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Article ; Online: Identification of therapeutic targets and prognostic biomarkers of the ephrin receptor subfamily in pancreatic adenocarcinoma.

Zou, Jingjng / Zhang, Kun / Zhu, Jinde / Tu, Chaoyong / Guo, Jingqiang

The Journal of international medical research

2024 Volume 52, Issue 1, Page(s) 3000605231218559

Abstract: Objectives: We aimed to examine the significance of ephrin receptor A2 (EphA2) expression in pancreatic adenocarcinoma (PAAD) and its associated mechanism.: Methods: EphA2 mRNA expression patterns were compared in pancreatic cancer and normal tissues ...

Abstract	Objectives: We aimed to examine the significance of ephrin receptor A2 (EphA2) expression in pancreatic adenocarcinoma (PAAD) and its associated mechanism. Methods: EphA2 mRNA expression patterns were compared in pancreatic cancer and normal tissues using GEPIA. Kaplan-Meier analysis was used to examine the correlation between EphA2 expression and PAAD patient prognosis. EphA2 gene methylation and associations with tumor immune cell infiltration were analyzed with UALCAN and TIMER, respectively. EphA2-interacting proteins were investigated with GeneMANIA, while STRING helped predict potentially relevant signaling pathways. EphA2 protein expression was examined with immunohistochemistry (IHC) in PAAD patient tissues. Results: EphA2 was highly expressed in pancreatic cancer tissues and associated with pathological stage. PAAD patients with high EphA2 expression had shorter overall survival and disease-free survival times. EphA2 expression levels were significantly and positively associated with CD4 Conclusions: EphA2 is highly expressed in PAAD and closely related to poor patient prognosis, and is therefore a potential biomarker and target for PAAD diagnosis and treatment.
MeSH term(s)	Humans ; Adenocarcinoma/diagnosis ; Adenocarcinoma/genetics ; Pancreatic Neoplasms/diagnosis ; Pancreatic Neoplasms/genetics ; Receptor, EphA2/genetics ; Prognosis ; RNA, Messenger/genetics ; Ephrins
Chemical Substances	Receptor, EphA2 (EC 2.7.10.1) ; RNA, Messenger ; Ephrins
Language	English
Publishing date	2024-01-05
Publishing country	England
Document type	Journal Article
ZDB-ID	184023-x
ISSN	1473-2300 ; 0300-0605 ; 0142-2596
ISSN (online)	1473-2300
ISSN	0300-0605 ; 0142-2596
DOI	10.1177/03000605231218559
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Article ; Online: Identification of therapeutic targets and prognostic biomarkers of the ephrin receptor subfamily in pancreatic adenocarcinoma

Jingjng Zou / Kun Zhang / Jinde Zhu / Chaoyong Tu / Jingqiang Guo

Journal of International Medical Research, Vol

2024 Volume 52

Abstract: Objectives We aimed to examine the significance of ephrin receptor A2 (EphA2) expression in pancreatic adenocarcinoma (PAAD) and its associated mechanism. Methods EphA2 mRNA expression patterns were compared in pancreatic cancer and normal tissues using ... ...

Abstract	Objectives We aimed to examine the significance of ephrin receptor A2 (EphA2) expression in pancreatic adenocarcinoma (PAAD) and its associated mechanism. Methods EphA2 mRNA expression patterns were compared in pancreatic cancer and normal tissues using GEPIA. Kaplan–Meier analysis was used to examine the correlation between EphA2 expression and PAAD patient prognosis. EphA2 gene methylation and associations with tumor immune cell infiltration were analyzed with UALCAN and TIMER, respectively. EphA2-interacting proteins were investigated with GeneMANIA, while STRING helped predict potentially relevant signaling pathways. EphA2 protein expression was examined with immunohistochemistry (IHC) in PAAD patient tissues. Results EphA2 was highly expressed in pancreatic cancer tissues and associated with pathological stage. PAAD patients with high EphA2 expression had shorter overall survival and disease-free survival times. EphA2 expression levels were significantly and positively associated with CD4 + T cell infiltration. EphA2 can interact with ENFNA1, ACP1, and CDC42. High EphA2 mRNA expression was enriched for regulation of cell size and cell proliferation. IHC assays suggested that pancreatic cancer tissues had higher EphA2 protein levels than normal pancreatic tissues. Conclusions EphA2 is highly expressed in PAAD and closely related to poor patient prognosis, and is therefore a potential biomarker and target for PAAD diagnosis and treatment.
Keywords	Medicine (General) ; R5-920
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The complete chloroplast genome of

Tu, Chaoyong / Lin, Hao / Wang, Qiang / Wu, Lijun / Yang, Yulian / Zou, Lijuan / Wu, Qinggui

Mitochondrial DNA. Part B, Resources

2021 Volume 6, Issue 3, Page(s) 1071–1072

Abstract: ... Ottelia ... ...

