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Article ; Online: Construction of hierarchical porous and polydopamine/salicylaldoxime functionalized zeolitic imidazolate framework-8

Tuo, Kai / Li, Jin / Li, Yi / Liang, Chuyao / Shao, Cuicui / Hou, Weifeng / Li, Zhijian / Pu, Shouzhi / Deng, Chunhui

2024

Abstract: Efficient uranium extraction from seawater is critical for the development of the nuclear industry. Herein, a polydopamine/salicylaldoxime decorated hierarchical zeolitic imidazolate framework-8 (H-PDA/SA-ZIF-8) is constructed by using a controlled ... ...

Abstract	Efficient uranium extraction from seawater is critical for the development of the nuclear industry. Herein, a polydopamine/salicylaldoxime decorated hierarchical zeolitic imidazolate framework-8 (H-PDA/SA-ZIF-8) is constructed by using a controlled etching process. Benefiting from the combination of PDA/SA and the zeolitic imidazolate framework-8 (ZIF-8), as well as a controlled etching process, the H-PDA/SA-ZIF-8 possesses multiaffinity sites, excellent specific surface area (1234.92 m
Language	English
Publishing date	2024-04-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2744250-0
ISSN	2051-6355 ; 2051-6347
ISSN (online)	2051-6355
ISSN	2051-6347
DOI	10.1039/d3mh02108d
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Article ; Online: Analysis of Helicobacter pylori resistance in patients with different gastric diseases.

Shao, Yongfu / Lin, Yifan / Fang, Ziyi / Yan, Jianing / Zheng, Tuo / Ye, Guoliang

Scientific reports

2024 Volume 14, Issue 1, Page(s) 4912

Abstract: Helicobacter pylori (H. pylori) resistance is the most important risk factor for eradication failure. However, in most regions, antibiotic resistance rates of H. pylori in patients with different types of gastric mucosal lesions are still unclear. An 8- ... ...

Abstract	Helicobacter pylori (H. pylori) resistance is the most important risk factor for eradication failure. However, in most regions, antibiotic resistance rates of H. pylori in patients with different types of gastric mucosal lesions are still unclear. An 8-year clinical retrospective cohort study involving 2847 patients was performed. In this study, we first summarized and compared the resistance status of H. pylori in different years, ages, sexes, and gastric diseases. The resistance profiles of amoxicillin (AMX), clarithromycin (CLR), levofloxacin (LVX) and furazolidone (FR) and their changing trends in the clinic were described. Then, multiple antibiotic resistance in different gastric diseases and years were described and compared. The relationship between proton pump inhibitor (PPI) medication history and antibiotic resistance in H. pylori was also explored. Finally, an antibiotic resistance risk model was constructed for clinical resistance risk prediction. The overall resistance rates of AMX, CLR, LVX and FR in gastric diseases were 8.18%, 38.11%, 43.98%, and 13.73%, respectively. The mono resistance, double resistance, triple resistance, and quadruple resistance rates were 30.17%, 25.96%, 6.46%, and 0.63%, respectively. Compared with the period from 2014 to 2016, the rates of mono-resistance and multiple resistance all showed relatively downward trends in the past 5 years. Factors including age, sex, type of gastric lesions and recent PPI treatment history are associated with the antibiotic resistance rate of H. pylori. Atrophic gastritis is an important clinical feature of high-risk antibiotic resistance in H. pylori-infected patients. Patients with atrophic gastritis have higher risk of resistant strains infection. In this study, our data provide the association between antibiotic resistance of H. pylori and gastritis pattern, which indicate the higher risk of resistant strain infection if the patients with atrophic gastritis, PPI history and older age.
MeSH term(s)	Humans ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Helicobacter pylori ; Helicobacter Infections/drug therapy ; Helicobacter Infections/epidemiology ; Retrospective Studies ; Gastritis, Atrophic ; Amoxicillin/pharmacology ; Clarithromycin/therapeutic use ; Stomach Diseases/drug therapy ; Levofloxacin/pharmacology ; Proton Pump Inhibitors/therapeutic use ; Proton Pump Inhibitors/pharmacology ; Furazolidone/pharmacology ; Furazolidone/therapeutic use ; Drug Resistance, Bacterial ; Metronidazole/pharmacology
Chemical Substances	Anti-Bacterial Agents ; Amoxicillin (804826J2HU) ; Clarithromycin (H1250JIK0A) ; Levofloxacin (6GNT3Y5LMF) ; Proton Pump Inhibitors ; Furazolidone (5J9CPU3RE0) ; Metronidazole (140QMO216E)
Language	English
Publishing date	2024-02-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-55589-2
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Article ; Online: The Role of Immunocyte Infiltration Regulatory Network Based on hdWGCNA and Single-Cell Bioinformatics Analysis in Intervertebral Disc Degeneration.

