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Article ; Online: Endoscopic management of benign and malignant hilar stricture.

Pimpinelli, Marcella / Makar, Michael / Kahaleh, Michel

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society

2023 Volume 35, Issue 4, Page(s) 443–452

Abstract: Management of hilar strictures pose a significant challenge for endoscopists. Several strategies have been demonstrated in the last decade beyond decompression, however, there remains controversy and minimal consensus in the literature. This review seeks ...

Abstract	Management of hilar strictures pose a significant challenge for endoscopists. Several strategies have been demonstrated in the last decade beyond decompression, however, there remains controversy and minimal consensus in the literature. This review seeks to summarize the current literature and discuss emerging therapies, such as photodynamic therapy and radiofrequency ablation.
MeSH term(s)	Humans ; Bile Duct Neoplasms/surgery ; Constriction, Pathologic/surgery ; Endoscopy ; Drainage ; Radiofrequency Ablation ; Stents
Language	English
Publishing date	2023-01-10
Publishing country	Australia
Document type	Journal Article ; Review
ZDB-ID	1171589-3
ISSN	1443-1661 ; 0915-5635
ISSN (online)	1443-1661
ISSN	0915-5635
DOI	10.1111/den.14487
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Zs.A 3854: Show issues

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Article ; Online: Time to face the facts: EUS gallbladder drainage is here to stay.

Makar, Michael / Tyberg, Amy

Gastrointestinal endoscopy

2021 Volume 93, Issue 4, Page(s) 805–806

MeSH term(s)	Cholecystitis, Acute/surgery ; Cholecystostomy ; Drainage ; Gallbladder/diagnostic imaging ; Gallbladder/surgery ; Humans ; Network Meta-Analysis
Language	English
Publishing date	2021-03-19
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	391583-9
ISSN	1097-6779 ; 0016-5107
ISSN (online)	1097-6779
ISSN	0016-5107
DOI	10.1016/j.gie.2020.11.005
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Zs.B 283: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 519: Show issues

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Article ; Online: Re: Liam Bourke, Stephen Gilbert, Richard Hooper, et al. Lifestyle changes for improving disease-specific quality of life in sedentary men on long-term androgen-deprivation therapy for advanced prostate cancer: a randomised controlled trial. Eur Urol 2014;65:865-72; Re: Daniel A. Galvão, Nigel Spry, James Denham, et al. A multicentre year-long randomised controlled trial of exercise training targeting physical functioning in men with prostate cancer previously treated with androgen suppression and radiation from TROG 03.04 RADAR. Eur Urol 2014;65:856-64; Re: Nancy L. Keating, Pang-Hsiang Liu, A. James O'Malley, Stephen J. Freedland, Matthew R. Smith. Androgen-deprivation therapy and diabetes control among diabetic men with prostate cancer. Eur Urol 2014;65:816-24; Re: Christina G. Jespersen, Mette Nørgaard, Michael Borre. Androgen-deprivation therapy in treatment of prostate cancer and risk of myocardial infarction and stroke: a nationwide Danish population-based cohort study. Eur Urol 2014;65:704-9.

Goonewardene, Sanchia S / Persad, Raj / Young, Annie / Makar, Adel

European urology

2014 Volume 66, Issue 3, Page(s) e51–2

MeSH term(s)	Androgen Antagonists/adverse effects ; Diabetes Complications/therapy ; Diabetes Mellitus/drug therapy ; Exercise Therapy/methods ; Fatigue/therapy ; Gonadotropin-Releasing Hormone/adverse effects ; Humans ; Male ; Myocardial Infarction/epidemiology ; Myocardial Infarction/etiology ; Orchiectomy/adverse effects ; Physical Conditioning, Human/methods ; Physical Conditioning, Human/physiology ; Physical Fitness/physiology ; Prostatic Neoplasms/complications ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/physiopathology ; Prostatic Neoplasms/therapy ; Quality of Life ; Sedentary Behavior ; Stroke/epidemiology ; Stroke/etiology
Chemical Substances	Androgen Antagonists ; Gonadotropin-Releasing Hormone (33515-09-2)
Language	English
Publishing date	2014-05-10
Publishing country	Switzerland
Document type	Letter ; Comment
ZDB-ID	193790-x
ISSN	1873-7560 ; 1421-993X ; 0302-2838
ISSN (online)	1873-7560 ; 1421-993X
ISSN	0302-2838
DOI	10.1016/j.eururo.2014.04.018
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Zs.A 1247: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 294: Show issues

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Article: Learning Concept Credible Models for Mitigating Shortcuts.

