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Article ; Online: Antibiotic Resistance, Susceptibility Testing and Stewardship in

Ng, Ho-Yu / Leung, Wai K / Cheung, Ka-Shing

International journal of molecular sciences

2023 Volume 24, Issue 14

Abstract: Despite the declining trend ... ...

Abstract	Despite the declining trend of
MeSH term(s)	Humans ; Helicobacter Infections/drug therapy ; Helicobacter Infections/epidemiology ; Helicobacter pylori ; Drug Resistance, Bacterial ; Drug Therapy, Combination ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Clarithromycin/pharmacology
Chemical Substances	Anti-Bacterial Agents ; Clarithromycin (H1250JIK0A)
Language	English
Publishing date	2023-07-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241411708
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Big data approach in the field of gastric and colorectal cancer research.

Cheung, Ka Shing

Journal of gastroenterology and hepatology

2024

Abstract: Big data is characterized by three attributes: volume, variety,, and velocity. In healthcare setting, big data refers to vast dataset that is electronically stored and managed in an automated manner and has the potential to enhance human health and ... ...

Abstract	Big data is characterized by three attributes: volume, variety,, and velocity. In healthcare setting, big data refers to vast dataset that is electronically stored and managed in an automated manner and has the potential to enhance human health and healthcare system. In this review, gastric cancer (GC) and postcolonoscopy colorectal cancer (PCCRC) will be used to illustrate application of big data approach in the field of gastrointestinal cancer research. Helicobacter pylori (HP) eradication only reduces GC risk by 46% due to preexisting precancerous lesions. Apart from endoscopy surveillance, identifying medications that modify GC risk is another strategy. Population-based cohort studies showed that long-term use of proton pump inhibitors (PPIs) associated with higher GC risk after HP eradication, while aspirin and statins associated with lower risk. While diabetes mellitus conferred 73% higher GC risk, metformin use associated with 51% lower risk, effect of which was independent of glycemic control. Nonetheless, nonsteroidal anti-inflammatory drugs (NA-NSAIDs) are not associated with lower GC risk. CRC can still occur after initial colonoscopy in which no cancer was detected (i.e. PCCRC). Between 2005 and 2013, the rate of interval-type PCCRC-3y (defined as CRC diagnosed between 6 and 36 months of index colonoscopy which was negative for CRC) was 7.9% in Hong Kong, with >80% being distal cancers and higher cancer-specific mortality compared with detected CRC. Certain clinical and endoscopy-related factors were associated with PCCRC-3 risk. Medications shown to have chemopreventive effects on PCCRC include statins, NA-NSAIDs, and angiotensin-converting enzyme inhibitors/angiotensin receptor blockers.
Language	English
Publishing date	2024-02-27
Publishing country	Australia
Document type	Journal Article
ZDB-ID	632882-9
ISSN	1440-1746 ; 0815-9319
ISSN (online)	1440-1746
ISSN	0815-9319
DOI	10.1111/jgh.16527
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Zs.A 2180: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 299: Show issues

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Article ; Online: The Age–Period–Cohort Problem in Hedonic House Prices Models

Chung-Yim Yiu / Ka-Shing Cheung

Econometrics, Vol 10, Iss 4, p

2022 Volume 4

Abstract: The age–period–cohort problem has been studied for decades but without resolution. There have been many suggested solutions to make the three effects estimable, but these solutions mostly exploit non-linear specifications. Yet, these approaches may ... ...

Abstract	The age–period–cohort problem has been studied for decades but without resolution. There have been many suggested solutions to make the three effects estimable, but these solutions mostly exploit non-linear specifications. Yet, these approaches may suffer from misspecification or omitted variable bias. This paper is a practical-oriented study with an aim to empirically disentangle age–period–cohort effects by providing external information on the actual depreciation of housing structure rather than taking age as a proxy. It is based on appraisals of the improvement values of properties in New Zealand to estimate the age-depreciation effect. This research method provides a novel means of solving the identification problem of the age, period, and cohort trilemma. Based on about half a million housing transactions from 1990 to 2019 in the Auckland Region of New Zealand, the results show that traditional hedonic prices models using age and time dummy variables can result, ceteris paribus , in unreasonable positive depreciation rates. The use of the improvement values model can help improve the accuracy of home value assessment and reduce estimation biases. This method also has important practical implications for property valuations.
Keywords	age–period–cohort problem ; hedonic price models ; multicollinearity ; improvement values ; Economics as a science ; HB71-74
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Low Bone Mineral Density as a Risk Factor for Liver Cirrhosis: A Prospective Cohort Study.

