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Article ; Online: Second primary tumors following a diagnosis of meningioma in Sweden, 1958-1997.

Davis, Faith / Tavelin, Björn / Grutsch, James / Malmer, Beatrice

2007 Volume 29, Issue 1-2, Page(s) 101–106

Abstract: This study quantifies the risk of second primary tumors following a diagnosis of meningioma. 12,012 meningiomas and 926 second primary cancers were identified (ICD7, path code 461) between 1958 and 1997 using Swedish Cancer Registry data. Standardized ... ...

Abstract	This study quantifies the risk of second primary tumors following a diagnosis of meningioma. 12,012 meningiomas and 926 second primary cancers were identified (ICD7, path code 461) between 1958 and 1997 using Swedish Cancer Registry data. Standardized incidence ratios (SIRs) and exact 95% confidence intervals (CIs) were calculated. An elevated risk of any second primary cancer diagnosis (SIR = 1.2, 95% CI = 1.1-1.3) was observed. Elevated and statistically significant SIRs were observed for renal cancer (SIR = 1.6), melanoma (SIR = 1.7), thyroid cancer (SIR = 2.6) and brain tumors (SIR = 2.6). A consistent pattern of risk over time supports the evaluation of common risk factor profiles for renal, melanoma and thyroid cancers. Radiation exposures increase the risk of these rare tumors, so quantifying the cumulative and shared effects of environmental and treatment exposures is of further interest.
MeSH term(s)	Adult ; Age Distribution ; Aged ; Female ; Humans ; Male ; Meningeal Neoplasms/diagnosis ; Meningeal Neoplasms/epidemiology ; Meningioma/diagnosis ; Meningioma/epidemiology ; Middle Aged ; Neoplasms, Second Primary/epidemiology ; Neoplasms, Second Primary/pathology ; Registries ; Risk Factors ; Sex Distribution ; Sweden/epidemiology ; Time Factors
Language	English
Publishing date	2007
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	603189-4
ISSN	1423-0208 ; 0251-5350
ISSN (online)	1423-0208
ISSN	0251-5350
DOI	10.1159/000109823
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Article ; Online: Genetic variants in association studies--review of strengths and weaknesses in study design and current knowledge of impact on cancer risk.

Andersson, Ulrika / McKean-Cowdin, Roberta / Hjalmars, Ulf / Malmer, Beatrice

Acta oncologica (Stockholm, Sweden)

2009 Volume 48, Issue 7, Page(s) 948–954

Abstract: Sequencing of the human genome has recently been completed and mapping of the complete genomic variation is ongoing. During the last decade there has been a huge expansion of studies of genetic variants, both with respect to association studies of ... ...

Abstract	Sequencing of the human genome has recently been completed and mapping of the complete genomic variation is ongoing. During the last decade there has been a huge expansion of studies of genetic variants, both with respect to association studies of disease risk and for studies of genetic factors of prognosis and treatments response, i.e., pharmacogenomics. The use of genetics to predict a patient's risk of disease or treatment response is one step toward an improved personalised prevention and screening modality for the prevention of cancer and treatment selection. The technology and statistical methods for completing whole genome tagging of variants and genome wide association studies has developed rapidly over the last decade. After identifying the genetic loci with the strongest, statistical associations with disease risk, future studies will need to further characterise the genotype-phenotype relationship to provide a biological basis for prevention and treatment decisions according to genetic profile. This review discusses some of the general issues and problems of study design; we also discuss challenges in conducting valid association studies in rare cancers such as paediatric brain tumours, where there is support for genetic susceptibility but difficulties in assembling large sample sizes. The clinical interpretation and implementation of genetic association studies with respect to disease risk and treatment is not yet well defined and remains an important area of future research.
MeSH term(s)	Genetic Markers ; Genetic Predisposition to Disease ; Genetic Variation ; Genome, Human ; Genome-Wide Association Study/methods ; Genotype ; Humans ; Neoplasms/epidemiology ; Neoplasms/genetics ; Neoplasms/prevention & control ; Pharmacogenetics ; Phenotype ; Polymorphism, Genetic ; Predictive Value of Tests ; Rare Diseases/genetics ; Research Design ; Risk Assessment ; Sample Size
Chemical Substances	Genetic Markers
Language	English
Publishing date	2009-10-23
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	896449-x
ISSN	1651-226X ; 0349-652X ; 0284-186X ; 1100-1704
ISSN (online)	1651-226X
ISSN	0349-652X ; 0284-186X ; 1100-1704
DOI	10.1080/02841860903124648
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Article ; Online: Co-incidental increase in gene copy number of ERBB2 and LRIG1 in breast cancer.

