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Article ; Online: Discrimination of the moving direction is improved depending on the pattern of the mechanical tactile stimulation intervention.

Maruyama, Yuki / Kojima, Sho / Onishi, Hideaki

2024 Volume 25, Issue 1, Page(s) 15

Abstract: Background: The mechanical tactile stimulation, such as plastic pins and airflow-driven membrane, induces cortical activity. The cortical activity depends on the mechanical tactile stimulation pattern. Therefore, the stimulation pattern of mechanical ... ...

Abstract	Background: The mechanical tactile stimulation, such as plastic pins and airflow-driven membrane, induces cortical activity. The cortical activity depends on the mechanical tactile stimulation pattern. Therefore, the stimulation pattern of mechanical tactile stimuli intervention may influence its effect on the somatosensory function. However, the effect of the mechanical tactile stimulation input pattern on the somatosensory function has not yet been investigated at the behavioral level. The present study aimed to clarify the effects of mechanical tactile stimuli intervention with different stimulation patterns on the ability to discriminate moving directions. Results: Twenty healthy adults participated in the experiment. Three conditions were used for mechanical tactile stimuli intervention: (1) the whole stimulus surface was stimulated, (2) the stimulus moved within the stimulus surface, and (3) a no-stimulus condition. The effects of mechanical tactile stimuli intervention on tactile discrimination were evaluated using a simple reaction task and a choice reaction task to discriminate the movement direction. Reaction time, correct rate, and rate correct score were calculated to measure task performance. We examined the effects of mechanical tactile stimuli intervention on the ability to discriminate the moving direction for a certain period under three intervention conditions. The results showed that the mean reaction time during the simple reaction task did not differ significantly before and after the intervention under all intervention conditions. Similarly, we compared the data obtained before and after the intervention during the choice reaction task. Our results revealed that the mean reaction time and correct rate did not differ significantly under vertical and horizontal conditions. However, the rate correct score showed a significant improvement after the horizontal moving tactile stimulation intervention under both vertical and horizontal conditions. Conclusions: Our results showed that the effect of mechanical tactile stimuli intervention on mechanical tactile stimulation moving direction discrimination function depended on the input pattern of mechanical tactile stimuli intervention. Our results suggest the potential therapeutic benefits of sustained tactile stimulation intervention. This study revealed that it is possible to change behavioral levels via mechanical tactile stimuli intervention as well as the potential of mechanical tactile stimuli intervention in the field of rehabilitation.
MeSH term(s)	Adult ; Humans ; Movement ; Reaction Time ; Time Factors
Language	English
Publishing date	2024-03-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2041344-0
ISSN	1471-2202 ; 1471-2202
ISSN (online)	1471-2202
ISSN	1471-2202
DOI	10.1186/s12868-024-00855-2
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Article ; Online: Rotationally equivariant super-resolution of velocity fields in two-dimensional flows using convolutional neural networks

Yuki Yasuda / Ryo Onishi

APL Machine Learning, Vol 1, Iss 2, Pp 026107-026107-

2023 Volume 19

Abstract: This paper investigates the super-resolution of velocity fields in two-dimensional flows from the viewpoint of rotational equivariance. Super-resolution refers to techniques that enhance the resolution of an image from low to high resolution, and it has ... ...

Abstract	This paper investigates the super-resolution of velocity fields in two-dimensional flows from the viewpoint of rotational equivariance. Super-resolution refers to techniques that enhance the resolution of an image from low to high resolution, and it has recently been applied in fluid mechanics. Rotational equivariance of super-resolution models is defined as the property by which the super-resolved velocity field is rotated according to a rotation of the input, leading to inferences that are covariant with the orientation of fluid systems. In physics, covariance is often related to symmetries. To better understand the connection with symmetries, the notion of rotational consistency of datasets is introduced within the framework of supervised learning, which is defined as the invariance of pairs of low- and high-resolution velocity fields with respect to rotation. This consistency is sufficient and necessary for super-resolution models to learn rotational equivariance from large datasets. Such a large dataset is not required when rotational equivariance is imposed on super-resolution models through the use of prior knowledge in the form of equivariant kernel patterns. Nonetheless, even if a fluid system has rotational symmetry, this symmetry may not carry over to a velocity dataset, which is not rotationally consistent. This inconsistency can arise when the rotation does not commute with the generation of low-resolution velocity fields. These theoretical assertions are supported by the results of numerical experiments, where two existing convolutional neural networks (CNNs) are converted into rotationally equivariant CNNs and the inferences of these CNNs are compared after the supervised training.
Keywords	Physics ; QC1-999 ; Electronic computers. Computer science ; QA75.5-76.95
Subject code	532
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	AIP Publishing LLC
Document type	Article ; Online
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Article ; Online: Relationship between extravascular leakage and clinical outcome on computed tomography of isolated traumatic brain injury.

