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  1. Book ; Online: Pediatric Cancers

    Agarwal, Saurabh / Yang, Jianhua

    2023  

    Keywords Medicine ; Oncology ; infections ; cancer ; children ; bacteremia ; pneumonia ; sarcoma ; solid tumor ; outcome ; KI67 ; EZRIN ; 18F-FDG PET/CT ; random forest ; radiogenomics ; chemotherapy response ; metastasis ; serine-threonine kinase receptor-associated protein ; neuroblastoma ; CRISPR-Cas9 ; metronomic chemotherapy ; maintenance therapy ; high-risk ; Ewing sarcoma ; RNA-binding proteins ; regulation network ; prognosis prediction ; risk model ; melanotic neuroectodermal tumor of infancy ; inoperable ; metastatic ; recurrent ; chemotherapy ; adjuvant ; neoadjuvant ; systemic treatment ; childhood malignant bone tumors ; survivorship ; late effects ; somatic disease ; cohort study ; rhabdomyosarcoma ; targeted therapies ; cell surface proteomics ; B7-H3 ; stress ; allostasis ; stress regulatory pathways ; stress dysregulation ; stress reactivity ; early life stress ; childhood cancer ; cytotoxic cancer treatment ; interventions ; ependymoma ; risk stratification ; molecular group ; prognosis ; nephroblastoma ; clinical malformations ; cancer predisposition syndromes ; tumor surveillance ; n/a ; DSRCT ; EWSR1-WT1 ; preclinical model ; in vitro model ; pediatric cancer ; pediatric ; brain ; tumor ; medulloblastoma ; glioma ; natural products ; drug discovery ; fungal secondary metabolites ; soil microbes ; RH30 ; RD ; EZH2 ; epigenetic ; EPZ005687 ; DZNep ; AdOx ; malignant rhabdoid tumor ; hepatoblastoma ; small cell undifferentiated (SCUD) hepatoblastoma ; SMARCB1 ; INI1 ; pediatric liver tumors ; drug repurposing ; PI3K pathway ; epigenetics ; Fimepinostat ; LPAR1 ; LPA ; tumor metastasis ; bioinformatics analysis ; ulixertinib ; ERK inhibition ; combination therapy ; c-Myc/N-Myc ; cell differentiation ; ATRA ; SOX4 ; diffuse intrinsic pontine glioma ; immunotherapy ; immune microenvironment ; immune checkpoint inhibitor ; vaccine ; oncolytic virus ; myeloid sarcoma ; chloroma ; acute myeloid leukemia ; pediatric cancers ; VIPN ; DIC ; MDR ; drug transporters ; childhood acute leukemia ; early complication ; hyperleukocytosis ; risk factor ; survival outcome
    Language English
    Size 1 electronic resource (456 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030646158
    ISBN 9783036590257 ; 3036590250
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Pediatric Cancers: Insights and Novel Therapeutic Approaches.

    Agarwal, Saurabh

    Cancers

    2023  Volume 15, Issue 14

    Abstract: Pediatric cancers cast a dark shadow over the lives of countless children and their families and represent a leading cause of mortality among children worldwide [ ... ]. ...

    Abstract Pediatric cancers cast a dark shadow over the lives of countless children and their families and represent a leading cause of mortality among children worldwide [...].
    Language English
    Publishing date 2023-07-08
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15143537
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Unravelling the role of Sildenafil and SB204741 in suppressing fibrotic potential of peritoneal fibroblasts obtained from PD patients.

    Chaturvedi, Saurabh / Singh, Harshit / Agarwal, Vikas / Jaiswal, Akhilesh / Prasad, Narayan

    Frontiers in pharmacology

    2024  Volume 14, Page(s) 1279330

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2024-01-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1279330
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Lipodystrophy following diphtheria, pertussis and tetanus (DPT) vaccine.