Ljuslinder, Ingrid / Golovleva, Irina / Henriksson, Roger / Grankvist, Kjell / Malmer, Beatrice / Hedman, Håkan

Breast cancer research : BCR

2009 Volume 11, Issue 3, Page(s) 403

MeSH term(s)	Breast/metabolism ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Chromosome Mapping ; Female ; Gene Dosage ; Gene Expression Regulation, Neoplastic ; Genomics ; Humans ; In Situ Hybridization, Fluorescence ; Membrane Glycoproteins/biosynthesis ; Membrane Glycoproteins/genetics ; Receptor, ErbB-2/biosynthesis ; Receptor, ErbB-2/genetics
Chemical Substances	LRIG1 protein, human ; Membrane Glycoproteins ; ERBB2 protein, human (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1)
Language	English
Publishing date	2009-05-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2015059-3
ISSN	1465-542X ; 1465-5411
ISSN (online)	1465-542X
ISSN	1465-5411
DOI	10.1186/bcr2248
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Zs.A 5494: Show issues

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Article: Reproductive factors have low impact on the risk of different primary brain tumours in offspring.

Mogren, Ingrid / Malmer, Beatrice / Tavelin, Björn / Damber, Lena

Neuroepidemiology

2003 Volume 22, Issue 4, Page(s) 249–254

Abstract: Objectives: The aim of our study was to investigate whether reproductive factors influence the risk of primary brain tumours (PBT) in offspring.: Methods: Data on all deliveries in two Swedish counties from 1955 to 1990 were extracted from two birth ... ...

Abstract	Objectives: The aim of our study was to investigate whether reproductive factors influence the risk of primary brain tumours (PBT) in offspring. Methods: Data on all deliveries in two Swedish counties from 1955 to 1990 were extracted from two birth registries. The follow-up period closed at the end of 1994, with subjects followed up to early middle age. Incidence rates of malignancy for 1958-1994 were obtained from the Swedish Cancer Registry. Standardised incidence ratios (SIR) and relative risks were calculated for astrocytomas, primitive neuroectodermal tumour, ependymoma and meningiomas in offspring. Results: Few associations were detected. High birth weight indicated an increased risk for astrocytomas grade I and II for all primary brain tumours, and the risk was close to significance for astrocytomas grade I-II (SIR = 3.64; CI = 0.98-9.31). For children under 15 years of age the risk for astrocytomas grade I and II was further increased (SIR = 4.44; CI = 1.19-11.38). Conclusions: A consistent pattern of non-association indicated a low impact of intrauterine environment on the future development of primary brain tumours in offspring up to early middle age.
MeSH term(s)	Adolescent ; Adult ; Birth Weight ; Brain Neoplasms/etiology ; Child ; Child, Preschool ; Female ; Gestational Age ; Humans ; Infant ; Infant, Newborn ; Middle Aged ; Pregnancy ; Pregnancy Complications ; Reproduction ; Retrospective Studies ; Risk Factors
Language	English
Publishing date	2003-07
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603189-4
ISSN	1423-0208 ; 0251-5350
ISSN (online)	1423-0208
ISSN	0251-5350
DOI	10.1159/000070567
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Article: Familial brain tumours-genetics or environment? A nationwide cohort study of cancer risk in spouses and first-degree relatives of brain tumour patients.

Malmer, Beatrice / Henriksson, Roger / Grönberg, Henrik

International journal of cancer

2003 Volume 106, Issue 2, Page(s) 260–263

Abstract: Our study investigated whether the familial aggregation of glioma is due to environmental or genetic effects and it investigated and compared the risk to spouses and first-degree relatives (FDR) of patients with primary brain tumours (PBT) for developing ...