Shao, Tuo / Gao, Qichang / Tang, Weilong / Ma, Yiming / Gu, Jiaao / Yu, Zhange

Inflammation

2024

Abstract: Immune infiltration plays a crucial role in intervertebral disc degeneration (IDD). In this study, we explored the immune microenvironment of IDD through single-cell bioinformatics analysis. Three single-cell datasets were integrated into this study. ... ...

Abstract	Immune infiltration plays a crucial role in intervertebral disc degeneration (IDD). In this study, we explored the immune microenvironment of IDD through single-cell bioinformatics analysis. Three single-cell datasets were integrated into this study. Nucleus pulposus cells (NPCs) were divided into subgroups based on characteristic genes, and the role of each subgroup in the IDD process was analyzed through pseudo-time trajectory analysis. The hub genes were obtained using hdWGCNA, further identified by bulk datasets and pseudo-time sequence. The expression of the hub genes defined the NPCs related to immune infiltration, and the interaction between these NPCs and immunocytes was explored. The NPCs were divided into four subgroups: reserve NPCs, HCL-NPCs, response NPCs, and support NPCs, which, respectively, dominate the four processes of IDD: non, mild, moderate, and severe degeneration. SPP1 and ICAM1 were identified as the nucleus pulposus immune infiltration hub genes. Macrophages and myelocytes played pro-inflammatory roles in the SPP1-ICAM both-up NPC group through the SPP1-CD44 pathway and ICAM1-ITGB2 ligand-receptor pathway, respectively. At the same time, both-up NPCs sought self-help inflammation remission from neutrophils through the ANXA1-FPR1 pathway. The systematic analysis of the differentiation and immune infiltration landscapes helps to understand IDD's overall development process. Our data suggest that SPP1 and ICAM1 may be new targets for the treatment of inflammatory infiltration in IDD.
Language	English
Publishing date	2024-04-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	434408-x
ISSN	1573-2576 ; 0360-3997
ISSN (online)	1573-2576
ISSN	0360-3997
DOI	10.1007/s10753-024-02020-7
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Zs.A 1401: Show issues

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Article ; Online: Chronobiology of the Tumor Microenvironment: Implications for Therapeutic Strategies and Circadian-Based Interventions.

Li, Dengxiong / Yu, Qingxin / Wu, Ruicheng / Tuo, Zhouting / Zhu, Weizhen / Wang, Jie / Shao, Fanglin / Ye, Luxia / Ye, Xing / Yoo, Koo Han / Ke, Mang / Yang, Yubo / Wei, Wuran / Feng, Dechao

Aging and disease

2024

Abstract: Numerous research works have emphasized the critical role that circadian rhythm plays in the tumor microenvironment (TME). The goal of clarifying chrono-pharmacological strategies for improving cancer treatment in clinical settings is a continuous ... ...

