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  1. Article ; Online: A novel computational tool for tracking cancer energy hijacking from immune cells.

    Zhang, Hongyi / Li, Bo

    Clinical and translational medicine

    2024  Volume 14, Issue 1, Page(s) e1533

    Abstract: Recent studies revealed a new biological process that malignant cancer cells hijack mitochondria from nearby T cells, providing another potential mechanism for immune evasion. We further confirmed this process at the single-cell genomic level through ... ...

    Abstract Recent studies revealed a new biological process that malignant cancer cells hijack mitochondria from nearby T cells, providing another potential mechanism for immune evasion. We further confirmed this process at the single-cell genomic level through MERCI, a novel algorithm for tracking mitochondrial (MT) transfer. Applied to human cancer samples, MERCI identified a new cancer phenotype linked to MT hijacking, correlating with rapid tumour proliferation and poor patient survival. This discovery offers insights into the limitations of current cancer immunotherapies and suggests new therapeutic avenues targeting MT transfer to enhance cancer treatment efficacy.
    MeSH term(s) Humans ; Mitochondria ; Algorithms ; Genomics ; Immunotherapy ; Neoplasms/therapy
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2697013-2
    ISSN 2001-1326 ; 2001-1326
    ISSN (online) 2001-1326
    ISSN 2001-1326
    DOI 10.1002/ctm2.1533
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A sustainable metal-free and additive-free olefination route to

    Cui, Hongyi / Zhang, Chunyan / Ji, Yuqi / Zhang, Guoying

    RSC advances

    2024  Volume 14, Issue 7, Page(s) 4339–4344

    Abstract: A green and sustainable metal-free, additive-free olefination approach is proposed for the facile synthesis of various ... ...

    Abstract A green and sustainable metal-free, additive-free olefination approach is proposed for the facile synthesis of various unsaturated
    Language English
    Publishing date 2024-01-31
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d4ra00189c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Recruitment Patterns and Environmental Sensitivity of Glass Eels of

    Guo, Hongyi / Zhang, Xuguang / Zhang, Ya / Tang, Wenqiao / Liu, Kai

    Biology

    2024  Volume 13, Issue 1

    Abstract: The decline of Japanese eel ( ...

    Abstract The decline of Japanese eel (
    Language English
    Publishing date 2024-01-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology13010056
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  4. Article ; Online: 3D power frequency intensive electric field sensor based on a lithium niobate electro-optic crystal.

    Zhang, Jiahong / Chen, Zewen / Lei, Hongyi

    Applied optics

    2024  Volume 63, Issue 7, Page(s) 1761–1768

    Abstract: In order to conveniently measure the power frequency intensive electric field in any direction in space, a lithium niobate (LN) crystal-based three dimensional (3D) intensive electric field sensor with an all-dielectric structure has been developed. A ... ...

    Abstract In order to conveniently measure the power frequency intensive electric field in any direction in space, a lithium niobate (LN) crystal-based three dimensional (3D) intensive electric field sensor with an all-dielectric structure has been developed. A regular triangular prism structure with three 1D (one-dimensional) electric field sensors fixed on its three sides is designed and fabricated. By setting the orientation of the
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4522
    ISSN (online) 1539-4522
    DOI 10.1364/AO.514702
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  5. Article ; Online: Will temperature affect the export quality of firms? Evidence from China

    Junmei Zhang / Hongyi Li

    International Journal of Climate Change Strategies and Management, Vol 15, Iss 4, Pp 493-

    2023  Volume 514

    Abstract: Purpose – This study aims to investigate whether temperature affects the product quality of exporters and whether the effect is non-linear. More specifically, whether the impact of high temperatures differs from the impact of low temperatures, and ... ...

