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  1. Article: Deciphering Latent Health Information in Social Media Using a Mixed-Methods Design.

    Shaw, George / Zimmerman, Margaret / Vasquez-Huot, Ligia / Karami, Amir

    Healthcare (Basel, Switzerland)

    2022  Volume 10, Issue 11

    Abstract: Natural language processing techniques have increased the volume and variety of text data that can be analyzed. The aim of this study was to identify the positive and negative topical sentiments among diet, diabetes, exercise, and obesity tweets. Using a ...

    Abstract Natural language processing techniques have increased the volume and variety of text data that can be analyzed. The aim of this study was to identify the positive and negative topical sentiments among diet, diabetes, exercise, and obesity tweets. Using a sequential explanatory mixed-method design for our analytical framework, we analyzed a data corpus of 1.7 million diet, diabetes, exercise, and obesity (DDEO)-related tweets collected over 12 months. Sentiment analysis and topic modeling were used to analyze the data. The results show that overall, 29% of the tweets were positive, and 17% were negative. Using sentiment analysis and latent Dirichlet allocation (LDA) topic modeling, we analyzed 800 positive and negative DDEO topics. From the 800 LDA topics-after the qualitative and computational removal of incoherent topics-473 topics were characterized as coherent. Obesity was the only query health topic with a higher percentage of negative tweets. The use of social media by public health practitioners should focus not only on the dissemination of health information based on the topics discovered but also consider what they can do for the health consumer as a result of the interaction in digital spaces such as social media. Future studies will benefit from using multiclass sentiment analysis methods associated with other novel topic modeling approaches.
    Language English
    Publishing date 2022-11-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare10112320
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  2. Article ; Online: Vitamin D analyses in veterinary feeds by gas chromatography-tandem mass spectrometry.

    Lehner, Andreas / Johnson, Margaret / Zimmerman, Alan / Zyskowski, Justin / Buchweitz, John

    European journal of mass spectrometry (Chichester, England)

    2021  Volume 27, Issue 1, Page(s) 48–62

    Abstract: This report examines the feasibility of determination of Vitamin D3, D2 and their 25-hydroxy metabolites utilizing Gas Chromatography Tandem Mass Spectrometry (GC/MS/MS) as a potential alternative to popular Liquid Chromatography Tandem Mass ... ...

    Abstract This report examines the feasibility of determination of Vitamin D3, D2 and their 25-hydroxy metabolites utilizing Gas Chromatography Tandem Mass Spectrometry (GC/MS/MS) as a potential alternative to popular Liquid Chromatography Tandem Mass Spectrometric (LC/MS/MS) methodologies. The GC/MS/MS approach was found to operate reasonably well despite long-standing concerns that gas-liquid chromatography of vitamin D compounds invoke thermal rearrangements owing to the relatively high inlet and capillary column temperatures used. The workup procedure involved incubation of feed samples with concentrated potassium hydroxide for overnight fat saponification, extraction of D Vitamins in n-hexane and reaction with N,O-bis(trimethylsilyl)trifluoroacetamide at 70 °C for 30 mins. In addition to parent compounds, small amounts of pyro-, isopyro-, and iso-vitamin D and isotachysterol3 variants were obtained from each Vitamin D-related compound upon extraction and GC/MS/MS analysis. Mass spectral and chromatographic behavior of these compounds are herein described and interpreted. Multiple Reaction Monitoring settings on GC/MS/MS included
    MeSH term(s) Animals ; Chromatography, Liquid ; Dogs ; Gas Chromatography-Mass Spectrometry ; Tandem Mass Spectrometry ; Vitamin D ; Vitamins
    Chemical Substances Vitamins ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2021-03-15
    Publishing country England
    Document type Journal Article
    ISSN 1751-6838
    ISSN (online) 1751-6838
    DOI 10.1177/14690667211000244
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  3. Article ; Online: Safety and Efficacy of Rivaroxaban and Apixaban in Patients with Increased Body Mass: a Systematic Review.