Abstract	Numerous research works have emphasized the critical role that circadian rhythm plays in the tumor microenvironment (TME). The goal of clarifying chrono-pharmacological strategies for improving cancer treatment in clinical settings is a continuous endeavor. Consequently, to enhance the use of time-based pharmaceutical therapies in oncology, combining existing knowledge on circadian rhythms' roles within the TME is essential. This perspective elucidates the functions of circadian rhythms in the TME across various stages of cancer development, progression, and metastasis. Specifically, aging, angiogenesis, and inflammation are implicated in modulating circadian rhythm within the TME. Furthermore, circadian rhythm exerts a profound influence on current cancer treatments and thereby generates chronotheray to manage tumors. From a TME perspective, circadian rhythm offers promising opportunities for cancer prevention and treatment; nevertheless, further study is needed to address unanswered scientific problems.
Language	English
Publishing date	2024-03-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2625789-0
ISSN	2152-5250 ; 2152-5250
ISSN (online)	2152-5250
ISSN	2152-5250
DOI	10.14336/AD.2024.0327
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Article: Poly(ADP-ribose) polymerase (PARP)-targeted PET imaging in non-oncology application: a pilot study in preclinical models of nonalcoholic steatohepatitis.

Jeppesen, Troels E / Shao, Tuo / Chen, Jiahui / Patel, Jimmy S / Zhou, Xin / Kjaer, Andreas / Liang, Steven H

American journal of nuclear medicine and molecular imaging

2024 Volume 14, Issue 1, Page(s) 41–47

Abstract: Poly(ADP-ribose) polymerase (PARP) activation often indicates a disruptive signal to lipid metabolism, the physiological alteration of which may be implicated in the development of non-alcoholic fatty liver disease. The objective of this study was to ... ...

Abstract	Poly(ADP-ribose) polymerase (PARP) activation often indicates a disruptive signal to lipid metabolism, the physiological alteration of which may be implicated in the development of non-alcoholic fatty liver disease. The objective of this study was to evaluate the capability of [
Language	English
Publishing date	2024-02-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2623515-8
ISSN	2160-8407
ISSN	2160-8407
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Article ; Online: Recurrent submucosal uterine fibroids in adolescence

Hu Qiuxia, Huang Xiaoqin, Shao Yanxia, Tuo Jun, Peng Na, Zhou Dan

Xin yixue, Vol 53, Iss 3, Pp 221-

a case report

2022 Volume 224

Abstract: Uterine fibroids are the most common benign tumors of the uterus. They primarily occur in women aged 30-50 years old, rarely in adolescents. In this article, the diagnosis and treatment of a 16-year-old teenager with recurrent submucosal fibroids were ... ...

Abstract	Uterine fibroids are the most common benign tumors of the uterus. They primarily occur in women aged 30-50 years old, rarely in adolescents. In this article, the diagnosis and treatment of a 16-year-old teenager with recurrent submucosal fibroids were reported. The patient underwent hysteroscopic myomectomy due to abnormal uterine bleeding （AUB）, whereas failed to receive postoperative follow-up on a regular basis. At 18 months after the operation, she was admitted to hospital again due to AUB. Transvaginal ultrasound detected a space-occupying mass of 5.2 cm×4.6 cm×3.8 cm in the uterine cavity. She repeatedly underwent hysteroscopic partial myomectomy. Postoperative pathological biopsy indicated the diagnosis of submucosal uterine fibroids. The diagnosis and treatment of this case suggests that in the diagnosis and treatment of recurrent uterine fibroids in adolescents, it is necessary to differentiate fibroids from sarcomatosis. Meantime, the patient’s fertility should be preserved to the largest extent and postoperative follow-up should be strengthened.
Keywords	\|adolescent\|submucosal uterine fibroid\|recurrence\|abnormal uterine bleeding\|hysteroscopy ; Medicine ; R
Subject code	610
Language	Chinese
Publishing date	2022-03-01T00:00:00Z
Publisher	Editorial Office of Journal of New Medicine
Document type	Article ; Online
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Article ; Online: FGF21 Depletion Attenuates Colitis through Intestinal Epithelial IL-22-STAT3 Activation in Mice.

Liu, Liming / Li, Fengyuan / Shao, Tuo / Zhang, Lihua / Lee, Jiyeon / Dryden, Gerald / McClain, Craig J / Zhao, Cuiqing / Feng, Wenke

Nutrients

2023 Volume 15, Issue 9

Abstract: Fibroblast growth factor 21 (FGF21) is a glucose and lipid metabolic regulator. Recent research revealed that FGF21 was also induced by inflammatory stimuli. Its role in inflammatory bowel disease (IBD) has not been investigated. In this study, an ... ...