    Abstract Purpose – This study aims to investigate whether temperature affects the product quality of exporters and whether the effect is non-linear. More specifically, whether the impact of high temperatures differs from the impact of low temperatures, and whether different types of companies or industries are affected differently. Design/methodology/approach – The paper uses detailed data covering all Chinese exporters from 2000 to 2016 to estimate the effects of temperature on the product quality of export firms. To clarify the relationship between them, the authors use a semi-parametric regression method, trying to test whether there is a non-linear relationship between temperature and the export quality of firms. Findings – The increase in the number of high temperature days significantly reduces the quality of exported products, and this negative effect increases as the temperature rises. High temperature has the most significant negative impact on export quality for firms with low technical complexity, private firms and firms with no intermediate imports and located in historical hot cities. Product quality of both labor-intensive and capital-intensive firms will be affected by heat. High temperatures have the greatest negative impact on the export quality of newly entering products, followed by exiting products, with the least negative impact on persisting product. Originality/value – To the best of the authors’ knowledge, this paper is the first to examine the impact of temperature on the quality of economic development. The findings of this paper again show that the potential economic impacts of global warming are huge. In addition to some potentially devastating impacts in the future, global warming is already causing imperceptible impacts in the present. Public and economic agents need to fully understand the possible adverse impacts of climate change and take corresponding adaptation measures to cope with global warming.
    Keywords Temperature ; Climate change ; Export quality ; China ; Heterogeneous effect ; Environmental sciences ; GE1-350 ; Meteorology. Climatology ; QC851-999
    Subject code 381
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher Emerald Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Clear cell renal cell carcinoma: immunological significance of alternative splicing signatures.

    Zhang, Jiayu / Jiang, Hongyi / Rao, Dapang / Jin, Xishi

    Frontiers in oncology

    2024  Volume 13, Page(s) 1206882

    Abstract: Background: Renal cell carcinoma (RCC) accounts for 90% of renal cancers, of which clear cell carcinoma (ccRCC) is the most usual histological type. The process of alternative splicing (AS) contributes to protein diversity, and the dysregulation of ... ...

    Abstract Background: Renal cell carcinoma (RCC) accounts for 90% of renal cancers, of which clear cell carcinoma (ccRCC) is the most usual histological type. The process of alternative splicing (AS) contributes to protein diversity, and the dysregulation of protein diversity may have a great influence on tumorigenesis. We developed a prognostic signature and comprehensively analyzed the role of tumor immune microenvironment (TIME) and immune checkpoint blocking (ICB) treatment in ccRCC.
    Methods: To identify prognosis-related AS events, univariate Cox regression was used and functional annotation was performed using gene set enrichment analysis (GSEA). In this study, prognostic signatures were developed based on multivariate Cox, univariate Cox, and LASSO regression models. Moreover, to assess the prognostic value, the proportional hazards model, Kruskal-Wallis analysis, and ROC curves were used. To obtain a better understanding of TIME in ccRCC, the ESTIMATE R package, single sample gene set enrichment analysis (ssGSEA) algorithm, CIBERSORT method, and the tumor immune estimation resource (TIMER) were applied. The database was searched to verify the expression of
    Results: There were 9,347 AS cases associated with the survival of ccRCC patients screened. A total of eight AS prognostic signatures were developed with stable prognostic predictive accuracy based on splicing subtypes. In addition, a qualitative prognostic nomogram was developed, and the prognostic prediction showed high effectiveness. In addition, we found that the combined signature was significantly associated with the diversity of TIME and ICB treatment-related genes.
    Conclusion: We found novel and robust indicators (i.e., risk signature, prognostic nomogram, etc.) for the prognostic prediction of ccRCC. A new and reliable prognostic nomogram was established to quantitatively predict the clinical outcome. The AS-SF networks could provide a new way for the study of potential regulatory mechanisms, and the important roles of AS events in the context of TIME and immunotherapy efficiency were exhibited.
    Language English
    Publishing date 2024-01-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1206882
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  7. Article ; Online: Association of the sarcopenia index with cognitive impairment in a middle-aged to older patients with acute ischemic stroke or transient ischemic attack: A multicenter cohort study.

    Li, Siqi / Yan, Hongyi / Pan, Yuesong / Zhang, Yumei

    The journal of nutrition, health & aging

    2024  Volume 28, Issue 7, Page(s) 100241

    Abstract: Objectives: The sarcopenia (SI) index, defined as the serum creatinine to cystatin C ratio, is considered a predictor of poor muscle health and malnutrition, which is related to major adverse cardiovascular events. However, the effect of the SI index on ...