Abstract	Ottelia acuminate
Language	English
Publishing date	2021-03-22
Publishing country	England
Document type	Journal Article
ISSN	2380-2359
ISSN (online)	2380-2359
DOI	10.1080/23802359.2021.1899860
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Article ; Online: The value of preoperative systemic immune-inflammation index in predicting vascular invasion of hepatocellular carcinoma: a meta-analysis.

Wu, YiFeng / Tu, ChaoYong / Shao, ChuXiao

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas

2021 Volume 54, Issue 4, Page(s) e10273

Abstract: Vascular invasion and systemic immune-inflammation index (SII) are risk factors for the prognosis of patients with hepatocellular carcinoma. At present, the correlation between the two is not clear. This meta-analysis explored the relationship between ... ...

Abstract	Vascular invasion and systemic immune-inflammation index (SII) are risk factors for the prognosis of patients with hepatocellular carcinoma. At present, the correlation between the two is not clear. This meta-analysis explored the relationship between preoperative SII and vascular invasion in patients with hepatocellular carcinoma. According to the search formula, the Pubmed, Embase, Cochrane, Web of Science, and CNKI databases were searched for the relevant research until March 2020. After the quality evaluation of the included literature, the odds ratio (OR) and its corresponding 95% confidence interval (CI) were used as the effect measure. Stata 15. 0 software was used for statistical analysis. The meta-analysis eventually included seven retrospective cohort studies of 3583 patients with hepatocellular carcinoma. The results showed that the choice of SII cut-off value affects SII's efficiency in predicting the risk of vascular invasion. In the cohort of studies with appropriate SII cut-off value, the high SII preoperative group had a higher risk of vascular invasion (OR=2.62; 95%CI: 2.07-3.32; P=0.000) and microvascular invasion (OR=1.82; 95%CI: 1.01-3.25; P=0.045) than the low SII group. The tumor diameter (OR=2.88; 95%CI: 1.73-4. 80; P=0.000) of the high SII group was larger than that of the low SII group. There was no publication bias in this study (Begg's test, P=0.368). As a routine, cheap, and easily available index, SII can provide a certain reference value for clinicians to evaluate vascular invasion before operation.
MeSH term(s)	Carcinoma, Hepatocellular/surgery ; Humans ; Inflammation ; Liver Neoplasms/surgery ; Retrospective Studies ; Risk Factors
Language	English
Publishing date	2021-02-26
Publishing country	Brazil
Document type	Journal Article ; Meta-Analysis
ZDB-ID	786234-9
ISSN	1414-431X ; 0100-879X
ISSN (online)	1414-431X
ISSN	0100-879X
DOI	10.1590/1414-431X202010273
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Article ; Online: Inflammatory indexes in preoperative blood routine to predict early recurrence of hepatocellular carcinoma after curative hepatectomy.

Wu, YiFeng / Tu, ChaoYong / Shao, ChuXiao

BMC surgery

2021 Volume 21, Issue 1, Page(s) 178

Abstract: Background: The inflammation indexes in blood routine play an essential role in evaluating the prognosis of patients with hepatocellular carcinoma, but the effect on early recurrence has not been clarified. The study aimed to investigate the risk ... ...

