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Article ; Online: James G. Anderson Tribute.

Donahue, Neil M / Dubey, Manvendra K / Wennberg, Paul O / Brune, William H

The journal of physical chemistry. A

2016 Volume 120, Issue 9, Page(s) 1317–1319

Language	English
Publishing date	2016-03-10
Publishing country	United States
Document type	Journal Article
ISSN	1520-5215
ISSN (online)	1520-5215
DOI	10.1021/acs.jpca.5b11957
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Article ; Online: Safety of COVID-19 mRNA Vaccination Among Young Children in the Vaccine Safety Datalink.

Goddard, Kristin / Donahue, James G / Lewis, Ned / Hanson, Kayla E / Weintraub, Eric S / Fireman, Bruce / Klein, Nicola P

Pediatrics

2023 Volume 152, Issue 1

MeSH term(s)	Child ; Child, Preschool ; Humans ; COVID-19/prevention & control ; RNA, Messenger ; Vaccination/adverse effects ; Vaccines ; COVID-19 Vaccines/adverse effects
Chemical Substances	RNA, Messenger ; Vaccines ; COVID-19 Vaccines
Language	English
Publishing date	2023-06-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	207677-9
ISSN	1098-4275 ; 0031-4005
ISSN (online)	1098-4275
ISSN	0031-4005
DOI	10.1542/peds.2023-061894
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Article ; Online: Mechanism of HO

Kroll, Jesse H / Clarke, James S / Donahue, Neil M / Anderson, James G / Demerjian, Kenneth L

The journal of physical chemistry. A

2021 Volume 105, Issue 9, Page(s) 1554–1560

Abstract: The gas-phase reaction of ozone with alkenes is known to be a dark source of ... ...

Abstract	The gas-phase reaction of ozone with alkenes is known to be a dark source of HO
Language	English
Publishing date	2021-09-10
Publishing country	United States
Document type	Journal Article
ISSN	1520-5215
ISSN (online)	1520-5215
DOI	10.1021/jp002121r
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Article: Vein-first

Singh, Gagandip / Abraham, Peter J / Xie, Rongbing / Donahue, James M / Wei, Benjamin

Journal of thoracic disease

2024 Volume 16, Issue 1, Page(s) 368–378

Abstract: Background: Data remains limited as to whether the order of pulmonary vessel division during performance of a lobectomy for non-small cell lung cancer (NSCLC) affects survival outcomes. Some authors have suggested that ligation of the pulmonary veins ... ...

Abstract	Background: Data remains limited as to whether the order of pulmonary vessel division during performance of a lobectomy for non-small cell lung cancer (NSCLC) affects survival outcomes. Some authors have suggested that ligation of the pulmonary veins should be conducted first in order to minimize the spread of tumor cells secondary to manipulation of the lung. This study examines whether there is a difference in outcomes between patients who undergo robotic lobectomies for NSCLC using a vein-first (V-first) Methods: A retrospective review of electronic medical record data was performed for patients who underwent robotic lobectomies from January 2013 to May 2019. Patients were separated into two groups based on the sequence in which the pulmonary vessels were divided: V-first or A-first. Baseline characteristics and postoperative events were recorded and compared between groups using Chi-squared and Student's Results: A total of 374 patients were identified: 94 V-first and 280 A-first patients. There was no significant difference between the V-first and A-first groups with regards to postoperative complications, length of stay, recurrence-free survival, or overall survival. Conclusions: Our study suggests that choosing a V-first
Language	English
Publishing date	2024-01-15
Publishing country	China
Document type	Journal Article
ZDB-ID	2573571-8
ISSN	2077-6624 ; 2072-1439
ISSN (online)	2077-6624
ISSN	2072-1439
DOI	10.21037/jtd-22-1576
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Article ; Online: Post-recovery health domain scores among outpatients by SARS-CoV-2 testing status during the pre-Delta period.

