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Article ; Online: Hydrogeochemical characterization, quality assessment, and potential nitrate health risk of shallow groundwater in Dongwen River Basin, North China.

Wang, Shou / Chen, Jing / Zhang, Shuxuan / Bai, Yanjie / Zhang, Xiaoyan / Chen, Dan / Tong, Hao / Liu, Bingxiao / Hu, Jiahong

Environmental science and pollution research international

2024 Volume 31, Issue 13, Page(s) 19363–19380

Abstract: ... from the Dongwen River Basin (DRB) to comprehensively assess the hydrochemical sources, groundwater quality status ...

Abstract	Assessing groundwater geochemical formation processes and pollution circumstances is significant for sustainable watershed management. In the present study, 58 shallow groundwater samples were taken from the Dongwen River Basin (DRB) to comprehensively assess the hydrochemical sources, groundwater quality status, and potential risks of NO
MeSH term(s)	Child ; Male ; Infant ; Female ; Humans ; Environmental Monitoring/methods ; Nitrates/analysis ; Rivers ; Water Pollutants, Chemical/analysis ; Water Quality ; Groundwater/chemistry ; China ; Risk Assessment
Chemical Substances	Nitrates ; Water Pollutants, Chemical
Language	English
Publishing date	2024-02-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-024-32426-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Band Gap Alteration of Halide Mixing in Hybrid Perovskites: A First-Principles Study with Statistical Analysis.

Shahzadi, Urooj / Yang, Dongwen / Fatima, Kaneez / Wang, Fei

The journal of physical chemistry. A

2024 Volume 128, Issue 6, Page(s) 1173–1180

Abstract: Despite numerous studies on the band gap of three-dimensional halide perovskites using the first-principles calculations, there are still significant discrepancies between theoretical and experimental values. Various solutions have been proposed, such as ...

Abstract	Despite numerous studies on the band gap of three-dimensional halide perovskites using the first-principles calculations, there are still significant discrepancies between theoretical and experimental values. Various solutions have been proposed, such as employing a system-specific hybrid functional with varying degrees of exact exchange and explicitly incorporating spin-orbit coupling effects. Our research involved a comprehensive investigation of three typical lead-containing three-dimensional perovskites MAPbI
Language	English
Publishing date	2024-02-07
Publishing country	United States
Document type	Journal Article
ISSN	1520-5215
ISSN (online)	1520-5215
DOI	10.1021/acs.jpca.3c08076
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A Comparison of In-Person and Online Training in a Statewide Clinical Education Program for Dissemination of HIV, HCV and STD Clinical Evidence.

Wang, Dongwen

Studies in health technology and informatics

2019 Volume 264, Page(s) 2003–2004

Abstract: We compared in-person and online training in a statewide education program to disseminate HIV, HCV, and STD clinical evidence. In a study period of three months, 250 clinicians completed four training courses delivered in dual formats. Course evaluation ... ...

Abstract	We compared in-person and online training in a statewide education program to disseminate HIV, HCV, and STD clinical evidence. In a study period of three months, 250 clinicians completed four training courses delivered in dual formats. Course evaluation was positive regarding useful information, easy comprehension, knowledgeable trainer, appropriate format, knowledge increase, intention to use knowledge, and plan to change practice. Online training became a preferred format by clinicians when compared to in-person training (p=0.01).
MeSH term(s)	HIV ; Hepatitis C ; Humans ; Internet ; Sexually Transmitted Diseases
Language	English
Publishing date	2019-07-18
Publishing country	Netherlands
Document type	Journal Article
ISSN	1879-8365
ISSN (online)	1879-8365
DOI	10.3233/SHTI190756
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Network Analyses on Hyperlinked Online Resources for Dissemination of Clinical Evidence - Updates of COVID-19 Vaccine Information Over Time and Measuring the Freshness of Information.

Abrams, Meredith / Wang, Dongwen

Studies in health technology and informatics

2022 Volume 290, Page(s) 985–986

Abstract: We collected the COVID-19 vaccine online resources and captured the timestamps of their updates. We computed an average lifetime of 68 days for update and derived the speed of their freshness depreciation. The preliminary results have demonstrated the ... ...

Abstract	We collected the COVID-19 vaccine online resources and captured the timestamps of their updates. We computed an average lifetime of 68 days for update and derived the speed of their freshness depreciation. The preliminary results have demonstrated the feasibility to incorporate freshness measures into network anaysis to identify both the importance and freshness of online resources.
MeSH term(s)	COVID-19/prevention & control ; COVID-19 Vaccines ; Humans
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2022-06-08
Publishing country	Netherlands
Document type	Journal Article
ISSN	1879-8365
ISSN (online)	1879-8365
DOI	10.3233/SHTI220230
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Article: The mechanism of long-chain acyl-CoA synthetase 3 in inhibiting cell proliferation, migration, and invasion in clear cell renal cell carcinoma.

