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Article ; Online: Pathophysiology of Inflammatory Bowel Diseases. Reply.

Chang, John T

2021 Volume 384, Issue 14, Page(s) 1378

MeSH term(s)	Humans ; Inflammatory Bowel Diseases ; Risk Factors
Language	English
Publishing date	2021-04-07
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMc2101562
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Article ; Online: Pathophysiology of Inflammatory Bowel Diseases.

Chang, John T

The New England journal of medicine

2020 Volume 383, Issue 27, Page(s) 2652–2664

MeSH term(s)	Fecal Microbiota Transplantation ; Host Microbial Interactions/physiology ; Humans ; Inflammatory Bowel Diseases/genetics ; Inflammatory Bowel Diseases/immunology ; Inflammatory Bowel Diseases/physiopathology ; Inflammatory Bowel Diseases/therapy ; Interleukins/physiology ; Intestinal Mucosa/immunology ; Intestinal Mucosa/physiopathology ; T-Lymphocytes/physiology
Chemical Substances	Interleukins
Language	English
Publishing date	2020-12-31
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMra2002697
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Article ; Online: Clone Wars: Survival of the Fittest CD8

Louis, Tiani L / Chang, John T

Immunity

2021 Volume 54, Issue 1, Page(s) 4–6

Abstract: In this issue of Immunity, Hirai et al. illuminate competition for the cytokine TGFβ as a key regulator of ... ...

Abstract	In this issue of Immunity, Hirai et al. illuminate competition for the cytokine TGFβ as a key regulator of CD8
MeSH term(s)	CD8-Positive T-Lymphocytes ; Cells, Cultured ; Clone Cells ; Immunologic Memory ; Skin
Language	English
Publishing date	2021-01-10
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/j.immuni.2020.12.015
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Zs.A 4227: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Systematic literature review of the epidemiology of glyphosate and neurological outcomes.

Chang, Ellen T / Odo, Nnaemeka U / Acquavella, John F

International archives of occupational and environmental health

2022 Volume 96, Issue 1, Page(s) 1–26

Abstract: Purpose: Human health risk assessments of glyphosate have focused on animal toxicology data for determining neurotoxic potential. Human epidemiological studies have not yet been systematically reviewed for glyphosate neurotoxicity hazard identification. ...

Abstract	Purpose: Human health risk assessments of glyphosate have focused on animal toxicology data for determining neurotoxic potential. Human epidemiological studies have not yet been systematically reviewed for glyphosate neurotoxicity hazard identification. The objective of this systematic literature review was to summarize the available epidemiology of glyphosate exposure and neurological outcomes in humans. Methods: As of December 2021, 25 eligible epidemiological studies of glyphosate exposure and neurological endpoints were identified and assessed for five quality dimensions using guidance from the U.S. Environmental Protection Agency. Studies that assessed personal use of glyphosate were prioritized, whereas those assessing indirect exposure (other than personal use) were rated as low quality, since biomonitoring data indicate that indirect metrics of glyphosate exposure almost always equate to non-detectable glyphosate doses. Results: Overall, the scientific evidence on glyphosate and neurotoxicity in humans is sparse and methodologically limited, based on nine included epidemiological studies of neurodegenerative outcomes (two high quality), five studies of neurobehavioral outcomes (two high quality), six studies of neurodevelopmental outcomes (none high quality), and five studies of other and mixed neurological outcomes (one high quality). The five high-quality studies showed no association between glyphosate use and risk of depression, Parkinson disease, or peripheral nerve conduction velocity. Results were mixed among the eight moderate-quality studies, which did not demonstrate consistent associations with any neurological endpoints or categories. Low-quality studies were considered uninformative about possible neurotoxic effects due primarily to questionable assessments of indirect exposure. Conclusions: No association has been demonstrated between glyphosate and any neurological outcomes in humans. To move the state of science forward, epidemiological studies should focus on scenarios involving direct and frequent use of glyphosate while collecting information on validated health outcomes, concomitant agricultural exposures, and relevant personal characteristics.
MeSH term(s)	Animals ; Humans ; Environmental Exposure/adverse effects ; Herbicides/toxicity ; Glycine/toxicity ; Risk Assessment ; Neurotoxicity Syndromes/epidemiology ; Neurotoxicity Syndromes/etiology ; Glyphosate
Chemical Substances	Herbicides ; Glycine (TE7660XO1C)
Language	English
Publishing date	2022-05-23
Publishing country	Germany
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	129038-1
ISSN	1432-1246 ; 0340-0131 ; 0367-9977
ISSN (online)	1432-1246
ISSN	0340-0131 ; 0367-9977
DOI	10.1007/s00420-022-01878-0
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Article ; Online: Surgical Pearls and Pitfalls for Anatomic Acromioclavicular/Coracoclavicular Ligament Reconstruction.