Ito, Hiroshi / Nakamura, Youhei / Togami, Yuki / Onishi, Shinya / Nakao, Shunichiro / Ogura, Hiroshi / Oda, Jun

Acute medicine & surgery

2024 Volume 11, Issue 1, Page(s) e931

Abstract: Aim: This study investigated whether contrast extravasation on computed tomography (CT) angiography in patients with traumatic brain injury (TBI) is associated with death or surgical procedures.: Methods: Patients over 18 years old, directly brought ... ...

Abstract	Aim: This study investigated whether contrast extravasation on computed tomography (CT) angiography in patients with traumatic brain injury (TBI) is associated with death or surgical procedures. Methods: Patients over 18 years old, directly brought in by ambulance with an isolated head injury and confirmed to have acute intracranial hemorrhage on a CT scan upon admission between 2010 and 2020, were included. The primary outcome was mortality, and the secondary outcome was neurosurgical procedures performed from admission to discharge from the intensive care unit. Multivariable logistic regression analyses were performed to evaluate the association between these outcomes and contrast extravasation. Results: The analysis included 188 patients with a median age of 65 years, 123 men (65.4%), 34 deaths (18.1%), and 91 surgeries (48.4%). Among the 66 patients with contrast extravasation, 22 (33.3%) died and 47 (71.2%) required surgery. Among the 122 patients with no contrast extravasation, 12 (9.8%) died, and 44 (36.1%) required surgery. The presence or absence of extravascular leakage was associated with death (odds ratio, 3.6 [95% CI: 1.2-12.2]) and surgery (odds ratio, 7.6 [95% CI: 2.5-22.7]). Conclusion: Contrast extravasation was associated with mortality and performance of surgery in patients with an isolated head injury.
Language	English
Publishing date	2024-02-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2751184-4
ISSN	2052-8817 ; 2052-8817
ISSN (online)	2052-8817
ISSN	2052-8817
DOI	10.1002/ams2.931
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Article: Clinical impact of aortic valve replacement in patients with moderate mixed aortic valve disease.

Onishi, Hirokazu / Izumo, Masaki / Ouchi, Toru / Yuki, Haruhito / Naganuma, Toru / Nakao, Tatsuya / Nakamura, Sunao

Frontiers in cardiovascular medicine

2023 Volume 10, Page(s) 1259188

Abstract: Background: Information is scarce regarding the clinical implications of aortic valve replacement (AVR) for patients suffering from moderate mixed aortic valve disease (MAVD), characterized by a combination of moderate aortic stenosis (AS) and ... ...

Abstract	Background: Information is scarce regarding the clinical implications of aortic valve replacement (AVR) for patients suffering from moderate mixed aortic valve disease (MAVD), characterized by a combination of moderate aortic stenosis (AS) and regurgitation (AR). The objective of this retrospective study was to explore the clinical effects of AVR in individuals with moderate MAVD. Methods: We examined the clinical data from patients with moderate MAVD and preserved left ventricular ejection fraction, who had undergone echocardiography in the period spanning from 2010 to 2018. Moderate AS was defined as aortic valve area index of 0.60-0.85 cm Results: Among 88 patients (mean age, 74.4 ± 6.8 years; 48.9%, men), 44 (50.0%) required AVR during a median follow-up period of 3.3 years (interquartile range, 0.5-4.9). Mean values of specific aortic valve variables are as follows: aortic valve area index, 0.64 ± 0.04 cm Conclusions: Approximately half of the patients diagnosed with moderate MAVD eventually necessitated AVR throughout the period of observation, leading to positive clinical results. Vigilant tracking of these patients and watchful monitoring for signs requiring AVR during this time frame are essential.
Language	English
Publishing date	2023-08-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2023.1259188
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Article: Dual Lumen Microcatheter in Percutaneous Biliary Drainage for Postoperative Bile Leakage: A Case Report.