King, Jennifer P / Chung, Jessie R / Donahue, James G / Martin, Emily T / Leis, Aleda M / Monto, Arnold S / Gaglani, Manjusha / Dunnigan, Kayan / Raiyani, Chandni / Saydah, Sharon / Flannery, Brendan / Belongia, Edward A

BMC infectious diseases

2024 Volume 24, Issue 1, Page(s) 300

Abstract: Background: Symptoms of COVID-19 including fatigue and dyspnea, may persist for weeks to months after SARS-CoV-2 infection. This study compared self-reported disability among SARS-CoV-2-positive and negative persons with mild to moderate COVID-19-like ... ...

Abstract	Background: Symptoms of COVID-19 including fatigue and dyspnea, may persist for weeks to months after SARS-CoV-2 infection. This study compared self-reported disability among SARS-CoV-2-positive and negative persons with mild to moderate COVID-19-like illness who presented for outpatient care before widespread COVID-19 vaccination. Methods: Unvaccinated adults with COVID-19-like illness enrolled within 10 days of illness onset at three US Flu Vaccine Effectiveness Network sites were tested for SARS-CoV-2 by molecular assay. Enrollees completed an enrollment questionnaire and two follow-up surveys (7-24 days and 2-7 months after illness onset) online or by phone to assess illness characteristics and health status. The second follow-up survey included questions measuring global health, physical function, fatigue, and dyspnea. Scores in the four domains were compared by participants' SARS-CoV-2 test results in univariate analysis and multivariable Gamma regression. Results: During September 22, 2020 - February 13, 2021, 2712 eligible adults were enrolled, 1541 completed the first follow-up survey, and 650 completed the second follow-up survey. SARS-CoV-2-positive participants were more likely to report fever at acute illness but were otherwise comparable to SARS-CoV-2-negative participants. At first follow-up, SARS-CoV-2-positive participants were less likely to have reported fully or mostly recovered from their illness compared to SARS-CoV-2-negative participants. At second follow-up, no differences by SARS-CoV-2 test results were detected in the four domains in the multivariable model. Conclusion: Self-reported disability was similar among outpatient SARS-CoV-2-positive and -negative adults 2-7 months after illness onset.
MeSH term(s)	Adult ; Humans ; SARS-CoV-2 ; Outpatients ; COVID-19/diagnosis ; COVID-19 Testing ; COVID-19 Vaccines ; Dyspnea ; Fatigue
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2024-03-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-024-09108-3
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Article ; Online: Effectiveness of Recombinant Zoster Vaccine Against Herpes Zoster in a Real-World Setting.

Zerbo, Ousseny / Bartlett, Joan / Fireman, Bruce / Lewis, Ned / Goddard, Kristin / Dooling, Kathleen / Duffy, Jonathan / Glanz, Jason / Naleway, Allison / Donahue, James G / Klein, Nicola P

Annals of internal medicine

2024 Volume 177, Issue 2, Page(s) 189–195

Abstract: Background: A 2-dose series of recombinant zoster vaccine (RZV) was 97% effective against herpes zoster (HZ) in a pivotal clinical trial.: Objective: To evaluate real-world effectiveness of RZV against HZ.: Design: Prospective cohort study.: ... ...

Abstract	Background: A 2-dose series of recombinant zoster vaccine (RZV) was 97% effective against herpes zoster (HZ) in a pivotal clinical trial. Objective: To evaluate real-world effectiveness of RZV against HZ. Design: Prospective cohort study. Setting: Four health care systems in the Vaccine Safety Datalink. Participants: Persons aged 50 years or older. Measurements: The outcome was incident HZ defined by a diagnosis with an antiviral prescription. Cox regression was used to estimate the hazard of HZ in vaccinated persons compared with unvaccinated persons, with adjustment for covariates. Vaccine effectiveness (VE) was calculated as 1 minus the adjusted hazard ratio and was estimated by time since the last RZV dose and by corticosteroid use. Results: The study included nearly 2.0 million persons who contributed 7.6 million person-years of follow-up. After adjustment, VE of 1 dose was 64% and VE of 2 doses was 76%. After 1 dose only, VE was 70% during the first year, 45% during the second year, 48% during the third year, and 52% after the third year. After 2 doses, VE was 79% during the first year, 75% during the second year, and 73% during the third and fourth years. Vaccine effectiveness was 65% in persons who received corticosteroids before vaccination and 77% in those who did not. Limitation: Herpes zoster could not be identified as accurately in these observational data as in the previous clinical trials. Conclusion: Two doses of RZV were highly effective, although less effective than in the previous clinical trials. Two-dose effectiveness waned very little during the 4 years of follow-up. However, 1-dose effectiveness waned substantially after 1 year, underscoring the importance of the second dose. Primary funding source: Centers for Disease Control and Prevention.
MeSH term(s)	Humans ; Herpes Zoster/prevention & control ; Herpes Zoster Vaccine ; Herpesvirus 3, Human ; Prospective Studies ; Vaccination ; Vaccines, Synthetic/adverse effects ; Middle Aged ; Clinical Trials as Topic
Chemical Substances	Herpes Zoster Vaccine ; Vaccines, Synthetic
Language	English
Publishing date	2024-01-09
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	336-0
ISSN	1539-3704 ; 0003-4819
ISSN (online)	1539-3704
ISSN	0003-4819
DOI	10.7326/M23-2023
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Article ; Online: Impact of the COVID-19 Pandemic on Health Care Utilization in the Vaccine Safety Datalink: Retrospective Cohort Study.