    Prabhakaran, Kalyana / Agarwal, Saurabh / Goyal, Jagdish Prasad / Kumar, Prawin

    BMJ case reports

    2024  Volume 17, Issue 3

    MeSH term(s) Humans ; Tetanus Toxoid ; Diphtheria ; Whooping Cough ; Tetanus ; Corynebacterium ; Lipodystrophy
    Chemical Substances Tetanus Toxoid
    Language English
    Publishing date 2024-03-04
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2023-259514
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A Computational Model for Determining Tiger Dispersal and Related Patterns in a Landscape Complex

    Saurabh Shanu / Alok Agarwal

    Sustainability, Vol 15, Iss 8539, p

    2023  Volume 8539

    Abstract: Species dispersal from one territorial zone to another is a complex process. The reasons for species dispersal are determined by both natural and human factors. The purpose of this study is to develop a cost surface for a hypothetical landscape that ... ...

    Abstract Species dispersal from one territorial zone to another is a complex process. The reasons for species dispersal are determined by both natural and human factors. The purpose of this study is to develop a cost surface for a hypothetical landscape that accounts for various species dispersion features. With tigers ( Panthera tigris tigris ) as the focal species, a computational model for a landscape has been proposed to predict the dispersion patterns of the species’ individuals from one habitat patch to another. Knowing how tigers disperse is very crucial because it improves the likelihood of successful conservation. The likelihood is raised because it strengthens conservation efforts in the targeted regions identified by the proposed model and encourages landscape continuity for tiger dispersal. Initially, four major factors influencing tiger dispersal are explored. Following that, grids are overlaid over the tiger-carrying landscape map. Further, game theory assigns a score to each grid in the landscape matrix based on the landscape features in the focal landscape. Specific predefined ratings are also utilized for scenarios that are very complex and may change depending on variables, such as the interaction of the dispersing tiger with co-predators. The two scores mentioned above are combined to create a cost matrix that is shown across a landscape complex to estimate the impact of each landscape component on tiger dispersal. This approach helps wildlife managers develop conservation plans by recognizing important characteristics in the landscape. The results of the model described in this work might be beneficial for a wide range of wildlife management activities, such as corridor management, smart patrols, and so on. A cost surface over any focal landscape may serve as a basis for policy and purpose design based on current landscape conditions.
    Keywords computation ; cost allocation ; dispersal ; game theory ; landscape ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 710
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Dual Targeting of PI3K and HDAC by CUDC-907 Inhibits Pediatric Neuroblastoma Growth.

    Chilamakuri, Rameswari / Agarwal, Saurabh

    Cancers

    2022  Volume 14, Issue 4

    Abstract: The dysregulation of PI3K, HDACs, and MYCN are well known for promoting multiple cancer types, including neuroblastoma (NB). Targeting the upstream regulators of MYCN, including HDACs and PI3K, was shown to suppress cancer growth. In the present study, ... ...

    Abstract The dysregulation of PI3K, HDACs, and MYCN are well known for promoting multiple cancer types, including neuroblastoma (NB). Targeting the upstream regulators of MYCN, including HDACs and PI3K, was shown to suppress cancer growth. In the present study, we analyze different NB patient datasets to reveal that high
    Language English
    Publishing date 2022-02-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14041067
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Direct Targeting of the Raf-MEK-ERK Signaling Cascade Inhibits Neuroblastoma Growth.

    Chilamakuri, Rameswari / Agarwal, Saurabh

    Current oncology (Toronto, Ont.)

    2022  Volume 29, Issue 9, Page(s) 6508–6522

    Abstract: The Raf-MEK-ERK signaling network has been the subject of intense research due to its role in the development of human cancers, including pediatric neuroblastoma (NB). MEK and ERK are the central components of this signaling pathway and are attractive ... ...

