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  1. Article: Seed Germination Enhancement of Two

    Seid, Mohammed Adefa / Wondimu, Tigist / Degu, Asfaw / Assefa, Awol

    Scientifica

    2023  Volume 2023, Page(s) 5571489

    Abstract: ... B. ... ...

    Abstract B. aegyptiaca
    Language English
    Publishing date 2023-12-26
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2672321-9
    ISSN 2090-908X
    ISSN 2090-908X
    DOI 10.1155/2023/5571489
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Thesis: Study of cytokines in canine rheumatoid arthritis

    Abebe, Assefa Wondimu

    2002  

    Author's details Assefa Wondimu Abebe
    Keywords Rheumatoide Arthritis ; Cytokine ; Tiermodell
    Subject Zytokine ; Arthritis rheumatica ; Chronische Polyarthritis ; Chronisch-entzündlicher Gelenkrheumatismus ; Entzündlicher Gelenkrheumatismus ; PCP ; Polyarthritis rheumatica acuta ; Primär chronische Polyarthritis ; Progrediente chronische Polyarthritis ; Rheumatische Arthritis ; Rheumatische Gelenkerkrankung
    Language English
    Size XII, 134 S. : Ill., graph. Darst., 21 cm
    Edition 1. Aufl.
    Publisher Köster
    Publishing place Berlin
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Berlin, Humboldt-Univ., Diss., 2002
    HBZ-ID HT013811922
    ISBN 3-89574-453-0 ; 978-3-89574-453-2
    Database Catalogue ZB MED Medicine, Health

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  3. Article ; Online: Seed Germination Enhancement of Two Balanites Species (B. aegyptiaca (L.) Del. and B. rotundifolia (Tiegh.) Blatt.) Using Different Presowing Treatments in Ethiopia

    Mohammed Adefa Seid / Tigist Wondimu / Asfaw Degu / Awol Assefa

    Scientifica, Vol

    2023  Volume 2023

    Abstract: B. aegyptiaca and B. rotundifolia are known to be multipurpose trees with various uses and values. Therefore, the aim of this study was to investigate the seed germination behaviours of B. aegyptiaca and B. rotundifolia under different presowing ... ...

    Abstract B. aegyptiaca and B. rotundifolia are known to be multipurpose trees with various uses and values. Therefore, the aim of this study was to investigate the seed germination behaviours of B. aegyptiaca and B. rotundifolia under different presowing treatments. Hence, seeds were collected from the Central and Southern Ethiopian Rift Valley regions. Then, a total of 864 fruits (seeds) subjected to eight different presowing treatments and planted in pots arranged in a completely randomized design (CRD) were tested for each species. The mean germination percentage (GP), mean daily germination percentage (GD), mean germination time (GT), and mean germination index (GI) were computed. One-way ANOVA showed the presence of significant GP, GD, GT, and GI among treatment groups at p<0.05 under both Balanites species. For B. aegyptiaca, Tukey’s HSD test showed that seeds soaked with 98% H2SO4 for 10 minutes (98HSO10m) and 20 minutes (98HSO20m) have the highest GPs (87 ± 8.8 and 82 ± 10.2, respectively) that are significant at p<0.05. The seeds soaked in 75°C hot water for 10 minutes and subsequently cooled for 12 hours (HW75d), 98HSO10m, and 98HSO20m have the highest GDs (2%) that are significant at p<0.05. Moreover, 98HSO20m, 98HSO10m, and seeds soaked in cold water for 48 hours at room temperature of 25°C (CW48h) have the shortest GTs (24 ± 2.2, 25 ± 0.5, and 25 ± 1.3, respectively), and 98HSO10m and 98HSO20m have the highest GIs (1.04 ± 0.09 and 1.01 ± 0.08, respectively) that are significant at p<0.05. For B. rotundifolia, the control recorded the highest cumulative germination (i.e., 71), followed by CW48h (i.e., 51). However, Tukey’s HSD tests generally indicated that no treatment group resulted in significant differences in the means of GP, GD, GT, and GI at p<0.05. So, no treatment group was observed to enhance the germination of B. rotundifolia compared to the control. However, this study generally indicated potential seed enhancement technologies for B. aegyptiaca with greater implications for ...
    Keywords Medicine ; R ; Science ; Q
    Subject code 630
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Incidence and pattern of childhood cancer in Addis Ababa, Ethiopia (2012-2017).

