LIVIVO - Search results -

Search results

Result 1 - 10 of total 3125

Search options

Article: Indanylidenes. 2. Design and synthesis of (E)-2-(4-chloro-6-fluoro-1-indanylidene)-N-methylacetamide, a potent antiinflammatory and analgesic agent without centrally acting muscle relaxant activity.

Musso, David L / Orr, G Faye / Cochran, Felicia R / Kelley, James L / Selph, Jeffrey L / Rigdon, Greg C / Cooper, Barrett R / Jones, Michael L

Journal of medicinal chemistry

2003 Volume 46, Issue 3, Page(s) 409–416

Abstract: ... acetamide, 1, has given rise to (E)-2-(4-chloro-6-fluoro-1-indanylidene)-N-methylacetamide, 2. Compound 2 is ... of the nonsedating potent muscle relaxant, antiinflammatory, and analgesic agent (E)-2-(4,6-difluoro-1-indanylidene ...

Abstract	Extension of the structure-activity relationship studies that led to the discovery of the nonsedating potent muscle relaxant, antiinflammatory, and analgesic agent (E)-2-(4,6-difluoro-1-indanylidene)acetamide, 1, has given rise to (E)-2-(4-chloro-6-fluoro-1-indanylidene)-N-methylacetamide, 2. Compound 2 is a potent antiinflammatory and analgesic agent without centrally acting muscle relaxant activity.
MeSH term(s)	Acetamides/chemical synthesis ; Acetamides/chemistry ; Acetamides/pharmacology ; Analgesics/chemical synthesis ; Analgesics/chemistry ; Analgesics/pharmacology ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Hypnotics and Sedatives/chemical synthesis ; Hypnotics and Sedatives/chemistry ; Hypnotics and Sedatives/pharmacology ; Indans/chemical synthesis ; Indans/chemistry ; Indans/pharmacology ; Mice ; Muscle Relaxants, Central/chemical synthesis ; Muscle Relaxants, Central/chemistry ; Muscle Relaxants, Central/pharmacology ; Rats ; Stereoisomerism ; Structure-Activity Relationship
Chemical Substances	2-(4-chloro-6-fluoro-1-indanylidene)-N-methylacetamide ; Acetamides ; Analgesics ; Anti-Inflammatory Agents, Non-Steroidal ; Hypnotics and Sedatives ; Indans ; Muscle Relaxants, Central
Language	English
Publishing date	2003-01-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/jm020068k
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 151: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MB 1: Show issues

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Recycling of

Kretowicz, Margarita N / Barrett, Kendall E / Barnhart, Todd E / Engle, Jonathan W

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

2023 Volume 200, Page(s) 110924

Abstract: ... ...

Abstract	52g
Language	English
Publishing date	2023-07-05
Publishing country	England
Document type	Journal Article
ZDB-ID	1142596-9
ISSN	1872-9800 ; 0883-2889 ; 0969-8043
ISSN (online)	1872-9800
ISSN	0883-2889 ; 0969-8043
DOI	10.1016/j.apradiso.2023.110924
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ue I Zs.279: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Trauma-informed prevention programmes for depression, anxiety, and substance use among young people: protocol for a mixed-methods systematic review.

Bailey, S / Newton, N / Perry, Y / Grummitt, L / Baams, L / Barrett, E

Systematic reviews

2023 Volume 12, Issue 1, Page(s) 203

Abstract: Background: Mental ill-health and substance use bear a substantial burden and harm on young people and often arise from co-occurring and compounding risk factors, such as traumatic stress. Trauma-informed prevention of mental ill-health and substance ... ...