Abstract	Fibroblast growth factor 21 (FGF21) is a glucose and lipid metabolic regulator. Recent research revealed that FGF21 was also induced by inflammatory stimuli. Its role in inflammatory bowel disease (IBD) has not been investigated. In this study, an experimental IBD model was established in FGF21 knockout (KO) and wild-type (WT) mice by adding 2.5% (wt/vol) dextran sodium sulfate (DSS) to their drinking water for 7 days. The severity of the colitis and the inflammation of the mouse colon tissues were analyzed. In WT mice, acute DSS treatment induced an elevation in plasma FGF21 and a significant loss of body weight in a time-dependent manner. Surprisingly, the loss of body weight and the severity of the colitis induced by DSS treatment in WT mice were significantly attenuated in FGF21 KO mice. Colon and circulating pro-inflammatory factors were significantly lower in the FGF21 KO mice compared to the WT mice. As shown by BrdU staining, the FGF21 KO mice demonstrated increased colonic epithelial cell proliferation. DSS treatment reduced intestinal Paneth cell and goblet cell numbers in the WT mice, and this effect was attenuated in the FGF21 KO mice. Mechanistically, FGF21 deficiency significantly increased the signal transducer and activator of transcription (STAT)-3 activation in intestinal epithelial cells and increased the expression of IL-22. Further study showed that the expression of suppressor of cytokine signaling-2/3 (SOCS 2/3), a known feedback inhibitor of STAT3, was significantly inhibited in the DSS-treated FGF2 KO mice compared to the WT mice. We conclude that FGF21 deficiency attenuated the severity of DSS-induced acute colitis, which is likely mediated by enhancing the activation of the IL-22-STAT3 signaling pathway in intestinal epithelial cells.
MeSH term(s)	Animals ; Mice ; Colitis/chemically induced ; Inflammatory Bowel Diseases ; Body Weight ; Interleukin-22
Chemical Substances	fibroblast growth factor 21
Language	English
Publishing date	2023-04-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15092086
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Article ; Online: Comparison between percutaneous short-segment fixation and percutaneous vertebroplasty in treating Kummell's disease: A minimum 2-year follow-up retrospective study.

Shen, Hongtao / Tang, Weilong / Yin, Xiaoyu / Shao, Tuo / Liu, Xing / Gu, Jiaao / Hu, Yuhang / Yu, Lei / Yu, Zhange / Zhang, Zhenyu

Journal of back and musculoskeletal rehabilitation

2023 Volume 37, Issue 1, Page(s) 195–203

Abstract: Background: Percutaneous kyphoplasty (PKP) or percutaneous short-segment fixation (PSSF) is often used to treat Kummell's disease. However, it is not clear which treatment is better for patients.: Objective: To retrospectively compare the clinical ... ...

Abstract	Background: Percutaneous kyphoplasty (PKP) or percutaneous short-segment fixation (PSSF) is often used to treat Kummell's disease. However, it is not clear which treatment is better for patients. Objective: To retrospectively compare the clinical efficacy of PVP and PSSF for the treatment of Kummell's disease. Method: 60 patients were involved in this research and the period of follow-up was at least 2 years. 27 of them were treated with PVP (Group I) and the rest who received PSSF (Group II). The visual analog scale (VAS) and radiographic indexes of each participant had been measured preoperatively as well as 1 week, 3 months, and 2 years postoperatively. Additionally, the Oswestry Disability Index (ODI) scores were assessed at the last time point. Results: Comparing the two groups, no statistical significance was found among all parameters preoperatively. The time of operations and blood loss is less in Group I. At each time point after operation, the imaging indices in Group II are lower (P< 0.05). One week after treatments, the VAS scores are lower in Group I, and similarly, 3 months are the same (P< 0.05), while VAS are similar at the last time point. In the aspect of ODI scores, they are lower in Group II during long-term follow-up. Conclusion: For the treatment of Kummell's disease, both PVP and PSSF have been found to be effective. PVP can provide rapid pain relief with a shorter operation time. However, in cases with severe kyphosis deformity, PSSF should be given priority.
MeSH term(s)	Humans ; Follow-Up Studies ; Vertebroplasty/adverse effects ; Retrospective Studies ; Spinal Fractures/surgery ; Kyphoplasty/methods ; Treatment Outcome ; Spondylosis ; Fractures, Compression/surgery
Language	English
Publishing date	2023-09-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1184721-9
ISSN	1878-6324 ; 1053-8127
ISSN (online)	1878-6324
ISSN	1053-8127
DOI	10.3233/BMR-230083
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Zs.A 4580: Show issues

