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Article ; Online: Delayed Versus Immediate Start of Chemotherapy in Asymptomatic Patients With Advanced Cancer: A Meta-Analysis.

Augustinus, Simone / Thurairajah, Gajanan / Besselink, Marc G / van Laarhoven, Hanneke W M / van Oijen, Martijn G H / Mackay, Tara M / Wilmink, Johanna W

The oncologist

2023 Volume 28, Issue 11, Page(s) 961–968

Abstract: Background: Due to increased use of imaging, advanced stages of cancer are increasingly being diagnosed in an early, asymptomatic phase. Traditionally, chemotherapy is started immediately in these patients. However, a strategy wherein chemotherapy is ... ...

Abstract	Background: Due to increased use of imaging, advanced stages of cancer are increasingly being diagnosed in an early, asymptomatic phase. Traditionally, chemotherapy is started immediately in these patients. However, a strategy wherein chemotherapy is withheld until symptoms occur may be beneficial for patients in terms of quality of life (QOL). A systematic review regarding optimal timing of chemotherapy including survival and QOL is lacking. Methods: We systematically searched PubMed, EMBASE, and Cochrane for studies investigating the timing of start of chemotherapy in asymptomatic patients with advanced cancer. Overall survival (OS) was abstracted as primary, QOL, and toxicity as secondary outcomes. A meta-analysis was performed on OS. QOL was described using the global health status derived from the EORTC-QLQ-C30 questionnaire and toxicity as grade 3-4 adverse events. Results: Overall, 919 patients from 4 randomized controlled trials and 1 retrospective study were included. The included studies investigated colorectal cancer (n = 3), ovarian cancer (n = 1), and gastric cancer (n = 1). Pooled analysis demonstrated no significant differences in OS between delayed and immediate start of chemotherapy (pooled HR: 1.05, 95% CI, 0.90-1.22, P = .52). QOL, evaluated in 3 studies, suggested a better QOL in the delayed treatment group. Toxicity, evaluated in 2 studies, did not differ significantly between groups. Conclusion: This meta-analysis confirms the need for prospective studies on timing of start of chemotherapy in asymptomatic patients with advanced cancer. The limited evidence available suggests that delayed start of chemotherapy, once symptoms occur, as compared to immediate start in asymptomatic patients does not worsen OS while it may preserve QOL.
MeSH term(s)	Female ; Humans ; Quality of Life ; Prospective Studies ; Retrospective Studies ; Stomach Neoplasms ; Ovarian Neoplasms
Language	English
Publishing date	2023-08-16
Publishing country	England
Document type	Systematic Review ; Meta-Analysis ; Journal Article
ZDB-ID	1409038-7
ISSN	1549-490X ; 1083-7159
ISSN (online)	1549-490X
ISSN	1083-7159
DOI	10.1093/oncolo/oyad235
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Zs.A 4845: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 494: Show issues

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Article ; Online: The association between wearable device metrics and clinical outcomes in oncology: A systematic review with evidence synthesis and meta-analysis.

Kos, Milan / Brouwer, Calvin G / van Laarhoven, Hanneke W M / Hopman, Maria T E / van Oijen, Martijn G H / Buffart, Laurien M

Critical reviews in oncology/hematology

2023 Volume 185, Page(s) 103979

Abstract: Background: The emerging study of wearable devices (WDs) in patients with cancer provides opportunities to harness real-time patient data for predicting clinical outcomes. We conducted a systematic review with best evidence synthesis to examine the ... ...

