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  1. Article ; Online: Editorial: NK cells in viral immunology and immunotherapy.

    Mulik, Sachin / Dogra, Pranay / Jabrane-Ferrat, Nabila

    Frontiers in immunology

    2023  Volume 14, Page(s) 1216158

    MeSH term(s) Killer Cells, Natural ; Immunotherapy
    Language English
    Publishing date 2023-05-23
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1216158
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  2. Article ; Online: Efbalropendekin Alfa enhances human natural killer cell cytotoxicity against tumor cell lines

    Shehata, Hesham M / Dogra, Pranay / Gierke, Sarah / Holder, Patrick / Sanjabi, Shomyseh

    Frontiers in immunology

    2024  Volume 15, Page(s) 1341804

    Abstract: IL-15 has shown preclinical activity by enhancing the functional maturation of natural killer (NK) cells. Clinical evaluation of the potential anticancer activity of most cytokines, including IL-15, has been limited by low tolerability and ... ...

    Abstract IL-15 has shown preclinical activity by enhancing the functional maturation of natural killer (NK) cells. Clinical evaluation of the potential anticancer activity of most cytokines, including IL-15, has been limited by low tolerability and rapid
    MeSH term(s) Humans ; Interleukin-15/pharmacology ; Interleukin-15/metabolism ; Antineoplastic Agents/pharmacology ; Cytokines/metabolism ; Immunologic Factors/metabolism ; Killer Cells, Natural ; Cell Line, Tumor
    Chemical Substances Interleukin-15 ; Antineoplastic Agents ; Cytokines ; Immunologic Factors
    Language English
    Publishing date 2024-03-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1341804
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  3. Article ; Online: Stealth Killing by Uterine NK Cells for Tolerance and Tissue Homeostasis.

    Dogra, Pranay / Farber, Donna L

    Cell

    2020  Volume 182, Issue 5, Page(s) 1074–1076

    Abstract: Human natural killer (NK) cells are critical for innate defense against pathogens through direct cytotoxicity of infected cells and are the predominant immune cell at the maternal-fetal interface. In this issue of Cell, Crespo et al. show that human NK ... ...

    Abstract Human natural killer (NK) cells are critical for innate defense against pathogens through direct cytotoxicity of infected cells and are the predominant immune cell at the maternal-fetal interface. In this issue of Cell, Crespo et al. show that human NK cells in the decidual region of the uterus can clear a bacterial infection from the developing fetus by infusion of granulysin into placental trophoblast cells via nanotubes, thus removing the intracellular pathogen without damage to the placental cell. These findings reveal a mechanism for targeted immune protection of the developing fetus that maintains tolerance at the maternal-fetal interface.
    MeSH term(s) Bacteria ; Female ; Homeostasis ; Humans ; Killer Cells, Natural ; Pregnancy ; Trophoblasts ; Uterus
    Keywords covid19
    Language English
    Publishing date 2020-10-01
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2020.08.018
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  4. Article: Stealth Killing by Uterine NK Cells for Tolerance and Tissue Homeostasis

    Dogra, Pranay / Farber, Donna L

    Cell. 2020 Sept. 03, v. 182, no. 5

    2020  

    Abstract: Human natural killer (NK) cells are critical for innate defense against pathogens through direct cytotoxicity of infected cells and are the predominant immune cell at the maternal-fetal interface. In this issue of Cell, Crespo et al. show that human NK ... ...

    Abstract Human natural killer (NK) cells are critical for innate defense against pathogens through direct cytotoxicity of infected cells and are the predominant immune cell at the maternal-fetal interface. In this issue of Cell, Crespo et al. show that human NK cells in the decidual region of the uterus can clear a bacterial infection from the developing fetus by infusion of granulysin into placental trophoblast cells via nanotubes, thus removing the intracellular pathogen without damage to the placental cell. These findings reveal a mechanism for targeted immune protection of the developing fetus that maintains tolerance at the maternal-fetal interface.
    Keywords bacterial infections ; cytotoxicity ; fetus ; homeostasis ; humans ; nanotubes ; pathogens ; trophoblast ; uterus
    Language English
    Dates of publication 2020-0903
    Size p. 1074-1076.
    Publishing place Elsevier Inc.
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2020.08.018
    Database NAL-Catalogue (AGRICOLA)

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  5. Article: Stealth Killing by Uterine NK Cells for Tolerance and Tissue Homeostasis

    Dogra, Pranay / Farber, Donna L

    Cell

    Abstract: Human natural killer (NK) cells are critical for innate defense against pathogens through direct cytotoxicity of infected cells and are the predominant immune cell at the maternal-fetal interface. In this issue of Cell, Crespo et al. show that human NK ... ...

