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  1. Article ; Online: Early Features of Chronic Obstructive Pulmonary Disease in Patients with Asthma: Is there ACO before ACO?

    Boulet, Louis-Philippe

    Immunology and allergy clinics of North America

    2022  Volume 42, Issue 3, Page(s) 549–558

    Abstract: The diagnosis of asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) is considered when a patient presents features of both asthma and COPD, usually including a component of irreversible airway obstruction (IRAO). However, some patients ... ...

    Abstract The diagnosis of asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) is considered when a patient presents features of both asthma and COPD, usually including a component of irreversible airway obstruction (IRAO). However, some patients with asthma, particularly smokers, may have various features typical of COPD in the absence of such component of IRAO. Features of early COPD can be found at a young age in such patients even with normal spirometry. More longitudinal studies should be conducted to determine steps needed to improve clinical outcomes of these patients including the early recognition of these changes and the application of preventative/therapeutic interventions.
    MeSH term(s) Airway Obstruction ; Asthma/diagnosis ; Asthma/drug therapy ; Asthma/epidemiology ; Forced Expiratory Volume ; Humans ; Pulmonary Disease, Chronic Obstructive/complications ; Pulmonary Disease, Chronic Obstructive/diagnosis
    Language English
    Publishing date 2022-06-30
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 92606-1
    ISSN 1557-8607 ; 0889-8561
    ISSN (online) 1557-8607
    ISSN 0889-8561
    DOI 10.1016/j.iac.2022.03.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Asthma-Chronic Obstructive Pulmonary Disease: An Update.

    Hanania, Nicola A / Boulet, Louis-Philippe

    Immunology and allergy clinics of North America

    2022  Volume 42, Issue 3, Page(s) xiii–xiv

    MeSH term(s) Asthma/diagnosis ; Asthma/epidemiology ; Asthma/therapy ; Humans ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Pulmonary Disease, Chronic Obstructive/therapy
    Language English
    Publishing date 2022-06-30
    Publishing country United States
    Document type Editorial
    ZDB-ID 92606-1
    ISSN 1557-8607 ; 0889-8561
    ISSN (online) 1557-8607
    ISSN 0889-8561
    DOI 10.1016/j.iac.2022.04.010
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  3. Article ; Online: When Asthma and Chronic Obstructive Pulmonary Disease Overlap; Current Knowledge and Unmet Needs.

    Boulet, Louis-Philippe / Hanania, Nicola A

    Immunology and allergy clinics of North America

    2022  Volume 42, Issue 3, Page(s) 499–505

    Abstract: Asthma and chronic obstructive pulmonary disease (COPD) are common diseases that often overlap. The term asthma-COPD overlap (ACO) has been used to define this entity but there remain several speculations on its exact definition, impact, pathophysiology, ...

    Abstract Asthma and chronic obstructive pulmonary disease (COPD) are common diseases that often overlap. The term asthma-COPD overlap (ACO) has been used to define this entity but there remain several speculations on its exact definition, impact, pathophysiology, and clinical features. Patients with ACO have greater morbidity than those with asthma or COPD alone, but the information on the best therapeutic approach to this group of patients is still limited. Current treatment recommendations rely on expert opinions, roundtable discussions, and strategy documents. It is prudent to examine existing knowledge about ACO and determine the path for future research.
    MeSH term(s) Asthma/diagnosis ; Asthma/epidemiology ; Asthma/therapy ; Humans ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Pulmonary Disease, Chronic Obstructive/therapy
    Language English
    Publishing date 2022-08-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 92606-1
    ISSN 1557-8607 ; 0889-8561
    ISSN (online) 1557-8607
    ISSN 0889-8561
    DOI 10.1016/j.iac.2022.05.001
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  4. Article: War-time asthma: lessons from Syria.

    Boulet, Louis-Philippe

    Journal of thoracic disease

    2017  Volume 9, Issue 9, Page(s) 3412–3414

    Language English
    Publishing date 2017-12-18
    Publishing country China
    Document type Editorial
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd.2017.08.91
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  5. Article ; Online: Oral Corticosteroids Tapering in Severe Asthma.

    Boulet, Louis-Philippe / Godbout, Krystelle

    American journal of respiratory and critical care medicine

    2020  Volume 203, Issue 7, Page(s) 795–796

    MeSH term(s) Adrenal Cortex Hormones ; Asthma/drug therapy ; Consensus ; Delphi Technique ; Humans
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2020-11-18
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202010-4001ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Serum and sputum MMP-9/TIMP-1 in winter sports athletes and swimmers: relationships with airway function.

    Bougault, Valérie / Turmel, Julie / Boulet, Louis-Philippe

    Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals

    2022  Volume 27, Issue 2, Page(s) 127–137

    Abstract: Introduction: Skiers and swimmers present characteristics of airway inflammation and remodelling of the extracellular matrix similar to what is observed in mild asthma. We aimed to compare serum and sputum MMP-9/TIMP-1 levels, to assess the balance ... ...

