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Article ; Online: Update on Pediatric Nuclear Medicine in Acute Care.

Chin, Joshua / Vali, Reza / Charron, Martin / Shammas, Amer

2023 Volume 53, Issue 6, Page(s) 820–839

Abstract: Various radiopharmaceuticals are available for imaging pediatric patients in the acute care setting. This article focuses on the common applications used on a pediatric patient in acute care. To confirm the clinical diagnosis of brain death, brain ... ...

Abstract	Various radiopharmaceuticals are available for imaging pediatric patients in the acute care setting. This article focuses on the common applications used on a pediatric patient in acute care. To confirm the clinical diagnosis of brain death, brain scintigraphy is considered accurate and has been favorably compared with other methods of detecting the presence or absence of cerebral blood flow. Ventilation-perfusion lung scans are easy and safe to perform with less radiation exposure than computed tomography pulmonary angiography and remain an appropriate procedure to perform on children with suspected pulmonary embolism as a first imaging test in a hemodynamically stable patient with no history of lung disease and normal chest radiograph.
MeSH term(s)	Humans ; Child ; Radiopharmaceuticals ; Nuclear Medicine ; Radionuclide Imaging ; Gastrointestinal Hemorrhage/etiology ; Tomography, X-Ray Computed
Chemical Substances	Radiopharmaceuticals
Language	English
Publishing date	2023-05-19
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	120248-0
ISSN	1558-4623 ; 0001-2998
ISSN (online)	1558-4623
ISSN	0001-2998
DOI	10.1053/j.semnuclmed.2023.04.006
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Article ; Online: Implication des kinases MEK1 et MEK2 dans la maturation du système immunitaire chez la souris.

Houde, Nicolas / Espéli, Marion / Charron, Jean

Medecine sciences : M/S

2022 Volume 38, Issue 6-7, Page(s) 529–532

Title translation	Involvement of MEK1 and MEK2 kinases in the maturation of the mouse immune system.
MeSH term(s)	Animals ; Immune System/metabolism ; Mice ; Mitogen-Activated Protein Kinase Kinases ; Phosphorylation ; Protein-Tyrosine Kinases
Chemical Substances	Protein-Tyrosine Kinases (EC 2.7.10.1) ; Mitogen-Activated Protein Kinase Kinases (EC 2.7.12.2)
Language	French
Publishing date	2022-06-29
Publishing country	France
Document type	Journal Article
ZDB-ID	632733-3
ISSN	1958-5381 ; 0767-0974
ISSN (online)	1958-5381
ISSN	0767-0974
DOI	10.1051/medsci/2022071
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Article ; Online: Pregnancy and cardiac maternal outcomes in women with inherited cardiomyopathy: interest of the CARPREG II risk score.

Wallet, Thomas / Legrand, Lise / Isnard, Richard / Gandjbakhch, Estelle / Pousset, Françoise / Proukhnitzky, Julie / Dommergues, Marc / Nizard, Jacky / Charron, Philippe

ESC heart failure

2024

Abstract: Aims: Inherited cardiomyopathies are relatively rare but carry a high risk of cardiac maternal morbidity and mortality during pregnancy and postpartum. However, data for risk stratification are scarce. The new CARPREG II score improves prediction of ... ...

Abstract	Aims: Inherited cardiomyopathies are relatively rare but carry a high risk of cardiac maternal morbidity and mortality during pregnancy and postpartum. However, data for risk stratification are scarce. The new CARPREG II score improves prediction of prognosis in pregnancies associated with heart disease, though its role in inherited cardiomyopathies is unclear. We aim to describe characteristics and cardiac maternal outcomes in patients with inherited cardiomyopathy during pregnancy, and to evaluate the interest of the CARPREG II risk score in this population. Methods and results: In this retrospective single-centre study, 90 consecutive pregnancies in 74 patients were included (mean age 32 ± 5 years), including 28 cases of dilated cardiomyopathy (DCM), 46 of hypertrophic cardiomyopathy, 11 of arrhythmogenic right ventricular cardiomyopathy and 5 of left ventricular noncompaction, excluding peripartum cardiomyopathy. The discriminatory power of several risk scores was assessed by the area under the receiver-operating characteristic curve (AUC). Median CARPREG II score was 2 [0;3] and was higher in the DCM subgroup. A severe cardiac maternal complication was observed in 18 (20%) pregnancies, mainly driven by arrhythmia and heart failure (each event in 10 pregnancies), with 3 cardiovascular deaths. Forty-three pregnancies (48%) presented foetal/neonatal complications (18 premature delivery, 3 foetal/neonatal death). CARPREG II was significantly associated with cardiac maternal complications (P < 0.05 for all) and showed a higher AUC (0.782) than CARPREG (0.755), mWHO (0.697) and ZAHARA (0.604). Conclusions: Pregnancy in women with inherited cardiomyopathy carries a high risk of maternal cardiovascular complications. CARPREG II is the most efficient predictor of cardiovascular complications in this population.
Language	English
Publishing date	2024-02-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2814355-3
ISSN	2055-5822 ; 2055-5822
ISSN (online)	2055-5822
ISSN	2055-5822
DOI	10.1002/ehf2.14694
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Article ; Online: Advanced practice physiotherapy surgical triage and management of adults with spinal disorders referred to specialized spine medical care: a retrospective observational study.