    Abstract Human natural killer (NK) cells are critical for innate defense against pathogens through direct cytotoxicity of infected cells and are the predominant immune cell at the maternal-fetal interface. In this issue of Cell, Crespo et al. show that human NK cells in the decidual region of the uterus can clear a bacterial infection from the developing fetus by infusion of granulysin into placental trophoblast cells via nanotubes, thus removing the intracellular pathogen without damage to the placental cell. These findings reveal a mechanism for targeted immune protection of the developing fetus that maintains tolerance at the maternal-fetal interface.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32888492
    Database COVID19

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  6. Article ; Online: Exhausted intratumoral Vδ2

    Rancan, Chiara / Arias-Badia, Marcel / Dogra, Pranay / Chen, Brandon / Aran, Dvir / Yang, Hai / Luong, Diamond / Ilano, Arielle / Li, Jacky / Chang, Hewitt / Kwek, Serena S / Zhang, Li / Lanier, Lewis L / Meng, Maxwell V / Farber, Donna L / Fong, Lawrence

    Nature immunology

    2023  Volume 24, Issue 4, Page(s) 612–624

    Abstract: Gamma delta (γδ) T cells reside within human tissues including tumors, but their function in mediating antitumor responses to immune checkpoint inhibition is unknown. Here we show that kidney cancers are infiltrated by ... ...

    Abstract Gamma delta (γδ) T cells reside within human tissues including tumors, but their function in mediating antitumor responses to immune checkpoint inhibition is unknown. Here we show that kidney cancers are infiltrated by Vδ2
    MeSH term(s) Humans ; CD8-Positive T-Lymphocytes/metabolism ; Receptors, Antigen, T-Cell, gamma-delta/metabolism ; Programmed Cell Death 1 Receptor/metabolism ; Kidney Neoplasms/metabolism ; T-Lymphocyte Subsets ; Tumor Microenvironment
    Chemical Substances Receptors, Antigen, T-Cell, gamma-delta ; Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2023-03-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-023-01448-7
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  7. Article ; Online: What we have learned from animal models of HCMV.

    Dogra, Pranay / Sparer, Tim E

    Methods in molecular biology (Clifton, N.J.)

    2014  Volume 1119, Page(s) 267–288

    Abstract: Although human cytomegalovirus (HCMV) primary infection is generally asymptomatic, in immune-compromised patients HCMV increases morbidity and mortality. As a member of the betaherpesvirus family, in vivo studies of HCMV are limited due to its species ... ...

    Abstract Although human cytomegalovirus (HCMV) primary infection is generally asymptomatic, in immune-compromised patients HCMV increases morbidity and mortality. As a member of the betaherpesvirus family, in vivo studies of HCMV are limited due to its species specificity. CMVs from other species are often used as surrogates to express HCMV genes/proteins or used as models for inferring HCMV protein function in humans. Using innovative experiments, these animal models have answered important questions about CMV's life cycle, dissemination, pathogenesis, immune evasion, and host immune response. This chapter provides CMV biologists with an overview of the insights gained using these animal models. Subsequent chapters will provide details of the specifics of the experimental methods developed for each of the animal models discussed here.
    MeSH term(s) Animals ; Cytomegalovirus/genetics ; Cytomegalovirus/immunology ; Cytomegalovirus/pathogenicity ; Cytomegalovirus Infections/genetics ; Cytomegalovirus Infections/virology ; Disease Models, Animal ; Humans ; Immune Evasion ; Molecular Biology/methods
    Language English
    Publishing date 2014
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-62703-788-4_15
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  8. Article ; Online: Inhaled particulate accumulation with age impairs immune function and architecture in human lung lymph nodes.