Abstract	Background: The inflammation indexes in blood routine play an essential role in evaluating the prognosis of patients with hepatocellular carcinoma, but the effect on early recurrence has not been clarified. The study aimed to investigate the risk factors of early recurrence (within 2 years) and recurrence-free survival after curative hepatectomy and explore the role of inflammatory indexes in predicting early recurrence. Methods: The baseline data of 161 patients with hepatocellular carcinoma were analyzed retrospectively. The optimal cut-off value of the inflammatory index was determined according to the Youden index. Its predictive performance was compared by the area under the receiver operating characteristic curve. Logistic and Cox regression analyses were used to determine the risk factors of early recurrence and recurrence-free survival. Results: The area under the curve of monocyte to lymphocyte ratio (MLR) for predicting early recurrence was 0.700, which was better than systemic inflammatory response index (SIRI), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and systemic immune-inflammatory index (SII). MLR, tumour size, tumour differentiation and BCLC stage are all risk factors for early recurrence and recurrence-free survival of HCC. Combining the above four risk factors to construct a joint index, the area under the curve for predicting early recurrence was 0.829, which was better than single MLR, tumour size, tumour differentiation and BCLC stage. Furthermore, with the increase of risk factors, the recurrence-free survival of patients is worse. Conclusion: The combination of MLR and clinical risk factors is helpful for clinicians to identify high-risk patients with early recurrence and carry out active postoperative adjuvant therapy to improve the prognosis of patients.
MeSH term(s)	Carcinoma, Hepatocellular/blood ; Carcinoma, Hepatocellular/surgery ; Hepatectomy ; Humans ; Inflammation/blood ; Liver Neoplasms/blood ; Liver Neoplasms/surgery ; Lymphocyte Count ; Monocytes ; Neoplasm Recurrence, Local/blood ; Predictive Value of Tests ; Preoperative Period ; Prognosis ; Retrospective Studies ; Risk Assessment/methods ; Risk Factors
Language	English
Publishing date	2021-04-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2050442-1
ISSN	1471-2482 ; 1471-2482
ISSN (online)	1471-2482
ISSN	1471-2482
DOI	10.1186/s12893-021-01180-9
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Article ; Online: The value of preoperative systemic immune-inflammation index in predicting vascular invasion of hepatocellular carcinoma

YiFeng Wu / ChaoYong Tu / ChuXiao Shao

Brazilian Journal of Medical and Biological Research, Vol 54, Iss

a meta-analysis

2021 Volume 4

Abstract	Vascular invasion and systemic immune-inflammation index (SII) are risk factors for the prognosis of patients with hepatocellular carcinoma. At present, the correlation between the two is not clear. This meta-analysis explored the relationship between preoperative SII and vascular invasion in patients with hepatocellular carcinoma. According to the search formula, the Pubmed, Embase, Cochrane, Web of Science, and CNKI databases were searched for the relevant research until March 2020. After the quality evaluation of the included literature, the odds ratio (OR) and its corresponding 95% confidence interval (CI) were used as the effect measure. Stata 15. 0 software was used for statistical analysis. The meta-analysis eventually included seven retrospective cohort studies of 3583 patients with hepatocellular carcinoma. The results showed that the choice of SII cut-off value affects SII's efficiency in predicting the risk of vascular invasion. In the cohort of studies with appropriate SII cut-off value, the high SII preoperative group had a higher risk of vascular invasion (OR=2.62; 95%CI: 2.07-3.32; P=0.000) and microvascular invasion (OR=1.82; 95%CI: 1.01-3.25; P=0.045) than the low SII group. The tumor diameter (OR=2.88; 95%CI: 1.73-4. 80; P=0.000) of the high SII group was larger than that of the low SII group. There was no publication bias in this study (Begg's test, P=0.368). As a routine, cheap, and easily available index, SII can provide a certain reference value for clinicians to evaluate vascular invasion before operation.
Keywords	Hepatocellular carcinoma ; Meta-analysis ; Vascular invasion ; Microvascular invasion ; Systemic immune-inflammation index ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
Subject code	616
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	Associação Brasileira de Divulgação Científica
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Enhancement of ice-phase precipitation caused by thermal forcing produces ghost echoes over the Tibetan Plateau

Yilun Chen / Aoqi Zhang / Shumin Chen / Chaoyong Tu / Weibiao Li / Yunfei Fu

npj Climate and Atmospheric Science, Vol 4, Iss 1, Pp 1-

2021 Volume 6

Abstract: Abstract Whether tall storms produce heavy precipitation is currently a controversial topic. Here, we used seven years of observations from the dual-frequency precipitation radar and found that there is a rare but unique vertical precipitation structure ... ...

Abstract	Abstract Whether tall storms produce heavy precipitation is currently a controversial topic. Here, we used seven years of observations from the dual-frequency precipitation radar and found that there is a rare but unique vertical precipitation structure over the Tibetan Plateau. The radar echo peaks above the freezing height, which we refer to as a “ghost echo”. The existence of a ghost echo increases the echo-top height but suppresses the increase in droplet size below it, and therefore weakens the near-surface precipitation. Compared with normal echoes, ghost echoes appear more often in the afternoon. The potentially unstable environment produced by thermal forcing is the main cause of ghost echoes, rather than the dynamic factor of wind shear. The ghost echo, which is essentially a mechanism of ice-phase precipitation enhancement, represents a type of tall but weak precipitation. Its existence adds to our current perception of the nature of precipitation.
Keywords	Environmental sciences ; GE1-350 ; Meteorology. Climatology ; QC851-999
Subject code	910
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: MiR-20b-5p promotes hepatocellular carcinoma cell proliferation, migration and invasion by down-regulating CPEB3.

