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Article ; Online: Metástasis pulmonares de origen colorrectal: supervivencia y factores de progresión tras la resección.

Perfecto, Arkaitz / Gastaca, Mikel / Prieto, Mikel / Cervera, Jorge / Rumbero, Juan Carlos / Uribe-Etxebarria, Naia / Ojanguren, Odile / García, José María / Valdivieso, Andrés / Rojo, Rafael

Open respiratory archives

2021 Volume 3, Issue 4, Page(s) 100128

Title translation	Lung Metastases of Colorectal Cancer: Survival and Prognostic Factors after Resection.
Language	Spanish
Publishing date	2021-08-28
Publishing country	Spain
Document type	Case Reports
ISSN	2659-6636
ISSN (online)	2659-6636
DOI	10.1016/j.opresp.2021.100128
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Article ; Online: Phenobarbital in super-refractory status epilepticus (PIRATE): A retrospective, multicenter analysis.

Kunst, Stefan / Rojo, Mikel / Schmidbauer, Moritz L / Pelz, Johann O / Mueller, Annekatrin / Minnerup, Jens / Meyer, Lennart / Madžar, Dominik / Reindl, Caroline / Madlener, Marie / Malter, Michael / Neumann, Bernhard / Dimitriadis, Konstantinos

Epilepsia

2023 Volume 64, Issue 6, Page(s) 1482–1492

Abstract: Objective: Super-refractory status epilepticus (SRSE) is an enduring or recurring SE after 24 h or more of general anesthesia. This study aimed to evaluate the efficacy and safety of phenobarbital (PB) for the treatment of SRSE.: Methods: This ... ...

Abstract	Objective: Super-refractory status epilepticus (SRSE) is an enduring or recurring SE after 24 h or more of general anesthesia. This study aimed to evaluate the efficacy and safety of phenobarbital (PB) for the treatment of SRSE. Methods: This retrospective, multicenter study included neurointensive care unit (NICU) patients with SRSE treated with PB between September 2015 and September 2020 from six participating centers of the Initiative of German NeuroIntensive Trial Engagement (IGNITE) to evaluate the efficacy and safety of PB treatment for SRSE. The primary outcome measure was seizure termination. In addition, we evaluated maximum reached serum levels, treatment duration, and clinical complications using a multivariate generalized linear model. Results: Ninety-one patients were included (45.1% female). Seizure termination was achieved in 54 patients (59.3%). Increasing serum levels of PB were associated with successful seizure control (per μg/mL: adjusted odds ratio [adj.OR] = 1.1, 95% confidence interval [CI] 1.0-1.2, p < .01). The median length of treatment in the NICU was 33.7 [23.2-56.6] days across groups. Clinical complications occurred in 89% (n = 81) of patients and included ICU-acquired infections, hypotension requiring catecholamine therapy, and anaphylactic shock. There was no association between clinical complications and treatment outcome or in-hospital mortality. The overall average modified Rankin scale (mRS) at discharge from the NICU was 5 ± 1. Six patients (6.6%) reached mRS ≤3, of whom five were successfully treated with PB. In-hospital mortality was significantly higher in patients in whom seizure control could not be achieved. Significance: We observed a high rate in attainment of seizure control in patients treated with PB. Success of treatment correlated with higher dosing and serum levels. However, as one would expect in a cohort of critically ill patients with prolonged NICU treatment, the rate of favorable clinical outcome at discharge from the NICU remained extremely low. Further prospective studies evaluating long-term clinical outcome of PB treatment as well as an earlier use of PB at higher doses would be of value.
MeSH term(s)	Humans ; Female ; Male ; Retrospective Studies ; Prospective Studies ; Status Epilepticus/therapy ; Phenobarbital/therapeutic use ; Seizures/drug therapy ; Hospital Mortality
Chemical Substances	Phenobarbital (YQE403BP4D)
Language	English
Publishing date	2023-04-16
Publishing country	United States
Document type	Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	216382-2
ISSN	1528-1167 ; 0013-9580
ISSN (online)	1528-1167
ISSN	0013-9580
DOI	10.1111/epi.17608
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Article ; Online: Modifying Critical Exponents of Magnetic Phase Transitions via Nanoscale Materials Design.

Fallarino, Lorenzo / López Rojo, Eva / Quintana, Mikel / Salcedo Gallo, Juan Sebastián / Kirby, Brian J / Berger, Andreas

Physical review letters

2021 Volume 127, Issue 14, Page(s) 147201

Abstract: We demonstrate a nanoscale materials design path that allows us to bypass universality in thin ferromagnetic films and enables us to tune the critical exponents of ferromagnetic phase transitions in a very wide parameter range, while at the same time ... ...