Abstract	Background: Mental ill-health and substance use bear a substantial burden and harm on young people and often arise from co-occurring and compounding risk factors, such as traumatic stress. Trauma-informed prevention of mental ill-health and substance use demonstrates significant promise in reducing this burden. A systematic literature review is required to identify and summarise the effectiveness, feasibility, acceptability, and design principles underpinning existing trauma-informed mental ill-health and/or substance use prevention programmes for young people aged 12-24 years. Methods: MEDLINE, Embase, CINAHL, PsychINFO, and Cochrane Library will be searched from 2012 through September 2022. Reference lists of included articles will be citation-chained. Title and abstracts will be screened and two reviewers will review articles full-text. One reviewer will extract data from eligible articles using a piloted data extraction form, and 20% of the data will be verified by a second reviewer. Risk of bias will be assessed using the Cochrane risk-of-bias tool for randomised trials (RoB 2), Risk of Bias in Non-randomised Studies of Interventions (ROBINS-I), and The Joanna Briggs Institute Critical Appraisal Checklist for Quasi-Experimental Studies and The Joanna Briggs Institute Critical Appraisal Checklist for Qualitative Research (CASP), depending on the study type. Characteristics of existing trauma-informed mental ill-health and/or substance use prevention programmes for young people will be summarised narratively. Effectiveness, feasibility, and acceptability will be qualitatively described and summarised, with proportions and effect sizes quantitatively synthesised, where possible. Discussion: Trauma-informed approaches to prevention demonstrate significant promise, yet to date, no study has systematically summarised and synthesised the available literature. To fill this gap, the present review will systematically identify and summarise the effectiveness, feasibility, acceptability, and design principles underpinning existing trauma-informed mental health and/or substance use prevention programmes for young people aged 12-24. This review will inform the development, adaptation, evaluation, and implementation of future trauma-informed mental ill-health and substance use prevention programmes for young people. Findings will inform critical efforts to interrupt and prevent already elevated trajectories of mental ill-health, substance use, and related harms among those young people exposed to adversity. Systematic review registration: PROSPERO CRD42022353883.
MeSH term(s)	Humans ; Adolescent ; Depression ; Substance-Related Disorders/prevention & control ; Anxiety ; Anxiety Disorders ; Mental Health ; Systematic Reviews as Topic
Language	English
Publishing date	2023-10-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2662257-9
ISSN	2046-4053 ; 2046-4053
ISSN (online)	2046-4053
ISSN	2046-4053
DOI	10.1186/s13643-023-02365-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: 'Being in a place where it matters': GPs who do and do not work in Aboriginal Health Services.

Prentice, Shaun / Barrett, Alexandra / Benson, Jill / Elliott, Taryn

Australian journal of primary health

2024 Volume 30, Issue 1, Page(s) NULL

Abstract: ... who remained (n =11) and left (n =9) AMSs after placements participated in semi-structured interviews across ... in rural and other under-served areas. Training providers can better prepare (e.g. more comprehensive ... orientations) and support registrars during their placements (e.g. greater mentoring). Registrars' perceptions ...

Abstract	Background: Few general practitioners (GPs) pursue a career in Aboriginal and Torres Strait Islander health. This research examined factors motivating Australian General Practice Training Program (AGPT) graduates to remain in, or leave, Aboriginal Medical Services (AMSs). Methods: AGPT graduates who remained (n =11) and left (n =9) AMSs after placements participated in semi-structured interviews across two studies. Thematic analysis informed by grounded theory was employed. Results: Both participant groups highlighted similar motivations for requesting an AMS placement, particularly their interest in Aboriginal health or culture. Participants enjoyed organisational structures and relationships, and faced similar barriers to working in AMSs. Those who left placed greater emphasis on the politics and bureaucracy, and unpredictability, and also faced the barrier of ties to their current practice. Those who remained in Aboriginal health more proactively addressed barriers and had a more external view of barriers. Conclusions: Factors influencing career decisions of GPs in Aboriginal health overlap with those for GPs in rural and other under-served areas. Training providers can better prepare (e.g. more comprehensive orientations) and support registrars during their placements (e.g. greater mentoring). Registrars' perceptions of, and reactions to, barriers may be pivotal in determining whether they remain in Aboriginal health. This article provides guidance for training providers to better support AMS registrars and encourage more GPs to work in this sector.
MeSH term(s)	Humans ; Australia ; Australian Aboriginal and Torres Strait Islander Peoples ; General Practitioners ; Health Services, Indigenous
Language	English
Publishing date	2024-02-19
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2566332-X
ISSN	1836-7399 ; 1448-7527
ISSN (online)	1836-7399
ISSN	1448-7527
DOI	10.1071/PY23105
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: A long-term ketogenic diet in young and aged rats has dissociable effects on prelimbic cortex and CA3 ensemble activity.