Zhang, Lin / Wu, Bo / Wang, Dongwen

American journal of cancer research

2023 Volume 13, Issue 3, Page(s) 835–851

Abstract: Long-chain acyl-CoA synthases 3 (ACSL3) can activate long-chain fatty acids, which are often deregulated in tumors. However, the biological function of ACSL3 in clear cell renal cell carcinoma (ccRCC) is still unclear. In this research, the expression ... ...

Abstract	Long-chain acyl-CoA synthases 3 (ACSL3) can activate long-chain fatty acids, which are often deregulated in tumors. However, the biological function of ACSL3 in clear cell renal cell carcinoma (ccRCC) is still unclear. In this research, the expression level, prognostic value, GO and KEGG functional enrichment analyses, genomic changes, clinical significance, immune infiltration of ACSL3 in ccRCC were comprehensively analysed. The expression levels of ACSL3 in ccRCC tissues were detected by quantitative reverse transcription-polymerase chain reaction (RT-qPCR), immunohistochemical staining (IHC), and Western blotting analysis. The proliferation, invasion, migration, apoptotic and lipid synthesis abilities of ccRCC cells were assessed using the cell counting kit (CCK-8), clone formation, scratch assay, Transwell assay, flow cytometry and Oil Red O assay, respectively. The results showed that ACSL3 was obviously downregulated in ccRCC and significantly associated with poor prognosis and clinicopathological factors of ccRCC patients. Additionally, the functional enrichment analysis indicated that ACSL3 was mainly involved in lipid synthesis and metabolism. The result of immune infiltration analysis proved that ACSL3 might regulate the tumor microenvironment of ccRCC. In addition, we demonstrated that overexpression of the ACSL3 could inhibit the proliferation, migration, and invasion of ccRCC cells, and promote apoptosis, reduce abnormal lipid accumulation. In conclusion, ACSL3 might be a novel ccRCC biomarker and the target for ccRCC tumor therapy.
Language	English
Publishing date	2023-03-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2589522-9
ISSN	2156-6976
ISSN	2156-6976
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Use Contexts and Usage Patterns of Interactive Case Simulation Tools by HIV Healthcare Providers in a Statewide Online Clinical Education Program.

Wang, Dongwen

Studies in health technology and informatics

2017 Volume 245, Page(s) 1242

Abstract: We analyzed four interactive case simulation tools (ICSTs) from a statewide online clinical education program. Results have shown that ICSTs are increasingly used by HIV healthcare providers. Smart phone has become the primary usage platform for specific ...

Abstract	We analyzed four interactive case simulation tools (ICSTs) from a statewide online clinical education program. Results have shown that ICSTs are increasingly used by HIV healthcare providers. Smart phone has become the primary usage platform for specific ICSTs. Usage patterns depend on particular ICST modules, usage stages, and use contexts. Future design of ICSTs should consider these usage patterns for more effective dissemination of clinical evidence to healthcare providers.
MeSH term(s)	HIV Infections ; Health Personnel ; Humans ; Internet ; Simulation Training
Language	English
Publishing date	2017-12-29
Publishing country	Netherlands
Document type	Journal Article
ISSN	1879-8365
ISSN (online)	1879-8365
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Article ; Online: My Contraceptive Choice: A Decision Support Tool for College Women.

Redman, Molly / Brian, Jenny / Wang, Dongwen

Studies in health technology and informatics

2022 Volume 290, Page(s) 1096–1097

Abstract: We developed an online decision aid, My Contraceptive Choice (MCC), for college women to select the appropriate birth control methods. MCC consists of a short quiz, customized recommendations, and educational resources. Evaluations from a focus group, an ...

Abstract	We developed an online decision aid, My Contraceptive Choice (MCC), for college women to select the appropriate birth control methods. MCC consists of a short quiz, customized recommendations, and educational resources. Evaluations from a focus group, an online survey, and test cases showed that the tool is accurate, usable, and useful. Future work is required to further improve MCC's compliance with user needs/preferences and to include additional resources to make it more useful.
MeSH term(s)	Contraception/methods ; Contraceptive Agents ; Female ; Focus Groups ; Humans ; Surveys and Questionnaires ; Universities
Chemical Substances	Contraceptive Agents
Language	English
Publishing date	2022-06-08
Publishing country	Netherlands
Document type	Journal Article
ISSN	1879-8365
ISSN (online)	1879-8365
DOI	10.3233/SHTI220285
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Research Progress of the Salt Barrier in Saline Alkali Land

Sun Xiaomei / Wang Jian / Hua Dongwen

E3S Web of Conferences, Vol 338, p

2022 Volume 01041

Abstract: As an important land resource, the poor physical and chemical properties of soil in saline alkali land are the biggest obstacle to plant growth and development in saline alkali land. Carrying out targeted research on saline alkali land improvement is of ... ...

