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  1. Article ; Online: Kiwira Virus, a Newfound Hantavirus Discovered in Free-tailed Bats (Molossidae) in East and Central Africa.

    Weiss, Sabrina / Sudi, Lwitiho E / Düx, Ariane / Mangu, Chacha D / Ntinginya, Nyanda Elias / Shirima, Gabriel M / Köndgen, Sophie / Schubert, Grit / Witkowski, Peter T / Muyembe, Jean-Jacques / Ahuka, Steve / Klempa, Boris / Leendertz, Fabian H / Krüger, Detlev H

    Viruses

    2022  Volume 14, Issue 11

    Abstract: A novel hantavirus, named Kiwira virus, was molecularly detected in six Angolan free-tailed bats ( ...

    Abstract A novel hantavirus, named Kiwira virus, was molecularly detected in six Angolan free-tailed bats (
    MeSH term(s) Animals ; Humans ; Orthohantavirus/genetics ; Chiroptera ; Phylogeny ; Hantavirus Infections/epidemiology ; Hantavirus Infections/veterinary ; RNA Viruses ; Communicable Diseases ; Africa, Central
    Language English
    Publishing date 2022-10-27
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14112368
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Analysis of the integrin β

    Müller, Alexander / Baumann, Alexandra / Essbauer, Sandra / Radosa, Lukáš / Krüger, Detlev H / Witkowski, Peter T / Zeier, Martin / Krautkrämer, Ellen

    Virus research

    2019  Volume 267, Page(s) 36–40

    Abstract: Host reservoir specificity of pathogens is complex and may depend on receptor variability. For pathogenic orthohantaviruses, integrin ... ...

    Abstract Host reservoir specificity of pathogens is complex and may depend on receptor variability. For pathogenic orthohantaviruses, integrin β
    MeSH term(s) Animals ; Arvicolinae/virology ; Cell Line ; Disease Reservoirs/veterinary ; Disease Reservoirs/virology ; Hantaan virus/genetics ; Hantaan virus/pathogenicity ; Hemorrhagic Fever with Renal Syndrome/veterinary ; Hemorrhagic Fever with Renal Syndrome/virology ; Host Specificity ; Integrin beta3/genetics ; Murinae/virology
    Chemical Substances Integrin beta3
    Language English
    Publishing date 2019-05-01
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605780-9
    ISSN 1872-7492 ; 0168-1702
    ISSN (online) 1872-7492
    ISSN 0168-1702
    DOI 10.1016/j.virusres.2019.04.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article: [No title information]

    Witkowski, Peter T / Heinemann, Patrick / Klempa, Boris / Krüger, Detlev H

    Biospektrum : Zeitschrift der Gesellschaft fur Biologishe Chemie (GBCH) und der Vereinigung fur Allgemeine und Angewandte Mikrobiologie (VAAM)

    2015  Volume 21, Issue 5, Page(s) 503–506

    Abstract: In addition to classical virus isolation in cell culture, the molecular detection of new virus variants by PCR techniques allows broader epidemiological insights into the world of viral pathogens. For the detection of hantaviruses-zoonotic viruses ... ...

    Title translation Molekulare Identifikation von Hantaviren in neuen Wirten.
    Abstract In addition to classical virus isolation in cell culture, the molecular detection of new virus variants by PCR techniques allows broader epidemiological insights into the world of viral pathogens. For the detection of hantaviruses-zoonotic viruses leading to fever and organ failure in humans-we developed a genus-wide nested RT-PCR format, which enables the discovery of new members within this virus genus. The methodological approach allowed the demonstration of first hantaviruses from Africa and revealed new hantavirus reservoir hosts, as shrews, moles, and bats.
    Keywords covid19
    Language German
    Publishing date 2015-08-27
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ZDB-ID 2203536-9
    ISSN 1868-6249 ; 0947-0867
    ISSN (online) 1868-6249
    ISSN 0947-0867
    DOI 10.1007/s12268-015-0609-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Planning for the Maintenance of Floristic Diversity in the Face of Land Cover and Climate Change.