Hernandez, Abbi R / Barrett, Maya E / Lubke, Katelyn N / Maurer, Andrew P / Burke, Sara N

bioRxiv : the preprint server for biology

2023

Abstract: Age-related cognitive decline has been linked to distinct patterns of cellular dysfunction in the prelimbic cortex (PL) and the CA3 subregion of the hippocampus. Because higher cognitive functions require both structures, selectively targeting a ... ...

Abstract	Age-related cognitive decline has been linked to distinct patterns of cellular dysfunction in the prelimbic cortex (PL) and the CA3 subregion of the hippocampus. Because higher cognitive functions require both structures, selectively targeting a neurobiological change in one region, at the expense of the other, is not likely to restore normal behavior in older animals. One change with age that both the PL and CA3 share, however, is a reduced ability to utilize glucose, which can produce aberrant neural activity patterns. The current study used a ketogenic diet (KD) intervention, which reduces the brainâ€™s reliance on glucose, and has been shown to improve cognition, as a metabolic treatment for restoring neural ensemble dynamics in aged rats. Expression of the immediate-early genes Significance statement: This study extends understanding of how a ketogenic diet (KD) intervention may improve cognitive function in older adults. Young and aged rats were given 3 months of a KD or a calorie-match control diet and then expression of the immediate-early genes
Language	English
Publishing date	2023-02-19
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.02.18.529095
Database	MEDical Literature Analysis and Retrieval System OnLINE

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article: A long-term ketogenic diet in young and aged rats has dissociable effects on prelimbic cortex and CA3 ensemble activity.

Hernandez, Abbi R / Barrett, Maya E / Lubke, Katelyn N / Maurer, Andrew P / Burke, Sara N

Frontiers in aging neuroscience

2023 Volume 15, Page(s) 1274624

Abstract: Introduction: Age-related cognitive decline has been linked to distinct patterns of cellular dysfunction in the prelimbic cortex (PL) and the CA3 subregion of the hippocampus. Because higher cognitive functions require both structures, selectively ... ...

Abstract	Introduction: Age-related cognitive decline has been linked to distinct patterns of cellular dysfunction in the prelimbic cortex (PL) and the CA3 subregion of the hippocampus. Because higher cognitive functions require both structures, selectively targeting a neurobiological change in one region, at the expense of the other, is not likely to restore normal behavior in older animals. One change with age that both the PL and CA3 share, however, is a reduced ability to utilize glucose, which can produce aberrant neural activity patterns. Methods: The current study used a ketogenic diet (KD) intervention, which reduces the brain's reliance on glucose, and has been shown to improve cognition, as a metabolic treatment for restoring neural ensemble dynamics in aged rats. Expression of the immediate-early genes Results: Aged rats on the control diet had increased activity in CA3 and less ensemble overlap in PL between different task conditions than did the young animals. In the PL, the KD was associated with increased activation of neurons in the superficial cortical layers, establishing a clear link between dietary macronutrient content and frontal cortical activity. The KD did not lead to any significant changes in CA3 activity. Discussion: These observations suggest that the availability of ketone bodies may permit the engagement of compensatory mechanisms in the frontal cortices that produce better cognitive outcomes.
Language	English
Publishing date	2023-12-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2558898-9
ISSN	1663-4365
ISSN	1663-4365
DOI	10.3389/fnagi.2023.1274624
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: An Umbrella Review of the Links Between Adverse Childhood Experiences and Substance Misuse

Grummitt L / Barrett E / Kelly E / Newton N

Substance Abuse and Rehabilitation, Vol Volume 13, Pp 83-

What, Why, and Where Do We Go from Here?

2022 Volume 100

Abstract: Lucinda Grummitt, Emma Barrett, Erin Kelly, Nicola Newton The Matilda Centre for Research ...

