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  1. Book: Rab GTPases

    Li, Guangpu / Segev, Nava

    methods and protocols

    (Methods in molecular biology ; 2293 ; Springer protocols)

    2021  

    Author's details edited by Guangpu Li, Nava Segev
    Series title Methods in molecular biology ; 2293
    Springer protocols
    Collection
    Language English
    Size XII, 310 Seiten, Illustrationen
    Edition Second edition
    Publisher Humana Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT021073525
    ISBN 978-1-0716-1345-0 ; 9781071613467 ; 1-0716-1345-6 ; 1071613464
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 7042 -2293- verfügbar in Königswinter Königswinter

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  2. Book: Trafficking inside cells

    Segev, Nava

    pathways, mechanisms and regulation

    (Molecular biology intelligence unit)

    2009  

    Author's details Nava Segev [ed.]
    Series title Molecular biology intelligence unit
    Keywords Protein Transport ; Cell Membrane / metabolism ; Cell Physiological Process ; Signal Transduction
    Language English
    Size XIX, 445 S. : Ill., 235 mm x 155 mm
    Publisher Landes Bioscience ; Springer Science+Business Media
    Publishing place Austin, Tex ; New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT016141901
    ISBN 978-0-387-93876-9 ; 0-387-93876-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 5773 order for loan Magazin

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  3. Article ; Online: ESCRTing proteasomes to the lysosome.

    Segev, Nava

    PLoS genetics

    2020  Volume 16, Issue 3, Page(s) e1008631

    MeSH term(s) AMP-Activated Protein Kinases ; Endosomal Sorting Complexes Required for Transport ; Glucose ; Lysosomes ; Microautophagy ; Proteasome Endopeptidase Complex
    Chemical Substances Endosomal Sorting Complexes Required for Transport ; AMP-Activated Protein Kinases (EC 2.7.11.31) ; Proteasome Endopeptidase Complex (EC 3.4.25.1) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2020-03-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2186725-2
    ISSN 1553-7404 ; 1553-7390
    ISSN (online) 1553-7404
    ISSN 1553-7390
    DOI 10.1371/journal.pgen.1008631
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Newer Methods Drive Recent Insights into Rab GTPase Biology: An Overview.

    Li, Guangpu / Segev, Nava

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2293, Page(s) 1–18

    Abstract: The conserved Ypt/Rab GTPases regulate all major intracellular protein traffic pathways, including secretion, endocytosis and autophagy. These GTPases undergo distinct changes in conformation between their GTP- and GDP-bound forms and cycle between the ... ...

    Abstract The conserved Ypt/Rab GTPases regulate all major intracellular protein traffic pathways, including secretion, endocytosis and autophagy. These GTPases undergo distinct changes in conformation between their GTP- and GDP-bound forms and cycle between the cytoplasm and membranes with the aid of their upstream regulators. When activated on the membrane in the GTP-bound form, they recruit their downstream effectors, which include components of vesicular transport. Progress in the past 5 years regarding mechanisms of Rab action, functions, and the effects of disruption of these functions on the well-being of cells and organisms has been propelled by advances in methodologies in molecular and cellular biology. Here, we highlight methods used recently to analyze regulation, localization, interactions, and function of Rab GTPases and their roles in human disease. We discuss contributions of these methods to new insights into Rabs, as well as their future use in addressing open questions in the field of Rab biology.
    MeSH term(s) Biological Transport ; Biology ; Endocytosis ; Guanosine Triphosphate ; Humans ; rab GTP-Binding Proteins/genetics ; rab GTP-Binding Proteins/metabolism
    Chemical Substances Guanosine Triphosphate (86-01-1) ; rab GTP-Binding Proteins (EC 3.6.5.2)
    Language English
    Publishing date 2021-08-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1346-7_1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: A note from the Editor-in-Chief.

    Segev, Nava

    Cellular logistics

    2012  Volume 2, Issue 4, Page(s) 175

    Language English
    Publishing date 2012-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2682440-1
    ISSN 2159-2799 ; 2159-2780
    ISSN (online) 2159-2799
    ISSN 2159-2780
    DOI 10.4161/cl.24015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: A note from the Editor-in-Chief.

    Segev, Nava

    Cellular logistics

    2012  Volume 2, Issue 1, Page(s) 1

    Language English
    Publishing date 2012-05-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2682440-1
    ISSN 2159-2799 ; 2159-2780
    ISSN (online) 2159-2799
    ISSN 2159-2780
    DOI 10.4161/cl.20234
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: A note from the Editor-in-Chief.

    Segev, Nava

    Cellular logistics

    2012  Volume 2, Issue 3, Page(s) 137

    Language English
    Publishing date 2012-11-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2682440-1
    ISSN 2159-2799 ; 2159-2780
    ISSN (online) 2159-2799
    ISSN 2159-2780
    DOI 10.4161/cl.22643
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: A note from the Editor-in-Chief.

    Segev, Nava

    Cellular logistics

    2012  Volume 2, Issue 2, Page(s) 53

    Language English
    Publishing date 2012-06-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2682440-1
    ISSN 2159-2799 ; 2159-2780
    ISSN (online) 2159-2799
    ISSN 2159-2780
    DOI 10.4161/cl.22029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Dual function of Rab1A in secretion and autophagy: hypervariable domain dependence.

    Gyurkovska, Valeriya / Murtazina, Rakhilya / Zhao, Sarah F / Shikano, Sojin / Okamoto, Yukari / Segev, Nava

    Life science alliance

    2023  Volume 6, Issue 5

    Abstract: We currently understand how the different intracellular pathways, secretion, endocytosis, and autophagy are regulated by small GTPases. In contrast, it is unclear how these pathways are coordinated to ensure efficient cellular response to stress. Rab ... ...

    Abstract We currently understand how the different intracellular pathways, secretion, endocytosis, and autophagy are regulated by small GTPases. In contrast, it is unclear how these pathways are coordinated to ensure efficient cellular response to stress. Rab GTPases localize to specific organelles through their hypervariable domain (HVD) to regulate discrete steps of individual pathways. Here, we explored the dual role of Rab1A/B (92% identity) in secretion and autophagy. We show that although either Rab1A or Rab1B is required for secretion, Rab1A, but not Rab1B, localizes to autophagosomes and is required early in stress-induced autophagy. Moreover, replacing the HVD of Rab1B with that of Rab1A enables Rab1B to localize to autophagosomes and regulate autophagy. Therefore, Rab1A-HVD is required for the dual functionality of a single Rab in two different pathways: secretion and autophagy. In addition to this mechanistic insight, these findings are relevant to human health because both the pathways and Rab1A/B were implicated in diseases ranging from cancer to neurodegeneration.
    MeSH term(s) Humans ; rab1 GTP-Binding Proteins/genetics ; rab1 GTP-Binding Proteins/metabolism ; Autophagy ; rab GTP-Binding Proteins/metabolism ; Autophagosomes/metabolism
    Chemical Substances rab1 GTP-Binding Proteins (EC 3.6.5.2) ; rab GTP-Binding Proteins (EC 3.6.5.2)
    Language English
    Publishing date 2023-02-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2575-1077
    ISSN (online) 2575-1077
    DOI 10.26508/lsa.202201810
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Focusing on Arf GAPs.

    Segev, Nava

    Cellular logistics

    2011  Volume 1, Issue 2, Page(s) 47–48

    Language English
    Publishing date 2011-05-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2682440-1
    ISSN 2159-2799 ; 2159-2780
    ISSN (online) 2159-2799
    ISSN 2159-2780
    DOI 10.4161/cl.1.2.15738
    Database MEDical Literature Analysis and Retrieval System OnLINE

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