    Buck, Margaret M / Haddon, Alexa M / Paneccasio, Antonietta / Skoloda, Daniel J / Zimmerman, David E / Guarascio, Anthony J / Nemecek, Branden D / Covvey, Jordan R / Montepara, Courtney A

    Clinical drug investigation

    2021  Volume 41, Issue 4, Page(s) 353–369

    Abstract: Background and objective: Rivaroxaban and apixaban are direct oral anticoagulants increasing in popularity as convenient alternatives to warfarin. However, current guidelines recommend against use in patients with a BMI > 40 kg/m: Methods: A ... ...

    Abstract Background and objective: Rivaroxaban and apixaban are direct oral anticoagulants increasing in popularity as convenient alternatives to warfarin. However, current guidelines recommend against use in patients with a BMI > 40 kg/m
    Methods: A systematic literature review (guided by PRISMA) was performed through January 27, 2021 using PubMed, Embase, and Scopus. Key search term clusters included drug and weight-related concepts (overweight/obese, body mass index [BMI], waist circumference). DistillerSR was utilized to review and process search results. Studies met inclusion if they analyzed the risk of bleeding and/or thrombosis in patients with increased body mass (i.e., via BMI or other criteria) receiving rivaroxaban or apixaban. Clinical guidelines, case reports/series, pharmacokinetic/dynamic analyses, and commentaries were excluded. Bias was examined qualitatively across studies.
    Results: After duplicates were removed, the original search rendered 1822 abstracts and 200 full-texts for screening, ultimately providing a final set of 24 studies for qualitative review. Of these studies, 13 (54.2%) enabled comparisons between patients of increased versus normal body mass, while 11 (45.8%) reported outcomes only for patients of increased body mass. The working definition of 'increased body mass' varied amongst the studies, including 11 (45.8%) studies that utilized BMI, seven (29.2%) with a combination of BMI and body measurement, two (8.3%) that relied on body weight alone, and four (16.7%) that identified obesity-related ICD codes. All 13 comparative studies found similar or reduced rates of safety and efficacy outcomes with rivaroxaban and apixaban.
    Conclusion: The literature reports similar or lower bleeding and thrombotic risk for rivaroxaban and apixaban in patients of increased body mass compared to patients of normal body mass. Future prospective controlled studies are needed to further define guidelines for use in this population.
    MeSH term(s) Administration, Oral ; Anticoagulants/therapeutic use ; Atrial Fibrillation/drug therapy ; Body Mass Index ; Hemorrhage/chemically induced ; Humans ; Pyrazoles/administration & dosage ; Pyridones/administration & dosage ; Rivaroxaban/therapeutic use ; Warfarin/therapeutic use
    Chemical Substances Anticoagulants ; Pyrazoles ; Pyridones ; apixaban (3Z9Y7UWC1J) ; Warfarin (5Q7ZVV76EI) ; Rivaroxaban (9NDF7JZ4M3)
    Language English
    Publishing date 2021-03-07
    Publishing country New Zealand
    Document type Systematic Review
    ZDB-ID 1220136-4
    ISSN 1179-1918 ; 0114-2402 ; 1173-2563
    ISSN (online) 1179-1918
    ISSN 0114-2402 ; 1173-2563
    DOI 10.1007/s40261-021-01019-4
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  4. Article ; Online: Inconsistent blood pressure phenotype in female Dahl salt-sensitive rats.

    Zimmerman, Margaret A / Lindsey, Sarah H

    American journal of physiology. Renal physiology

    2016  Volume 311, Issue 6, Page(s) F1391–F1392

    MeSH term(s) Animals ; Blood Pressure ; Female ; Humans ; Hypertension ; Phenotype ; Rats ; Rats, Inbred Dahl
    Language English
    Publishing date 2016-12-12
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00454.2016
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  5. Article ; Online: Pediatric Critical Care in the Twenty-first Century and Beyond.

    Dahmer, Mary / Jennings, Aimee / Parker, Margaret / Sanchez-Pinto, Lazaro N / Thompson, Ann / Traube, Chani / Zimmerman, Jerry J

    Critical care clinics

    2022  Volume 39, Issue 2, Page(s) 407–425

    Abstract: Pediatric critical care addresses prevention, diagnosis, and treatment of organ dysfunction in the setting of increasingly complex patients, therapies, and environments. Soon burgeoning data science will enable all aspects of intensive care: driving ... ...