Abstract	Lucinda Grummitt, Emma Barrett, Erin Kelly, Nicola Newton The Matilda Centre for Research in Mental Health and Substance Use, The University of Sydney, Camperdown, NSW, AustraliaCorrespondence: Lucinda Grummitt, The Matilda Centre, Level 6, Jane Foss Russell Building, The University of Sydney, Camperdown, NSW, Australia, Tel +61 423 864 931, Email lucinda.grummitt@sydney.edu.auBackground and Objectives: A wealth of research has identified adverse childhood experiences (ACEs; abuse, neglect, violence or disorder in the home) as a strong risk factor for substance misuse. Synthesis of the existing evidence is critical to shape policy and inform directions for future research. Existing reviews have focused on specific substances or substance use outcomes (eg, disorder), and do not include discussion of the mechanisms that operate between ACEs and substance misuse. The current umbrella review aims to synthesize reviews on the relationship between ACEs and substance misuse, review the evidence on the mechanisms linking these, identify existing gaps in our knowledge, and discuss critical directions for future research, practice, and public policy.Methods: Two electronic databases (PsycINFO and Medline) were searched for reviews published between 1998 and 2022 on the link between ACEs and substance misuse. Twenty articles met eligibility criteria and were qualitatively synthesized.Results: Results overwhelmingly demonstrated an elevated risk of substance misuse or disorder, among adolescents and adults exposed to ACEs. Research on the mechanisms that explain this link highlights a multitude of potential intervention targets, with childhood stress propelling a cascade of effects across neurobiological, endocrine, immune, metabolic, and nervous systems, impacting psychosocial and cognitive functioning. Nonetheless, the literature is subject to limitations surrounding potential unmeasured cofounders and causality, as well as decontextualizing childhood adversity from broader structural issues that influence the link ...
Keywords	adverse childhood experiences ; substance misuse ; umbrella review ; social determinants of health ; Public aspects of medicine ; RA1-1270
Subject code	360 ; 300
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	Dove Medical Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Unfractionated heparin reverses aspirin inhibition of platelets during coronary artery bypass graft surgery.

Turnbull, Robert E / Hafeez, Azhar / Sander, Katrin N / Barrett, David A / Murphy, Gavin J / Goodall, Alison H

Scientific reports

2024 Volume 14, Issue 1, Page(s) 8572

Abstract: ... to heparin. We studied this phenomenon in patients undergoing cardiac artery bypass grafting (n = 17 ...

Abstract	Unfractionated heparin (UFH) is an effective antithrombotic during surgery but has known adverse effects, in particular on platelets. A marked increase in platelet responsiveness has previously been observed in patients within minutes of receiving UFH, despite adequate inhibition by aspirin prior to heparin. We studied this phenomenon in patients undergoing cardiac artery bypass grafting (n = 17) to determine whether the effects of heparin were systemic or platelet-specific. All patients' platelets were fully inhibited by aspirin prior to surgery, but within 3 min of receiving heparin spontaneous aggregation and responses to arachidonic acid (AA) and ADP increased significantly (p ≥ 0.0002), and activated platelets were found in the circulation. While there was no rise in thromboxane in the plasma following heparin, levels of the major platelet 12-lipoxygenase product, 12-HETE, rose significantly. Mixing experiments demonstrated that the changes caused by heparin resided primarily in the platelets, while addition of AA pathway inhibitors, and analysis of oxylipins provided evidence that, following heparin, aggregating platelets regained their ability to synthesise thromboxane. These findings highlight potentially unrecognised pro-thrombotic and pro-inflammatory changes during CABG surgery, and provide further evidence of adverse effects associated with UFH.
MeSH term(s)	Humans ; Heparin/pharmacology ; Drug-Related Side Effects and Adverse Reactions ; Arachidonic Acid ; Aspirin/pharmacology ; Coronary Artery Bypass ; Thromboxanes
Chemical Substances	Heparin (9005-49-6) ; Arachidonic Acid (27YG812J1I) ; Aspirin (R16CO5Y76E) ; Thromboxanes
Language	English
Publishing date	2024-04-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-58005-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Trends in repeat general anaesthesia for treatment of dental caries at a children's hospital in Toronto, Canada: a 10-year retrospective investigation.

