Article: GLYCOSAMINOGLYCANS AND PROTEOGLYCANS IN PALMAR FASCIA OF PATIENTS WITH DUPUYTREN.
2015 Volume 24, Issue 2, Page(s) 98–101
Abstract: Objective: : To evaluate and compare the behavior of glycosaminoglycans (GAGs) in Dupuytren disease (DD).: Methods: : This is an experimental study with 23 patients diagnosed with DD. Tissue collected through fasciectomy with incision type Brunner or ...
| Abstract | Objective: : To evaluate and compare the behavior of glycosaminoglycans (GAGs) in Dupuytren disease (DD). Methods: : This is an experimental study with 23 patients diagnosed with DD. Tissue collected through fasciectomy with incision type Brunner or McCash were evaluated by electrophoresis for identification of GAGs. The quantification was carried out by immunofluorescence and dosage of proteins for different types of glycosaminoglycans. The results were expressed in percentage and statistically evaluated. Results: : A significant increase was observed through eletrophoresis in GAGs, as compared to the control (p<0.05). Immunofluorescence of hyaluronic acid was reduced (23 times) when compared to the control (p<0.0001). Conclusion: : An increase of sulfated GAGs in Dupuytren's disease, mainly dermatan sulfate, was evident from our results, as well as a pronounced decrease of hyaluronic acid in the palmar aponeurosis from the same patients. Level of Evidence III, Case-Control Study. |
|---|---|
| Language | English |
| Publishing date | 2015-08-01 |
| Publishing country | Brazil |
| Document type | Journal Article |
| ZDB-ID | 2105206-2 |
| ISSN | 1809-4406 ; 1413-7852 |
| ISSN (online) | 1809-4406 |
| ISSN | 1413-7852 |
| DOI | 10.1590/1413-785220162402154342 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.