Wang, Jiaxuan / Jabbour, Sarah / Makar, Maggie / Sjoding, Michael / Wiens, Jenna

Advances in neural information processing systems

2023 Volume 35, Page(s) 33343–33356

Abstract: During training, models can exploit spurious correlations as shortcuts, resulting in poor generalization performance when shortcuts do not persist. In this work, assuming access to a representation based on domain knowledge ( ...

Abstract	During training, models can exploit spurious correlations as shortcuts, resulting in poor generalization performance when shortcuts do not persist. In this work, assuming access to a representation based on domain knowledge (
Language	English
Publishing date	2023-12-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1012320-9
ISSN	1049-5258
ISSN	1049-5258
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Article: Personalized Approach to the Role of Endoscopic Ultrasound in the Diagnosis and Management of Pancreaticobiliary Malignancies.

Makar, Michael / Zhao, Eric / Tyberg, Amy

Journal of personalized medicine

2021 Volume 11, Issue 3

Abstract: Pancreaticobiliary malignancies arise from different areas within the pancreas and biliary tree. Endoscopic ultrasound (EUS) is a well-recognized diagnostic and therapeutic modality in the treatment of pancreaticobiliary diseases, and more specifically, ... ...

Abstract	Pancreaticobiliary malignancies arise from different areas within the pancreas and biliary tree. Endoscopic ultrasound (EUS) is a well-recognized diagnostic and therapeutic modality in the treatment of pancreaticobiliary diseases, and more specifically, pancreaticobiliary malignancies. Traditionally used for diagnostic purposes, EUS plays a critical role in tissue sampling and cancer staging. The emergence of the new field of interventional EUS has allowed EUS to also play a critical role in therapeutic management. Novel interventional EUS procedures such as EUS-guided gastrojejunostomy (EUS-GE), EUS-guided biliary drainage (EUS-BD), and EUS-guided gallbladder drainage (EUS-GLB) can be utilized to treat complications of pancreaticobiliary malignancies such as gastric outlet obstruction, obstructive jaundice, and cholecystitis. In addition, interventional EUS procedures can be utilized for the palliation of unresectable malignancies both for source control with EUS-radiofrequency ablation (EUS-RFA) and for the treatment of abdominal pain refractory to opioid medications with EUS-guided celiac axis neurolysis. However, patient selection remains a critical component in both diagnostic and therapeutic interventions and must be tailored to individual patient wishes, disease pathology, and overall prognosis.
Language	English
Publishing date	2021-03-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm11030180
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Article ; Online: Outcomes and complications of nonagenarians undergoing cardiac surgery: a scoping review protocol.

Ludski, Jarryd / Carp, Bradly / Makar, Tim / Yii, Michael / Lee, Dong-Kyu / Weinberg, Laurence

BMJ open

2023 Volume 13, Issue 7, Page(s) e072293

Abstract: Introduction: Continually rising life expectancy and a shift towards an ageing population are resulting in an increasing population of nonagenarians. By 2030, the global population of nonagenarians is expected to exceed 30 million. The incidence of ... ...

Abstract	Introduction: Continually rising life expectancy and a shift towards an ageing population are resulting in an increasing population of nonagenarians. By 2030, the global population of nonagenarians is expected to exceed 30 million. The incidence of symptomatic cardiac disease is reported to occur in 25% of those aged over 75 years. Therefore, the number of nonagenarians undergoing cardiac surgery is also expected to increase. A linear relationship between advanced age and surgical risk has previously been demonstrated; however, it is not yet known whether this knowledge extends to the perioperative course and mortality of nonagenarians undergoing cardiac surgery. This scoping review aims to review the literature, assess whether a deficiency exists in the published literature and potentially identify knowledge gaps to guide future efforts to improve the understanding of nonagenarians undergoing cardiac surgery. Methods and analysis: Following the relevant aspects of the Preferred Reporting Items for Systematic Review and Meta-Analysis Extension for Scoping Review guidelines, electronic databases of MEDLINE, EMBASE and the Cochrane Library will be systematically searched, with additional reference tracking of eligible studies. Studies reporting the outcomes of nonagenarians undergoing open cardiac surgery or minimally invasive cardiac surgery requiring cardiopulmonary bypass will be included. Screening and data extraction will be performed by two reviewers independently. The data will be analysed and summarised descriptively with a narrative approach. Qualitative data that capture quality-of-life outcomes will be subjected to thematic analysis where feasible. Additionally, reporting results will highlight similarities and differences in nonagenarian selection for surgery. Ethics and dissemination: Ethics approval was not required. The findings will be disseminated through professional networks, conference presentations and publications in scientific journals.
MeSH term(s)	Aged, 80 and over ; Humans ; Aged ; Nonagenarians ; Cardiac Surgical Procedures/adverse effects ; Heart Diseases/epidemiology ; Heart Diseases/surgery ; Quality of Life ; Minimally Invasive Surgical Procedures ; Research Design ; Systematic Reviews as Topic ; Meta-Analysis as Topic
Language	English
Publishing date	2023-07-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-072293
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Article ; Online: Immediate-use strategy is as safe and effective as delayed-use strategy following percutaneous endoscopic gastrostomy tube placement: A retrospective cohort study.