Abstract	Our study investigated whether the familial aggregation of glioma is due to environmental or genetic effects and it investigated and compared the risk to spouses and first-degree relatives (FDR) of patients with primary brain tumours (PBT) for developing both PBT and the risk for other types of cancer. All PBT patients identified in Sweden from 1958-97 in The Swedish Cancer Registry (SCR) were linked to the nationwide Swedish Family Database, including persons in Sweden born from 1932-97. The cohorts of spouses and FDR were linked to the SCR to identify observed cases of PBT and other cancer. Standardised incidence ratios (SIR) were calculated using the incidence rates from SCR as the reference. We found that there were no increased risks for any specific type of PBT in the cohort of spouses. In the FDR cohort, generally the risk for a PBT was significantly increased by 2 to 3 times for the same histopathology as the probands. Spouses of PBT patients had an increased risk of skin cancer. We conclude that FDR, not spouses, have a significantly increased risk, which indicates a genetic origin of the familial aggregation of brain tumours.
MeSH term(s)	Adult ; Aged ; Brain Neoplasms/epidemiology ; Brain Neoplasms/etiology ; Brain Neoplasms/genetics ; Cohort Studies ; Environment ; Family ; Female ; Glioma/epidemiology ; Glioma/etiology ; Glioma/genetics ; Humans ; Incidence ; Male ; Middle Aged ; Neoplasm Staging ; Risk Factors ; Spouses ; Sweden/epidemiology
Language	English
Publishing date	2003-08-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218257-9
ISSN	1097-0215 ; 0020-7136
ISSN (online)	1097-0215
ISSN	0020-7136
DOI	10.1002/ijc.11213
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Zs.A 478: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Second primary cancers in men with prostate cancer: an increased risk of male breast cancer.

Thellenberg, Camilla / Malmer, Beatrice / Tavelin, Björn / Grönberg, Henrik

The Journal of urology

2003 Volume 169, Issue 4, Page(s) 1345–1348

Abstract: Purpose: Evaluation of second primary cancers provides valuable insight about etiology and shared risk factors. Studies of second primary cancers following prostate cancer conclude that overall risk of second primary cancers decreases. However, risk of ... ...

Abstract	Purpose: Evaluation of second primary cancers provides valuable insight about etiology and shared risk factors. Studies of second primary cancers following prostate cancer conclude that overall risk of second primary cancers decreases. However, risk of bladder cancer and kidney cancer increases. We examine the risk of common and rare second primary cancers following prostate cancer in a large population based cohort to identify possible common etiological factors. Materials and methods: All prostate cancer cases in the Swedish Cancer Registry (135, 713) from 1958 to the end of 1996 constituted the study base. Risk (standardized incidence ratio) of second primary cancers was calculated as the ratio between observed and expected number of cancers. We used 2-tailed 95% confidence intervals (CI) to test significance. Results: An overall increased risk (standardized incidence ratio 1.17, 95% CI 1.15-1.19) of second primary cancers was found but was only seen in the first 6 months of followup (ratio 3.45, 3.32-3.57). The most interesting finding was an increased risk (ratio 2.01, 95% CI 1.44-2.74) of male breast cancer. Other tumor sites with increased risk were the small intestine (standardized incidence ratio 1.39, 95% CI 1.09-1.51), skin melanoma (ratio 1.33, 95% CI 1.16-1.51) and endocrine tumors (ratio 1.41, 95% CI 1.13-1.74). Conclusions: A small but increased risk of second primary cancers following prostate cancer was found, most likely due to increased surveillance during the first 6 months after diagnosis. However, following prostate cancer there is an increased risk of endocrine related second primary cancers such as male breast cancer and carcinoids in the small intestine. To our knowledge these associations have not been reported previously, and they warrant more study.
MeSH term(s)	Adenocarcinoma/epidemiology ; Aged ; Aged, 80 and over ; Breast Neoplasms, Male/epidemiology ; Breast Neoplasms, Male/etiology ; Cohort Studies ; Endocrine Gland Neoplasms/epidemiology ; Endocrine Gland Neoplasms/etiology ; Follow-Up Studies ; Humans ; Incidence ; Intestinal Neoplasms/epidemiology ; Intestinal Neoplasms/etiology ; Intestine, Small ; Male ; Melanoma/epidemiology ; Melanoma/etiology ; Middle Aged ; Neoplasms, Second Primary/epidemiology ; Neoplasms, Second Primary/etiology ; Prostatic Neoplasms/epidemiology ; Registries ; Risk ; Skin Neoplasms/epidemiology ; Skin Neoplasms/etiology ; Sweden
Language	English
Publishing date	2003-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3176-8
ISSN	1527-3792 ; 0022-5347
ISSN (online)	1527-3792
ISSN	0022-5347
DOI	10.1097/01.ju.0000056706.88960.7c
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Zs.MO 331: Show issues

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Article ; Online: A case for the worldwide collection of primary benign brain tumors.

McCarthy, Bridget J / Schellinger, Kate A / Propp, Jennifer M / Kruchko, Carol / Malmer, Beatrice

Neuroepidemiology

2009 Volume 33, Issue 3, Page(s) 268–275

Abstract: Background: Incidence data on malignant tumors are reported by the International Agency for Research on Cancer, with 189,485 new malignant brain tumors globally in 2002. However, collection and reporting of benign brain tumors are not universal. The ... ...