Qian, Lei / Sy, Lina S / Hong, Vennis / Glenn, Sungching C / Ryan, Denison S / Nelson, Jennifer C / Hambidge, Simon J / Crane, Bradley / Zerbo, Ousseny / DeSilva, Malini B / Glanz, Jason M / Donahue, James G / Liles, Elizabeth / Duffy, Jonathan / Xu, Stanley

JMIR public health and surveillance

2024 Volume 10, Page(s) e48159

Abstract: Background: Understanding the long-term impact of the COVID-19 pandemic on health care utilization is important to health care organizations and policy makers for strategic planning, as well as to researchers when designing studies that use ... ...

Abstract	Background: Understanding the long-term impact of the COVID-19 pandemic on health care utilization is important to health care organizations and policy makers for strategic planning, as well as to researchers when designing studies that use observational electronic health record data during the pandemic period. Objective: This study aimed to evaluate the changes in health care utilization across all care settings among a large, diverse, and insured population in the United States during the COVID-19 pandemic. Methods: We conducted a retrospective cohort study within 8 health care organizations participating in the Vaccine Safety Datalink Project using electronic health record data from members of all ages from January 1, 2017, to December 31, 2021. The visit rates per person-year were calculated monthly during the study period for 4 health care settings combined as well as by inpatient, emergency department (ED), outpatient, and telehealth settings, both among all members and members without COVID-19. Difference-in-difference analysis and interrupted time series analysis were performed to assess the changes in visit rates from the prepandemic period (January 2017 to February 2020) to the early pandemic period (April-December 2020) and the later pandemic period (July-December 2021), respectively. An exploratory analysis was also conducted to assess trends through June 2023 at one of the largest sites, Kaiser Permanente Southern California. Results: The study included more than 11 million members from 2017 to 2021. Compared with the prepandemic period, we found reductions in visit rates during the early pandemic period for all in-person care settings. During the later pandemic period, overall use reached 8.36 visits per person-year, exceeding the prepandemic level of 7.49 visits per person-year in 2019 (adjusted percent change 5.1%, 95% CI 0.6%-9.9%); inpatient and ED visits returned to prepandemic levels among all members, although they remained low at 0.095 and 0.241 visits per person-year, indicating a 7.5% and 8% decrease compared to pre-pandemic levels among members without COVID-19, respectively. Telehealth visits, which were approximately 42% of the volume of outpatient visits during the later pandemic period, were increased by 97.5% (95% CI 86.0%-109.7%) from 0.865 visits per person-year in 2019 to 2.35 visits per person-year in the later pandemic period. The trends in Kaiser Permanente Southern California were similar to those of the entire study population. Visit rates from January 2022 to June 2023 were stable and appeared to be a continuation of the use levels observed at the end of 2021. Conclusions: Telehealth services became a mainstay of the health care system during the late COVID-19 pandemic period. Inpatient and ED visits returned to prepandemic levels, although they remained low among members without evidence of COVID-19. Our findings provide valuable information for strategic resource allocation for postpandemic patient care and for designing observational studies involving the pandemic period.
MeSH term(s)	Humans ; Pandemics/prevention & control ; Retrospective Studies ; COVID-19/epidemiology ; COVID-19/prevention & control ; Patient Acceptance of Health Care ; Telemedicine ; Vaccines
Chemical Substances	Vaccines
Language	English
Publishing date	2024-01-23
Publishing country	Canada
Document type	Journal Article
ISSN	2369-2960
ISSN (online)	2369-2960
DOI	10.2196/48159
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Article ; Online: Integrative Analyses of Tumor and Peripheral Biomarkers in the Treatment of Advanced Renal Cell Carcinoma.

