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Article: Gastrointestinal bezoars: history and current treatment paradigms.

Eng, Katharine / Kay, Marsha

2014 Volume 8, Issue 11, Page(s) 776–778

Language	English
Publishing date	2014-02-02
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2386402-3
ISSN	1554-7914
ISSN	1554-7914
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Zs.A 6543: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Colonic polyps and polyposis syndromes in pediatric patients.

Kay, Marsha / Eng, Katharine / Wyllie, Robert

Current opinion in pediatrics

2015 Volume 27, Issue 5, Page(s) 634–641

Abstract: Purpose of review: Gastrointestinal polyps are commonly encountered during childhood and are one of the most common causes of rectal bleeding in this age group. Most polyps are benign and located in the colon, with the most frequent type being juvenile ... ...

Abstract	Purpose of review: Gastrointestinal polyps are commonly encountered during childhood and are one of the most common causes of rectal bleeding in this age group. Most polyps are benign and located in the colon, with the most frequent type being juvenile polyps. However, in older pediatric patients, if multiple polyps are present, in patients who have a positive family history, or if polyps are located outside of the colon, either adenomatous polyps or polyps associated with genetic abnormalities are more common. Recent findings: Imaging techniques such as ultrasound and computed tomographic colonoscopy have recently been utilized to identify simple juvenile colonic polyps in children with rectal bleeding in whom there is a high index of suspicion. Colonoscopy with polypectomy is still required for histologic evaluation and resection of the polyp. There have been significant advances in genetic testing and management of hereditary gastrointestinal cancer syndromes with onset in childhood or adolescence that may ultimately reduce long-term morbidity and mortality. In addition to enhanced gastrointestinal and extraintestinal malignancy screening for affected individuals, specific gene mutations within a given condition such as adenomatous polyposis coli may predict clinical course and timing of specific interventions such as colectomy. In other conditions such as phosphatase and tensin homolog hamartoma tumor syndrome, phenotype may not be predicted by genotype. Summary: Pediatricians, pediatric gastroenterologists, and adult gastroenterologists caring for children should understand how to differentiate benign polyps in the pediatric age group from those associated with a higher risk of complications including recurrence risk and risk of development of intestinal or extraintestinal malignancy. Recent advances in genetic testing, as well as development of consensus guidelines, are key in the identification, screening, and follow-up of children and adolescents with polyposis syndromes.
MeSH term(s)	Adenomatous Polyposis Coli/complications ; Adenomatous Polyposis Coli/diagnosis ; Adolescent ; Child ; Child, Preschool ; Colonic Polyps/complications ; Colonic Polyps/diagnosis ; Colonoscopy/methods ; Colorectal Neoplasms/prevention & control ; Gastrointestinal Hemorrhage/diagnosis ; Gastrointestinal Hemorrhage/etiology ; Genetic Testing ; Humans ; Phenotype
Language	English
Publishing date	2015-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1049374-8
ISSN	1531-698X ; 1040-8703
ISSN (online)	1531-698X
ISSN	1040-8703
DOI	10.1097/MOP.0000000000000265
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Zs.A 3049: Show issues

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Article ; Online: Virtual Surgical Fellowship Recruitment During COVID-19 and Its Implications for Resident/Fellow Recruitment in the Future.

Vining, Charles C / Eng, Oliver S / Hogg, Melissa E / Schuitevoerder, Darryl / Silverman, Rebecca S / Yao, Katharine A / Winchester, David J / Roggin, Kevin K / Talamonti, Mark S / Posner, Mitchell C / Turaga, Kiran K / Tseng, Jennifer

Annals of surgical oncology

2020 Volume 27, Issue Suppl 3, Page(s) 911–915

Abstract: Background: The COVID-19 pandemic has overlapped with the scheduled interview periods of over 20 surgical subspecialty fellowships, including the Complex General Surgical Oncology (CGSO) fellowships in the National Resident Matching Program and the ... ...