    Abstract Pediatric critical care addresses prevention, diagnosis, and treatment of organ dysfunction in the setting of increasingly complex patients, therapies, and environments. Soon burgeoning data science will enable all aspects of intensive care: driving facilitated diagnostics, empowering a learning health-care environment, promoting continuous advancement of care, and informing the continuum of critical care outside the intensive care unit preceding and following critical illness/injury. Although novel technology will progressively objectify personalized critical care, humanism, practiced at the bedside, defines the essence of pediatric critical care now and in the future.
    MeSH term(s) Humans ; Child ; Critical Care ; Intensive Care Units ; Critical Illness ; Intensive Care Units, Pediatric
    Language English
    Publishing date 2022-11-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1006423-0
    ISSN 1557-8232 ; 0749-0704
    ISSN (online) 1557-8232
    ISSN 0749-0704
    DOI 10.1016/j.ccc.2022.09.013
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  6. Article ; Online: Fibrinogen consumption and use of heparin are risk factors for delayed bleeding during acute promyelocytic leukemia induction.

    Hambley, Bryan C / Norsworthy, Kelly J / Jasem, Jagar / Zimmerman, Jacquelyn W / Shenderov, Eugene / Webster, Jonathan A / Showel, Margaret M / Gondek, Lukasz P / Dalton, William B / Prince, Gabrielle / Gladstone, Douglas E / Streiff, Michael B / Pratz, Keith W / Gojo, Ivana / Ghiaur, Gabriel / Levis, Mark J / Smith, B Douglas / DeZern, Amy E

    Leukemia research

    2019  Volume 83, Page(s) 106174

    MeSH term(s) Adult ; Aged ; Female ; Fibrinogen/metabolism ; Hemorrhage/blood ; Hemorrhage/drug therapy ; Hemorrhage/mortality ; Heparin/administration & dosage ; Humans ; Leukemia, Promyelocytic, Acute/blood ; Leukemia, Promyelocytic, Acute/drug therapy ; Leukemia, Promyelocytic, Acute/mortality ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors
    Chemical Substances Fibrinogen (9001-32-5) ; Heparin (9005-49-6)
    Language English
    Publishing date 2019-06-21
    Publishing country England
    Document type Clinical Trial ; Letter
    ZDB-ID 752396-8
    ISSN 1873-5835 ; 0145-2126
    ISSN (online) 1873-5835
    ISSN 0145-2126
    DOI 10.1016/j.leukres.2019.106174
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  7. Article ; Online: A critical role for staphylococcal nitric oxide synthase in controlling flavohemoglobin toxicity.

    Singh, Ryan M / Chaudhari, Sujata S / Panda, Sasmita / Hutfless, Elizabeth H / Heim, Cortney E / Shinde, Dhananjay / Alqarzaee, Abdulelah A / Sladek, Margaret / Kumar, Vineet / Zimmerman, Matthew C / Fey, Paul D / Kielian, Tammy / Thomas, Vinai C

    Redox biology

    2023  Volume 67, Page(s) 102935

    Abstract: Most coagulase-negative staphylococcal species, including the opportunistic pathogen Staphylococcus epidermidis, struggle to maintain redox homeostasis and grow under nitrosative stress. Under these conditions, growth can only resume once nitric oxide ( ... ...