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Article ; Online: Layered Organic Metal Chalcogenides (OMCs): From Bulk to Two-Dimensional Materials.

Wang, Guan-E / Luo, ShaoZhen / Di, Tuo / Fu, ZhiHua / Xu, Gang

Angewandte Chemie (International ed. in English)

2022 Volume 61, Issue 27, Page(s) e202203151

Abstract: The modification of inorganic two-dimensional (2D) materials with organic functional motifs is in high demand for the optimization of their properties, but it is still a daunting challenge. Organic metal chalcogenides (OMCs) are a type of newly emerging ... ...

Abstract	The modification of inorganic two-dimensional (2D) materials with organic functional motifs is in high demand for the optimization of their properties, but it is still a daunting challenge. Organic metal chalcogenides (OMCs) are a type of newly emerging 2D materials, with metal chalcogenide layers covalently anchored by long-range ordered organic functional motifs, these materials are extremely desirable but impossible to realize by traditional methods. Both the inorganic layer and organic functional motifs of OMCs are highly designable and thus provide this type of 2D materials with enormous variety in terms of their structure and properties. This Minireview aims to review the latest developments in OMCs and their bulk precursors. Firstly, the structure types of the bulk precursors for OMCs are introduced. Second, the synthesis and applications of OMC 2D materials in photoelectricity, catalysis, sensors, and energy transfer are explored. Finally, the challenges and perspectives for future research on OMCs are discussed.
Language	English
Publishing date	2022-05-20
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202203151
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Article ; Online: PET/SPECT Molecular Probes for the Diagnosis and Staging of Nonalcoholic Fatty Liver Disease.

Shao, Tuo / Josephson, Lee / Liang, Steven H

Molecular imaging

2019 Volume 18, Page(s) 1536012119871455

Abstract: Nonalcoholic fatty liver disease (NAFLD) is a significant public health challenge afflicting approximately 1 billion individuals both in the Western world and in the East world. While liver biopsy is considered as gold standard in the diagnosis and ... ...

Abstract	Nonalcoholic fatty liver disease (NAFLD) is a significant public health challenge afflicting approximately 1 billion individuals both in the Western world and in the East world. While liver biopsy is considered as gold standard in the diagnosis and staging of liver fibrosis, noninvasive imaging technologies, including ultrasonography, computed tomography, single-photon emission computed tomography (SPECT), magnetic resonance imaging, and positron emission tomography (PET) could offer more sensitive, comprehensive, and quantitative measurement for NAFLD. In this review, we focus on recent development and applications of PET/SPECT molecular probes that enable multispatial/temporal visualization and quantification of physiopathological progress at the molecular level in the NAFLD. We shall also discuss the limitations of current radioligands and future direction for PET/SPECT probe development.
MeSH term(s)	Biomarkers/metabolism ; Hematology/methods ; Humans ; Molecular Probes/analysis ; Non-alcoholic Fatty Liver Disease/diagnostic imaging ; Non-alcoholic Fatty Liver Disease/metabolism ; Positron-Emission Tomography/methods ; Tomography, Emission-Computed, Single-Photon/methods
Chemical Substances	Biomarkers ; Molecular Probes
Language	English
Publishing date	2019-09-03
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2137435-1
ISSN	1536-0121 ; 1535-3508
ISSN (online)	1536-0121
ISSN	1535-3508
DOI	10.1177/1536012119871455
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Zs.A 5994: Show issues

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