

    2022  

    Abstract: Due to the drawback of traditional and current diagnostic methods including serological and molecular assays, the development of the rapid and free-PCR techniques can be an alternative technique for the human T-cell lymphotropic virus (HTLV-1) DNA ... ...

    Abstract Due to the drawback of traditional and current diagnostic methods including serological and molecular assays, the development of the rapid and free-PCR techniques can be an alternative technique for the human T-cell lymphotropic virus (HTLV-1) DNA detection sequences. On the other hand, early detection of HTLV-1 prevents two dangerous diseases including Adult T-cell leukemia/lymphoma and HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis. The biosensor-based methods are sensitive techniques that can provide new opportunities to detect infectious diseases, particularly in the early stage. This study provides a comparative view among recently designed biosensors for the detection of HTLV-1.
    Keywords DNA ; T-lymphocytes ; adults ; biosensors ; humans ; leukemia ; lymphoma ; molecular biology ; viruses
    Language English
    Dates of publication 2022-02
    Size p. 1513-1517.
    Publishing place Springer Netherlands
    Document type Article
    Note Review
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-021-06959-w
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  9. Article ; Online: Future developments in biosensors for field‐ready SARS‐CoV‐2 virus diagnostics

    Fani, Mona / Zandi, Milad / Soltani, Saber / Abbasi, Samaneh

    Biotechnology and Applied Biochemistry ; ISSN 0885-4513 1470-8744

    2020  

    Keywords Biotechnology ; Process Chemistry and Technology ; Molecular Medicine ; Applied Microbiology and Biotechnology ; Bioengineering ; Drug Discovery ; Biomedical Engineering ; General Medicine ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1002/bab.2033
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  10. Article ; Online: The role of SARS-CoV-2 accessory proteins in immune evasion.

    Zandi, Milad / Shafaati, Maryam / Kalantar-Neyestanaki, Davood / Pourghadamyari, Hossein / Fani, Mona / Soltani, Saber / Kaleji, Hassan / Abbasi, Samaneh

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2022  Volume 156, Page(s) 113889

    Abstract: Many questions on the SARS-CoV-2 pathogenesis remain to answer. The SARS-CoV-2 genome encodes some accessory proteins that are essential for infection. Notably, accessory proteins of SARS-CoV-2 play significant roles in affecting immune escape and viral ... ...

    Abstract Many questions on the SARS-CoV-2 pathogenesis remain to answer. The SARS-CoV-2 genome encodes some accessory proteins that are essential for infection. Notably, accessory proteins of SARS-CoV-2 play significant roles in affecting immune escape and viral pathogenesis. Therefore SARS-CoV-2 accessory proteins could be considered putative drug targets. IFN-I and IFN-III responses are the primary mechanisms of innate antiviral immunity in infection clearance. Previous research has shown that SARS-CoV-2 suppresses IFN-β by infecting host cells via ORF3a, ORF3b, ORF6, ORF7a, ORF7b, ORF8, and ORF9b. Furthermore, ORF3a, ORF7a, and ORF7b have a role in blocking IFNα signaling, and ORF8 represses IFNβ signaling. The ORF3a, ORF7a, and ORF7b disrupt the STAT1/2 phosphorylation. ORF3a, ORF6, ORF7a, and ORF7b could prevent the ISRE promoter activity. The main SARS-CoV-2 accessory proteins involved in immune evasion are discussed here for comprehensive learning on viral entry, replication, and transmission in vaccines and antiviral development.
    MeSH term(s) Humans ; SARS-CoV-2 ; Immune Evasion ; COVID-19 ; Interferon-beta/genetics ; Antiviral Agents
    Chemical Substances Interferon-beta (77238-31-4) ; Antiviral Agents
    Language English
    Publishing date 2022-10-17
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2022.113889
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