    Abstract Most coagulase-negative staphylococcal species, including the opportunistic pathogen Staphylococcus epidermidis, struggle to maintain redox homeostasis and grow under nitrosative stress. Under these conditions, growth can only resume once nitric oxide (NO) is detoxified by the flavohemoglobin Hmp. Paradoxically, S. epidermidis produces endogenous NO through its genetically encoded nitric oxide synthase (seNOS) and heavily relies on its activity for growth. In this study, we investigate the basis of the growth advantage attributed to seNOS activity. Our findings reveal that seNOS supports growth by countering Hmp toxicity. S. epidermidis relies on Hmp activity for its survival in the host under NO stress. However, in the absence of nitrosative stress, Hmp generates significant amounts of the harmful superoxide radical (O
    MeSH term(s) Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Oxidative Stress ; Nitric Oxide Synthase/metabolism ; Oxidation-Reduction ; Nitric Oxide/metabolism
    Chemical Substances Bacterial Proteins ; Nitric Oxide Synthase (EC 1.14.13.39) ; Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2023-10-16
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2701011-9
    ISSN 2213-2317 ; 2213-2317
    ISSN (online) 2213-2317
    ISSN 2213-2317
    DOI 10.1016/j.redox.2023.102935
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  8. Article ; Online: Hypertension: what's sex got to do with it?

    Zimmerman, Margaret A / Sullivan, Jennifer C

    Physiology (Bethesda, Md.)

    2013  Volume 28, Issue 4, Page(s) 234–244

    Abstract: Hypertension is a complex and multifaceted disease, and there are well established sex differences in many aspects of blood pressure (BP) control. The intent of this review is to highlight recent work examining sex differences in the molecular mechanisms ...

    Abstract Hypertension is a complex and multifaceted disease, and there are well established sex differences in many aspects of blood pressure (BP) control. The intent of this review is to highlight recent work examining sex differences in the molecular mechanisms of BP control in hypertension to assess whether the "one-size-fits-all" approach to BP control is appropriate with regard to sex.
    MeSH term(s) Animals ; Antihypertensive Agents/therapeutic use ; Blood Pressure/physiology ; Disease Models, Animal ; Female ; Humans ; Hypertension/drug therapy ; Hypertension/epidemiology ; Hypertension/physiopathology ; Male ; Risk Factors ; Sex Factors ; Treatment Outcome
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2013-06-28
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2158667-6
    ISSN 1548-9221 ; 1548-9213
    ISSN (online) 1548-9221
    ISSN 1548-9213
    DOI 10.1152/physiol.00013.2013
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  9. Article: Data to knowledge: how to get meaning from your result.

    Berman, Helen M / Gabanyi, Margaret J / Groom, Colin R / Johnson, John E / Murshudov, Garib N / Nicholls, Robert A / Reddy, Vijay / Schwede, Torsten / Zimmerman, Matthew D / Westbrook, John / Minor, Wladek

    IUCrJ

    2015  Volume 2, Issue Pt 1, Page(s) 45–58

    Abstract: Structural and functional studies require the development of sophisticated 'Big Data' technologies and software to increase the knowledge derived and ensure reproducibility of the data. This paper presents summaries of the Structural Biology Knowledge ... ...

    Abstract Structural and functional studies require the development of sophisticated 'Big Data' technologies and software to increase the knowledge derived and ensure reproducibility of the data. This paper presents summaries of the Structural Biology Knowledge Base, the VIPERdb Virus Structure Database, evaluation of homology modeling by the Protein Model Portal, the ProSMART tool for conformation-independent structure comparison, the LabDB 'super' laboratory information management system and the Cambridge Structural Database. These techniques and technologies represent important tools for the transformation of crystallographic data into knowledge and information, in an effort to address the problem of non-reproducibility of experimental results.
    Language English
    Publishing date 2015-01-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2754953-7
    ISSN 2052-2525
    ISSN 2052-2525
    DOI 10.1107/S2052252514023306
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  10. Article ; Online: Data Science for the Transformation of Environmental and Chemical Research and Development.

    Ren, Zhiyong Jason / Lowry, Gregory V / Arnold, William A / Brooks, Bryan W / Gago-Ferrero, Pablo / Garcia, Jeannette M / Leonard, Kevin C / Mills, Margaret / Serrano, Julio F / Wang, Shuxiao / Zimmerman, Julie B

    Environmental science & technology

    2022  Volume 57, Issue 46, Page(s) 17663–17664

    MeSH term(s) Data Science ; Research
    Language English
    Publishing date 2022-10-25
    Publishing country United States
    Document type Editorial
    ISSN 1520-5851
    ISSN (online) 1520-5851
    DOI 10.1021/acs.est.2c07679
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