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  1. Article ; Online: Emerging New Biomarkers for Cardiovascular Disease.

    Rochette, Luc

    International journal of molecular sciences

    2022  Volume 23, Issue 6

    Abstract: In this Special Issue of ... ...

    Abstract In this Special Issue of the
    MeSH term(s) Biomarkers ; Cardiovascular Diseases/diagnosis ; Humans
    Chemical Substances Biomarkers
    Language English
    Publishing date 2022-03-18
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23063274
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  2. Article ; Online: Emerging New Biomarkers for Cardiovascular Disease

    Luc Rochette

    International Journal of Molecular Sciences, Vol 23, Iss 3274, p

    2022  Volume 3274

    Abstract: In this Special Issue of the International Journal of Molecular Sciences , we include insightful reviews and research papers on the subject “Emerging New Biomarkers for Cardiovascular Disease” [.] ...

    Abstract In this Special Issue of the International Journal of Molecular Sciences , we include insightful reviews and research papers on the subject “Emerging New Biomarkers for Cardiovascular Disease” [.]
    Keywords n/a ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  3. Article: Stress: Eight Decades after Its Definition by Hans Selye: "Stress Is the Spice of Life".

    Rochette, Luc / Dogon, Geoffrey / Vergely, Catherine

    Brain sciences

    2023  Volume 13, Issue 2

    Abstract: July 1936: Hans Selye describes in 74 lines in the prestigious ... ...

    Abstract July 1936: Hans Selye describes in 74 lines in the prestigious journal
    Language English
    Publishing date 2023-02-12
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci13020310
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Mechanics Insights of Alpha-Lipoic Acid against Cardiovascular Diseases during COVID-19 Infection.

    Rochette, Luc / Ghibu, Steliana

    International journal of molecular sciences

    2021  Volume 22, Issue 15

    Abstract: Coronavirus disease 2019 (COVID-19) was first reported in Wuhan, China, in late December 2019. Since then, COVID-19 has spread rapidly worldwide and was declared a global pandemic on 20 March 2020. Cardiovascular complications are rapidly emerging as a ... ...

    Abstract Coronavirus disease 2019 (COVID-19) was first reported in Wuhan, China, in late December 2019. Since then, COVID-19 has spread rapidly worldwide and was declared a global pandemic on 20 March 2020. Cardiovascular complications are rapidly emerging as a major peril in COVID-19 in addition to respiratory disease. The mechanisms underlying the excessive effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on patients with cardiovascular comorbidities remain only partly understood. SARS-CoV-2 infection is caused by binding of the viral surface spike (S) protein to the human angiotensin-converting enzyme 2 (ACE2), followed by the activation of the S protein by transmembrane protease serine 2 (TMPRSS2). ACE2 is expressed in the lung (mainly in type II alveolar cells), heart, blood vessels, small intestine, etc., and appears to be the predominant portal to the cellular entry of the virus. Based on current information, most people infected with SARS-CoV-2 virus have a good prognosis, while a few patients reach critical condition, especially the elderly and those with chronic underlying diseases. The "cytokine storm" observed in patients with severe COVID-19 contributes to the destruction of the endothelium, leading to "acute respiratory distress syndrome" (ARDS), multiorgan failure, and death. At the origin of the general proinflammatory state may be the SARS-CoV-2-mediated redox status in endothelial cells via the upregulation of ACE/Ang II/AT1 receptors pathway or the increased mitochondrial reactive oxygen species (mtROS) production. Furthermore, this vicious circle between oxidative stress (OS) and inflammation induces endothelial dysfunction, endothelial senescence, high risk of thrombosis and coagulopathy. The microvascular dysfunction and the formation of microthrombi in a way differentiate the SARS-CoV-2 infection from the other respiratory diseases and bring it closer to cardiovascular diseases like myocardial infarction and stroke. Due the role played by OS in the evolution of viral infection and in the development of COVID-19 complications, the use of antioxidants as adjuvant therapy seems appropriate in this new pathology. Alpha-lipoic acid (ALA) could be a promising candidate that, through its wide tissue distribution and versatile antioxidant properties, interferes with several signaling pathways. Thus, ALA improves endothelial function by restoring the endothelial nitric oxide synthase activity and presents an anti-inflammatory effect dependent or independent of its antioxidant properties. By improving mitochondrial function, it can sustain the tissues' homeostasis in critical situation and by enhancing the reduced glutathione it could indirectly strengthen the immune system. This complex analysis could open a new therapeutic perspective for ALA in COVID-19 infection.
    MeSH term(s) Angiotensin-Converting Enzyme 2/metabolism ; Animals ; Antioxidants/chemistry ; Antioxidants/therapeutic use ; COVID-19/complications ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/etiology ; Cytokine Release Syndrome/etiology ; Cytokine Release Syndrome/metabolism ; Endothelial Cells/metabolism ; Humans ; Thioctic Acid/chemistry ; Thioctic Acid/therapeutic use ; COVID-19 Drug Treatment
    Chemical Substances Antioxidants ; Thioctic Acid (73Y7P0K73Y) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Language English
    Publishing date 2021-07-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22157979
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Antitumoral Activity of Molecular Hydrogen and Proton in the Treatment of Glioblastoma: An Atypical Pharmacology?