Abstract	As an important land resource, the poor physical and chemical properties of soil in saline alkali land are the biggest obstacle to plant growth and development in saline alkali land. Carrying out targeted research on saline alkali land improvement is of great significance to ensure food security and protect the ecological environment. In recent years, it is urgent to fully tap the potential of such areas in agricultural production and ecological greening through economic and effective original soil improvement measures. The existing research and engineering projects of saline alkali land treatment at home and abroad are mostly realized through water conservancy, physics, chemistry, biology and other measures, and tend to form a comprehensive treatment system integrating engineering, plant, microorganism and other technologies. Among them, salt separation layer + concealed pipe drainage is a more effective and commonly used engineering measure in saline alkali land treatment. Through the research and development of supporting new materials and processes, constantly improving the technical system can greatly promote saline alkali land treatment. This paper discusses the improvement of salt barrier in saline alkali soil
Keywords	salt barrier ; saline alkali land ; biochar ; Environmental sciences ; GE1-350
Subject code	333
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Temporary consumption of western diet trains the immune system to reduce future gut inflammation.

Wu, Dongwen / Wang, Xiaotong / Yang, Xiang / Gu, Lei / McGeachy, Mandy J / Liu, Xiaowei

iScience

2023 Volume 26, Issue 6, Page(s) 106915

Abstract: Urbanization drives the popularity of western diet (WD), which increased burden in metabolic diseases but also in inflammatory diseases. Here, we show continuous WD disrupted the gut barrier, initiating low-grade inflammation and enhancing the colitis ... ...

Abstract	Urbanization drives the popularity of western diet (WD), which increased burden in metabolic diseases but also in inflammatory diseases. Here, we show continuous WD disrupted the gut barrier, initiating low-grade inflammation and enhancing the colitis response. Nevertheless, transient WD consumption followed by
Language	English
Publishing date	2023-05-20
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2023.106915
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Article ; Online: Can we infer tumor presence of single cell transcriptomes and their tumor of origin from bulk transcriptomes by machine learning?

Hua-Ping Liu / Dongwen Wang / Hung-Ming Lai

Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 2672-

2022 Volume 2679

Abstract: There is a growing need to build a model that uses single cell RNA-seq (scRNA-seq) to separate malignant cells from nonmalignant cells and to identify tumor of origin of single cells and/or circulating tumor cells (CTCs). Currently, it is infeasible to ... ...

Abstract	There is a growing need to build a model that uses single cell RNA-seq (scRNA-seq) to separate malignant cells from nonmalignant cells and to identify tumor of origin of single cells and/or circulating tumor cells (CTCs). Currently, it is infeasible to build a tumor of origin model learnt from scRNA-seq by machine learning (ML). We then wondered if an ML model learnt from bulk transcriptomes is applicable to scRNA-seq to infer single cells’ tumor presence and further indicate their tumor of origin. We used k-nearest neighbors, one-versus-all support vector machine, one-versus-one support vector machine, random forest and introduced scTumorTrace to conduct a pioneering experiment containing leukocytes and seven major cancer types where bulk RNA-seq and scRNA-seq data were available. 13 ML models learnt from bulk RNA-seq were all reliable to use (F-score > 96%) shown by a validation set of bulk transcriptomes, but none of them was applicable to scRNA-seq except scTumorTrace. Making inferences from bulk RNA-seq to scRNA-seq was impaired by feature selection and improved by log2-transformed TPM units. scTumorTrace with transcriptome-wide 2-tuples showed F-score beyond 98.74 and 94.29% in inferring tumor presence and tumor of origin at single-cell resolution and correctly identified 45 single candidate prostate CTCs but lineage-confirmed non-CTCs as leukocytes. We concluded that modern ML techniques are quantitative and could hardly address the raised questions. scTumorTrace with transcriptome-wide 2-tuples is qualitative, standardization-free and not subject to log2-transformed quantities, enabling us to infer tumor presence of single cell transcriptomes and their tumor of origin from bulk transcriptomes.
Keywords	Single cell transcriptomes ; Circulating tumor cells ; RNA-seq ; Translational bioinformatics ; Digit medicine ; Biotechnology ; TP248.13-248.65
Subject code	572
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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