Vertullo, L / Barrett, E / Quinonez, C / Sidhu, N / Casas, M

European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry

2021 Volume 22, Issue 6, Page(s) 1087–1093

Abstract: Background: Treatment of early childhood caries (ECC) under general anaesthesia (GA) was the most common day surgical procedure performed for preschool children in Canada. Evidence with regard to the rate of repeat GA for dental care for Canadian ... ...

Abstract	Background: Treatment of early childhood caries (ECC) under general anaesthesia (GA) was the most common day surgical procedure performed for preschool children in Canada. Evidence with regard to the rate of repeat GA for dental care for Canadian Children is limited. Aim: To determine the rate of repeat dental caries treatment performed under GA over a 10-year period and to assess the relationship between the frequency of repeat dental treatment under GA and medical comorbidities. Design: This was a retrospective assessment of the dental records of 973 children who required repeat dental treatment under GA over a 10-year period. The rate of repeat dental treatment under GA was calculated. A Chi-square analysis was performed to determine associations between medical comorbidities and the frequency of repeat dental treatment under GA. Results: The rate of repeat dental treatment under GA over a 10-year period was 10.8%. The yearly repeat rate and simple moving 5-year rate of repeat dental treatment under GA increased. Having a medical comorbidity was not associated with repeat dental treatment under GA. Conclusions: The rate of repeat dental treatment under GA was consistent with the rates reported in the dental literature and increased over the 10-year period.
MeSH term(s)	Anesthesia, Dental ; Anesthesia, General ; Canada ; Child, Preschool ; Dental Caries/epidemiology ; Dental Caries/therapy ; Hospitals ; Humans ; Retrospective Studies
Language	English
Publishing date	2021-10-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2472851-2
ISSN	1996-9805 ; 1818-6300
ISSN (online)	1996-9805
ISSN	1818-6300
DOI	10.1007/s40368-021-00667-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 6730: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Rethinking the Definition of Medicalized Female Genital Mutilation/Cutting.

Van Eekert, Nina / Barrett, Hazel / Kimani, Samuel / Hidayana, Irwan / Leye, Els

Archives of sexual behavior

2024 Volume 53, Issue 2, Page(s) 441–453

Abstract: In 2015, the international community agreed to end Female Genital Mutilation/Cutting (FGM/C) by 2030. However, the target is unlikely to be met as changes in practice, including medicalized female genital mutilation/cutting (mFGM/C), challenge ... ...

Abstract	In 2015, the international community agreed to end Female Genital Mutilation/Cutting (FGM/C) by 2030. However, the target is unlikely to be met as changes in practice, including medicalized female genital mutilation/cutting (mFGM/C), challenge abandonment strategies. This paper critically reviews the current World Health Organization (WHO) definition of mFGM/C to demonstrate that mFGM/C, as currently defined, lacks detail and clarity, and may serve as an obstacle to the collection of credible, reliable, and comparable data relevant to targeted FGM/C prevention policies and programs. The paper argues that it is necessary to initiate a discussion on the revision of the current WHO definition of mFGM/C, where different components (who-how-where-what) should be taken into account. This is argued by discussing different scenarios that compare the current WHO definition of mFGM/C with the actual practice of FGM/C on the ground. The cases discussed within these scenarios are based on existing published research and the research experience of the authors. The scenarios focus on countries where mFGM/C is prevalent among girls under 18 years, using data from Demographic Health Surveys and/or Multiple Indicator Cluster Surveys, and thus the focus is on the Global South. The paper places its arguments in relation to wider debates concerning female genital cosmetic surgery, male genital circumcision and consent. It calls for more research on these topics to ensure that definitions of FGM/C and mFGM/C reflect the real-world contexts and ensure that the human rights of girls and women are protected.
MeSH term(s)	Female ; Male ; Humans ; Adolescent ; Circumcision, Female ; Human Rights ; Health Surveys ; Surveys and Questionnaires ; Circumcision, Male
Language	English
Publishing date	2024-01-29
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	184221-3
ISSN	1573-2800 ; 0004-0002
ISSN (online)	1573-2800
ISSN	0004-0002
DOI	10.1007/s10508-023-02772-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1106: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito