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  1. Article ; Online: Xiao-Xu-Ming decoction extracts promotes mitochondrial biogenesis and improves neurobehavioral deficits in cerebral ischemia/reperfusion rats

    Xiao Cheng / Ying-Lin Yang / Wei-Han Li / Man Liu / Shan-Shan Zhang / Dong-Ni Liu / Li-Da Du / Yue-Hua Wang / Guan-Hua Du

    Pharmacological Research - Modern Chinese Medicine, Vol 5, Iss , Pp 100192- (2022)

    2022  

    Abstract: ... Traditional Chinese medicine plays an important role in preventing and treatment of stroke. Xiao-Xu-Ming decoction (XXM) is ...

    Abstract Introduction: Stroke is one of the leading causes of death and disability in the worldwide. Traditional Chinese medicine plays an important role in preventing and treatment of stroke. Xiao-Xu-Ming decoction (XXM) is an effective traditional Chinese prescription for the treatment of stroke and its sequelae. Previous studies have reported the extracts of XXM has a good therapeutic effect on experimental animal stroke. However, the mechanism is unclear. Our present study focused on metabolic remodeling in cerebral ischemia-reperfusion to investigate the mechanism of XXM on cerebral ischemia/reperfusion (I/R). Methods: The cerebral I/R rat model was established by 90 min middle cerebral artery occlusion following reperfusion. XXM at doses of 37.5, 75 and 150 mg/kg was administered for the continuous 7 day after cerebral I/R. Behavioral testing, cerebral infarction detected by TTC staining, Nissl staining, NeuN immunohistochemical staining, and MAP2 immunofluorescence staining were conducted to evaluate the effect of XXM treatment on cerebral I/R of rats. TUNEL staining was used to detect DNA damage. The expression of related proteins was detected by qPCR and western blotting. Results: 7 day XXM treatment improved neurological and behavioral deficits, regulated the biogenesis and dynamic process of mitochondria, promoted the recovery of mitochondrial function, and improved the energy metabolism disorder after cerebral I/R. Furthermore, XXM also had an improving effect on mitochondrial-dependent apoptosis after cerebral I/R. Conclusion: we found that XXM regulated metabolic remodeling in cerebral ischemia-reperfusion and improve neurological deficits.
    Keywords Xiao-Xu-Ming decoction ; Cerebral Ischemia ; Metabolic remodeling ; Mitochondrial function ; Apoptosis ; Other systems of medicine ; RZ201-999 ; Therapeutics. Pharmacology ; RM1-950
    Subject code 610
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Book: Yi yong ren ti jie pou jian ming tu

    Man, Shi

    [Simplified illustrations on human anatomy for artists

    1948  

    MeSH term(s) Anatomy, Artistic
    Language Chinese
    Size 146 p., illus.
    Publisher Dongbei hua bao she
    Publishing place Harbin
    Document type Book
    Database Catalogue of the US National Library of Medicine (NLM)

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  3. Book: Shu pi bu yin wen tao yu zao zhi yin shua shu fa ming

    Ling, Shunsheng / Ling, Mary Man-li

    Bark-cloth, impressed pottery, and the inventions of paper and printing

    (Academia Sinica Monographs ; 3 ; Zhong yang yan jiu yuan min zu xue yan jiu suo zhuan kan ; 3 ; 中央研究院民族學研究所專刊 ; 3)

    1963  

    Title variant Shu-pi-bu yin-wen-tao yu zao-zhi yin-shua-shu fa-ming
    Institution Minzuxue-Yanjiusuo
    Author's details by Shun-sheng Ling, with a contribution by Mary Man-li Ling
    Series title Academia Sinica Monographs ; 3
    Zhong yang yan jiu yuan min zu xue yan jiu suo zhuan kan ; 3
    中央研究院民族學研究所專刊 ; 3
    Language Chinese ; English
    Size VII, 257 S, Ill., 27 cm
    Publisher Zhong yang yan jiu yuan min zu xue yan jiu suo
    Publishing place Tai bei
    Document type Book
    Database Former special subject collection: coastal and deep sea fishing

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  4. Article ; Online: Context-dependent functions of pattern recognition receptors in cancer.