    Abstract The Raf-MEK-ERK signaling network has been the subject of intense research due to its role in the development of human cancers, including pediatric neuroblastoma (NB). MEK and ERK are the central components of this signaling pathway and are attractive targets for cancer therapy. Approximately 3-5% of the primary NB samples and about 80% of relapsed samples contain mutations in the Raf-MEK-ERK pathway. In the present study, we analyzed the NB patient datasets and revealed that high
    MeSH term(s) Benzamides ; Child ; Humans ; MAP Kinase Signaling System/physiology ; Mitogen-Activated Protein Kinase Kinases/metabolism ; Mitogen-Activated Protein Kinase Kinases/pharmacology ; Mitogen-Activated Protein Kinase Kinases/therapeutic use ; Neoplasm Recurrence, Local ; Neuroblastoma/drug therapy ; Neuroblastoma/pathology ; Signal Transduction
    Chemical Substances 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide ; Benzamides ; Mitogen-Activated Protein Kinase Kinases (EC 2.7.12.2)
    Language English
    Publishing date 2022-09-10
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1236972-x
    ISSN 1718-7729 ; 1198-0052
    ISSN (online) 1718-7729
    ISSN 1198-0052
    DOI 10.3390/curroncol29090512
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4305: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: The Role of Automation for Early Diagnosis of Non-fermenter Superbugs in Critically Ill Septicemic Hospitalized Patients.

    Agarwal, Karvi / Agrawal, Saurabh / Begum, Naila / Jindal, Sonal

    Cureus

    2023  Volume 15, Issue 7, Page(s) e41484

    Abstract: Introduction Non-fermenting Gram-negative bacilli (NFGNB) are emerging superbugs of bloodstream infections (BSI), causing increased mortality in hospitalized patients. NFGNB are challenging to identify using conventional identification techniques. Hence, ...

    Abstract Introduction Non-fermenting Gram-negative bacilli (NFGNB) are emerging superbugs of bloodstream infections (BSI), causing increased mortality in hospitalized patients. NFGNB are challenging to identify using conventional identification techniques. Hence, automation is beneficial for accurate and fast diagnosis; it also facilitates rapid treatment and recovery of patients. This study aims to isolate/identify NFGNB from BSI and determine its antimicrobial susceptibility pattern. Material and methods This study was conducted in the Department of Microbiology, LLRMMC, Meerut, for a period of six months (June to November 2022). The samples were processed using automated blood culture (BD BACTEC) and an identification/sensitivity testing system (BD Phoenix). Results Out of 1340 blood cultures, 347 (25.7%) were flagged positive for microbial growth. A total of 103 (7.6%) NFGNB were isolated, showing their strong association with BSI. The NFGNB isolates were
    Language English
    Publishing date 2023-07-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.41484
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Chitosan as excellent bio-macromolecule with myriad of anti-activities in biomedical applications - A review.

    Jagdale, Sachin / Agarwal, Babita / Dixit, Abhishek / Gaware, Saurabh

    International journal of biological macromolecules

    2023  Volume 257, Issue Pt 2, Page(s) 128697

    Abstract: The aim of the study is to explore the myriad of anti-activities of chitosan - deacylated derivative of chitin in biomedical applications. Chitosan consists of reactive residual amino groups, which can be modified chemically to obtain wide range of ... ...

    Abstract The aim of the study is to explore the myriad of anti-activities of chitosan - deacylated derivative of chitin in biomedical applications. Chitosan consists of reactive residual amino groups, which can be modified chemically to obtain wide range of derivatives. These derivatives exhibit the controlled physicochemical characteristics, which in turn improve its functional properties. Such derivatives find numerous applications in the field of biomedical science, agriculture, tissue engineering, bone regeneration and environmental science. This study presents a comprehensive overview of the multifarious anti-activities of chitosan and its derivatives in the field of biomedical science including anti-microbial, antioxidant, anti-tumor, anti-HIV, anti-fungal, anti- inflammatory, anti-Alzheimer's, anti-hypertensive and anti-diabetic activity. It briefly details these anti-activities with respect to its mode of action, pharmacological effects and potential applications. It also presents the overview of current research exploring novel derivatives of chitosan and its anti- activities in the recent past. Finally, the review projects the prospective potential of chitosan and its derivatives and expects to encourage the readers to develop new drug delivery systems based on such chitosan derivatives and explore its applications in biomedical science for benefit of mankind.
    MeSH term(s) Chitosan/chemistry ; Chitin/chemistry ; Drug Delivery Systems ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Tissue Engineering ; Biocompatible Materials/chemistry
    Chemical Substances Chitosan (9012-76-4) ; Chitin (1398-61-4) ; Antioxidants ; Biocompatible Materials
    Language English
    Publishing date 2023-12-13
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.128697
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2374: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  10. Article ; Online: Biochemical and gene expression alterations due to individual exposure of atrazine, dichlorvos, and imidacloprid and their combination in zebrafish.