    Belay, Amanuel / Ali, Ahmed / Ayele, Wondimu / Assefa, Mathewos / Jemal, Ahmedin / Kantelhardt, Eva J

    BMC cancer

    2023  Volume 23, Issue 1, Page(s) 1261

    Abstract: Background: Cancer is becoming a major public health problem globally and a leading cause of death in children in developed countries. However, little is known about the epidemiology of childhood cancer in Ethiopia. This study, therefore, assessed ... ...

    Abstract Background: Cancer is becoming a major public health problem globally and a leading cause of death in children in developed countries. However, little is known about the epidemiology of childhood cancer in Ethiopia. This study, therefore, assessed childhood cancer incidence patterns in Addis Ababa using the Addis Ababa city population-based cancer registry data from 2012 to 2017.
    Methods: Invasive cancer cases diagnosed in ages 0-14 years from 2012 to 2017 were obtained from the Addis Ababa City population-based Cancer Registry. Cases were grouped according to the International Classification of Childhood Cancer, 3rd edition (ICCC-3) based on morphology and primary anatomic site. Age-standardized incidence rates (ASR) were calculated by the direct method using the world standard population.
    Results: The overall average annual incidence rate during 2012-2017 in children was 84.6 cases per million, with rates higher in boys (98.97 per million) than in girls (69.7 per million). By age, incidence rates per million increased from 70.8 cases in ages 0-4 years to 88.4 cases in ages 5-9 years to 110.0 cases 10-14 years. Leukaemia was the most common childhood cancer in both boys (29.1%) and girls (26.8%), followed by lymphoma in boys (24.7%) and renal tumours (13.1%) in girls. The overall cancer incidence rate decreased from 87.02 per million in 2012 to 51.07 per million in 2017.
    Conclusion: The burden of childhood cancer is considerably high in Addis Ababa. The observed distribution of childhood cancer in Addis Ababa differs from other African countries. This study highlights the need for further research and understanding of the variations in cancer patterns and risk factors across the region.
    MeSH term(s) Male ; Female ; Humans ; Child ; Infant, Newborn ; Infant ; Child, Preschool ; Incidence ; Ethiopia/epidemiology ; Lymphoma ; Risk Factors ; Kidney Neoplasms
    Language English
    Publishing date 2023-12-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041352-X
    ISSN 1471-2407 ; 1471-2407
    ISSN (online) 1471-2407
    ISSN 1471-2407
    DOI 10.1186/s12885-023-11765-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A preliminary study to evaluate the impact of pharmaceutical care services on clinical outcome and medication adherence in type 2 diabetes mellitus patients from Ethiopian perspective.

    Billoro, Bruke Berhanu / Abdi, Abdikarem Mohamed / Abero, Wondimu Assefa / Fite, Abdi Bedassa / Basgut, Bilgen

    African health sciences

    2023  Volume 22, Issue 4, Page(s) 104–118

    Abstract: Background: The role of clinical pharmacist in hospital settings of Ethiopia is still new and infant.: Objective: To evaluate the impact of pharmaceutical care on clinical outcome and medication adherence in type 2 diabetes mellitus (T2DM) patients.!# ...