    Rochette, Luc / Dogon, Geoffrey / Zeller, Marianne / Cottin, Yves / Vergely, Catherine

    Brain sciences

    2023  Volume 13, Issue 8

    Abstract: Antioxidants in cancer therapy have been a hot topic in the medical field for 20 years. Antioxidants are able to reduce the risk of cancer formation by neutralizing free radicals. Protons (H+) and molecular hydrogen (H2) interact in the cell and are ... ...

    Abstract Antioxidants in cancer therapy have been a hot topic in the medical field for 20 years. Antioxidants are able to reduce the risk of cancer formation by neutralizing free radicals. Protons (H+) and molecular hydrogen (H2) interact in the cell and are essential in a wide variety of processes. The antioxidant, anti-inflammatory, and antiapoptotic effects of H2 have been studied in numerous experimental and clinical studies. Experimental data indicate that H2 is an antitumor agent in the treatment of glioblastoma (GBM). In vivo H2 inhalation could suppress the growth of GBM tumors, thereby extending the survival of mice with GBM. The sphere-forming ability of glioma cells was suppressed by hydrogen treatment. In addition, H2 treatment also suppressed the migration, invasion, and colony-forming ability of glioma cells. Proton therapy and proton beam radiotherapy offer some advantages over other modern conformal photon-based therapies when used in the treatment of central nervous system malignancies.
    Language English
    Publishing date 2023-08-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci13081168
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Mechanics Insights of Alpha-Lipoic Acid against Cardiovascular Diseases during COVID-19 Infection

    Luc Rochette / Steliana Ghibu

    International Journal of Molecular Sciences, Vol 22, Iss 7979, p

    2021  Volume 7979

    Abstract: Coronavirus disease 2019 (COVID-19) was first reported in Wuhan, China, in late December 2019. Since then, COVID-19 has spread rapidly worldwide and was declared a global pandemic on 20 March 2020. Cardiovascular complications are rapidly emerging as a ... ...

    Abstract Coronavirus disease 2019 (COVID-19) was first reported in Wuhan, China, in late December 2019. Since then, COVID-19 has spread rapidly worldwide and was declared a global pandemic on 20 March 2020. Cardiovascular complications are rapidly emerging as a major peril in COVID-19 in addition to respiratory disease. The mechanisms underlying the excessive effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on patients with cardiovascular comorbidities remain only partly understood. SARS-CoV-2 infection is caused by binding of the viral surface spike (S) protein to the human angiotensin-converting enzyme 2 (ACE2), followed by the activation of the S protein by transmembrane protease serine 2 (TMPRSS2). ACE2 is expressed in the lung (mainly in type II alveolar cells), heart, blood vessels, small intestine, etc., and appears to be the predominant portal to the cellular entry of the virus. Based on current information, most people infected with SARS-CoV-2 virus have a good prognosis, while a few patients reach critical condition, especially the elderly and those with chronic underlying diseases. The “cytokine storm” observed in patients with severe COVID-19 contributes to the destruction of the endothelium, leading to “acute respiratory distress syndrome” (ARDS), multiorgan failure, and death. At the origin of the general proinflammatory state may be the SARS-CoV-2-mediated redox status in endothelial cells via the upregulation of ACE/Ang II/AT1 receptors pathway or the increased mitochondrial reactive oxygen species (mtROS) production. Furthermore, this vicious circle between oxidative stress (OS) and inflammation induces endothelial dysfunction, endothelial senescence, high risk of thrombosis and coagulopathy. The microvascular dysfunction and the formation of microthrombi in a way differentiate the SARS-CoV-2 infection from the other respiratory diseases and bring it closer to cardiovascular diseases like myocardial infarction and stroke. Due the role played by OS in the evolution of viral ...
    Keywords COVID-19 ; SARS-CoV-2 ; alpha-lipoic acid ; cardiovascular disease ; oxidative stress ; inflammation ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article ; Online: The Yin and Yang of alarmin S100B in the protection of myocardium.

    Rochette, Luc / Malka, Gabriel / Cottin, Yves

    Archives of cardiovascular diseases

    2021  Volume 114, Issue 6-7, Page(s) 439–442

    MeSH term(s) Alarmins ; Humans ; Myocardial Infarction ; Myocardium ; S100 Calcium Binding Protein beta Subunit
    Chemical Substances Alarmins ; S100 Calcium Binding Protein beta Subunit ; S100B protein, human
    Language English
    Publishing date 2021-06-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2408778-6
    ISSN 1875-2128 ; 1875-2136
    ISSN (online) 1875-2128
    ISSN 1875-2136
    DOI 10.1016/j.acvd.2021.04.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui IV Zs 8: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Antitumor Activity of Protons and Molecular Hydrogen: Underlying Mechanisms.