    Ural, Basak B / Caron, Daniel P / Dogra, Pranay / Wells, Steven B / Szabo, Peter A / Granot, Tomer / Senda, Takashi / Poon, Maya M L / Lam, Nora / Thapa, Puspa / Lee, Yoon Seung / Kubota, Masaru / Matsumoto, Rei / Farber, Donna L

    Nature medicine

    2022  Volume 28, Issue 12, Page(s) 2622–2632

    Abstract: Older people are particularly susceptible to infectious and neoplastic diseases of the lung and it is unclear how lifelong exposure to environmental pollutants affects respiratory immune function. In an analysis of human lymph nodes (LNs) from 84 organ ... ...

    Abstract Older people are particularly susceptible to infectious and neoplastic diseases of the lung and it is unclear how lifelong exposure to environmental pollutants affects respiratory immune function. In an analysis of human lymph nodes (LNs) from 84 organ donors aged 11-93 years, we found a specific age-related decline in lung-associated, but not gut-associated, LN immune function linked to the accumulation of inhaled atmospheric particulate matter. Increasing densities of particulates were found in lung-associated LNs with age, but not in the corresponding gut-associated LNs. Particulates were specifically contained within CD68
    MeSH term(s) Humans ; Aged ; Lymph Nodes/pathology ; Lung ; Disease Susceptibility/pathology ; Dust ; Immunity
    Chemical Substances Dust
    Language English
    Publishing date 2022-11-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-022-02073-x
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  9. Article ; Online: Intrathymic differentiation of natural antibody-producing plasma cells in human neonates

    Hector Cordero / Rodney G. King / Pranay Dogra / Chloe Dufeu / Sarah B. See / Alexander M. Chong / Anne-Catrin Uhlemann / Siu-Hong Ho / David M. Kalfa / Emile A. Bacha / John F. Kearney / Emmanuel Zorn

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 16

    Abstract: The thymus is known as the organ of T lymphocyte development. Here authors show that terminal B cell differentiation also takes place in the thymus of human neonates, leading to antibody production against commensal and pathogenic bacteria. ...

    Abstract The thymus is known as the organ of T lymphocyte development. Here authors show that terminal B cell differentiation also takes place in the thymus of human neonates, leading to antibody production against commensal and pathogenic bacteria.
    Keywords Science ; Q
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Site-specific development and progressive maturation of human tissue-resident memory T cells over infancy and childhood.

    Connors, Thomas J / Matsumoto, Rei / Verma, Shivali / Szabo, Peter A / Guyer, Rebecca / Gray, Joshua / Wang, Zicheng / Thapa, Puspa / Dogra, Pranay / Poon, Maya M L / Rybkina, Ksenia / Bradley, Marissa C / Idzikowski, Emma / McNichols, James / Kubota, Masaru / Pethe, Kalpana / Shen, Yufeng / Atkinson, Mark A / Brusko, Maigan /
    Brusko, Todd M / Yates, Andrew J / Sims, Peter A / Farber, Donna L

    Immunity

    2023  Volume 56, Issue 8, Page(s) 1894–1909.e5

    Abstract: Infancy and childhood are critical life stages for generating immune memory to protect against pathogens; however, the timing, location, and pathways for memory development in humans remain elusive. Here, we investigated T cells in mucosal sites, ... ...

    Abstract Infancy and childhood are critical life stages for generating immune memory to protect against pathogens; however, the timing, location, and pathways for memory development in humans remain elusive. Here, we investigated T cells in mucosal sites, lymphoid tissues, and blood from 96 pediatric donors aged 0-10 years using phenotypic, functional, and transcriptomic profiling. Our results revealed that memory T cells preferentially localized in the intestines and lungs during infancy and accumulated more rapidly in mucosal sites compared with blood and lymphoid organs, consistent with site-specific antigen exposure. Early life mucosal memory T cells exhibit distinct functional capacities and stem-like transcriptional profiles. In later childhood, they progressively adopt proinflammatory functions and tissue-resident signatures, coincident with increased T cell receptor (TCR) clonal expansion in mucosal and lymphoid sites. Together, our findings identify staged development of memory T cells targeted to tissues during the formative years, informing how we might promote and monitor immunity in children.
    MeSH term(s) Child ; Humans ; Infant ; CD8-Positive T-Lymphocytes ; Immunologic Memory ; Lymphoid Tissue/metabolism ; Memory T Cells ; Mucous Membrane ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/metabolism ; Infant, Newborn ; Child, Preschool
    Chemical Substances Receptors, Antigen, T-Cell
    Language English
    Publishing date 2023-07-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2023.06.008
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