    Abstract Background: The role of clinical pharmacist in hospital settings of Ethiopia is still new and infant.
    Objective: To evaluate the impact of pharmaceutical care on clinical outcome and medication adherence in type 2 diabetes mellitus (T2DM) patients.
    Methods: A single cantered, pre-post interventional study design was carried out by enrolling 100 uncontrolled T2DM patients from March 1-August 30, 2020. The intervention package included assessment of pharmacological and non-pharmacological needs, counselling patients in person at the clinic, and providing educational materials.
    Results: Of the 100 patients initially enrolled, 87(87%) completed the follow-up and included in the final data analysis. The intervention showed a decrease in average FBG, systolic blood pressure (SBP), low density lipoprotein cholesterol (LDL-C) by 47.3 mg/dL, 22.6mmHg and 31.4mg/dL, while high density lipoprotein cholesterol (HDL-C) and estimated glomerular filtration rate (eGFR) exhibited significant increase by 13.4 mg/dL and 11.5 ml/min/1.73m2 respectively (p<0.0001). In addition, diastolic blood pressure, lipid values, kidney function parameters, and liver function parameters showed significant decrease in post intervention compared to pre-intervention (p<0.05). Medication adherence of the patients increased significantly at 6-month follow-up (p<0.001).
    Conclusion: These results also suggest the benefits of integrating clinical pharmacist services in multidisciplinary healthcare teams and diabetes management in Ethiopia.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/drug therapy ; Medication Adherence ; Pharmaceutical Services ; Blood Pressure/physiology ; Ethiopia ; Pharmacists
    Language English
    Publishing date 2023-03-22
    Publishing country Uganda
    Document type Journal Article
    ZDB-ID 2240308-5
    ISSN 1729-0503 ; 1680-6905
    ISSN (online) 1729-0503
    ISSN 1680-6905
    DOI 10.4314/ahs.v22i4.14
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: SIR MODEL BASED ANALYSIS ON COVID-19 DYNAMICS IN ETHIOPIA

    Abere Wondimu Kassie / Assefa Legesse Sisay

    International Journal of Current Research and Modern Education (IJCRME) 5(1) 21-26

    2020  

    Abstract: The COVID-19 pandemic rapidly spread out worldwide and has caused a serious crisis affecting the public health systems, with many negative effects on the countries’ social, economic and cultural aspects in the world. Thus the main focus of the study is ... ...

    Abstract The COVID-19 pandemic rapidly spread out worldwide and has caused a serious crisis affecting the public health systems, with many negative effects on the countries’ social, economic and cultural aspects in the world. Thus the main focus of the study is to assess the distributing pattern of COVID-19 pandemic by estimating the transmission rate of disease and to predict the future spread of disease in Ethiopia. The data on COVID-19 daily confirmed cases report is taken from Mistry of health, Ethiopia, since the outbreak started on March, 13 2020 to May 27, 2020. The SIR model has used to analyze the dynamics of COVID-19 pandemic. The optimized SIR model parameters are estimated and the contact rate, and recovery delay, from the daily confirmed cases. The basic reproductive number, could also be estimated as 1.2. While, the predicted SIR model parameters were considerably taken as with other previous studies. The result of the study revealed that the spread of COVID-19 pandemic in Ethiopia indicated that the number of infection will peak on July08, 2020, where 23.4 per cent of the total population could be potentially infected. Hopefully, the actual number will be lower than predicted number of infections.As our predicted SIR model is based on the epidemic progression as it currently has beenthat it doesn’t account additional measures put in place to curb the spread of the virus like social distancing, school closure, lockdown etc. As a conclusion from this study, the SIR model on COVID-19 pandemic in Ethiopia shows that the infection could spread at an exponential rate unless proper and effective measures will be taken to reduce its transmission due safety practice such as social distancing, lockdown and large scale testing of suspected cases in all part of the country.
    Keywords Basic Reproduction Number ; COVID-19 ; Pandemic ; SIR Model & Transmission Rate ; covid19
    Subject code 910
    Publishing date 2020-06-24
    Publishing country eu
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Health system cost of breast cancer treatment in Addis Ababa, Ethiopia.

    Demeke, Tamiru / Ayele, Wondimu / Haile Mariam, Damen / Wienke, Andreas / Assefa, Mathewos / Addissie, Adamu / Mikolajczyk, Rafael / Unverzagt, Susanne / Kantelhardt, Eva Johanna

    PloS one

    2022  Volume 17, Issue 10, Page(s) e0275171

    Abstract: Background: Breast cancer is the leading cancer among women with an annual crude incidence of 27.4 per 100,000 in Ethiopia. The aims of this study were to (a) estimate the unit cost of breast cancer treatment for the standard Ethiopian patient, (b) ... ...