Abstract	Background: The emerging study of wearable devices (WDs) in patients with cancer provides opportunities to harness real-time patient data for predicting clinical outcomes. We conducted a systematic review with best evidence synthesis to examine the association between WD metrics and clinical outcomes in patients with cancer. Methods: MEDLINE and Embase were searched from inception until June 2022. Risk of bias assessment and best evidence synthesis were performed and, If possible, meta-analysis was conducted. Results: A total of 34 studies was included. We found moderate-to-strong evidence for associations between circadian rest-activity metrics and OS. Disrupted I<O was associated with increased hazard for death (HR 2.08; 95 %CI: 1.50-2.88). For most associations there was insufficient evidence due to lack of studies (n = 32) or inconsistent results (n = 14).<br />Conclusion: Meta-analysis was greatly hampered due to heterogeneity and different methodology used between studies. Studies primarily designed to investigate the association between WD metrics and clinical outcomes are warranted.
MeSH term(s)	Humans ; Benchmarking ; Neoplasms/therapy ; Wearable Electronic Devices
Language	English
Publishing date	2023-03-30
Publishing country	Netherlands
Document type	Systematic Review ; Meta-Analysis ; Journal Article ; Review
ZDB-ID	605680-5
ISSN	1879-0461 ; 0737-9587 ; 1040-8428
ISSN (online)	1879-0461
ISSN	0737-9587 ; 1040-8428
DOI	10.1016/j.critrevonc.2023.103979
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Zs.A 1931: Show issues

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Article ; Online: Time to reimbursement of novel anticancer drugs in Europe: a case study of seven European countries.

Post, H C / Schutte, T / van Oijen, M G H / van Laarhoven, H W M / Hollak, C E M

ESMO open

2023 Volume 8, Issue 2, Page(s) 101208

Abstract: Background: Time to reimbursement (TTR) of new anticancer medicines differs between countries and contributes to unequal access. We aimed to investigate TTR of new anticancer medicines and explore factors influencing the reimbursement process in seven ... ...

Abstract	Background: Time to reimbursement (TTR) of new anticancer medicines differs between countries and contributes to unequal access. We aimed to investigate TTR of new anticancer medicines and explore factors influencing the reimbursement process in seven high-income European countries. Materials and methods: We carried out a retrospective case study of anticancer medicines with European Union Market Access (EU-MA) and a positive Committee for Medicinal Products for Human Use opinion from 2016 until 2021 with subsequent national reimbursement approval (NRA). The National Health Technology Assessment (HTA) and reimbursement websites of Germany, France, UK, the Netherlands, Belgium, Norway and Switzerland were used to identify TTR, defined as time from EU-MA to NRA. Additionally, we investigated medication-, country-, indication- and pharma-related factors potentially influencing TTR. Results: Thirty-five medicines were identified for which TTR ranged from -81 days to 2320 days (median 407 days). At data cut-off, 16 (46%) were reimbursed in all seven countries. Overall, the shortest TTR was in Germany (median 3 days, all medicines reimbursed <5 days). The time limit for reimbursement of 180 days stated by the Council of European Communities after the EU-MA (EU Transparency Directive) was met for 100% of included medicines in Germany, 51% in France, 29% in the UK and the Netherlands, 14% in Switzerland, 6% in Norway and 3% in Belgium. The TTR was significantly different between countries (P < 0.001). In multivariate analysis, factors associated with shorter TTR were higher gross domestic product (GDP), absence of a pre-assessment procedure and submission by a big pharmaceutical company. Conclusions: TTR of anticancer medicines varies significantly between seven high-income European countries and leads to inequality in access. Among explored medication-, country-, indication- and pharma-related factors we found that a high GDP, the absence of a pre-assessment procedure and submission by big pharmaceutical companies were associated with shorter TTR.
MeSH term(s)	Humans ; Retrospective Studies ; Europe ; European Union ; Antineoplastic Agents/therapeutic use ; Pharmaceutical Preparations
Chemical Substances	Antineoplastic Agents ; Pharmaceutical Preparations
Language	English
Publishing date	2023-04-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2059-7029
ISSN (online)	2059-7029
DOI	10.1016/j.esmoop.2023.101208
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Article ; Online: One Health Determinants of

Smit, Chloé C H / Lambert, Maarten / Rogers, Kris / Djordjevic, Steven P / Van Oijen, Antoine M / Keighley, Caitlin / Taxis, Katja / Robertson, Hamish / Pont, Lisa G

International journal of molecular sciences

2023 Volume 24, Issue 24

Abstract: To date, the scientific literature on health variables ... ...