Abstract	Background: Incidence data on malignant tumors are reported by the International Agency for Research on Cancer, with 189,485 new malignant brain tumors globally in 2002. However, collection and reporting of benign brain tumors are not universal. The objective here is to encourage the collection of primary benign brain tumors worldwide. Methods: Worldwide numbers of primary benign brain tumors were estimated through published articles and cancer registry reports presenting directly or indirectly reported benign incidence rates or frequencies for regions or countries. Results: An estimated 186,678 benign brain tumors were diagnosed worldwide in 2002. The estimated numbers of benign brain tumors were higher in females than males (105,918 vs. 80,759). Since many countries do not report primary benign brain tumors, the incidence rate estimates vary significantly by region. Conclusions: This is the first survey to assess worldwide numbers of benign brain tumors. Under-reporting, non-standardized collection, lack of age-adjustment, and other causes of the varying incidence rates must be considered. However, the estimated number of benign brain tumors approximately equals, and could exceed, the number of malignant brain tumors globally. Registration of primary benign brain histologies in different geographical areas and ethnicities could provide clues to the underlying causes of these tumors.
MeSH term(s)	Brain Neoplasms/epidemiology ; Global Health ; Humans ; Internationality ; Registries/standards
Language	English
Publishing date	2009
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	603189-4
ISSN	1423-0208 ; 0251-5350
ISSN (online)	1423-0208
ISSN	0251-5350
DOI	10.1159/000230808
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Article ; Online: Long-term risk of cardiovascular disease in Hodgkin lymphoma survivors--retrospective cohort analyses and a concept for prospective intervention.

Andersson, Anne / Näslund, Ulf / Tavelin, Björn / Enblad, Gunilla / Gustavsson, Anita / Malmer, Beatrice

International journal of cancer

2009 Volume 124, Issue 8, Page(s) 1914–1917

Abstract: Previous studies have shown increased cardiovascular mortality as late side effects in Hodgkin lymphoma (HL) patients. This study identifies stratifying risk factors for surveillance and defines concepts for a clinical feasible and noninvasive ... ...

Abstract	Previous studies have shown increased cardiovascular mortality as late side effects in Hodgkin lymphoma (HL) patients. This study identifies stratifying risk factors for surveillance and defines concepts for a clinical feasible and noninvasive prospective protocol for intervention of cardiovascular side effects. HL patients diagnosed between 1965 and 1995 (n = 6.946) and their first-degree relatives (FDR) were identified through the Swedish Cancer Registry and the Swedish Multigeneration Registry. For the HL and FDR cohort, in-patient care for cardiovascular disease (CVD) was registered through the Hospital Discharge Registry, Sweden. Standard incidence ratios of developing CVD for the HL cohort were calculated. A markedly increased risk for in-patient care of CVD was observed in HL patients with HL diagnosed at age 40 years or younger and with more than 10 years follow-up. In the HL survivors, a family history of congestive heart failure (CHF) and coronary artery disease (CAD) increased the risk for these diseases. The Swedish Hodgkin Intervention and Prevention study started in 2007. In the pilot feasibility study for prospective intervention (47 patients), about 25% of the cases had side effects and laboratory abnormalities. These patients were referred to a cardiologist or general practitioner. In the prospective cohort, a positive family history for CHF or CAD could be a stratifying risk factor when setting up a surveillance model. The prospective on-going study presents an intervention model that screens and treats for comorbidity factors. This article also presents an overview of the study concept.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Cardiovascular Diseases/complications ; Cardiovascular Diseases/therapy ; Child ; Child, Preschool ; Cohort Studies ; Comorbidity ; Female ; Follow-Up Studies ; Hodgkin Disease/complications ; Hodgkin Disease/therapy ; Humans ; Male ; Middle Aged ; Prospective Studies ; Retrospective Studies ; Risk
Language	English
Publishing date	2009-04-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218257-9
ISSN	1097-0215 ; 0020-7136
ISSN (online)	1097-0215
ISSN	0020-7136
DOI	10.1002/ijc.24147
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Zs.A 478: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Breast cancer as a second primary in patients with prostate cancer--estrogen treatment or association with family history of cancer?

Karlsson, Camilla Thellenberg / Malmer, Beatrice / Wiklund, Fredrik / Grönberg, Henrik

The Journal of urology

2006 Volume 176, Issue 2, Page(s) 538–543

Abstract: Purpose: In a large population based study we reported an increased risk of male breast cancer after prostate cancer. In the current study we performed a comprehensive investigation of whether treatment for prostate cancer and/or family history is ... ...