    Abstract Background: Breast cancer is the leading cancer among women with an annual crude incidence of 27.4 per 100,000 in Ethiopia. The aims of this study were to (a) estimate the unit cost of breast cancer treatment for the standard Ethiopian patient, (b) identify the cost drivers, (c) project the total cost of breast cancer treatment for the next five years, and (d) estimate the economic burden of the disease in the main specialized tertiary hospital-Tikur Anbessa Specialized Hospital (TASH) Addis Ababa.
    Methods: Primary data were collected from health and non-health professionals. Secondary data were collected from patient`s charts and official reports from various national and international organisations including data from TASH. To establish work-time estimates, we asked professionals on their time usage.
    Result: A total of US$ 33,261 was incurred to treat 52 Addis Ababa resident female breast cancer patients in TASH between July 2017 and June 2019. The unit cost of treatment for a hypothetical breast cancer patient to complete her treatment was US$ 536 for stage I and US$ 705 for stage II and III using the existing infrastructure. This cost increased to US$ 955 for stage I and US$ 1157 for stage II and III when infrastructure amortization was considered. The projected total costs of breast cancer treatment in TASH is between US$ 540,000 and US$ 1.48million. However, this will increase to US$ 870,000 and US$ 2.29 million when the existing fixed assets are changed.
    Conclusion: The economic burden of breast cancer treatment is high compared to the economic status of the country. Thus, it is recommended that TASH should revise its charges and breast cancer should be included in the Social and Community based health insurance scheme. JEL classification: H51, H75, I18, P46.
    MeSH term(s) Breast Neoplasms/epidemiology ; Breast Neoplasms/therapy ; Ethiopia/epidemiology ; Female ; Health Care Costs ; Hospitals, Special ; Humans ; Socioeconomic Factors
    Language English
    Publishing date 2022-10-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0275171
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Readiness of public schools before reopening during COVID-19 pandemic: School-based cross-sectional survey in southern Ethiopia.

    Endriyas, Misganu / Woldemariam, Belete / Shibru, Endashaw / Hussen, Mamush / Bedru, Bersabeh / Moges, Mathewos / Melka, Mintesinot / Lemango, Fiseha / Mate, Male / Lejiso, Tesfaye / Gebremedhin, Biruk / Tolcha, Alemu / Shiferaw, Biniam / Wondimu, Girma / Terefe, Tesfatsion / Ayele, Sinafikish / Misganaw, Tebeje / Samuel, Teka / Kelaye, Temesgen /
    Gebru, Agegnehu / Assefa, Amare / Getachew, Wogene / Yalew, Bereket / Geleta, Dereje

    PloS one

    2023  Volume 18, Issue 10, Page(s) e0293722

    Abstract: Background: School closures in response to the COVID-19 impacted children's education, protection, and wellbeing. After understanding these impacts and that children were not super spreaders, countries including Ethiopia decided to reopen schools with ... ...

    Abstract Background: School closures in response to the COVID-19 impacted children's education, protection, and wellbeing. After understanding these impacts and that children were not super spreaders, countries including Ethiopia decided to reopen schools with specified preconditions. But when deciding to reopen schools, the benefits and risks across education, public health and socio-economic factors have to be evaluated. However, there was information gap on status of schools as per preconditions. Hence, this study was designed to investigate status of schools in Southern Ethiopia.
    Methods: School based cross-sectional study was conducted in October 2020 in Southern Ethiopia. Sample of 430 schools were included. National school reopening guideline was used to develop checklist for assessment. Data was collected by public health experts at regional emergency operation center. Descriptive analysis was performed to summarize data.
    Results: A total of 430 schools were included. More than two thirds, 298 (69.3%), of schools were from rural areas while 132 (30.7%) were from urban settings. The general infection prevention and water, sanitation and hygiene (IPC-WASH) status of schools were poor and COVID-19 specific preparations were inadequate to meet national preconditions to reopen schools during the pandemic. Total score from 24 items observed ranged from 3 to 22 points with mean score of 11.75 (SD±4.02). No school scored 100% and only 41 (9.5%) scored above 75% while 216 (50.2%%) scored below half point that is 12 items.
    Conclusion: Both the basic and COVID-19 specific IPC-WASH status of schools were inadequate to implement national school reopening preconditions and general standards. Some of strategies planned to accommodate teaching process and preconditions maximized inequalities in education. Although COVID-19 impact lessened due to vaccination and other factors, it is rational to consider fulfilling water and basic sanitation facilities to schools to prevent communicable diseases of public health importance.
    MeSH term(s) Child ; Humans ; Cross-Sectional Studies ; Pandemics ; COVID-19/epidemiology ; COVID-19/prevention & control ; Ethiopia/epidemiology ; Sanitation ; Water
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2023-10-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0293722
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Evaluation of the diagnostic performance of PanbioTM Abbott SARS-CoV-2 rapid antigen test for the detection of COVID-19 from suspects attending ALERT center.