Abstract	We demonstrate a nanoscale materials design path that allows us to bypass universality in thin ferromagnetic films and enables us to tune the critical exponents of ferromagnetic phase transitions in a very wide parameter range, while at the same time preserving scaling in an extended phase space near the Curie temperature. Our detailed magnetometry results reveal that single crystal CoRu alloy films, in which the predefined depth dependent exchange coupling strength follows a V-shaped profile, exhibit critical scaling behavior over many orders of magnitude. Their critical exponents, however, can be designed and controlled by modifying their specific nanoscale structures, thus demonstrating full tunability of critical behavior. The reason for this tunability and the disappearance of universality is shown to be the competing relevance of collective versus interface propagating progression of ferromagnetic phase transitions, whose balance we find to be dependent on the specifics of the underlying exchange coupling strength profile.
Language	English
Publishing date	2021-10-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.127.147201
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Article ; Online: Acute portal vein thrombosis in mild cholecystitis. A consequence of coronavirus disease 2019 infection?

Rivera-Alonso, Daniel / Rivera-Alonso, Inés / Burneo-Esteves, Mauricio / Martínez-Ruíz, Carlos / Rojo-Abecia, Mikel / Moreno-Sanguino, Carlos

Cirugia y cirujanos

2021 Volume 89, Issue 3, Page(s) 399–402

Abstract: La infección por el virus SARS-CoV-2 provoca, además de cuadros respiratorios graves, episodios trombóticos en múltiples localizaciones debido a una mala regulación de la respuesta inmune. Presentamos el caso de un paciente con colecistitis incipiente ... ...

Title translation	Trombosis portal aguda en colecistitis incipiente. ¿una consecuencia de la infección por COVID-19?
Abstract	La infección por el virus SARS-CoV-2 provoca, además de cuadros respiratorios graves, episodios trombóticos en múltiples localizaciones debido a una mala regulación de la respuesta inmune. Presentamos el caso de un paciente con colecistitis incipiente que desarrolló trombosis portal aguda sin ningún otro antecedente salvo haber pasado de forma asintomática una infección por COVID-19. Dado que esta complicación es extremadamente infrecuente en pacientes sin factores predisponentes ni infecciones graves, consideramos que la infección por COVID-19 pudo ser un factor desencadenante de la trombosis portal y debemos de tenerlo en cuenta de cara al manejo y tratamiento de futuros casos similares. Severe acute respiratory syndrome coronavirus 2019 infection causes, in addition to severe respiratory symptoms, thrombotic episodes in multiple locations due to dysregulation of the immune response. We present the case of a patient with incipient cholecystitis who developed acute portal thrombosis with no other antecedents except having passed an asymptomatic coronavirus disease 2019 (COVID-19) infection. Since this complication is extremely rare in patients without predisposing factors or serious infections, we consider that COVID-19 infection could be a triggering factor for portal thrombosis and we must take it into account in the management and treatment of future similar cases.
MeSH term(s)	Acute Disease ; Asymptomatic Infections ; COVID-19/complications ; COVID-19/immunology ; Cholecystitis/complications ; Cholecystitis/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Portal Vein/diagnostic imaging ; Thrombosis/diagnostic imaging ; Thrombosis/etiology ; Tomography, X-Ray Computed
Language	English
Publishing date	2021-05-26
Publishing country	Mexico
Document type	Case Reports ; Journal Article
ZDB-ID	730699-4
ISSN	2444-054X ; 0009-7411
ISSN (online)	2444-054X
ISSN	0009-7411
DOI	10.24875/CIRU.20001044
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Article ; Online: Gastrointestinal Perforation After Treatment With Tocilizumab : An Unexpected Consequence of COVID-19 Pandemic.

Rojo, Mikel / Cano-Valderrama, Oscar / Picazo, Sara / Saez, Carlos / Gómez, Lorena / Sánchez, Cristina / Sanz-Ortega, Gonzalo / Torres, Antonio J