Abstract	Purpose: In a large population based study we reported an increased risk of male breast cancer after prostate cancer. In the current study we performed a comprehensive investigation of whether treatment for prostate cancer and/or family history is responsible for the excess risk. Materials and methods: This study had 2 parts. 1) We performed a nested case-control study in 41 men who had previously been identified with first prostate cancer, followed by male breast cancer and in 81 matched controls with prostate cancer only. The medical records of these men were retrieved and clinical data such as stage, grade and treatment were extracted. 2) We also performed a family study including relatives of men with a diagnosis of prostate as well as breast cancer, irrespective of which was first. The 878 relatives were identified through parish offices and linked to the Swedish Cancer Registry to evaluate the occurrence of breast, prostate and other cancers and calculate if there were any excess risks for different cancers. Results: Cases with prostate plus breast cancer received estrogen treatment more often than controls with prostate cancer only (p = 0.03). The period of estrogen treatment was longer in the cases, although it was not statistically significant. Mean time from prostate cancer diagnosis to breast cancer diagnosis was 47.6 months. Cases and controls did not differ in grade or stage. In the family study an increased risk of prostate cancer was found in relatives (SIR 2.14, 95% CI 1.09 to 3.18). For other cancers no significantly increased risks were found. In 2 families pedigree analysis using the BRCAPRO program (http://www3.utsouthwestern.edu/cancergene/) revealed an estimated 100% and 49% probability in families 1 and 2, respectively, that the proband was a BRCA2 carrier. Conclusions: Our data suggest that most of the increased risk of breast cancer following prostate cancer can be explained by estrogen treatment. However, in a small number of men with prostate as well as breast cancer pedigree analysis suggests that BRCA2 mutation might be the underlying cause.
MeSH term(s)	Aged ; Breast Neoplasms/genetics ; Breast Neoplasms, Male/chemically induced ; Breast Neoplasms, Male/genetics ; Case-Control Studies ; Estradiol/adverse effects ; Estradiol/analogs & derivatives ; Estradiol/therapeutic use ; Estrogens/adverse effects ; Estrogens/therapeutic use ; Female ; Humans ; Male ; Neoplasms, Second Primary/genetics ; Pedigree ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/genetics
Chemical Substances	Estrogens ; Estradiol (4TI98Z838E) ; polyestradiol phosphate (P14877CDX2)
Language	English
Publishing date	2006-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3176-8
ISSN	1527-3792 ; 0022-5347
ISSN (online)	1527-3792
ISSN	0022-5347
DOI	10.1016/j.juro.2006.03.036
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Article: Different aetiology of familial low-grade and high-grade glioma? A nationwide cohort study of familial glioma.

Malmer, Beatrice / Henriksson, Roger / Grönberg, Henrik

Neuroepidemiology

2002 Volume 21, Issue 6, Page(s) 279–286

Abstract: An increased risk for first-degree relatives (FDR) of glioma patients has previously been observed. The novel objective of this study was to investigate differences in familial risk among FDR of low-grade glioma (LGG) and high-grade glioma (HGG) cases, ... ...

Abstract	An increased risk for first-degree relatives (FDR) of glioma patients has previously been observed. The novel objective of this study was to investigate differences in familial risk among FDR of low-grade glioma (LGG) and high-grade glioma (HGG) cases, respectively. Two cohorts were constructed, one from 15,321 FDR of LGG cases and the other from 26,635 FDR of HGG cases calculating standardised incidence ratios (SIR). The risk for LGG among FDR of LGG cases was significantly increased, SIR 3.65 (95% CI 2.31-5.47). The risk was even higher in the cohort of siblings, SIR 7.00 (95% CI 3.35-12.87), and especially in the younger siblings (<40 years), SIR 9.01 (95% CI 4.31-16.57). When calculating the risk for HGG in the LGG cohort and the risk for HGG in the HGG cohort, there was a generally twofold increased risk, but no trends of increased risk in relatives of younger probands. Two different methods calculating familial risk displayed similar results. LGG families apparently have features manifesting a distinct pedigree pattern with sibpairs affected at a young age. These families could provide new insights into the aetiology of glioma.
MeSH term(s)	Adolescent ; Adult ; Age Factors ; Aged ; Brain Neoplasms/etiology ; Brain Neoplasms/genetics ; Brain Neoplasms/pathology ; Child ; Cohort Studies ; Female ; Glioma/etiology ; Glioma/genetics ; Glioma/pathology ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Pedigree ; Risk Factors ; United States/epidemiology
Language	English
Publishing date	2002-11
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603189-4
ISSN	1423-0208 ; 0251-5350
ISSN (online)	1423-0208
ISSN	0251-5350
DOI	10.1159/000065528
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