    Man, Si Ming / Jenkins, Brendan J

    Nature reviews. Cancer

    2022  Volume 22, Issue 7, Page(s) 397–413

    Abstract: The immune system plays a critical role in shaping all facets of cancer, from the early initiation stage through to metastatic disease and resistance to therapy. Our understanding of the importance of the adaptive arm of the immune system in antitumour ... ...

    Abstract The immune system plays a critical role in shaping all facets of cancer, from the early initiation stage through to metastatic disease and resistance to therapy. Our understanding of the importance of the adaptive arm of the immune system in antitumour immunity has led to the implementation of immunotherapy with immune checkpoint inhibitors in numerous cancers, albeit with differing efficacy. By contrast, the clinical utility of innate immunity in cancer has not been exploited, despite dysregulated innate immunity being a feature of at least one-third of all cancers associated with tumour-promoting chronic inflammation. The past two decades have seen innate immune pattern recognition receptors (PRRs) emerge as critical regulators of the immune response to microbial infection and host tissue damage. More recently, it has become apparent that in many cancer types, PRRs play a central role in modulating a vast array of tumour-inhibiting and tumour-promoting cellular responses both in immune cells within the tumour microenvironment and directly in cancer cells. Herein, we provide a comprehensive overview of the fast-evolving field of PRRs in cancer, and discuss the potential to target PRRs for drug development and biomarker discovery in a wide range of oncology settings.
    MeSH term(s) Humans ; Immunity, Innate ; Immunotherapy ; Neoplasms ; Receptors, Pattern Recognition ; Signal Transduction ; Tumor Microenvironment
    Chemical Substances Receptors, Pattern Recognition
    Language English
    Publishing date 2022-03-30
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2062767-1
    ISSN 1474-1768 ; 1474-175X
    ISSN (online) 1474-1768
    ISSN 1474-175X
    DOI 10.1038/s41568-022-00462-5
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  5. Article ; Online: Tripartite motif 2b (

    Fang, Hong / Wu, Xiao Man / Zheng, Si Yao / Chang, Ming Xian

    Journal of virology

    2024  , Page(s) e0015824

    Abstract: Tripartite motif (TRIM) proteins are involved in different cellular functions, including regulating virus infection. In teleosts, two orthologous genes of mammalian TRIM2 are identified. However, the functions and molecular mechanisms of piscine TRIM2 ... ...

    Abstract Tripartite motif (TRIM) proteins are involved in different cellular functions, including regulating virus infection. In teleosts, two orthologous genes of mammalian TRIM2 are identified. However, the functions and molecular mechanisms of piscine TRIM2 remain unclear. Here, we show that
    Language English
    Publishing date 2024-05-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/jvi.00158-24
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  6. Article ; Online: Primary Intestinal Fibroblasts: Isolation, Cultivation, and Maintenance.

    Pandey, Abhimanu / Kurera, Melan / Man, Si Ming

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2691, Page(s) 327–335

    Abstract: Intestinal fibroblasts maintain homeostasis and contribute to inflammatory responses and the development of cancer. Intestinal fibroblasts express pattern recognition receptors which can mount an immune response. Since intestinal fibroblasts interact ... ...

    Abstract Intestinal fibroblasts maintain homeostasis and contribute to inflammatory responses and the development of cancer. Intestinal fibroblasts express pattern recognition receptors which can mount an immune response. Since intestinal fibroblasts interact with diverse immune and nonimmune cells, further insights into the biology of intestinal fibroblasts could expand our knowledge of the development, homeostasis, and pathophysiology of the intestine. Here, we describe a simple protocol for the isolation, cultivation, and maintenance of primary fibroblasts from the mouse colon. These cells express α-smooth muscle actin, a characteristic of specialized contractile fibroblasts called myofibroblasts. We also outline the use of these colonic fibroblasts for immunoblotting and immunofluorescence assays with or without stimulation with a growth factor.
    MeSH term(s) Mice ; Animals ; Intestines ; Fibroblasts/metabolism ; Myofibroblasts/metabolism ; Colon/metabolism ; Actins/metabolism
    Chemical Substances Actins
    Language English
    Publishing date 2023-06-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3331-1_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Inflammasomes in the gastrointestinal tract: infection, cancer and gut microbiota homeostasis.