    Abstract Objectives: The sarcopenia (SI) index, defined as the serum creatinine to cystatin C ratio, is considered a predictor of poor muscle health and malnutrition, which is related to major adverse cardiovascular events. However, the effect of the SI index on cognitive function in stroke patients remains unknown. In this study, we aimed to examine the association between the SI and longitudinal cognitive impairment in patients with acute ischemic stroke or transient ischemic attack.
    Research design and methods: Participants who met the inclusion criteria in this national, multicenter, prospective cohort study were enrolled from the Impairment of Cognition and Sleep (ICONS) study of the China National Stroke Registry-3 (CNSR-3). They were categorized into four groups according to the quartile of the SI index. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA) scale. Multivariable-adjusted logistic regression models were performed to evaluate the association between the SI index and post-stroke cognitive impairment (PSCI) at the 3-month follow-up. Moreover, discrimination tests were used to evaluate the incremental predictive value of the SI index beyond the potential risk factors. Furthermore, we performed subgroup analyses to test interactions.
    Results: Among the enrolled participants, the lower the SI index was, the worse the cognitive performance. At the 3-month follow-up, participants in the lowest SI quartile group exhibited a 42% increase in the risk of cognitive impairment relative to the highest quartile group [OR 0.58 (95% CI 0.37-0.90)]. Moreover, after applying the discrimination test, adding the SI index into the potential risk factors resulted in a slight improvement in predicting the risk of cognitive impairment [NRI 14% (P = 0.01)].
    Conclusion: This study demonstrated that a lower sarcopenia index was positively associated with a higher prevalence of PSCI. Monitoring the SI index in stroke patients and early identification and treatment of individuals with low SI level may be helpful to reduce the risk of cognitive impairment.
    Language English
    Publishing date 2024-04-25
    Publishing country France
    Document type Journal Article
    ZDB-ID 2081921-3
    ISSN 1760-4788 ; 1279-7707
    ISSN (online) 1760-4788
    ISSN 1279-7707
    DOI 10.1016/j.jnha.2024.100241
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    In stock of ZB MED Bonn / Germany

    Z 7466: Show issues

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  8. Article: Metabolic Features of a Novel

    Ji, Huimin / Yu, Ruohan / Liu, Hongyi / Zhang, Hui / Wang, Xinhua / Chen, Jie / Li, Yaqian

    Metabolites

    2023  Volume 13, Issue 11

    Abstract: ... ...

    Abstract Trichoderma
    Language English
    Publishing date 2023-11-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo13111144
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  9. Article ; Online: The First Complete Mitochondrial Genome of the Genus

    Zhang, Gaoji / Gao, Ming / Chen, Yukun / Wang, Yinuo / Gan, Tianyi / Zhu, Fuyuan / Liu, Hongyi

    Genes

    2024  Volume 15, Issue 2

    Abstract: This study presents the complete mitochondrial genome (mitogenome) ... ...

    Abstract This study presents the complete mitochondrial genome (mitogenome) of
    MeSH term(s) Animals ; Genome, Mitochondrial/genetics ; Phylogeny ; Base Composition ; Arthropods/genetics ; Codon, Initiator
    Chemical Substances Codon, Initiator
    Language English
    Publishing date 2024-02-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes15020254
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  10. Article ; Online: Discovery and Mechanism of a Nematicide Candidate (

    Wang, Yu / Zhang, Yong / Wang, Sheng / Cai, Qingfeng / Song, Hongyi / Chen, Jixiang

    Journal of agricultural and food chemistry

    2024  Volume 72, Issue 11, Page(s) 5585–5594

    Abstract: To find novel nematicides, we screened the nematicidal activity of compounds in our laboratory compound library. Interestingly, the ... ...

    Abstract To find novel nematicides, we screened the nematicidal activity of compounds in our laboratory compound library. Interestingly, the compound
    MeSH term(s) Animals ; Amides/pharmacology ; Antinematodal Agents/pharmacology ; Antinematodal Agents/chemistry ; Tylenchida ; Tylenchoidea ; Reproduction
    Chemical Substances Amides ; Antinematodal Agents
    Language English
    Publishing date 2024-03-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.3c06696
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1172: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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