    Rochette, Luc / Zeller, Marianne / Cottin, Yves / Vergely, Catherine

    Cancers

    2021  Volume 13, Issue 4

    Abstract: Understanding the structure and dynamics of the various hydrogen forms has been a subject of numerous studies. Protons ( ... ...

    Abstract Understanding the structure and dynamics of the various hydrogen forms has been a subject of numerous studies. Protons (H
    Language English
    Publishing date 2021-02-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13040893
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Interplay between efferocytosis and atherosclerosis.

    Rochette, Luc / Dogon, Geoffrey / Rigal, Eve / Zeller, Marianne / Cottin, Yves / Vergely, Catherine

    Archives of cardiovascular diseases

    2023  Volume 116, Issue 10, Page(s) 474–484

    Abstract: In an adult human, billions of cells die and turn over daily. During this process, many apoptotic cells are produced and subsequently cleared by phagocytes - a process termed efferocytosis, which plays a critical role in tissue homeostasis. Efferocytosis ...

    Abstract In an adult human, billions of cells die and turn over daily. During this process, many apoptotic cells are produced and subsequently cleared by phagocytes - a process termed efferocytosis, which plays a critical role in tissue homeostasis. Efferocytosis is an important mechanism in the control of inflammatory processes. Efficient efferocytosis inhibits accumulation of apoptotic cells/debris and maintains homeostasis before the onset of necrosis (secondary necrosis), which promotes inflammation or injury. During efferocytosis, mitochondrial fission and the oxidative stress process are linked through reactive oxygen species production and oxidative stress control. Autophagy plays an important role in inhibiting inflammation and apoptosis, and in promoting efferocytosis by activated inflammatory cells, particularly neutrophils and macrophages. Autophagy in neutrophils is activated by phagocytosis of pathogens or activation of pattern recognition receptors. Autophagy is essential for major neutrophil functions, including degranulation, reactive oxygen species production, oxidative stress and release of neutrophil extracellular cytokines. Failed efferocytosis is a key mechanism driving the development and progression of chronic inflammatory diseases, including atherosclerosis, cardiometabolic pathology, neurodegenerative disease and cancer. Impairment of efferocytosis in apoptotic macrophages is a determinant of atherosclerosis severity and the vulnerability of plaques to rupture. Recent results suggest that inhibition of efferocytosis in the protection of the myocardium results in reduced infiltration of reparatory macrophages into the tissue, in association with oxidative stress reduction. Activated macrophages play a central role in the development and resolution of inflammation. The resolution of inflammation through efferocytosis is an endogenous process that protects host tissues from prolonged or excessive inflammation. Accordingly, therapeutic strategies that ameliorate efferocytosis control would be predicted to dampen inflammation and improve resolution. Thus, therapies targeting efferocytosis will provide a new means of treating and preventing cardiovascular and metabolic diseases involving the chronic inflammatory state.
    Language English
    Publishing date 2023-08-18
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2408778-6
    ISSN 1875-2128 ; 1875-2136
    ISSN (online) 1875-2128
    ISSN 1875-2136
    DOI 10.1016/j.acvd.2023.07.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui IV Zs 8: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Neuroprotective Potential of GDF11: Myth or Reality?

    Rochette, Luc / Malka, Gabriel

    International journal of molecular sciences

    2019  Volume 20, Issue 14

    Abstract: In the brain, aging is accompanied by cellular and functional deficiencies that promote vulnerability to neurodegenerative disorders. In blood plasma from young and old animals, various factors such as growth differentiation factor 11 (GDF11), whose ... ...

    Abstract In the brain, aging is accompanied by cellular and functional deficiencies that promote vulnerability to neurodegenerative disorders. In blood plasma from young and old animals, various factors such as growth differentiation factor 11 (GDF11), whose levels are elevated in young animals, have been identified. The blood concentrations of these factors appear to be inversely correlated with the age-related decline of neurogenesis. The identification of GDF11 as a "rejuvenating factor" opens up perspectives for the treatment of neurodegenerative diseases. As a pro-neurogenic and pro-angiogenic agent, GDF11 may constitute a basis for novel therapeutic strategies.
    MeSH term(s) Animals ; Biomarkers ; Bone Morphogenetic Proteins/genetics ; Bone Morphogenetic Proteins/metabolism ; Brain/physiology ; Growth Differentiation Factors/genetics ; Growth Differentiation Factors/metabolism ; Humans ; Neovascularization, Physiologic/genetics ; Neurogenesis/genetics ; Neuroprotection/genetics ; Rejuvenation
    Chemical Substances Biomarkers ; Bone Morphogenetic Proteins ; GDF11 protein, human ; Growth Differentiation Factors
    Language English
    Publishing date 2019-07-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms20143563
    Database MEDical Literature Analysis and Retrieval System OnLINE

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