    Ashagre, Wondimu / Atnafu, Abay / Wassie, Liya / Tschopp, Rea / Fentahun, Dessalegn / Assefa, Gebeyehu / Wegayehu, Teklu / Wondale, Biniam / Mulu, Andargachew / Miheret, Adane / Bobosha, Kidist

    PloS one

    2022  Volume 17, Issue 11, Page(s) e0277779

    Abstract: Background: The emergence and rapid spread of coronavirus disease 2019 (COVID-19), a potentially lethal disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is causing public health issues around the world. In resource- ... ...

    Abstract Background: The emergence and rapid spread of coronavirus disease 2019 (COVID-19), a potentially lethal disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is causing public health issues around the world. In resource-constrained nations, rapid Abbott SARS-CoV-2 antigen test kits are critical for addressing diagnostic gaps in health institutions and community screening. However, there is no evidence or proof of diagnostic performance in Ethiopia. The aim of this study was to compare the performance of PanbioTM Abbott SARS-CoV-2antigen rapid test kit to the gold standard, RT-PCR, in COVID-19 patients with clinical symptoms suggestive of COVID-19.
    Method: A prospective, cross-sectional study was conducted between November 2021 and April 2022, on 120 suspected patients recruited from outpatient, emergency, and intensive care units in one of the tertiary hospitals in Ethiopia. Nasopharyngeal swabs were collected from suspected cases and were tested using the Abbott SARS-CoV-2 kit, a rapid diagnostic test (RDT) and compared to the reference standard RT-PCR.
    Result: The sensitivity and specificity of the RDT were 74.2% and 100%, respectively. A total of 62 samples (51.6%) were RT-PCR positive. Of these, 46 were Ag-RDT positive. Sensitivity among symptomatic patients was 79.4% (95% CI 68.3-90). The Abbot RDT and RT-PCR had a Kappa value of agreement of 0.735 (p < 0.001). These values were acceptable when compared to the WHO's suggested thresholds.
    Conclusion: The finding from this study support the use of the Abbot RDT as a diagnostic tool in COVID-19 suspects, mainly in those with higher viral loads.
    MeSH term(s) Humans ; SARS-CoV-2/genetics ; COVID-19/diagnosis ; Cross-Sectional Studies ; Prospective Studies ; Sensitivity and Specificity
    Language English
    Publishing date 2022-11-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0277779
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Readiness of public schools before reopening during COVID-19 pandemic

    Misganu Endriyas / Belete Woldemariam / Endashaw Shibru / Mamush Hussen / Bersabeh Bedru / Mathewos Moges / Mintesinot Melka / Fiseha Lemango / Male Mate / Tesfaye Lejiso / Biruk Gebremedhin / Alemu Tolcha / Biniam Shiferaw / Girma Wondimu / Tesfatsion Terefe / Sinafikish Ayele / Tebeje Misganaw / Teka Samuel / Temesgen Kelaye /
    Agegnehu Gebru / Amare Assefa / Wogene Getachew / Bereket Yalew / Dereje Geleta

    PLoS ONE, Vol 18, Iss

    School-based cross-sectional survey in southern Ethiopia

    2023  Volume 10

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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