Onishi, Yasuyuki / Shimizu, Hironori / Masano, Yuki / Ito, Takashi / Nakamoto, Yuji

Cureus

2023 Volume 15, Issue 11, Page(s) e49274

Abstract: Percutaneous biliary intervention is widely accepted as an effective and safe treatment for various types of bile duct diseases. We present the case of a 44-year-old woman who developed bile leakage after a living-donor liver transplantation for locally ... ...

Abstract	Percutaneous biliary intervention is widely accepted as an effective and safe treatment for various types of bile duct diseases. We present the case of a 44-year-old woman who developed bile leakage after a living-donor liver transplantation for locally advanced cholangiocarcinoma. A percutaneous drainage tube was placed in the segment 8 bile duct via the blind end of the jejunum. However, the bile leakage was unchanged. Bile leakage from the right posterior hepatic duct was suspected. Using a dual lumen microcatheter, a percutaneous drainage tube was placed in the segment 7 bile duct via the blind end of the jejunum, which reduced the bile leakage. These results suggest that a dual lumen microcatheter is a valuable tool for navigating the biliary tree during difficult percutaneous biliary interventions.
Language	English
Publishing date	2023-11-23
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.49274
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Article ; Online: Energetically More Stable Singlet Cyclopentane-1,3-diyl Diradical with π-Single Bonding Character than the Corresponding σ-Single Bonded Compound.

Liu, Qian / Onishi, Keita / Miyazawa, Yuki / Wang, Zhe / Hatano, Sayaka / Abe, Manabu

Journal of the American Chemical Society

2023 Volume 145, Issue 49, Page(s) 27089–27094

Abstract: Carbon-carbon σ-single bonds are crucial for constructing molecules like ethane derivatives ( ... ...

Abstract	Carbon-carbon σ-single bonds are crucial for constructing molecules like ethane derivatives (R
Language	English
Publishing date	2023-11-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.3c10971
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Article ; Online: Optimal duration of antibiotic treatment for community-acquired pneumonia in adults: a systematic review and duration-effect meta-analysis.

Furukawa, Yuki / Luo, Yan / Funada, Satoshi / Onishi, Akira / Ostinelli, Edoardo / Hamza, Tasnim / Furukawa, Toshi A / Kataoka, Yuki

BMJ open

2023 Volume 13, Issue 3, Page(s) e061023

Abstract: Objectives: To find the optimal treatment duration with antibiotics for community-acquired pneumonia (CAP) in adults.: Design: Systematic review and duration-effect meta-analysis.: Data sources: MEDLINE, Embase and CENTRAL through 25 August 2021.!# ...