The American surgeon

2020 Volume 86, Issue 6, Page(s) 565–566

MeSH term(s)	Anti-Inflammatory Agents/therapeutic use ; Antibodies, Monoclonal, Humanized/adverse effects ; Betacoronavirus ; Colonic Diseases/chemically induced ; Colonic Diseases/diagnostic imaging ; Colonic Diseases/surgery ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Drug Therapy, Combination ; Fatal Outcome ; Female ; Hematoma/chemically induced ; Hematoma/diagnostic imaging ; Hematoma/surgery ; Humans ; Intestinal Perforation/chemically induced ; Intestinal Perforation/diagnostic imaging ; Intestinal Perforation/surgery ; Methylprednisolone/therapeutic use ; Middle Aged ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Tomography, X-Ray Computed
Chemical Substances	Anti-Inflammatory Agents ; Antibodies, Monoclonal, Humanized ; tocilizumab (I031V2H011) ; Methylprednisolone (X4W7ZR7023)
Keywords	covid19
Language	English
Publishing date	2020-07-19
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	202465-2
ISSN	1555-9823 ; 0003-1348
ISSN (online)	1555-9823
ISSN	0003-1348
DOI	10.1177/0003134820926481
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Article ; Online: Primary thyroid tuberculosis: a case report.

Rojo-Abecia, Mikel / Valdazo-Gómez, Adela Mª / Román, Carla Ferrero-San / Camacho-Aroca, Alfonso / León-Bretscher, Ana / Roldán-Cortés, David / Paseiro-Crespo, Gloria

Cirugia y cirujanos

2021 Volume 89, Issue S2, Page(s) 1–3

Abstract: Involvement of the thyroid gland by tuberculosis is very rare and is usually secondary to disseminated infection. Very few cases of primary thyroid tuberculosis have been described even in countries with a high incidence of this disease. We present the ... ...

Title translation	Tuberculosis tiroidea primaria: reporte de un caso.
Abstract	Involvement of the thyroid gland by tuberculosis is very rare and is usually secondary to disseminated infection. Very few cases of primary thyroid tuberculosis have been described even in countries with a high incidence of this disease. We present the case of a Spanish patient operated for a suspicious thyroid nodule that was finally diagnosed as primary thyroid tuberculosis.
MeSH term(s)	Humans ; Incidence ; Thyroid Gland/diagnostic imaging ; Thyroid Gland/surgery ; Tuberculosis
Language	English
Publishing date	2021-12-21
Publishing country	Mexico
Document type	Case Reports ; Journal Article
ZDB-ID	730699-4
ISSN	2444-054X ; 0009-7411
ISSN (online)	2444-054X
ISSN	0009-7411
DOI	10.24875/CIRU.21000027
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Article ; Online: Thyroid metastases from colorectal cancer 14 years later: A case report and literature review.

Rojo-Abecia, Mikel / Rivera-Alonso, Daniel / Herrero-Álvarez, Sonia / Ochagavía-Cámara, Santiago / Torres-García, Antonio José

Cirugia y cirujanos

2020 Volume 88, Issue 4, Page(s) 508–510

Abstract: Metastases to the thyroid gland are unusual, especially from a colorectal cancer. We present the case of an 85-year-old female with a history of colon cancer in 2004 treated with surgery, who 14 years later develop dysphonia and dysphagia associated to ... ...

Title translation	Metástasis tiroidea de un adenocarcinoma de colon 14 años después: informe de un caso y revisión de la bibliografía.
Abstract	Metastases to the thyroid gland are unusual, especially from a colorectal cancer. We present the case of an 85-year-old female with a history of colon cancer in 2004 treated with surgery, who 14 years later develop dysphonia and dysphagia associated to an elevation of carcinoembryonic antigen. A pathologic thyroid mass was evidenced in a positron emission tomography-computed tomography. The colorectal origin of the mass was confirmed with a biopsy. The patient received surgical treatment doing the right hemithyroidectomy. This entity must be suspected in patients with oncological history and a new thyroid nodule. Surgery is a therapeutic option with either curative or palliative intent.
MeSH term(s)	Adenocarcinoma/blood ; Adenocarcinoma/diagnostic imaging ; Adenocarcinoma/secondary ; Adenocarcinoma/surgery ; Aged, 80 and over ; Carcinoembryonic Antigen/blood ; Cecal Neoplasms/blood ; Cecal Neoplasms/pathology ; Cecal Neoplasms/surgery ; Deglutition Disorders/etiology ; Dysphonia/etiology ; Female ; Humans ; Lung Neoplasms/secondary ; Positron Emission Tomography Computed Tomography ; Thyroid Neoplasms/blood ; Thyroid Neoplasms/diagnostic imaging ; Thyroid Neoplasms/secondary ; Thyroid Neoplasms/surgery ; Time Factors
Chemical Substances	Carcinoembryonic Antigen
Language	English
Publishing date	2020-06-18
Publishing country	Mexico
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	730699-4
ISSN	2444-054X ; 0009-7411
ISSN (online)	2444-054X
ISSN	0009-7411
DOI	10.24875/CIRU.19001130
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Article ; Online: Gastrointestinal Perforation After Treatment With Tocilizumab ; An Unexpected Consequence of COVID-19 Pandemic

Rojo, Mikel / Cano-Valderrama, Oscar / Picazo, Sara / Saez, Carlos / Gómez, Lorena / Sánchez, Cristina / Sanz-Ortega, Gonzalo / Torres, Antonio J.