Abstract	To date, the scientific literature on health variables for
MeSH term(s)	Animals ; Humans ; Escherichia coli/genetics ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; One Health ; Drug Resistance, Bacterial ; Escherichia coli Infections/drug therapy ; Escherichia coli Infections/epidemiology
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2023-12-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242417204
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Article ; Online: Regulation of T7 gp2.5 binding dynamics by its C-terminal tail, template conformation and sequence.

Xu, Longfu / Cabanas-Danés, Jordi / Halma, Matthew T J / Heller, Iddo / Stratmann, Sarah A / van Oijen, Antoine M / Lee, Seung-Joo / Peterman, Erwin J G / Wuite, Gijs J L

Nucleic acids research

2023 Volume 51, Issue 13, Page(s) 6540–6553

Abstract: Bacteriophage T7 single-stranded DNA-binding protein (gp2.5) binds to and protects transiently exposed regions of single-stranded DNA (ssDNA) while dynamically interacting with other proteins of the replication complex. We directly visualize ... ...

Abstract	Bacteriophage T7 single-stranded DNA-binding protein (gp2.5) binds to and protects transiently exposed regions of single-stranded DNA (ssDNA) while dynamically interacting with other proteins of the replication complex. We directly visualize fluorescently labelled T7 gp2.5 binding to ssDNA at the single-molecule level. Upon binding, T7 gp2.5 reduces the contour length of ssDNA by stacking nucleotides in a force-dependent manner, suggesting T7 gp2.5 suppresses the formation of secondary structure. Next, we investigate the binding dynamics of T7 gp2.5 and a deletion mutant lacking 21 C-terminal residues (gp2.5-Δ21C) under various template tensions. Our results show that the base sequence of the DNA molecule, ssDNA conformation induced by template tension, and the acidic terminal domain from T7 gp2.5 significantly impact on the DNA binding parameters of T7 gp2.5. Moreover, we uncover a unique template-catalyzed recycling behaviour of T7 gp2.5, resulting in an apparent cooperative binding to ssDNA, facilitating efficient spatial redistribution of T7 gp2.5 during the synthesis of successive Okazaki fragments. Overall, our findings reveal an efficient binding mechanism that prevents the formation of secondary structures by enabling T7 gp2.5 to rapidly rebind to nearby exposed ssDNA regions, during lagging strand DNA synthesis.
MeSH term(s)	Bacteriophage T7/genetics ; DNA/metabolism ; DNA Replication ; DNA, Single-Stranded/genetics ; DNA, Single-Stranded/metabolism ; Molecular Conformation ; Viral Proteins/metabolism
Chemical Substances	DNA (9007-49-2) ; DNA, Single-Stranded ; Viral Proteins
Language	English
Publishing date	2023-05-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gkad485
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Zs.A 1067: Show issues

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Article ; Online: Timing of start of systemic treatment in patients with asymptomatic metastasized pancreatic cancer (TIMEPAN): a protocol of a multicenter prospective patient preference non-randomized trial.

Augustinus, Simone / Broekman, Thijmen / Creemers, Geert-Jan / Daamen, Lois A / van Dieren, Susan / de Groot, Jan-Willem B / Cirkel, Geert A / Homs, Marjolein Y V / van Laarhoven, Hanneke W M / van Leeuwen, Lobke / Los, Maartje / Luelmo, Saskia A C / van Oijen, Martijn G H / Spierings, Leontine E A M / de Vos-Geelen, Judith / Besselink, Marc G / Wilmink, Johanna W

Acta oncologica (Stockholm, Sweden)