Choueiri, Toni K / Donahue, Amber C / Braun, David A / Rini, Brian I / Powles, Thomas / Haanen, John B A G / Larkin, James / Mu, Xinmeng Jasmine / Pu, Jie / Teresi, Rosemary E / di Pietro, Alessandra / Robbins, Paul B / Motzer, Robert J

Cancer discovery

2024 Volume 14, Issue 3, Page(s) 406–423

Abstract: The phase III JAVELIN Renal 101 trial demonstrated prolonged progression-free survival (PFS) in patients (N = 886) with advanced renal cell carcinoma treated with first-line avelumab + axitinib (A+Ax) versus sunitinib. We report novel findings from ... ...

Abstract	The phase III JAVELIN Renal 101 trial demonstrated prolonged progression-free survival (PFS) in patients (N = 886) with advanced renal cell carcinoma treated with first-line avelumab + axitinib (A+Ax) versus sunitinib. We report novel findings from integrated analyses of longitudinal blood samples and baseline tumor tissue. PFS was associated with elevated lymphocyte levels in the sunitinib arm and an abundance of innate immune subsets in the A+Ax arm. Treatment with A+Ax led to greater T-cell repertoire modulation and less change in T-cell numbers versus sunitinib. In the A+Ax arm, patients with tumors harboring mutations in ≥2 of 10 previously identified PFS-associated genes (double mutants) had distinct circulating and tumor-infiltrating immunologic profiles versus those with wild-type or single-mutant tumors, suggesting a role for non-T-cell-mediated and non-natural killer cell-mediated mechanisms in double-mutant tumors. We provide evidence for different immunomodulatory mechanisms based on treatment (A+Ax vs. sunitinib) and tumor molecular subtypes. Significance: Our findings provide novel insights into the different immunomodulatory mechanisms governing responses in patients treated with avelumab (PD-L1 inhibitor) + axitinib or sunitinib (both VEGF inhibitors), highlighting the contribution of tumor biology to the complexity of the roles and interactions of infiltrating immune cells in response to these treatment regimens. This article is featured in Selected Articles from This Issue, p. 384.
MeSH term(s)	Humans ; Carcinoma, Renal Cell/drug therapy ; Carcinoma, Renal Cell/genetics ; Sunitinib/therapeutic use ; Axitinib ; Biomarkers ; Kidney Neoplasms/drug therapy ; Kidney Neoplasms/genetics
Chemical Substances	Sunitinib (V99T50803M) ; Axitinib (C9LVQ0YUXG) ; Biomarkers
Language	English
Publishing date	2024-03-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2625242-9
ISSN	2159-8290 ; 2159-8274
ISSN (online)	2159-8290
ISSN	2159-8274
DOI	10.1158/2159-8290.CD-23-0680
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Article ; Online: Comparison of Techniques for Correction of Chin-down Vertical Abnormal Head Position Associated with Infantile Nystagmus Syndrome.

Law, James J / Zheng, Yuxi / Holt, Derick G / Morrison, David G / Donahue, Sean P

American journal of ophthalmology

2020 Volume 213, Page(s) 57–61

Abstract: Purpose: We evaluated the relative effectiveness of combined recession-resection of vertical rectus muscles versus superior rectus recession with inferior oblique weakening for patients who underwent surgical correction of chin-down abnormal head ... ...