Li, Zhuokai / Wu, Lvzhong / Tan, Wei / Zhang, Kun / Lin, Qiaomei / Zhu, Jinde / Tu, Chaoyong / Lv, Xinliang / Jiang, Chuan

Annals of hepatology

2021 Volume 23, Page(s) 100345

Abstract: Introduction and objectives: This study aimed to explore the functional mechanism of the miRNA-20b-5p/cytoplasmic polyadenylation element binding protein 3 (miR-20b-5p/CPEB3) axis in hepatocellular carcinoma (HCC) so as to provide a new idea for ... ...

Abstract	Introduction and objectives: This study aimed to explore the functional mechanism of the miRNA-20b-5p/cytoplasmic polyadenylation element binding protein 3 (miR-20b-5p/CPEB3) axis in hepatocellular carcinoma (HCC) so as to provide a new idea for targeted therapy of HCC. Materials and methods: Bioinformatics analysis was employed to obtain markedly differentially expressed miRNAs and mRNAs in The Cancer Genome Atlas-Liver Hepatocellular Carcinoma (TCGA-LIHC) dataset, so as to find target miRNA and its target mRNA. Real-time quantitative PCR was conducted to detect miR-20b-5p and CPEB3 mRNA expression. Western blot was performed to determine CPEB3 protein expression. Dual-luciferase reporter assay was carried out to verify the targeting relationship between miR-20b-5p and CPEB3. Cell counting kit-8 assay, wound healing assay, Transwell invasion assay and flow cytometry were conducted to evaluate the proliferation, migration, invasion and apoptosis of HCC cells. Results: Bioinformatics analysis suggested that miR-20b-5p and CPEB3 were markedly highly and lowly expressed, respectively, in HCC tissue in TCGA-LIHC dataset. Over-expressing miR-20b-5p facilitated the proliferation, migration and invasion, and suppressed the apoptosis of HCC cells. Dual-luciferase reporter assay validated that there was a targeting relationship between miR-20b-5p and CPEB3. The inhibitory effect of CPEB3 over-expression on HCC cell proliferation, migration and invasion was reversed by over-expressing miR-20b-5p. Conclusions: The present study proved that miR-20b-5p promotes HCC cell proliferation, migration and invasion by inhibiting CPEB3 expression, which may provide a theoretical basis for the prognosis and treatment of HCC patients.
MeSH term(s)	Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Case-Control Studies ; Cell Culture Techniques ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Databases, Factual ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Neoplasm Invasiveness ; RNA, Messenger/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism
Chemical Substances	CPEB3 protein, human ; MIRN20b microRNA, human ; MicroRNAs ; RNA, Messenger ; RNA-Binding Proteins
Language	English
Publishing date	2021-03-31
Publishing country	Mexico
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2188733-0
ISSN	1665-2681
ISSN	1665-2681
DOI	10.1016/j.aohep.2021.100345
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Article ; Online: MiR-20b-5p promotes hepatocellular carcinoma cell proliferation, migration and invasion by down-regulating CPEB3

Zhuokai Li / Lvzhong Wu / Wei Tan / Kun Zhang / Qiaomei Lin / Jinde Zhu / Chaoyong Tu / Xinliang Lv / Chuan Jiang

Annals of Hepatology, Vol 23, Iss , Pp 100345- (2021)

2021

Abstract: Introduction and Objectives: This study aimed to explore the functional mechanism of the miRNA-20b-5p/cytoplasmic polyadenylation element binding protein 3 (miR-20b-5p/CPEB3) axis in hepatocellular carcinoma (HCC) so as to provide a new idea for targeted ...