2023 Volume 62, Issue 12, Page(s) 1973–1978

MeSH term(s)	Humans ; Multicenter Studies as Topic ; Pancreas/pathology ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/pathology ; Patient Preference ; Prospective Studies ; Clinical Trials as Topic ; Pancreatic Neoplasms
Language	English
Publishing date	2023-11-25
Publishing country	England
Document type	Journal Article
ZDB-ID	896449-x
ISSN	1651-226X ; 0349-652X ; 0284-186X ; 1100-1704
ISSN (online)	1651-226X
ISSN	0349-652X ; 0284-186X ; 1100-1704
DOI	10.1080/0284186X.2023.2273898
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Zs.A 6348: Show issues

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Article: Modelling responses of forages to climate change with a focus on nutritive value

Korhonen, Panu / Bellocchi, Gianni / Van Oijen, Marcel / Palosuo, Taru

FACCE MACSUR Reports, 10:L1.2-D2

2017

Abstract: European livestock agriculture is extraordinarily diverse, and so are the challenges it faces. This diversity has contributed to the development of a fragmented set of research communities. As a result, livestock research is often under-represented at ... ...

Abstract	European livestock agriculture is extraordinarily diverse, and so are the challenges it faces. This diversity has contributed to the development of a fragmented set of research communities. As a result, livestock research is often under-represented at policy level, despite its high relevance for the environment and food security. Understanding livestock systems and how they can sustainably adapt to global change requires inputs across research areas, including grasslands, nutrition, health, welfare and ecology. It also requires experimental researchers, modellers and stakeholders to work closely together. Networks and capacity building structures are vital to enable livestock research to meet the challenges of climate change. They need to maintain shared resources and provide non-competitive arenas to share and synthesize results for policy support. Long term strategic investment is needed to support such structures. Their leadership requires very different skills to those effective in scientific project coordination.
Keywords	climate change ; grassland ; nutritive value ; process-based models ; ruminant production
Language	English
Document type	Article
DOI	10.4126/FRL01-006413069
Database	Repository for Life Sciences

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Article ; Online: Rapid Exchange of Stably Bound Protein and DNA Cargo on a DNA Origami Receptor.

Brown, James W P / Alford, Rokiah G / Walsh, James C / Spinney, Richard E / Xu, Stephanie Y / Hertel, Sophie / Berengut, Jonathan F / Spenkelink, Lisanne M / van Oijen, Antoine M / Böcking, Till / Morris, Richard G / Lee, Lawrence K

ACS nano

2022 Volume 16, Issue 4, Page(s) 6455–6467

Abstract: Biomolecular complexes can form stable assemblies yet can also rapidly exchange their subunits to adapt to environmental changes. Simultaneously allowing for both stability and rapid exchange expands the functional capacity of biomolecular machines and ... ...

Abstract	Biomolecular complexes can form stable assemblies yet can also rapidly exchange their subunits to adapt to environmental changes. Simultaneously allowing for both stability and rapid exchange expands the functional capacity of biomolecular machines and enables continuous function while navigating a complex molecular world. Inspired by biology, we design and synthesize a DNA origami receptor that exploits multivalent interactions to form stable complexes that are also capable of rapid subunit exchange. The system utilizes a mechanism first outlined in the context of the DNA replisome, known as multisite competitive exchange, and achieves a large separation of time scales between spontaneous subunit dissociation, which requires days, and rapid subunit exchange, which occurs in minutes. In addition, we use the DNA origami receptor to demonstrate stable interactions with rapid exchange of both DNA and protein subunits, thus highlighting the applicability of our approach to arbitrary molecular cargo, an important distinction with canonical toehold exchange between single-stranded DNA. We expect this study to benefit future studies that use DNA origami structures to exploit multivalent interactions for the design and synthesis of a wide range of possible kinetic behaviors.
MeSH term(s)	Nanotechnology ; DNA/chemistry ; DNA, Single-Stranded ; Nanostructures/chemistry ; Nucleic Acid Conformation
Chemical Substances	DNA (9007-49-2) ; DNA, Single-Stranded
Language	English
Publishing date	2022-03-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.2c00699
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Article ; Online: Key predictors and burden of meticillin-resistant Staphylococcus aureus infection in comparison with meticillin-susceptible S. aureus infection in an Australian hospital setting.