Hanna, David / Makar, Michael / Berger, Andrea / Johal, Amitpal S / Confer, Bradley D / Khara, Harshit S

JPEN. Journal of parenteral and enteral nutrition

2023 Volume 48, Issue 1, Page(s) 120–127

Abstract: Background: Percutaneous endoscopic gastrostomy (PEG) tube placement is the most common enteral access for long-term feeding. The aim of our study is to assess the feasibility and safety of immediate PEG tube use after initial placement.: Methods: We ...

Abstract	Background: Percutaneous endoscopic gastrostomy (PEG) tube placement is the most common enteral access for long-term feeding. The aim of our study is to assess the feasibility and safety of immediate PEG tube use after initial placement. Methods: We conducted a single-center retrospective cohort study between August 2006 and August 2016. Prior to August 2011, tube feedings were delayed for ≥4 h after initial PEG placement, compared with immediate use (<1 h) after August 2011. Primary outcomes were complication rates within 30 days of placement. Secondary outcomes were impact of morbidity, mortality, length of stay, and need for repeat PEG placement. Results: Our study included 1296 patients during the 10-year period, of which 704 underwent delayed use and 592 underwent immediate use (744 inpatient and 552 outpatient). There were no significant differences between the delayed-use and immediate-use PEG with regard to complications (3.4% vs 4.4%; P = 0.76). Subgroup analysis also reflected no significant differences in complications between inpatient and outpatient groups. For inpatients, there were no substantial differences in inpatient mortality (3.9% vs 3.3%; P = 0.70), mortality within 30 days of discharge (13.8% vs 13.1%; P = 0.15), readmissions (38.2% vs 34.3%; P = 0.23), repeat PEG placement (0.7% vs 1.5%; P = 0.46), and length of stay (13.3 vs 13.9 days; P = 0.99). Conclusion: Patients who received immediate enteral nutrition after PEG tube placement did not have any increased complications, morbidity, or mortality; and it is just as safe when compared with patients who received delayed feeding.
MeSH term(s)	Humans ; Gastrostomy/adverse effects ; Retrospective Studies ; Intubation, Gastrointestinal/adverse effects ; Enteral Nutrition/adverse effects ; Patient Discharge
Language	English
Publishing date	2023-11-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	800861-9
ISSN	1941-2444 ; 0148-6071
ISSN (online)	1941-2444
ISSN	0148-6071
DOI	10.1002/jpen.2575
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Zs.A 1524: Show issues

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Article ; Online: The Accident Environment Resulting in Fragility Fractures: A 20-year National Epidemiologic Study.

Makar, Gabriel S / Davis, William / Suk, Michael / Bowen, Thomas R

The Journal of the American Academy of Orthopaedic Surgeons

2022 Volume 30, Issue 13, Page(s) e911–e918

Abstract: Introduction: Fragility fractures are an enduring source of morbidity in the elderly with unfortunate frequency and rising costs. Although the predominant cause of fractures is generally understood to be falls, the exact stratification of the causes of ... ...

Abstract	Introduction: Fragility fractures are an enduring source of morbidity in the elderly with unfortunate frequency and rising costs. Although the predominant cause of fractures is generally understood to be falls, the exact stratification of the causes of fractures presenting to the emergency department has not yet been described in the literature. We sought out to stratify the primary products associated with fractures in the elderly, further describing the anatomic location of the fracture and setting of injury. Methods: We queried the National Electronic Injury Surveillance System database for all fractures in patients older than 65 years from January 1, 2000, to December 31, 2019. We analyzed demographic data, patient disposition, anatomic fracture location, and injury setting for the top 20 causes of fractures. Trends, proportions and distributions were analyzed using descriptive statistics. Results: A total of 901,418 visits to the Emergency Department were reviewed. Of these, 216,657 (24%) were found to have fractures. The top 20 causes for fractures accounted for a total of 173,557 (19%) fractures. The average age in our population was 80.1 years (SD 8.7). Women constituted most of the patients (127,753 [74%]). Flooring (58,347 [33.6%]) was the most common product associated with the cause of fractures, with stairs/steps (29,804 [17.2%]) and bed/bed frames (19,004 [10.9%]) being the second and third most common, respectively. Lower extremity fractures (97,195 [56%]) were more common than upper extremity fractures (63,899 [37%]). The lower trunk (pelvis, femoral neck, and lower spine) was the most common anatomic location of fractures reported (64,132 [37.0%]). Most fractures occurred either at home (113,158 [65.2%]) or at a public setting (31,162 [18.0%]). Conclusions: Most products associated with fractures among mature adults were related to flooring, stairs, or bedding. This study offers a detailed understanding on the common products associated with fractures in mature adults and aids in discussing preventive measures for lowering fracture risk with patients, communities, and healthcare systems.
MeSH term(s)	Accidents ; Adult ; Aged ; Aged, 80 and over ; Databases, Factual ; Emergency Service, Hospital ; Epidemiologic Studies ; Female ; Fractures, Bone/epidemiology ; Fractures, Bone/etiology ; Fractures, Bone/prevention & control ; Humans
Language	English
Publishing date	2022-04-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	1200524-1
ISSN	1940-5480 ; 1067-151X
ISSN (online)	1940-5480
ISSN	1067-151X
DOI	10.5435/JAAOS-D-21-01169
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Zs.A 4048: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 274: Show issues