Abstract	Background: The COVID-19 pandemic has overlapped with the scheduled interview periods of over 20 surgical subspecialty fellowships, including the Complex General Surgical Oncology (CGSO) fellowships in the National Resident Matching Program and the Society of Surgical Oncology's Breast Surgical Oncology fellowships. We outline the successful implementation of and processes behind a virtual interview day for CGSO fellowship recruitment after the start of the pandemic. Methods: The virtual CGSO fellowship interview process at the University of Chicago Medicine and NorthShore University Health System was outlined and implemented. Separate voluntary, anonymous online secure feedback surveys were email distributed to interview applicants and faculty interviewers after the interview day concluded. Results: Sixteen of 20 interview applicants (80.0%) and 12 of 13 faculty interviewers (92.3%) completed their respective feedback surveys. Seventy-five percent (12/16) of applicants and all faculty respondents (12/12) stated the interview process was 'very seamless' or 'seamless'. Applicants and faculty highlighted decreased cost, time savings, and increased efficiency as some of the benefits to virtual interviewing. Conclusions: Current circumstances related to the COVID-19 pandemic require fellowship programs to adapt and conduct virtual interviews. Our report describes the successful implementation of a virtual interview process. This report describes the technical steps and pitfalls of organizing such an interview and provides insights into the experience of the interviewer and interviewee.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Chicago ; Coronavirus Infections/epidemiology ; Fellowships and Scholarships/methods ; Fellowships and Scholarships/organization & administration ; Fellowships and Scholarships/trends ; Humans ; Interviews as Topic/methods ; Organizational Innovation ; Pandemics ; Personnel Selection/trends ; Pneumonia, Viral/epidemiology ; Program Evaluation ; SARS-CoV-2 ; Specialties, Surgical/classification ; Specialties, Surgical/education ; Surgical Oncology/education ; User-Computer Interface
Keywords	covid19
Language	English
Publishing date	2020-05-18
Publishing country	United States
Document type	Letter
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-020-08623-2
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Zs.A 4042: Show issues

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Article ; Online: A non-invasive prediction model for non-alcoholic steatohepatitis in paediatric patients with non-alcoholic fatty liver disease.

Eng, Katharine / Lopez, Rocio / Liccardo, Daniela / Nobili, Valerio / Alkhouri, Naim

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

2014 Volume 46, Issue 11, Page(s) 1008–1013

Abstract: Background: Non-alcoholic fatty liver disease encompasses a spectrum of diseases that range from simple steatosis to the aggressive form of non-alcoholic steatohepatitis. Non-alcoholic steatohepatitis is currently diagnosed through liver biopsy.: Aim!# ...

Abstract	Background: Non-alcoholic fatty liver disease encompasses a spectrum of diseases that range from simple steatosis to the aggressive form of non-alcoholic steatohepatitis. Non-alcoholic steatohepatitis is currently diagnosed through liver biopsy. Aim: To develop a non-invasive predictive model of non-alcoholic steatohepatitis in children with non-alcoholic fatty liver disease. Methods: Anthropometric, laboratory, and histologic data were obtained in a cohort of children with biopsy-proven non-alcoholic fatty liver disease. Multivariable logistic regression analysis was employed to create a nomogram predicting the risk of non-alcoholic steatohepatitis. Internal validation was performed by bootstrapping. Results: Three hundred and two children were included in this analysis with a mean age of 12.3 ± 3.1 years, a mean body mass index percentile of 94.3 ± 6.9, and non-alcoholic steatohepatitis was present in 67%. Following stepwise variable selection, total cholesterol, waist circumference percentile, and total bilirubin were included as variables in the model, with good discrimination with an area under the receiver operating characteristic curve of 0.737. Conclusions: A nomogram was constructed with reasonable accuracy that can predict the risk of non-alcoholic steatohepatitis in children with non-alcoholic fatty liver disease. If validated externally, this tool could be utilized as a non-invasive method to diagnose non-alcoholic steatohepatitis in children with non-alcoholic fatty liver disease.
MeSH term(s)	Adolescent ; Biopsy, Needle ; Body Mass Index ; Child ; Cohort Studies ; Fatty Liver/pathology ; Fatty Liver/therapy ; Female ; Humans ; Immunohistochemistry ; Italy ; Liver Function Tests ; Logistic Models ; Male ; Multivariate Analysis ; Nomograms ; Non-alcoholic Fatty Liver Disease/diagnosis ; Non-alcoholic Fatty Liver Disease/pathology ; Non-alcoholic Fatty Liver Disease/therapy ; Predictive Value of Tests ; Prognosis ; ROC Curve ; Retrospective Studies ; Risk Assessment ; Severity of Illness Index ; Treatment Outcome ; Waist Circumference
Language	English
Publishing date	2014-11
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article ; Validation Studies
ZDB-ID	1459373-7
ISSN	1878-3562 ; 1125-8055
ISSN (online)	1878-3562
ISSN	1125-8055
DOI	10.1016/j.dld.2014.07.016
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Zs.A 1134: Show issues