    Jewitt, Debbie / Goodman, Peter S / Erasmus, Barend F N / O'Connor, Timothy G / Witkowski, Ed T F

    Environmental management

    2017  Volume 59, Issue 5, Page(s) 792–806

    Abstract: Habitat loss and climate change are primary drivers of global biodiversity loss. Species will need to track changing environmental conditions through fragmented and transformed landscapes such as KwaZulu-Natal, South Africa. Landscape connectivity is an ... ...

    Abstract Habitat loss and climate change are primary drivers of global biodiversity loss. Species will need to track changing environmental conditions through fragmented and transformed landscapes such as KwaZulu-Natal, South Africa. Landscape connectivity is an important tool for maintaining resilience to global change. We develop a coarse-grained connectivity map between protected areas to aid decision-making for implementing corridors to maintain floristic diversity in the face of global change. The spatial location of corridors was prioritised using a biological underpinning of floristic composition that incorporated high beta diversity regions, important plant areas, climate refugia, and aligned to major climatic gradients driving floristic pattern. We used Linkage Mapper to develop the connectivity network. The resistance layer was based on land-cover categories with natural areas discounted according to their contribution towards meeting the biological objectives. Three corridor maps were developed; a conservative option for meeting minimum corridor requirements, an optimal option for meeting a target amount of 50% of the landscape and an option including linkages in highly transformed areas. The importance of various protected areas and critical linkages in maintaining landscape connectivity are discussed, disconnected protected areas and pinch points identified where the loss of small areas could compromise landscape connectivity. This framework is suggested as a way to conserve floristic diversity into the future and is recommended as an approach for other global connectivity initiatives. A lack of implementation of corridors will lead to further habitat loss and fragmentation, resulting in further risk to plant diversity.
    MeSH term(s) Climate Change ; Conservation of Natural Resources ; Ecosystem ; Plants ; South Africa
    Language English
    Publishing date 2017-02-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1478932-2
    ISSN 1432-1009 ; 0364-152X
    ISSN (online) 1432-1009
    ISSN 0364-152X
    DOI 10.1007/s00267-017-0829-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Macropinocytosis and Clathrin-Dependent Endocytosis Play Pivotal Roles for the Infectious Entry of Puumala Virus.

    Bauherr, Sandy / Larsberg, Filip / Petrich, Annett / Sperber, Hannah Sabeth / Klose-Grzelka, Victoria / Luckner, Madlen / Azab, Walid / Schade, Matthias / Höfer, Chris Tina / Lehmann, Maik Joerg / Witkowski, Peter T / Krüger, Detlev H / Herrmann, Andreas / Schwarzer, Roland

    Journal of virology

    2020  Volume 94, Issue 14

    Abstract: Viruses from the ... ...

    Abstract Viruses from the family
    MeSH term(s) Animals ; Chlorocebus aethiops ; Clathrin/metabolism ; Hemorrhagic Fever with Renal Syndrome/metabolism ; Hemorrhagic Fever with Renal Syndrome/pathology ; Pinocytosis ; Puumala virus/metabolism ; Vero Cells ; Virus Internalization
    Chemical Substances Clathrin
    Language English
    Publishing date 2020-07-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/JVI.00184-20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 609: Show issues Location:
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  6. Article: Gastrointestinal Tract As Entry Route for Hantavirus Infection.

    Witkowski, Peter T / Perley, Casey C / Brocato, Rebecca L / Hooper, Jay W / Jürgensen, Christian / Schulzke, Jörg-Dieter / Krüger, Detlev H / Bücker, Roland

    Frontiers in microbiology

    2017  Volume 8, Page(s) 1721

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2017-09-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2017.01721
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Analysis of the integrin β3 receptor for pathogenic orthohantaviruses in rodent host species

    Müller, Alexander / Baumann, Alexandra / Essbauer, Sandra / Krautkrämer, Ellen / Krüger, Detlev H / Radosa, Lukáš / Witkowski, Peter T / Zeier, Martin

    Virus research. 2019 July 02, v. 267

    2019  

    Abstract: Host reservoir specificity of pathogens is complex and may depend on receptor variability. For pathogenic orthohantaviruses, integrin β3 had been previously identified as entry receptor and the presence of aspartic acid residue at position 39 (D39) in ... ...