Abstract	Objectives: To find the optimal treatment duration with antibiotics for community-acquired pneumonia (CAP) in adults. Design: Systematic review and duration-effect meta-analysis. Data sources: MEDLINE, Embase and CENTRAL through 25 August 2021. Eligibility criteria: All randomised controlled trials comparing the same antibiotics used at the same daily dosage but for different durations for CAP in adults. Both outpatients and inpatients were included but not those admitted to intensive care units. We imposed no date, language or publication status restriction. Data extraction and synthesis: Data extraction by two independent reviewers. We conducted a random-effects, one-stage duration-effect meta-analysis with restricted cubic splines. We tested the non-inferiority with the prespecified non-inferiority margin of 10% examined against 10 days . The primary outcome was clinical improvement on day 15 (range 7-45 days). Secondary outcomes: all-cause mortality, serious adverse events and clinical improvement on day 30 (15-60 days). Results: We included nine trials (2399 patients with a mean (SD) age of 61.2 (22.1); 39% women). The duration-effect curve was monotonic with longer duration leading to a lower probability of improvement, and shorter treatment duration (3-9 days) was likely to be non-inferior to 10-day treatment. Harmful outcome curves indicated no association. The weighted average percentage of the primary outcome in the 10-day treatment arms was 68%. Using that average, the absolute clinical improvement rates of the following durations were: 3-day treatment 75% (95% CI: 68% to 81%), 5-day treatment 72% (95% CI: 66% to 78%) and 7-day treatment 69% (95% CI: 61% to 76%). Conclusions: Shorter treatment duration (3-5 days) probably offers the optimal balance between efficacy and treatment burden for treating CAP in adults if they achieved clinical stability. However, the small number of included studies and the overall moderate-to-high risk of bias may compromise the certainty of the results. Further research on the shorter duration range is required. Prospero registration number: CRD 42021273357.
MeSH term(s)	Humans ; Adult ; Female ; Male ; Anti-Bacterial Agents ; Pneumonia/drug therapy ; Pneumonia/chemically induced ; Community-Acquired Infections/drug therapy ; Intensive Care Units
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2023-03-22
Publishing country	England
Document type	Systematic Review ; Meta-Analysis ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2022-061023
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Article ; Online: Prognostic relevance of B-type natriuretic peptide in patients with moderate mixed aortic valve disease.

Onishi, Hirokazu / Naganuma, Toru / Izumo, Masaki / Ouchi, Toru / Yuki, Haruhito / Mitomo, Satoru / Nakamura, Sunao

ESC heart failure

2022 Volume 9, Issue 4, Page(s) 2474–2483

Abstract: Aims: Data on B-type natriuretic peptide (BNP) levels and adverse outcomes in patients with moderate mixed aortic valve disease (MAVD), defined as moderate aortic stenosis (AS) and regurgitation (AR), are scarce. Therefore, this study investigated the ... ...

Abstract	Aims: Data on B-type natriuretic peptide (BNP) levels and adverse outcomes in patients with moderate mixed aortic valve disease (MAVD), defined as moderate aortic stenosis (AS) and regurgitation (AR), are scarce. Therefore, this study investigated the impact of BNP on the clinical outcomes in such patients. Methods and results: Clinical data from 81 patients (mean age, 74.1 ± 6.8 years; 50.6%, men) treated for moderate MAVD and left ventricular ejection fraction (LVEF) ≥ 50% during 2010-2018 were retrospectively analysed. Specific echocardiographic data of the study patients were LVEF of 57.8 ± 5.0%, aortic valve index of 0.64 ± 0.04 cm Conclusions: Patients with moderate MAVD are at higher risk of unfavourable clinical outcomes, and age and BNP are independently related to the occurrence of adverse events. High BNP levels may reflect extravalvular cardiac damage in patients with moderate MAVD.
MeSH term(s)	Aged ; Aged, 80 and over ; Aortic Valve Stenosis/diagnosis ; Aortic Valve Stenosis/surgery ; Female ; Humans ; Male ; Natriuretic Peptide, Brain ; Prognosis ; Retrospective Studies ; Stroke Volume ; Ventricular Function, Left
Chemical Substances	Natriuretic Peptide, Brain (114471-18-0)
Language	English
Publishing date	2022-05-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2814355-3
ISSN	2055-5822 ; 2055-5822
ISSN (online)	2055-5822
ISSN	2055-5822
DOI	10.1002/ehf2.13946
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Article ; Online: Contribution of sex hormones to the sexually dimorphic response of colorectal motility to noxious stimuli in rats.

Horii, Kazuhiro / Sawamura, Tomoya / Onishi, Ayaka / Yuki, Natsufu / Naitou, Kiyotada / Shiina, Takahiko / Shimizu, Yasutake

American journal of physiology. Gastrointestinal and liver physiology

2022 Volume 323, Issue 1, Page(s) G1–G8

Abstract: Our recent studies have shown that noxious stimuli in the colorectum enhance colorectal motility via the brain and spinal defecation centers in male rats. In female rats, however, noxious stimuli have no effect on colorectal motility. The purpose of this ...