Lafrance, Simon / Desmeules, François / Charron, Maxime / Elkaim, Lior M / Fernandes, Julio / Santaguida, Carlo

Physiotherapy theory and practice

2023 Volume 40, Issue 4, Page(s) 704–713

Abstract: Introduction: In this novel advanced practice physiotherapy (APP) model of care, advanced practice physiotherapists (APPTs) assess, triage, and manage adults with spinal disorders to alleviate the growing demands in specialized spine medical care.: ... ...

Abstract	Introduction: In this novel advanced practice physiotherapy (APP) model of care, advanced practice physiotherapists (APPTs) assess, triage, and manage adults with spinal disorders to alleviate the growing demands in specialized spine medical care. Objectives: To describe this APP model of care, to assess change in disability 3 months after rehabilitation care and to assess surgical triage and diagnostic concordance between APPTs and spine surgeons. Methods: In this retrospective observational study, consecutive patients who completed the 3-month follow-up data were analyzed. Sociodemographic, clinical characteristics, and self-reported disabilities including the Oswestry Disability Index (ODI) and Neck Disability Index (NDI) at baseline and 3 months were extracted. Paired Results: In this model, trained APPTs triaged surgical candidates and provided rehabilitation care including education and exercises to patients with spinal disorders. The APPTs referred only 18/46 participants to spine surgeons. Surgical triage and diagnostic concordance were high with raw agreement of 94% and 89%. At the 3-month follow-up, significant improvements in disability were observed among nonsurgical candidates with back (mean difference (MD): -13.0/100 [95%CI: -19.8 to -6.3], n = 23) or neck disorders (MD: -16.0/100 [95%CI: -29.6 to -2.4], n = 5), but not among surgical candidates referred by APPTs to spine surgeons. Conclusion: In this limited sample, adults with spinal disorders that were initially referred to a spine surgeon by family physicians were effectively assessed, triaged, and managed by an APPT.
MeSH term(s)	Adult ; Humans ; Triage ; Spinal Diseases/surgery ; Spine ; Exercise Therapy ; Retrospective Studies
Language	English
Publishing date	2023-01-03
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	1045333-7
ISSN	1532-5040 ; 0959-3985
ISSN (online)	1532-5040
ISSN	0959-3985
DOI	10.1080/09593985.2022.2158699
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Article ; Online: Complete Genome Sequence of a Canadian Strain of Escherichia coli with Multiple Metal and Antimicrobial Resistance Genes That Was Isolated from Municipal Biosolids.

Kang, Mingsong / Charron, Philippe / Hoover, Emily / Guan, Jiewen / Firth, Isaac / Naushad, Sohail / Huang, Hongsheng

Microbiology resource announcements

2023 Volume 12, Issue 5, Page(s) e0008323

Abstract: This announcement reports the complete genome sequence of a non-Shiga toxin-producing Escherichia coli strain that was isolated from municipal biosolids collected from a Canadian wastewater treatment plant. This strain contains multiple metal, ... ...

Abstract	This announcement reports the complete genome sequence of a non-Shiga toxin-producing Escherichia coli strain that was isolated from municipal biosolids collected from a Canadian wastewater treatment plant. This strain contains multiple metal, antimicrobial, and heat resistance genes, as determined by genome sequencing, and could be a useful bacterial model for future studies.
Language	English
Publishing date	2023-04-17
Publishing country	United States
Document type	Journal Article
ISSN	2576-098X
ISSN (online)	2576-098X
DOI	10.1128/mra.00083-23
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Article ; Online: Fetal Growth and Intrauterine Epigenetic Programming of Obesity and Cardiometabolic Disease.

Harary, David / Akinyemi, Ayodele / Charron, Maureen J / Fuloria, Mamta

NeoReviews

2022 Volume 23, Issue 6, Page(s) e363–e372

Abstract: Epidemiologic studies have shown an association between an adverse intrauterine environment (eg, exposure to malnutrition) and an increased risk of developing cardiometabolic disease in adulthood. These studies laid the foundation for the developmental ... ...