    Man, Si Ming

    Nature reviews. Gastroenterology & hepatology

    2018  Volume 15, Issue 12, Page(s) 721–737

    Abstract: Inflammasome signalling is an emerging pillar of innate immunity and has a central role in the regulation of gastrointestinal health and disease. Activation of the inflammasome complex mediates both the release of the pro-inflammatory cytokines IL-1β and ...

    Abstract Inflammasome signalling is an emerging pillar of innate immunity and has a central role in the regulation of gastrointestinal health and disease. Activation of the inflammasome complex mediates both the release of the pro-inflammatory cytokines IL-1β and IL-18 and the execution of a form of inflammatory cell death known as pyroptosis. In most cases, these mediators of inflammation provide protection against bacterial, viral and protozoal infections. However, unchecked inflammasome activities perpetuate chronic inflammation, which underpins the molecular and pathophysiological basis of gastritis, IBD, upper and lower gastrointestinal cancer, nonalcoholic fatty liver disease and obesity. Studies have also highlighted an inflammasome signature in the maintenance of gut microbiota and gut-brain homeostasis. Harnessing the immunomodulatory properties of the inflammasome could transform clinical practice in the treatment of acute and chronic gastrointestinal and extragastrointestinal diseases. This Review presents an overview of inflammasome biology in gastrointestinal health and disease and describes the value of experimental and pharmacological intervention in the treatment of inflammasome-associated clinical manifestations.
    MeSH term(s) Animals ; Gastrointestinal Diseases/immunology ; Gastrointestinal Diseases/microbiology ; Gastrointestinal Diseases/physiopathology ; Gastrointestinal Microbiome/immunology ; Gastrointestinal Microbiome/physiology ; Gastrointestinal Neoplasms/immunology ; Gastrointestinal Neoplasms/microbiology ; Gastrointestinal Neoplasms/physiopathology ; Gastrointestinal Tract/immunology ; Gastrointestinal Tract/microbiology ; Gastrointestinal Tract/physiopathology ; Homeostasis/physiology ; Humans ; Inflammasomes/immunology ; Inflammasomes/metabolism ; Inflammasomes/physiology
    Chemical Substances Inflammasomes
    Keywords covid19
    Language English
    Publishing date 2018-09-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2493722-8
    ISSN 1759-5053 ; 1759-5045
    ISSN (online) 1759-5053
    ISSN 1759-5045
    DOI 10.1038/s41575-018-0054-1
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  8. Article ; Online: Publisher Correction: Captain GBP1: inflammasomes assemble, pyroptotic endgame.

    Feng, Shouya / Man, Si Ming

    Nature immunology

    2020  Volume 21, Issue 11, Page(s) 1470

    Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.
    Language English
    Publishing date 2020-09-10
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-020-00804-1
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  9. Article ; Online: Streptococcus makes the cut: Gasdermin A-induced pyroptosis.

    Zhao, Anyang / Kirkby, Max / Man, Si Ming

    Cell host & microbe

    2022  Volume 30, Issue 4, Page(s) 410–412

    Abstract: The gasdermin family of cell death executor proteins are activated by different proteases under different physiological conditions. A recent study by Deng et al. in Nature revealed that the cysteine protease SpeB from the human pathogen Streptococcus ... ...

    Abstract The gasdermin family of cell death executor proteins are activated by different proteases under different physiological conditions. A recent study by Deng et al. in Nature revealed that the cysteine protease SpeB from the human pathogen Streptococcus pyogenes directly cleaves and activates Gasdermin A to induce pyroptosis in skin cells.
    MeSH term(s) Cell Death ; Humans ; Peptide Hydrolases ; Pyroptosis ; Streptococcus pyogenes
    Chemical Substances Peptide Hydrolases (EC 3.4.-)
    Language English
    Publishing date 2022-04-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2278004-X
    ISSN 1934-6069 ; 1931-3128
    ISSN (online) 1934-6069
    ISSN 1931-3128
    DOI 10.1016/j.chom.2022.03.003
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  10. Book ; Online ; E-Book: Soybean Physiology and Genetics

    Lam, Hon-Ming / Li, Man-Wah

    2022  

    Author's details edited by Hon-Ming Lam, Man-Wah Li
    Keywords Soybean/Physiology
    Subject code 633.34
    Language English
    Size 1 online resource (xvi, 375 pages) :, illustrations (chiefly colour)
    Publisher Academic Press
    Publishing place London
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-323-91219-2 ; 978-0-323-91219-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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