    Abstract Host reservoir specificity of pathogens is complex and may depend on receptor variability. For pathogenic orthohantaviruses, integrin β3 had been previously identified as entry receptor and the presence of aspartic acid residue at position 39 (D39) in human integrin β3 was described to be a prerequisite for infection of primate cells with Hantaan virus (HTNV). However, the role of integrin β3 in orthohantavirus infection of host animals is not completely understood. Therefore, we analyzed the nucleotide sequence of the integrin β3 gene of Myodes glareolus and Apodemus agrarius, the hosts of Puumala virus (PUUV) and HTNV, respectively. Sequence analysis in tissue samples demonstrated that the amino acid residue D39 is not present in integrin β3 of these natural orthohantavirus hosts. Furthermore, we analyzed the transcription and protein expression levels of integrin β3 in the renal cell line BVK168 generated from the PUUV host, bank vole. Transcription level of integrin β3 was 100-fold lower in BVK168 cells than in Vero E6 cells and integrin β3 expression was not detectable in BVK168 cells. However, despite the absence of amino acid residue D39 and no detectable integrin β3 expression, BVK168 cells are susceptible to infection with both PUUV and HTNV. These results indicate that the mechanism of orthohantaviral entry in rodent species does not correspond to the requirements that were described for the entry in primate cells in vitro.
    Keywords animal diseases ; Apodemus agrarius ; aspartic acid ; cell lines ; Clethrionomys glareolus ; disease susceptibility ; genes ; Hantaan orthohantavirus ; hosts ; humans ; integrins ; nucleotide sequences ; pathogens ; protein synthesis ; Puumala orthohantavirus ; rodents ; sequence analysis
    Language English
    Dates of publication 2019-0702
    Size p. 36-40.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 605780-9
    ISSN 1872-7492 ; 0168-1702
    ISSN (online) 1872-7492
    ISSN 0168-1702
    DOI 10.1016/j.virusres.2019.04.009
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

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  8. Article ; Online: Corrigendum to "Phylogenetic analysis of a newfound bat-borne hantavirus supports a Laurasiatherian host association for ancestral mammalian hantaviruses" [Infect. Genet. Evol. 41 (2016) 113-119].

    Witkowski, Peter T / Drexler, Jan F / Kallies, René / Ličková, Martina / Bokorová, Silvia / Maganga, Gael D / Szemes, Tomáš / Leroy, Eric M / Krüger, Detlev H / Drosten, Christian / Klempa, Boris

    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

    2018  Volume 67, Page(s) 245

    Language English
    Publishing date 2018-04-26
    Publishing country Netherlands
    Document type Journal Article ; Published Erratum
    ZDB-ID 2037068-4
    ISSN 1567-7257 ; 1567-1348
    ISSN (online) 1567-7257
    ISSN 1567-1348
    DOI 10.1016/j.meegid.2018.02.033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Mitral Valve Transcatheter Edge-to-Edge Repair: 1-Year Outcomes From the MiCLASP Study.

    Lurz, Philipp / Schmitz, Thomas / Geisler, Tobias / Hausleiter, Jörg / Eitel, Ingo / Rudolph, Volker / Lubos, Edith / von Bardeleben, Ralph Stephan / Brambilla, Nedy / De Marco, Federico / Berti, Sergio / Nef, Holger / Linke, Axel / Hengstenberg, Christian / Baldus, Stephan / Spargias, Konstantinos / Denti, Paolo / Nickenig, Georg / Möllmann, Helge /
    Rottbauer, Wolfgang / Praz, Fabien / Butter, Christian / Reinthaler, Markus / Van Mieghem, Nicolas M / Sherif, Mohammad / Swaans, Martin / Witkowski, Adam / Buch, Mamta / Seidler, Tim / Iñiguez, Andrés / Thiele, Holger / Eißmann, Mareike / Schreieck, Juergen / Näbauer, Michael / Marcoff, Leo / Koulogiannis, Konstantinos / Rassaf, Tienush / Luedike, Peter

    JACC. Cardiovascular interventions

    2024  Volume 17, Issue 7, Page(s) 890–903

    Abstract: Background: Mitral transcatheter edge-to-edge repair (M-TEER) is a guideline-recommended treatment option for patients with severe symptomatic mitral regurgitation (MR). Outcomes with the PASCAL system in a post-market setting have not been established.! ...