Abstract	Purpose: We evaluated the relative effectiveness of combined recession-resection of vertical rectus muscles versus superior rectus recession with inferior oblique weakening for patients who underwent surgical correction of chin-down abnormal head position (AHP) associated with infantile nystagmus syndrome (INS). Design: Retrospective interventional case series. Methods: This is a review of 22 patients who underwent surgical correction of chin-down vertical AHP associated with INS at an academic institution. The primary outcome was collapse of AHP. Unfavorable outcomes included repeat surgery and induced strabismus, in addition to failure of collapse of AHP. Results: Twenty-two patients had chin-down AHP. Recession-resection (bilateral superior rectus recession 6-9 mm; bilateral inferior rectus resection 5-9 mm) was performed in 11 cases; weakening of both elevators (bilateral superior rectus recession 5-8 mm, bilateral inferior oblique recession or myectomy) occurred in 11 cases. Unfavorable outcome rates were 64% (7/11) compared with 18% (2/11), respectively (P = .03). Reoperation was performed for 6 of 22 patients. Five patients were from the recession-resection group, namely 3 for induced V-pattern esotropia, 1 for alternating esotropia, and 1 to correct recurrent AHP. The last of the 6 who required reoperation was in the elevator weakening group, and required correction of a recurrent AHP (P = .06). Conclusions: While recession-resection of the vertical recti and weakening of both elevators each produce acceptable collapse of chin-down AHP, the former frequently induces a V-pattern esotropia requiring reoperation.
MeSH term(s)	Adolescent ; Child ; Child, Preschool ; Chin/surgery ; Female ; Follow-Up Studies ; Head/physiology ; Humans ; Infant ; Male ; Nystagmus, Congenital/physiopathology ; Nystagmus, Congenital/surgery ; Oculomotor Muscles/surgery ; Ophthalmologic Surgical Procedures ; Posture/physiology ; Reoperation ; Retrospective Studies ; Vision, Binocular/physiology ; Visual Acuity/physiology
Language	English
Publishing date	2020-01-15
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80030-2
ISSN	1879-1891 ; 0002-9394
ISSN (online)	1879-1891
ISSN	0002-9394
DOI	10.1016/j.ajo.2020.01.008
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Article ; Online: MiR-214-3p targets Ras-related protein 14 (RAB14) to inhibit cellular migration and invasion in esophageal Cancer cells.

Phatak, Pornima / Burrows, Whitney M / Creed, Timothy Michael / Youssef, Mariam / Lee, Goo / Donahue, James M

BMC cancer

2022 Volume 22, Issue 1, Page(s) 1265

Abstract: Background: MicroRNA (miR)-214-3p is emerging as an important tumor suppressor in esophageal cancer. In this study, we examined the interaction between miR-214-3p and RAB14, a membrane trafficking protein shown to exert oncogenic functions in other ... ...

Abstract	Background: MicroRNA (miR)-214-3p is emerging as an important tumor suppressor in esophageal cancer. In this study, we examined the interaction between miR-214-3p and RAB14, a membrane trafficking protein shown to exert oncogenic functions in other malignancies, in esophageal cancer cells. Methods: Studies were performed in a human esophageal epithelial cell line and a panel of esophageal cancer cell lines, as well in human specimens. MiR-214-3p expression was measured by digital PCR. Biotinylated RNA pull-down and luciferase reporter assays assessed binding. The xCELLigence RTCA system measured cell migration and invasion in real time. A lentiviral expression vector was used to create an esophageal cancer cell line stably expressing miR-214-3p. Results: MiR-214-3p expression was decreased in esophageal cancer cell lines and human specimens compared to non-malignant controls. RAB14 mRNA stability and protein expression were decreased following miR-214-3p overexpression. Binding between miR-214-3p and RAB14 mRNA was observed. Either forced expression of miR-214-3p or RAB14 silencing led to a marked decrease in cellular migration and invasion. Esophageal cancer cells stably expressing miR-214-3p demonstrated decreased growth in a subcutaneous murine model. Conclusions: These results further support the tumor-suppressive role of miR-214-3p in esophageal cancer cells by demonstrating its ability to regulate RAB14 expression.
Language	English
Publishing date	2022-12-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-022-10304-0
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