Chang, Peter S / Murphy, Colin P / Whalen, Ryan J / Apostolakos, John M / Provencher, Matthew T

Clinics in sports medicine

2023 Volume 42, Issue 4, Page(s) 621–632

Abstract: Injuries to the acromioclavicular (AC) joint are common shoulder injuries in contact/collision athletes. There are a number of different surgical options that can be used to treat these injuries. The majority of these injuries can be treated ... ...

Abstract	Injuries to the acromioclavicular (AC) joint are common shoulder injuries in contact/collision athletes. There are a number of different surgical options that can be used to treat these injuries. The majority of these injuries can be treated nonoperatively with an early return to play for type I and II injuries. Surgical intervention and AC/CC (coracoclavicular) ligament reconstruction have excellent postoperative outcomes if complications can be avoided. This review will focus on the pearls and pitfalls for anatomic AC and CC ligament reconstruction for high-grade AC joint injuries.
MeSH term(s)	Humans ; Acromioclavicular Joint/surgery ; Athletes ; Ligaments, Articular/surgery ; Shoulder Injuries
Language	English
Publishing date	2023-07-03
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	779944-5
ISSN	1556-228X ; 0278-5919
ISSN (online)	1556-228X
ISSN	0278-5919
DOI	10.1016/j.csm.2023.05.011
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Article: Down with the Bean Bag: A Multi-institutional Experience with Total Latissimus Muscle Free Flap Harvest in the Supine Position.

Shuck, John W / Felder, John A / Shammas, Ronnie L / Chang, Edward I / Selber, Jesse C / Phillips, Brett T

Plastic and reconstructive surgery. Global open

2023 Volume 11, Issue 1, Page(s) e4755

Abstract: The latissimus muscle continues to be a head to toe workhorse in free tissue transfer for coverage of large defects. Traditional full muscle harvest is performed in the lateral decubitus position which is frequently suboptimal or requires position change ...

Abstract	The latissimus muscle continues to be a head to toe workhorse in free tissue transfer for coverage of large defects. Traditional full muscle harvest is performed in the lateral decubitus position which is frequently suboptimal or requires position change based on the recipient site and laterality. We present a multi-institutional case series of full muscle flap harvest from the supine position for a range of defects in 32 patients. The relevant operative setup and technique are described. In our experience, supine harvest has become the preferred open harvest technique compared to lateral positioning for both optimal exposure of the pedicle and reduction in operating time.
Language	English
Publishing date	2023-01-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2851682-5
ISSN	2169-7574 ; 2169-7574
ISSN (online)	2169-7574
ISSN	2169-7574
DOI	10.1097/GOX.0000000000004755
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Article ; Online: Reply : Effect of time since primary laser-assisted in situ keratomileusis on flap relift success and epithelial ingrowth risk.

Chang, John S M / Liu, Sylvia C T / Ma, Nadine T C / Katsev, Blake / Ng, Jack C M

Journal of cataract and refractive surgery

2022 Volume 48, Issue 10, Page(s) 1225–1226

MeSH term(s)	Corneal Diseases/surgery ; Epithelium, Corneal/surgery ; Humans ; Keratomileusis, Laser In Situ ; Lasers ; Postoperative Complications/surgery ; Surgical Flaps
Language	English
Publishing date	2022-11-19
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	632744-8
ISSN	1873-4502 ; 0886-3350
ISSN (online)	1873-4502
ISSN	0886-3350
DOI	10.1097/j.jcrs.0000000000001031
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Article ; Online: IL-23 regulation of myeloid cell biology during inflammation.

Lee, Kevin M-C / Lupancu, Tanya / Chang, Leon / Manthey, Carl L / Zeeman, Martha / Fourie, Anne M / Hamilton, John A

Cytokine

2024 Volume 179, Page(s) 156619

Abstract: ... usually linked with helper T cell (Th17) biology. However, there is some data linking IL-23 with innate ...

Abstract	Interleukin (IL)-23 is implicated in the pathogenesis of several inflammatory diseases and is usually linked with helper T cell (Th17) biology. However, there is some data linking IL-23 with innate immune biology in such diseases. We therefore examined the effects of IL-23p19 genetic deletion and/or neutralization on in vitro macrophage activation and in an innate immune-driven peritonitis model. We report that endogenous IL-23 was required for maximal macrophage activation by zymosan as determined by pro-inflammatory cytokine production, including a dramatic upregulation of granulocyte-colony stimulating factor (G-CSF). Furthermore, both IL-23p19 genetic deletion and neutralization in zymosan-induced peritonitis (ZIP) led to a specific reduction in the neutrophil numbers, as well as a reduction in the G-CSF levels in exudate fluids. We conclude that endogenous IL-23 can contribute significantly to macrophage activation during an inflammatory response, mostly likely via an autocrine/paracrine mechanism; of note, endogenous IL-23 can directly up-regulate macrophage G-CSF expression, which in turn is likely to contribute to the regulation of IL-23-dependent neutrophil number and function during an inflammatory response, with potential significance for IL-23 targeting particularly in neutrophil-associated inflammatory diseases.
Language	English
Publishing date	2024-04-25
Publishing country	England
Document type	Journal Article
ZDB-ID	1018055-2
ISSN	1096-0023 ; 1043-4666
ISSN (online)	1096-0023
ISSN	1043-4666
DOI	10.1016/j.cyto.2024.156619
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Article ; Online: Assays for Apical Constriction Using the Xenopus Model.