    Abstract Introduction: Skiers and swimmers present characteristics of airway inflammation and remodelling of the extracellular matrix similar to what is observed in mild asthma. We aimed to compare serum and sputum MMP-9/TIMP-1 levels, to assess the balance between airway fibrogenesis and inflammation process in both categories of athletes, and to observe its seasonal variations in winter sports athletes.
    Methods: We conducted a retrospective study. Winter sports athletes (
    Results: No significant difference in serum or sputum MMP-9/TIMP-1 ratio was observed between groups, nor relationship with airway function or responsiveness. Serum MMP-9/TIMP-1 ratio was higher during the summer in winter sport athletes compared with winter season (median [Interquartile range]: 3.65 [2.47-4.03] ng.ml
    Conclusion: MMP-9/TIMP-1 ratio in sputum or serum may fluctuate with training or environment but does not correlate with airway function or responsiveness in athletes.
    MeSH term(s) Athletes ; Humans ; Matrix Metalloproteinase 9 ; Retrospective Studies ; Sputum ; Tissue Inhibitor of Metalloproteinase-1
    Chemical Substances Tissue Inhibitor of Metalloproteinase-1 ; Matrix Metalloproteinase 9 (EC 3.4.24.35)
    Language English
    Publishing date 2022-01-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1324372-x
    ISSN 1366-5804 ; 1354-750X
    ISSN (online) 1366-5804
    ISSN 1354-750X
    DOI 10.1080/1354750X.2021.2020902
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  7. Article ; Online: Airway remodeling in asthma: update on mechanisms and therapeutic approaches.

    Boulet, Louis-Philippe

    Current opinion in pulmonary medicine

    2017  Volume 24, Issue 1, Page(s) 56–62

    Abstract: Purpose of review: The term 'airway remodeling' reflects changes in the type, quantity, and nature of airway wall components and their organization. The purpose of this review is to look at recent publications on airway remodeling in asthma.: Recent ... ...

    Abstract Purpose of review: The term 'airway remodeling' reflects changes in the type, quantity, and nature of airway wall components and their organization. The purpose of this review is to look at recent publications on airway remodeling in asthma.
    Recent findings: Animal models and in-vitro studies have confirmed the involvement of airway epithelium, airway smooth muscle (ASM), and extracellular matrix components in asthma-related airway remodeling. They report influences on proliferation of ASM cells, and how their orientation or morphology, in addition to the heterogeneity of ASM mass at different levels of airways could influence their effects. Clinical benefits have been observed following reduction of ASM following bronchial thermoplasty. Asthmatic epithelial cell transcriptome alterations were found to involve metabolism and epigenetics, beyond epithelial mesenchymal trophic unit driven by injury and repair in chronic inflammation. New ways to explore airway remodeling such as imaging or endoscopic techniques have been evaluated. Finally, new data support the role of eosinophils and mast cells in remodeling and show the influence of new asthma drugs on this process.
    Summary: As recently stated by an American Thoracic Society task force, we need more research on airway remodeling, its determinants and clinical relevance, and on the effects of asthma drugs on its various components.
    MeSH term(s) Airway Remodeling/drug effects ; Airway Remodeling/physiology ; Animals ; Anti-Asthmatic Agents/therapeutic use ; Asthma/drug therapy ; Asthma/immunology ; Asthma/physiopathology ; Eosinophils/drug effects ; Humans ; Inflammation/drug therapy ; Inflammation/immunology ; Inflammation/physiopathology ; Mast Cells/drug effects ; Muscle, Smooth/drug effects ; Muscle, Smooth/immunology ; Muscle, Smooth/physiopathology ; Respiratory Physiological Phenomena
    Chemical Substances Anti-Asthmatic Agents
    Language English
    Publishing date 2017-10-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1285505-4
    ISSN 1531-6971 ; 1070-5287 ; 1078-1641
    ISSN (online) 1531-6971
    ISSN 1070-5287 ; 1078-1641
    DOI 10.1097/MCP.0000000000000441
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  8. Article ; Online: Inhaled Corticosteroids and Adult Asthma.

    Boulet, Louis-Philippe / Nair, Parameswaran

    American journal of respiratory and critical care medicine

    2019  Volume 200, Issue 12, Page(s) 1556–1557

    MeSH term(s) Adrenal Cortex Hormones ; Adult ; Asthma ; Humans
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2019-07-24
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.201907-1301LE
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  9. Article ; Online: Is asthma only an airways disorder?

    Bossé, Ynuk / Boulet, Louis-Philippe

    Respirology (Carlton, Vic.)

    2019  Volume 25, Issue 6, Page(s) 568–569

    MeSH term(s) Asthma ; Humans ; Lung ; Pulmonary Disease, Chronic Obstructive ; Respiration Disorders ; Respiratory Physiological Phenomena
    Language English
    Publishing date 2019-10-16
    Publishing country Australia
    Document type Editorial ; Comment
    ZDB-ID 1435849-9
    ISSN 1440-1843 ; 1323-7799
    ISSN (online) 1440-1843
    ISSN 1323-7799
    DOI 10.1111/resp.13716
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  10. Article: Asthma in the elderly patient.

    Boulet, Louis-Philippe

    Asthma research and practice

    2016  Volume 2, Page(s) 3

    Abstract: Asthma affects a significant proportion of elderly patients, but unfortunately, it is responsible for a high asthma-related morbidity and mortality in this population. This may be related not only to the development of a more severe asthma phenotype ... ...

    Abstract Asthma affects a significant proportion of elderly patients, but unfortunately, it is responsible for a high asthma-related morbidity and mortality in this population. This may be related not only to the development of a more severe asthma phenotype compared to younger patients, with more marked airway obstruction and a more neutrophilic type of airway inflammation, but also to the presence of many co-morbid conditions. Furthermore, in older patients, asthma is often under-diagnosed, undertreated and poorly managed. Unfortunately, elderly patients have usually been excluded of clinical trials on asthma and there is an urgent need to perform more research on the optimal management of asthma in this population.
    Language English
    Publishing date 2016-02-02
    Publishing country England
    Document type Journal Article
    ISSN 2054-7064
    ISSN 2054-7064
    DOI 10.1186/s40733-015-0015-1
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