The American Surgeon

2020 Volume 86, Issue 6, Page(s) 565–566

Keywords	General Medicine ; covid19
Language	English
Publisher	SAGE Publications
Publishing country	us
Document type	Article ; Online
ZDB-ID	202465-2
ISSN	1555-9823 ; 0003-1348
ISSN (online)	1555-9823
ISSN	0003-1348
DOI	10.1177/0003134820926481
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Article: Is prophylactic mesh closure effective to decrease the incidence of incisional hernia after laparotomy in colorectal surgery?

Cano-Valderrama, Oscar / García-Alonso, Mauricio / Sanz-Ortega, Gonzalo / Rojo, Mikel / Catalán, Vanesa / Domínguez-Serrano, Inmaculada / Dziakova, Jana / Sanz-López, Rodrigo / Torres, Antonio J

Acta chirurgica Belgica

2020 Volume 122, Issue 1, Page(s) 29–34

Abstract: Background: few studies have studied prophylactic mesh closure after laparotomy for colorectal surgery.: Methods: a retrospective cohort study was performed to compare patients with and without prophylactic mesh closure after open colorectal surgery.! ...

Abstract	Background: few studies have studied prophylactic mesh closure after laparotomy for colorectal surgery. Methods: a retrospective cohort study was performed to compare patients with and without prophylactic mesh closure after open colorectal surgery. Results: 309 patients were included from January 2014 to December 2016. Prophylactic mesh closure was performed in 98 patients (31.7%). After a mean follow-up of 21.7 months, incisional hernia was developed in 9 and 54 patients in the group with and without mesh respectively (9.2% vs. 25.7%, OR = 0.3, Conclusions: prophylactic mesh closure is effective to decrease the incidence of incisional hernia after colorectal surgery.
MeSH term(s)	Abdominal Wound Closure Techniques ; Colorectal Surgery ; Humans ; Incidence ; Incisional Hernia/epidemiology ; Incisional Hernia/etiology ; Incisional Hernia/prevention & control ; Laparotomy/adverse effects ; Retrospective Studies ; Surgical Mesh
Language	English
Publishing date	2020-11-16
Publishing country	England
Document type	Journal Article
ZDB-ID	210274-2
ISSN	0001-5458
ISSN	0001-5458
DOI	10.1080/00015458.2020.1846938
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Article ; Online: Schwannoma: Differential diagnosis of a subepithelial gastric lesion. Two case report.

Rojo-Abecia, Mikel / López-Antoñanzas, Leyre / Avellana-Moreno, Rocío B / Camarero-Rodríguez, Enrique / García-Romero, Eva / Talavera-Eguizabal, Pablo / Torres-García, Antonio J

Cirugia y cirujanos

2020 Volume 88, Issue Suppl 2, Page(s) 38–42

Abstract: The pre-operative differential diagnosis of gastric subepithelial lesions is complex. We can find pathologies with a very different behavior. Some of them, like gastrointestinal (GI) stromal tumors, can present a malignant behavior, and others like ... ...

Title translation	Schwannoma: diagnóstico diferencial de lesiones subepiteliales gástricas. Reporte de dos casos.
Abstract	The pre-operative differential diagnosis of gastric subepithelial lesions is complex. We can find pathologies with a very different behavior. Some of them, like gastrointestinal (GI) stromal tumors, can present a malignant behavior, and others like schwannomas are practically benign. Schwannomas of the GI tract originate from the Schwann cells of the Auerbach plexus and their most frequent location is the stomach. The definitive diagnosis is made by immunohistochemical analysis of the surgical specimen and its resection is curative. We report two cases of gastric subepithelial lesions with a definitive diagnosis of schwannoma.
MeSH term(s)	Diagnosis, Differential ; Gastrointestinal Stromal Tumors/diagnostic imaging ; Gastrointestinal Stromal Tumors/surgery ; Humans ; Neurilemmoma/diagnostic imaging ; Neurilemmoma/surgery ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/surgery
Language	English
Publishing date	2020-12-07
Publishing country	Mexico
Document type	Case Reports ; Journal Article
ZDB-ID	730699-4
ISSN	2444-054X ; 0009-7411
ISSN (online)	2444-054X
ISSN	0009-7411
DOI	10.24875/CIRU.20000220
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