Abstract	Epidemiologic studies have shown an association between an adverse intrauterine environment (eg, exposure to malnutrition) and an increased risk of developing cardiometabolic disease in adulthood. These studies laid the foundation for the developmental origins of health and disease hypothesis, which states that limited nutrient supply to the fetus results in physiologic and metabolic adaptations that favor survival but result in unfavorable consequences in the offspring if there is excess nutrition after birth. This discrepancy in the pre- and postnatal milieus, perceived as stress by the offspring, may confer an increased risk of developing cardiometabolic disease later in life. Thus, early life exposures result in programming or changes in cellular memory that have effects on health throughout the life course. One of the mechanisms by which programming occurs is via epigenetic modifications of genes, processes that result in functionally relevant changes in genes (ie, gene expression) without an alteration in the genotype. In this review, we will describe how fetal exposures, including under- and overnutrition, affect neonatal and childhood growth and the future risk for cardiometabolic disease.
MeSH term(s)	Adult ; Cardiovascular Diseases/complications ; Cardiovascular Diseases/genetics ; Child ; Epigenesis, Genetic ; Female ; Fetal Development/genetics ; Humans ; Infant, Newborn ; Obesity ; Prenatal Exposure Delayed Effects/genetics
Language	English
Publishing date	2022-05-31
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1526-9906
ISSN (online)	1526-9906
DOI	10.1542/neo.23-6-e363
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Article: Body Composition and Maximal Strength of Powerlifters: A Descriptive Quantitative and Longitudinal Study.

Ferland, Pierre-Marc / Charron, Jeremie / Brisebois-Boies, Mathieu / Miron, Fanie St-Jean / Comtois, Alain Steve

International journal of exercise science

2023 Volume 16, Issue 4, Page(s) 828–845

Abstract: ... on body composition. Thirty-four (age = 28.8 ± 8.7 yrs) classic powerlifters (M = 21; F = 13) completed at least one ...

Abstract	The purpose of this study was to present the relationships between maximal strength and body composition and to conduct yearly follow-ups presenting the chronic effects of maximal strength training on body composition. Thirty-four (age = 28.8 ± 8.7 yrs) classic powerlifters (M = 21; F = 13) completed at least one Dual-Energy X-Ray Absorptiometry (DXA) 43.97 ± 23.93 days after a sanctioned international powerlifting federation affiliate competition (Squat + Bench Press + Deadlift = Total (kg)). In addition, thirteen subjects (
Language	English
Publishing date	2023-07-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2411342-6
ISSN	1939-795X
ISSN	1939-795X
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Article ; Online: Fecal Metabolites as Biomarkers for Predicting Food Intake by Healthy Adults.

Shinn, Leila M / Mansharamani, Aditya / Baer, David J / Novotny, Janet A / Charron, Craig S / Khan, Naiman A / Zhu, Ruoqing / Holscher, Hannah D

The Journal of nutrition

2023 Volume 152, Issue 12, Page(s) 2956–2965

Abstract: Background: The fecal metabolome is affected by diet and includes metabolites generated by human and microbial metabolism. Advances in -omics technologies and analytic approaches have allowed researchers to identify metabolites and better utilize large ... ...

Abstract	Background: The fecal metabolome is affected by diet and includes metabolites generated by human and microbial metabolism. Advances in -omics technologies and analytic approaches have allowed researchers to identify metabolites and better utilize large data sets to generate usable information. One promising aspect of these advancements is the ability to determine objective biomarkers of food intake. Objectives: We aimed to utilize a multivariate, machine learning approach to identify metabolite biomarkers that accurately predict food intake. Methods: Data were aggregated from 5 controlled feeding studies in adults that tested the impact of specific foods (almonds, avocados, broccoli, walnuts, barley, and oats) on the gastrointestinal microbiota. Fecal samples underwent GC-MS metabolomic analysis; 344 metabolites were detected in preintervention samples, whereas 307 metabolites were detected postintervention. After removing metabolites that were only detected in either pre- or postintervention and those undetectable in ≥80% of samples in all study groups, changes in 96 metabolites relative concentrations (treatment postintervention minus preintervention) were utilized in random forest models to 1) examine the relation between food consumption and fecal metabolome changes and 2) rank the fecal metabolites by their predictive power (i.e., feature importance score). Results: Using the change in relative concentration of 96 fecal metabolites, 6 single-food random forest models for almond, avocado, broccoli, walnuts, whole-grain barley, and whole-grain oats revealed prediction accuracies between 47% and 89%. When comparing foods with one another, almond intake was differentiated from walnut intake with 91% classification accuracy. Conclusions: Our findings reveal promise in utilizing fecal metabolites as objective complements to certain self-reported food intake estimates. Future research on other foods at different doses and dietary patterns is needed to identify biomarkers that can be applied in feeding study compliance and clinical settings.
MeSH term(s)	Humans ; Adult ; Diet ; Metabolomics/methods ; Metabolome ; Juglans ; Edible Grain ; Biomarkers ; Eating
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-10-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	218373-0
ISSN	1541-6100 ; 0022-3166
ISSN (online)	1541-6100
ISSN	0022-3166
DOI	10.1093/jn/nxac195
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Article ; Online: Fecal Metagenomics to Identify Biomarkers of Food Intake in Healthy Adults: Findings from Randomized, Controlled, Nutrition Trials.