Abstract	Our recent studies have shown that noxious stimuli in the colorectum enhance colorectal motility via the brain and spinal defecation centers in male rats. In female rats, however, noxious stimuli have no effect on colorectal motility. The purpose of this study was to determine whether sex hormones are major contributing factors for sex-dependent differences in neural components of the spinal defecation center. Colorectal motility was measured using an in vivo method under ketamine and α-chloralose anesthesia in rats. Capsaicin was administered into the colorectal lumen as noxious stimuli. Orchiectomy in male rats had no effect on the capsaicin-induced response of colorectal motility. However, in ovariectomized female rats, capsaicin administration enhanced colorectal motility, though intact female animals did not show enhanced motility. When estradiol was administered by using a sustained-release preparation in ovariectomized female rats, capsaicin administration did not enhance colorectal motility unless a GABA
MeSH term(s)	Animals ; Capsaicin/pharmacology ; Colorectal Neoplasms ; Defecation/physiology ; Estradiol/pharmacology ; Female ; Gastrointestinal Motility/physiology ; Gonadal Steroid Hormones/pharmacology ; Male ; Rats ; Rats, Sprague-Dawley
Chemical Substances	Gonadal Steroid Hormones ; Estradiol (4TI98Z838E) ; Capsaicin (S07O44R1ZM)
Language	English
Publishing date	2022-04-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603840-2
ISSN	1522-1547 ; 0193-1857
ISSN (online)	1522-1547
ISSN	0193-1857
DOI	10.1152/ajpgi.00033.2022
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Article ; Online: ATP and its metabolite adenosine cooperatively upregulate the antigen-presenting molecules on dendritic cells leading to IFN-γ production by T cells.

Furuta, Kazuyuki / Onishi, Hiroka / Ikada, Yuki / Masaki, Kento / Tanaka, Satoshi / Kaito, Chikara

The Journal of biological chemistry

2023 Volume 299, Issue 4, Page(s) 104587

Abstract: Dendritic cells (DCs) present foreign antigens to T cells via the major histocompatibility complex (MHC), thereby inducing acquired immune responses. ATP accumulates at sites of inflammation or in tumor tissues, which triggers local inflammatory ... ...

Abstract	Dendritic cells (DCs) present foreign antigens to T cells via the major histocompatibility complex (MHC), thereby inducing acquired immune responses. ATP accumulates at sites of inflammation or in tumor tissues, which triggers local inflammatory responses. However, it remains to be clarified how ATP modulates the functions of DCs. In this study, we investigated the effects of extracellular ATP on mouse bone marrow-derived dendritic cells (BMDCs) as well as the potential for subsequent T cell activation. We found that high concentrations of ATP (1 mM) upregulated the cell surface expression levels of MHC-I, MHC-II, and co-stimulatory molecules CD80 and CD86 but not those of co-inhibitory molecules PD-L1 and PD-L2 in BMDCs. Increased surface expression of MHC-I, MHC-II, CD80, and CD86 was inhibited by a pan-P2 receptor antagonist. In addition, the upregulation of MHC-I and MHC-II expression was inhibited by an adenosine P1 receptor antagonist and by inhibitors of CD39 and CD73, which metabolize ATP to adenosine. These results suggest that adenosine is required for the ATP-induced upregulation of MHC-I and MHC-II. In the mixed leukocyte reaction assay, ATP-stimulated BMDCs activated CD4 and CD8T cells and induced interferon-γ (IFN-γ) production by these T cells. Collectively, these results suggest that high concentrations of extracellular ATP upregulate the expression of antigen-presenting and co-stimulatory molecules but not that of co-inhibitory molecules in BMDCs. Cooperative stimulation of ATP and its metabolite adenosine was required for the upregulation of MHC-I and MHC-II. These ATP-stimulated BMDCs induced the activation of IFN-γ-producing T cells upon antigen presentation.
MeSH term(s)	Mice ; Animals ; T-Lymphocytes ; Dendritic Cells ; Antigen Presentation ; Lymphocyte Activation ; Adenosine Triphosphate/metabolism
Chemical Substances	Adenosine Triphosphate (8L70Q75FXE)
Language	English
Publishing date	2023-03-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1016/j.jbc.2023.104587
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