Miyakis, S / Brentnall, S / Masso, M / Reynolds, G / Byrne, M K / Newton, P / Crawford, S / Fish, J / Nicholas, B / Hill, T / van Oijen, A M

The Journal of hospital infection

2022 Volume 129, Page(s) 41–48

Abstract: Background: Staphylococcus aureus is associated with significant mortality and increased burden on the healthcare system. Relatively few reliable estimates are available regarding the impact of meticillin-resistant S. aureus (MRSA) infection compared ... ...

Abstract	Background: Staphylococcus aureus is associated with significant mortality and increased burden on the healthcare system. Relatively few reliable estimates are available regarding the impact of meticillin-resistant S. aureus (MRSA) infection compared with meticillin-susceptible S. aureus (MSSA) infection. Aims: To compare patients with MRSA infection and MSSA infection to identify differences in inpatient mortality, length of stay and costs of hospital services, and identify predictors of MRSA as a cause of S. aureus infection. Methods: An analytical, retrospective, longitudinal study using non-identifiable linked data on adults admitted to hospitals of a health district in Australia with a diagnosis of S. aureus infection over a 10-year period. The main outcome measure was 30-day inpatient mortality. Secondary endpoints included total overnight stays, all-cause inpatient mortality, and hospitalization costs within 1 year of index admission. Findings: Inpatient mortality at 30, 100 and 365 days was estimated to be significantly greater for patients with MRSA infection. The mean additional cost of MRSA infection when controlling for additional factors was $5988 and 4 nights of additional hospital stay per patient within 1 year of index admission. Key predictors of MRSA infection were: date of index admission; higher comorbidity score; greater socio-economic disadvantage; admission to hospital other than via the emergency department; older age; and prior admission to hospital within 28 days of index admission. Conclusions: MRSA infection is associated with increased inpatient mortality, costs and hospital length of stay compared with MSSA infection. Efforts are required to alleviate the additional burden of MRSA infection on patients and healthcare systems.
MeSH term(s)	Adult ; Humans ; Methicillin-Resistant Staphylococcus aureus ; Staphylococcus aureus ; Methicillin/pharmacology ; Methicillin Resistance ; Retrospective Studies ; Longitudinal Studies ; Australia/epidemiology ; Staphylococcal Infections ; Hospitals
Chemical Substances	Methicillin (Q91FH1328A)
Language	English
Publishing date	2022-07-14
Publishing country	England
Document type	Journal Article
ZDB-ID	779366-2
ISSN	1532-2939 ; 0195-6701
ISSN (online)	1532-2939
ISSN	0195-6701
DOI	10.1016/j.jhin.2022.07.004
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Zs.A 1586: Show issues

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Article ; Online: Practice variation on hospital level in the systemic treatment of metastatic colorectal cancer in The Netherlands: a population-based study.

Keikes, Lotte / Koopman, Miriam / Stuiver, Martijn M / Lemmens, Valery E P P / van Oijen, Martijn G H / Punt, Cornelis J A

Acta oncologica (Stockholm, Sweden)

2020 Volume 59, Issue 4, Page(s) 395–403

Abstract: Introduction: ...

Abstract	Introduction:
MeSH term(s)	Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Antineoplastic Protocols/standards ; Biomarkers, Tumor/genetics ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Female ; Humans ; Male ; Middle Aged ; Molecular Targeted Therapy ; Mutation ; Neoplasm Metastasis ; Netherlands/epidemiology ; Practice Patterns, Physicians'/standards ; Practice Patterns, Physicians'/statistics & numerical data ; Registries/statistics & numerical data ; Survival Rate
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2020-02-12
Publishing country	England
Document type	Journal Article
ZDB-ID	896449-x
ISSN	1651-226X ; 0349-652X ; 0284-186X ; 1100-1704
ISSN (online)	1651-226X
ISSN	0349-652X ; 0284-186X ; 1100-1704
DOI	10.1080/0284186X.2020.1722320
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