Abstract	Introduction and Objectives: This study aimed to explore the functional mechanism of the miRNA-20b-5p/cytoplasmic polyadenylation element binding protein 3 (miR-20b-5p/CPEB3) axis in hepatocellular carcinoma (HCC) so as to provide a new idea for targeted therapy of HCC. Materials and Methods: Bioinformatics analysis was employed to obtain markedly differentially expressed miRNAs and mRNAs in The Cancer Genome Atlas-Liver Hepatocellular Carcinoma (TCGA-LIHC) dataset, so as to find target miRNA and its target mRNA. Real-time quantitative PCR was conducted to detect miR-20b-5p and CPEB3 mRNA expression. Western blot was performed to determine CPEB3 protein expression. Dual-luciferase reporter assay was carried out to verify the targeting relationship between miR-20b-5p and CPEB3. Cell counting kit-8 assay, wound healing assay, Transwell invasion assay and flow cytometry were conducted to evaluate the proliferation, migration, invasion and apoptosis of HCC cells. Results: Bioinformatics analysis suggested that miR-20b-5p and CPEB3 were markedly highly and lowly expressed, respectively, in HCC tissue in TCGA-LIHC dataset. Over-expressing miR-20b-5p facilitated the proliferation, migration and invasion, and suppressed the apoptosis of HCC cells. Dual-luciferase reporter assay validated that there was a targeting relationship between miR-20b-5p and CPEB3. The inhibitory effect of CPEB3 over-expression on HCC cell proliferation, migration and invasion was reversed by over-expressing miR-20b-5p. Conclusions: The present study proved that miR-20b-5p promotes HCC cell proliferation, migration and invasion by inhibiting CPEB3 expression, which may provide a theoretical basis for the prognosis and treatment of HCC patients.
Keywords	miR-20b-5p ; CPEB3 ; Hepatocellular carcinoma ; Proliferation ; Migration ; Invasion ; Specialties of internal medicine ; RC581-951
Subject code	616 ; 500
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Knockdown of PKMYT1 is associated with autophagy inhibition and apoptosis induction and suppresses tumor progression in hepatocellular carcinoma.

Wu, Fangnan / Tu, Chaoyong / Zhang, Kun / Che, Hanyang / Lin, Qiaomei / Li, Zhuokai / Zhou, Qingyun / Tang, Bufu / Yang, Yang / Chen, Minjiang / Shao, Chuxiao

Biochemical and biophysical research communications

2022 Volume 640, Page(s) 173–182

Abstract: Background: Hepatocellular carcinoma (HCC) is a cancerous tumor that ranks as the third leading cause of cancer death across the globe. Protein kinase membrane-associated tyrosine/threonine kinase 1 (PKMYT1) is overexpressed in many cancer types, ... ...

Abstract	Background: Hepatocellular carcinoma (HCC) is a cancerous tumor that ranks as the third leading cause of cancer death across the globe. Protein kinase membrane-associated tyrosine/threonine kinase 1 (PKMYT1) is overexpressed in many cancer types, including HCC, but the potential mechanism and biological function of PKMYT1 are not fully understood. Materials and methods: The expression level of PKMYT1 was detected in human HCC tissues and adjacent tissues. We then established HCC cell lines with PKMYT1 knockdown and observed proliferation, migration, autophagy, apoptosis in cell lines and tumor growth in a nude mouse model. To investigate the underlying mechanism by which PKMYT1 regulates autophagy and apoptosis, RNA sequencing was performed in HCC-LM3 cells with and without PKMYT1 knockdown. Results: Here, we observed that human HCC tissues had higher expression of PKMYT1 than adjacent tissues. Overexpression of PKMYT1 was closely associated with poor prognosis in HCC patients. PKMYT1 knockdown inhibited the proliferative potential and migration of HCC cell lines. We also found that downregulation of PKMYT1 inhibited autophagy and induced apoptosis. RNA sequencing analysis showed that the MAPK and PI3K-AKT pathways, which have been reported to affect autophagy and apoptosis, may be regulated after PKMYT1 knockdown by KEGG pathway enrichment analysis. Furthermore, we identified that knockdown of PKMYT1 attenuated the phosphorylation levels of p38 MAPK, ERK and PI3K/Akt/mTOR, which might mediate autophagy inhibition and apoptosis induction via these signaling pathways to inhibit the development of HCC. Conclusion: Our study suggests that PKMYT1 functions as an oncogene and may be a new target for HCC treatment.
MeSH term(s)	Animals ; Humans ; Mice ; Apoptosis/genetics ; Autophagy/genetics ; Carcinoma, Hepatocellular/pathology ; Cell Line, Tumor ; Cell Proliferation/genetics ; Liver Neoplasms/pathology ; Membrane Proteins/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Protein Serine-Threonine Kinases ; Protein-Tyrosine Kinases/genetics ; Proto-Oncogene Proteins c-akt/metabolism
Chemical Substances	Membrane Proteins ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; PKMYT1 protein, human (EC 2.7.11.1) ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Protein-Tyrosine Kinases (EC 2.7.10.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2022-12-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2022.11.084
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