Shinn, Leila M / Mansharamani, Aditya / Baer, David J / Novotny, Janet A / Charron, Craig S / Khan, Naiman A / Zhu, Ruoqing / Holscher, Hannah D

The Journal of nutrition

2023 Volume 154, Issue 1, Page(s) 271–283

Abstract: Background: Undigested components of the human diet affect the composition and function of the microorganisms present in the gastrointestinal tract. Techniques like metagenomic analyses allow researchers to study functional capacity, thus revealing the ... ...

Abstract	Background: Undigested components of the human diet affect the composition and function of the microorganisms present in the gastrointestinal tract. Techniques like metagenomic analyses allow researchers to study functional capacity, thus revealing the potential of using metagenomic data for developing objective biomarkers of food intake. Objectives: As a continuation of our previous work using 16S and metabolomic datasets, we aimed to utilize a computationally intensive, multivariate, machine-learning approach to identify fecal KEGG (Kyoto encyclopedia of genes and genomes) Orthology (KO) categories as biomarkers that accurately classify food intake. Methods: Data were aggregated from 5 controlled feeding studies that studied the individual impact of almonds, avocados, broccoli, walnuts, barley, and oats on the adult gastrointestinal microbiota. Deoxyribonucleic acid from preintervention and postintervention fecal samples underwent shotgun genomic sequencing. After preprocessing, sequences were aligned and functionally annotated with Double Index AlignMent Of Next-generation sequencing Data v2.0.11.149 and MEtaGenome ANalyzer v6.12.2, respectively. After the count normalization, the log of the fold change ratio for resulting KOs between pre- and postintervention of the treatment group against its corresponding control was utilized to conduct differential abundance analysis. Differentially abundant KOs were used to train machine-learning models examining potential biomarkers in both single-food and multi-food models. Results: We identified differentially abundant KOs in the almond (n = 54), broccoli (n = 2474), and walnut (n = 732) groups (q < 0.20), which demonstrated classification accuracies of 80%, 87%, and 86% for the almond, broccoli, and walnut groups using a random forest model to classify food intake into each food group's respective treatment and control arms, respectively. The mixed-food random forest achieved 81% accuracy. Conclusions: Our findings reveal promise in utilizing fecal metagenomics to objectively complement self-reported measures of food intake. Future research on various foods and dietary patterns will expand these exploratory analyses for eventual use in feeding study compliance and clinical settings.
MeSH term(s)	Adult ; Humans ; Gastrointestinal Microbiome ; Metagenome ; Diet ; Juglans ; Feces ; Biomarkers ; Eating ; Metagenomics/methods
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-11-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218373-0
ISSN	1541-6100 ; 0022-3166
ISSN (online)	1541-6100
ISSN	0022-3166
DOI	10.1016/j.tjnut.2023.11.001
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Article ; Online: Regional estimation of river water temperature at ungauged locations

Taha B.M.J. Ouarda / Christian Charron / André St-Hilaire

Journal of Hydrology X, Vol 17, Iss , Pp 100133- (2022)

2022

Abstract: River water temperature measurement networks suffer from an inadequate spatial coverage and a lack of data. No methods exist for the regional estimation of river water temperature at ungauged sites based on data series from gauged sites. The development ... ...

Abstract	River water temperature measurement networks suffer from an inadequate spatial coverage and a lack of data. No methods exist for the regional estimation of river water temperature at ungauged sites based on data series from gauged sites. The development of such methods is hence of significant importance. It is proposed in this study to develop a Temperature-Duration-Curve (TDC) based method to estimate river water temperature at ungauged sites on a real-time basis. A Generalised Additive Model (GAM) based method is used to estimate TDCs at ungauged sites. The estimated TDCs are then used in combination with a spatial interpolation method to obtain daily temperature estimates at ungauged sites. Results are compared with a simple method based on the geographical distance weighted average of neighboring stations. The approaches are applied to 126 river thermal stations located on Atlantic salmon rivers in eastern Canada. Leave-one-out cross validation results indicate that the TDC based methods are robust and outperform the geographical distance weighted method.
Keywords	River water temperature ; Regionalization ; Temperature duration curve ; GAM ; Spatial interpolation ; Ungauged site ; Environmental engineering ; TA170-171 ; Environmental sciences ; GE1-350
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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