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Article ; Online: Virtual Surgical Fellowship Recruitment During COVID-19 and Its Implications for Resident/Fellow Recruitment in the Future

Vining, Charles C. / Eng, Oliver S. / Hogg, Melissa E. / Schuitevoerder, Darryl / Silverman, Rebecca S. / Yao, Katharine A. / Winchester, David J. / Roggin, Kevin K. / Talamonti, Mark S. / Posner, Mitchell C. / Turaga, Kiran K. / Tseng, Jennifer

Annals of Surgical Oncology ; ISSN 1068-9265 1534-4681

2020

Keywords	Surgery ; Oncology ; covid19
Language	English
Publisher	Springer Science and Business Media LLC
Publishing country	us
Document type	Article ; Online
DOI	10.1245/s10434-020-08623-2
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Article ; Online: NUTMEG: A randomized phase II study of nivolumab and temozolomide versus temozolomide alone in newly diagnosed older patients with glioblastoma.

Sim, Hao-Wen / Wachsmuth, Luke / Barnes, Elizabeth H / Yip, Sonia / Koh, Eng-Siew / Hall, Merryn / Jennens, Ross / Ashley, David M / Verhaak, Roel G / Heimberger, Amy B / Rosenthal, Mark A / Hovey, Elizabeth J / Ellingson, Benjamin M / Tognela, Annette / Gan, Hui K / Wheeler, Helen / Back, Michael / McDonald, Kerrie L / Long, Anne /

Cuff, Katharine / Begbie, Stephen / Gedye, Craig / Mislang, Anna / Le, Hien / Johnson, Margaret O / Kong, Benjamin Y / Simes, John R / Lwin, Zarnie / Khasraw, Mustafa

Neuro-oncology advances

2023 Volume 5, Issue 1, Page(s) vdad124

Abstract: Background: There is an immunologic rationale to evaluate immunotherapy in the older glioblastoma population, who have been underrepresented in prior trials. The NUTMEG study evaluated the combination of nivolumab and temozolomide in patients with ... ...

Abstract	Background: There is an immunologic rationale to evaluate immunotherapy in the older glioblastoma population, who have been underrepresented in prior trials. The NUTMEG study evaluated the combination of nivolumab and temozolomide in patients with glioblastoma aged 65 years and older. Methods: NUTMEG was a multicenter 2:1 randomized phase II trial for patients with newly diagnosed glioblastoma aged 65 years and older. The experimental arm consisted of hypofractionated chemoradiation with temozolomide, then adjuvant nivolumab and temozolomide. The standard arm consisted of hypofractionated chemoradiation with temozolomide, then adjuvant temozolomide. The primary objective was to improve overall survival (OS) in the experimental arm. Results: A total of 103 participants were randomized, with 69 in the experimental arm and 34 in the standard arm. The median (range) age was 73 (65-88) years. After 37 months of follow-up, the median OS was 11.6 months (95% CI, 9.7-13.4) in the experimental arm and 11.8 months (95% CI, 8.3-14.8) in the standard arm. For the experimental arm relative to the standard arm, the OS hazard ratio was 0.85 (95% CI, 0.54-1.33). In the experimental arm, there were three grade 3 immune-related adverse events which resolved, with no unexpected serious adverse events. Conclusions: Due to insufficient evidence of benefit with nivolumab, the decision was made not to transition to a phase III trial. No new safety signals were identified with nivolumab. This complements the existing series of immunotherapy trials. Research is needed to identify biomarkers and new strategies including combinations.
Language	English
Publishing date	2023-09-22
Publishing country	England
Document type	Journal Article
ZDB-ID	3009682-0
ISSN	2632-2498 ; 2632-2498
ISSN (online)	2632-2498
ISSN	2632-2498
DOI	10.1093/noajnl/vdad124
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Article ; Online: The development of sexual stage malaria gametocytes in a Wave Bioreactor.

Demanga, Corine G / Eng, Jenny W L / Gardiner, Donald L / Roth, Alison / Butterworth, Alice / Adams, John H / Trenholme, Katharine R / Dalton, John P

Parasites & vectors

2017 Volume 10, Issue 1, Page(s) 216

Abstract: Background: Blocking malaria gametocyte development in RBCs or their fertilization in the mosquito gut can prevent infection of the mosquito vector and passage of disease to the human host. A 'transmission blocking' strategy is a component of future ... ...