    Abstract Background: Mitral transcatheter edge-to-edge repair (M-TEER) is a guideline-recommended treatment option for patients with severe symptomatic mitral regurgitation (MR). Outcomes with the PASCAL system in a post-market setting have not been established.
    Objectives: The authors report 30-day and 1-year outcomes from the MiCLASP (Transcatheter Repair of Mitral Regurgitation with Edwards PASCAL Transcatheter Valve Repair System) European post-market clinical follow-up study.
    Methods: Patients with symptomatic, clinically significant MR were prospectively enrolled. The primary safety endpoint was clinical events committee-adjudicated 30-day composite major adverse event rate and the primary effectiveness endpoint was echocardiographic core laboratory-assessed MR severity at discharge compared with baseline. Clinical, echocardiographic, functional, and quality-of-life outcomes were assessed at 1 year.
    Results: A total of 544 patients were enrolled (59% functional MR, 30% degenerative MR). The 30-day composite major adverse event rate was 6.8%. MR reduction was significant from baseline to discharge and sustained at 1 year with 98% of patients achieving MR ≤2+ and 82.6% MR ≤1+ (all P < 0.001 vs baseline). One-year Kaplan-Meier estimate for survival was 87.3%, and freedom from heart failure hospitalization was 84.3%. Significant functional and quality-of-life improvements were observed at 1 year, including 71.6% in NYHA functional class I/II, 14.4-point increase in Kansas City Cardiomyopathy Questionnaire score, and 24.2-m improvement in 6-minute walk distance (all P < 0.001 vs baseline).
    Conclusions: One-year outcomes of this large cohort from the MiCLASP study demonstrate continued safety and effectiveness of M-TEER with the PASCAL system in a post-market setting. Results demonstrate high survival and freedom from heart failure hospitalization, significant and sustained MR reduction, and improvements in symptoms, functional capacity, and quality of life.
    MeSH term(s) Humans ; Follow-Up Studies ; Mitral Valve/diagnostic imaging ; Mitral Valve/surgery ; Mitral Valve Insufficiency/diagnostic imaging ; Mitral Valve Insufficiency/surgery ; Quality of Life ; Treatment Outcome ; Heart Failure ; Heart Valve Prosthesis Implantation/adverse effects ; Cardiac Catheterization/adverse effects
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2024.02.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6669: Show issues Location:
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  10. Article ; Online: Cytotoxic CD8

    Friebel, Julian / Witkowski, Marco / Wegner, Max / Blöbaum, Leon / Lammel, Stella / Schencke, Philipp-Alexander / Jakobs, Kai / Puccini, Marianna / Reißner, Daniela / Steffens, Daniel / Moos, Verena / Schutheiss, Heinz-Peter / Landmesser, Ulf / Rauch, Ursula

    Cells

    2022  Volume 12, Issue 1

    Abstract: ... AF, a pro-inflammatory and cytotoxic subset of T lymphocytes (CD8: Conclusions: In patients ...

    Abstract Background: Atrial myopathy and atrial fibrillation (AF) accompany thrombo-inflammation. This facilitates disease progression and promotes major adverse cardiovascular events (MACEs). Thrombin receptor (protease-activated receptor 1, PAR1) signalling is central in mediating thrombo-inflammation. We hypothesised that PAR1 signalling links coagulation and inflammation through cytotoxic CD8
    Methods: A total of 210 patients were studied. We included data and blood samples from patients presenting with FDAF (
    Results: During early AF, a pro-inflammatory and cytotoxic subset of T lymphocytes (CD8
    Conclusions: In patients with FDAF, the TF-factor Xa-factor IIa-axis contributes to thrombo-inflammation via PAR1 in CD8
    MeSH term(s) Humans ; Atrial Fibrillation ; Receptor, PAR-1 ; CD8-Positive T-Lymphocytes ; Inflammation/complications ; Disease Progression
    Chemical Substances Receptor, PAR-1
    Language English
    Publishing date 2022-12-29
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12010141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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