Baldwin, Austin T / Popov, Ivan K / Wallingford, John B / Chang, Chenbei

Methods in molecular biology (Clifton, N.J.)

2022 Volume 2438, Page(s) 415–437

Abstract: Apical constriction refers to the active, actomyosin-driven process that reduces apical cell surface area in epithelial cells. Apical constriction is utilized in epithelial morphogenesis during embryonic development in multiple contexts, such as ... ...

Abstract	Apical constriction refers to the active, actomyosin-driven process that reduces apical cell surface area in epithelial cells. Apical constriction is utilized in epithelial morphogenesis during embryonic development in multiple contexts, such as gastrulation, neural tube closure, and organogenesis. Defects in apical constriction can result in congenital birth defects, yet our understanding of the molecular control of apical constriction is relatively limited. To uncover new genetic regulators of apical constriction and gain mechanistic insight into the cell biology of this process, we need reliable assay systems that allow real-time observation and quantification of apical constriction as it occurs and permit gain- and loss-of-function analyses to explore gene function and interaction during apical constriction. In this chapter, we describe using the early Xenopus embryo as an assay system to investigate molecular mechanisms involved in apical constriction during both gastrulation and neurulation.
MeSH term(s)	Animals ; Constriction ; Gastrulation ; Morphogenesis/genetics ; Neurulation ; Xenopus laevis/metabolism
Language	English
Publishing date	2022-01-19
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-2035-9_24
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Article ; Online: Metformin for sepsis-associated AKI: a protocol for the Randomized Clinical Trial of the Safety and FeasibiLity of Metformin as a Treatment for sepsis-associated AKI (LiMiT AKI).

Saraiva, Ivan E / Hamahata, Natsumi / Huang, David T / Kane-Gill, Sandra L / Rivosecchi, Ryan M / Shiva, Sruti / Nolin, Thomas D / Chen, Xinlei / Minturn, John / Chang, Chung-Chou H / Li, Xiaotong / Kellum, John / Gómez, Hernando

BMJ open

2024 Volume 14, Issue 4, Page(s) e081120

Abstract: Introduction: Acute kidney injury (AKI) is a common complication of sepsis associated with increased risk of death. Preclinical data and observational human studies suggest that activation of AMP-activated protein kinase, an ubiquitous master regulator ... ...

Abstract	Introduction: Acute kidney injury (AKI) is a common complication of sepsis associated with increased risk of death. Preclinical data and observational human studies suggest that activation of AMP-activated protein kinase, an ubiquitous master regulator of energy that can limit mitochondrial injury, with metformin may protect against sepsis-associated AKI (SA-AKI) and mortality. The Randomized Clinical Trial of the Safety and FeasibiLity of Metformin as a Treatment for sepsis-associated AKI (LiMiT AKI) aims to evaluate the safety and feasibility of enteral metformin in patients with sepsis at risk of developing SA-AKI. Methods and analysis: Blind, randomised, placebo-controlled clinical trial in a single-centre, quaternary teaching hospital in the USA. We will enrol adult patients (18 years of age or older) within 48 hours of meeting Sepsis-3 criteria, admitted to intensive care unit, with oral or enteral access. Patients will be randomised 1:1:1 to low-dose metformin (500 mg two times per day), high-dose metformin (1000 mg two times per day) or placebo for 5 days. Primary safety outcome will be the proportion of metformin-associated serious adverse events. Feasibility assessment will be based on acceptability by patients and clinicians, and by enrolment rate. Ethics and dissemination: This study has been approved by the Institutional Review Board. All patients or surrogates will provide written consent prior to enrolment and any study intervention. Metformin is a widely available, inexpensive medication with a long track record for safety, which if effective would be accessible and easy to deploy. We describe the study methods using the Standard Protocol Items for Randomized Trials framework and discuss key design features and methodological decisions. LiMiT AKI will investigate the feasibility and safety of metformin in critically ill patients with sepsis at risk of SA-AKI, in preparation for a future large-scale efficacy study. Main results will be published as soon as available after final analysis. Trial registration number: NCT05900284.
MeSH term(s)	Metformin/therapeutic use ; Humans ; Sepsis/complications ; Sepsis/drug therapy ; Acute Kidney Injury/etiology ; Feasibility Studies ; Hypoglycemic Agents/therapeutic use ; Randomized Controlled Trials as Topic ; Male
Chemical Substances	Metformin (9100L32L2N) ; Hypoglycemic Agents
Language	English
Publishing date	2024-04-30
Publishing country	England
Document type	Journal Article ; Clinical Trial Protocol ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Randomized Controlled Trial
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-081120
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