    Shukla, Saurabh / Jhamtani, Reena C / Agarwal, Rakhi

    Environmental science and pollution research international

    2023  Volume 30, Issue 56, Page(s) 118291–118303

    Abstract: In environmental toxicology, combined toxicity has emerged as an important concern. Atrazine (ATZ), dichlorvos (DIC), and imidacloprid (IMD) are the major pesticides, extensively used to control insect, flies, mosquitoes, and weed. Here, we investigate ... ...

    Abstract In environmental toxicology, combined toxicity has emerged as an important concern. Atrazine (ATZ), dichlorvos (DIC), and imidacloprid (IMD) are the major pesticides, extensively used to control insect, flies, mosquitoes, and weed. Here, we investigate whether the exposure to three different types of pesticides individually and in combination for 24 h alters antioxidant enzyme responses in zebrafish (Danio rerio). Oxidative stress parameters (biochemical and mRNA expression), acetylcholinesterase (AChE) activity, and Metallothionein-II (MT-II) mRNA expression levels were measured. Present work includes toxicological assessment of individual and combined (CMD) exposure of ATZ (185.4 µM), DIC (181 µM), IMD (97.8 µ), and CMD (ATZ 92.7 µM + DIC 90.5 µM + IMD 48.9 µM), in the liver, kidney, and brain of adult zebrafish. Lipid peroxidation (LPO), glutathione (GSH) content, AChE, superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activity along with mRNA expression of SOD, CAT, GPx, and MT-II were evaluated. Briefly, LPO, GSH content, the activity of AChE, and all antioxidant enzymes enhanced significantly in individual exposure, which was further altered in the CMD group. The mRNA expression of SOD, CAT, GPx, and MT-II in the liver and kidney showed significant down-regulation in all exposed groups. In the brain, significant upregulation in mRNA expression of SOD, CAT, GPx, and MT-II was observed in DIC and IMD groups, while ATZ and CMD showed significant downregulation except for GPx. Findings postulate that the CMD group exhibits synergistic toxic manifestation. The present study provides the baseline data on the combined toxic effects of pesticides and suggests regulating the use of pesticides.
    MeSH term(s) Animals ; Atrazine/metabolism ; Antioxidants/metabolism ; Zebrafish/metabolism ; Dichlorvos/toxicity ; Acetylcholinesterase/metabolism ; Water Pollutants, Chemical/metabolism ; Oxidative Stress ; Catalase/metabolism ; Glutathione/metabolism ; Gene Expression ; Superoxide Dismutase/metabolism ; Pesticides/metabolism ; RNA, Messenger/metabolism
    Chemical Substances Atrazine (QJA9M5H4IM) ; Antioxidants ; imidacloprid (3BN7M937V8) ; Dichlorvos (7U370BPS14) ; Acetylcholinesterase (EC 3.1.1.7) ; Water Pollutants, Chemical ; Catalase (EC 1.11.1.6) ; Glutathione (GAN16C9B8O) ; Superoxide Dismutase (EC 1.15.1.1) ; Pesticides ; RNA, Messenger
    Language English
    Publishing date 2023-10-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-023-30160-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 5915: Show issues

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