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Article: Large Pericardial Cyst Presenting as Acute Cough: A Rare Case Report.

Makar, Michael / Makar, Gabriel / Yousef, Kerolos

Case reports in cardiology

2018 Volume 2018, Page(s) 4796903

Abstract: Pericardial cysts are an uncommon cause of mediastinal masses and may be found incidentally on imaging. Symptoms commonly include cough, chest pain, and shortness of breath elucidating a broad differential on examination. Diagnosis is predominantly made ... ...

Abstract	Pericardial cysts are an uncommon cause of mediastinal masses and may be found incidentally on imaging. Symptoms commonly include cough, chest pain, and shortness of breath elucidating a broad differential on examination. Diagnosis is predominantly made using imaging modalities, such as CT, MRI, and CXR with treatment including resection for symptomatic cysts and observation for asymptomatic cysts. Due to a lack of specific signs and symptoms towards identifying pericardial cysts, many are identified at a later stage requiring resection by video-assisted thoracoscopic surgery (VATS). We present the rare case of a patient presenting with a sudden onset cough, shortness of breath, and pleuritic chest pain found to have a large pericardial cyst.
Language	English
Publishing date	2018-12-05
Publishing country	United States
Document type	Case Reports
ZDB-ID	2627627-6
ISSN	2090-6412 ; 2090-6404
ISSN (online)	2090-6412
ISSN	2090-6404
DOI	10.1155/2018/4796903
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Article ; Online: Refusal of Cancer-Directed Surgery in Patients with Colon Cancer: Risk Factors of Refusal and Survival Data.

Makar, Gabriel S / Makar, Michael / Obinero, Chioma / Davis, William / Gaughan, John P / Kwiatt, Michael

Annals of surgical oncology

2020 Volume 28, Issue 2, Page(s) 606–616

Abstract: Introduction: Colon cancer is the third leading cause of cancer-related deaths. Although there have been numerous advancements in treatment options, electing to undergo surgery is a difficult decision, and some patients may be hesitant to undergo ... ...

Abstract	Introduction: Colon cancer is the third leading cause of cancer-related deaths. Although there have been numerous advancements in treatment options, electing to undergo surgery is a difficult decision, and some patients may be hesitant to undergo surgery. We sought to understand the risk factors associated with refusal of surgery and predictors of mortality in patients with colon cancer. Methods: We retrospectively reviewed the Surveillance, Epidemiology, and End Results database for patients diagnosed with colon cancer from 1995 to 2015. We stratified patients according to whether they underwent surgery or refused recommended surgery. We analyzed numerous demographic, surgical, and oncologic variables and performed univariate analysis to assess predictors for refusal of surgery as well as survival and mortality risk in those refusing surgery. Results: Our analysis included 288,322 patients with primary colon cancer where 284,591 (98.7%) underwent cancer-direct surgery and 3731 (1.3%) refused recommended surgery. Those refusing cancer directed surgery were more likely to be > 70 years old, non-Hispanic black patients, and have distant staged cancer (all p < 0.001). In those refusing surgery, risks for mortality included older age, female gender, widowhood, higher grade or distant-staged cancer, and a positive CEA. Conclusions: Disparities in care related to patient race, gender, and insurance status were related to patients who refused surgical interventions. This study helps to identify patients who are more likely to refuse surgery and may assist in navigating conversations with patients who are contemplating treatment options.
MeSH term(s)	African Americans ; Aged ; Colonic Neoplasms/surgery ; Female ; Humans ; Male ; Retrospective Studies ; Risk Factors ; Treatment Refusal
Language	English
Publishing date	2020-07-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-020-08783-1
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