Abstract	Background: Blocking malaria gametocyte development in RBCs or their fertilization in the mosquito gut can prevent infection of the mosquito vector and passage of disease to the human host. A 'transmission blocking' strategy is a component of future malaria control. However, the lack of robust culture systems for producing large amounts of Plasmodium falciparum gametocytes has limited our understanding of sexual-stage malaria biology and made vaccine or chemotherapeutic discoveries more difficult. Methods: The Wave Bioreactor Results: We report a simple method for the induction of gametocytogenesis with N-acetylglucosamine (10 mM) within a Wave Bioreactor. By maintaining the culture for 14-16 days as many as 100 million gametocytes (stage V) were produced in a 1 l culture. Gametocytes isolated using magnetic activated cell sorting (MACS) columns were frozen in aliquots for storage. These were revitalised by thawing and shown to retain their ability to exflagellate and infect mosquitoes (Anopheles stephansi). Conclusions: The production of gametocytes in the Wave Bioreactor under GMP-compliant conditions will not only facilitate cellular, developmental and molecular studies of gametocytes, but also the high-throughput screening for new anti-malarial drugs and, possibly, the development of whole-cell gametocyte or sporozoite-based vaccines.
Language	English
Publishing date	2017-05-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2409480-8
ISSN	1756-3305 ; 1756-3305
ISSN (online)	1756-3305
ISSN	1756-3305
DOI	10.1186/s13071-017-2155-z
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Article ; Online: Physical activity and glioma: a case-control study with follow-up for survival.

Basiri, Zohreh / Yang, Yi / Bruinsma, Fiona J / Nowak, Anna K / McDonald, Kerrie L / Drummond, Katharine J / Rosenthal, Mark A / Koh, Eng-Siew / Harrup, Rosemary / Hovey, Elizabeth / Joseph, David / Benke, Geza / Leonard, Robyn / MacInnis, Robert J / Milne, Roger L / Giles, Graham G / Vajdic, Claire M / Lynch, Brigid M

Cancer causes & control : CCC

2022 Volume 33, Issue 5, Page(s) 749–757

Abstract: Purpose: High-grade disease accounts for ~ 70% of all glioma, and has a high mortality rate. Few modifiable exposures are known to be related to glioma risk or mortality.: Methods: We examined associations between lifetime physical activity and ... ...

Abstract	Purpose: High-grade disease accounts for ~ 70% of all glioma, and has a high mortality rate. Few modifiable exposures are known to be related to glioma risk or mortality. Methods: We examined associations between lifetime physical activity and physical activity at different ages (15-18 years, 19-29 years, 30-39 years, last 10 years) with the risk of glioma diagnosis, using data from a hospital-based family case-control study (495 cases; 371 controls). We followed up cases over a median of 25 months to examine whether physical activity was associated with all-cause mortality. Physical activity and potential confounders were assessed by self-administered questionnaire. We examined associations between physical activity (metabolic equivalent [MET]-h/wk) and glioma risk using unconditional logistic regression and with all-cause mortality in cases using Cox regression. Results: We noted a reduced risk of glioma for the highest (≥ 47 MET-h/wk) versus lowest (< 24 METh/wk) category of physical activity for lifetime activity (OR = 0.58, 95% CI: 0.38-0.89) and at 15-18 years (OR = 0.57, 95% CI: 0.39-0.83). We did not observe any association between physical activity and all-cause mortality (HR for lifetime physical activity = 0.91, 95% CI: 0.64-1.29). Conclusion: Our findings are consistent with previous research that suggested physical activity during adolescence might be protective against glioma. Engaging in physical activity during adolescence has many health benefits; this health behavior may also offer protection against glioma.
MeSH term(s)	Adolescent ; Case-Control Studies ; Exercise ; Follow-Up Studies ; Glioma/epidemiology ; Humans ; Risk Factors
Language	English
Publishing date	2022-02-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1064022-8
ISSN	1573-7225 ; 0957-5243
ISSN (online)	1573-7225
ISSN	0957-5243
DOI	10.1007/s10552-022-01559-w
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Zs.A 3375: Show issues

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Article ; Online: Australian genome-wide association study confirms higher female risk for adult glioma associated with variants in the region of CCDC26.

Neuro-oncology

2022 Volume 25, Issue 7, Page(s) 1355–1365

Abstract: Background: Glioma accounts for approximately 80% of malignant adult brain cancer and its most common subtype, glioblastoma, has one of the lowest 5-year cancer survivals. Fifty risk-associated variants within 34 glioma genetic risk regions have been ... ...

Abstract	Background: Glioma accounts for approximately 80% of malignant adult brain cancer and its most common subtype, glioblastoma, has one of the lowest 5-year cancer survivals. Fifty risk-associated variants within 34 glioma genetic risk regions have been found by genome-wide association studies (GWAS) with a sex difference reported for 8q24.21 region. We conducted an Australian GWAS by glioma subtype and sex. Methods: We analyzed genome-wide data from the Australian Genomics and Clinical Outcomes of Glioma (AGOG) consortium for 7 573 692 single nucleotide polymorphisms (SNPs) for 560 glioma cases and 2237 controls of European ancestry. Cases were classified as glioblastoma, non-glioblastoma, astrocytoma or oligodendroglioma. Logistic regression analysis was used to assess the associations of SNPs with glioma risk by subtype and by sex. Results: We replicated the previously reported glioma risk associations in the regions of 2q33.3 C2orf80, 2q37.3 D2HGDH, 5p15.33 TERT, 7p11.2 EGFR, 8q24.21 CCDC26, 9p21.3 CDKN2BAS, 11q21 MAML2, 11q23.3 PHLDB1, 15q24.2 ETFA, 16p13.3 RHBDF1, 16p13.3 LMF1, 17p13.1 TP53, 20q13.33 RTEL, and 20q13.33 GMEB2 (P < .05). We also replicated the previously reported sex difference at 8q24.21 CCDC26 (P = .0024) with the association being nominally significant for both sexes (P < .05). Conclusions: Our study supports a stronger female risk association for the region 8q24.21 CCDC26 and highlights the importance of analyzing glioma GWAS by sex. A better understanding of sex differences could provide biological insight into the cause of glioma with implications for prevention, risk prediction and treatment.
MeSH term(s)	Female ; Humans ; Adult ; Male ; Genome-Wide Association Study ; Genetic Predisposition to Disease ; Australia ; Glioma/genetics ; Brain Neoplasms/genetics ; Glioblastoma/genetics ; Polymorphism, Single Nucleotide ; Case-Control Studies ; Nerve Tissue Proteins ; Intracellular Signaling Peptides and Proteins/genetics
Chemical Substances	PHLDB1 protein, human ; Nerve Tissue Proteins ; Intracellular Signaling Peptides and Proteins
Language	English
Publishing date	2022-12-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2028601-6
ISSN	1523-5866 ; 1522-8517
ISSN (online)	1523-5866
ISSN	1522-8517
DOI	10.1093/neuonc/noac279
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Article ; Online: Preclinical Antitumor Activity and Biodistribution of a Novel Anti-GCC Antibody-Drug Conjugate in Patient-derived Xenografts.

Molecular cancer therapeutics

2020 Volume 19, Issue 10, Page(s) 2079–2088

Abstract: Guanylyl cyclase C (GCC) is a unique therapeutic target with expression restricted to the apical side of epithelial cell tight junctions thought to be only accessible by intravenously administered agents on malignant tissues where GCC expression is ... ...

Abstract	Guanylyl cyclase C (GCC) is a unique therapeutic target with expression restricted to the apical side of epithelial cell tight junctions thought to be only accessible by intravenously administered agents on malignant tissues where GCC expression is aberrant. In this study, we sought to evaluate the therapeutic potential of a second-generation investigational antibody-dug conjugate (ADC), TAK-164, comprised of a human anti-GCC mAb conjugated via a peptide linker to the highly cytotoxic DNA alkylator, DGN549. The
MeSH term(s)	Animals ; Female ; HEK293 Cells ; Humans ; Immunoconjugates/pharmacology ; Immunoconjugates/therapeutic use ; Mice ; Mice, Nude ; Tissue Distribution ; Xenograft Model Antitumor Assays
Chemical Substances	Immunoconjugates
Language	English
Publishing date	2020-08-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2063563-1
ISSN	1538-8514 ; 1535-7163
ISSN (online)	1538-8514
ISSN	1535-7163
DOI	10.1158/1535-7163.MCT-19-1102
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