Zhang, Xiaowen / Cheung, Ka-Shing / Mak, Lung-Yi / Tan, Kathryn C B / Kung, Annie W C / Wong, Ian Chi-Kei / Cheung, Ching-Lung

The Journal of clinical endocrinology and metabolism

2024

Abstract: Context: Bone metabolism interplays with liver metabolism, also known as the liver-bone axis. Osteoporosis is a common complication of cirrhosis, but whether bone mineral density (BMD) can predict cirrhosis development is unknown.: Objective: This ... ...

Abstract	Context: Bone metabolism interplays with liver metabolism, also known as the liver-bone axis. Osteoporosis is a common complication of cirrhosis, but whether bone mineral density (BMD) can predict cirrhosis development is unknown. Objective: This study aims to investigate the relationship between BMD and the risk of incident cirrhosis in the Hong Kong Osteoporosis Study (HKOS). Methods: BMD was measured at the lumbar spine, femoral neck, total hip, and trochanter of 7,752 participants by the dual-energy X-ray absorptiometer (DXA), and the incidence of cirrhosis and mortality were followed by linking to the territory-wide electronic health records database. Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% CI. Results: With a median follow-up of 18.43 years, 42 incident cirrhosis were identified. Higher BMD T-scores at the femoral neck, total hip and trochanter were significantly associated with a reduced risk of cirrhosis (femoral neck: HR 0.56, 95% CI 0.39 to 0.82; total hip: HR 0.60, 95% CI 0.44 to 0.82; trochanter: HR 0.63, 95% CI 0.46 to 0.88). Similar associations were observed in participants without risk factors of cirrhosis at the baseline and further adjusting for the baseline level of alkaline phosphatase, albumin, and alanine transaminase. Consistent relationships in multiple sensitivity analyses suggest the robustness of the results. Conclusion: Low BMD could be a novel risk factor and early predictor for cirrhosis, with consistent associations observed in multiple sensitivity analyses.
Language	English
Publishing date	2024-04-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/clinem/dgae223
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Article ; Online: Urban Zoning for Sustainable Tourism

Chung-Yim Yiu / Ka-Shing Cheung

Sustainability, Vol 13, Iss 7317, p

A Continuum of Accommodation to Enhance City Resilience

2021 Volume 7317

Abstract: While governments around the world are embarking on the path to recovery from the COVID-19 crisis, sustainable tourism planning is crucial, in particular in the hospitality sector, which enhances the resilience of destinations. However, many destination ... ...

Abstract	While governments around the world are embarking on the path to recovery from the COVID-19 crisis, sustainable tourism planning is crucial, in particular in the hospitality sector, which enhances the resilience of destinations. However, many destination management models overlook the role of urban zoning. Little is known about the impacts of land-use zoning on the hospitality and property industries, especially with the current disruption of short-term peer-to-peer accommodation like Airbnb. Euclidean zoning, also known as effects-based planning, has long been criticised in destination management for its exclusionary nature and lack of flexibility. With exclusionary zoning, property owners may only be able to use their land sub-optimally, and cities will be less efficient in responding to market changes in short-term and long-term accommodation demands, but planning intentions can be better controlled, and the property supply can be more stable. Taking Hong Kong as a noteworthy case, this study puts forward a conceptual framework that enables comparison of a novel zoning approach with the traditional zoning approach. This novel zoning approach encompasses both the short- and long-term rental sectors as a continuum of accommodation, ranging from hotels and serviced apartments to Airbnb and rental housing units under a unified regulatory and planning regime to enhance the switching options value. This novel zoning system can gear up the tourism sector with the rapid growth of the sharing economy and aligns with sustainable tourism to ensure long-term socioeconomic benefits to related stakeholders. We extract the data of Airbnb listings to construct the first Airbnb ADR Index (ADRI) by Repeat-sales method, and the results support our Switching Option Hypothesis.
Keywords	sustainable destination management ; city resilience ; exclusionary zoning ; accommodation continuum ; sharing economy ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	710
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Features of Gastrointestinal Malignant Melanoma on Endoscopic Ultrasonography.

Qin, Jian / Cheung, Ka Shing / Guo, Yue

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

2024

Language	English
Publishing date	2024-01-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2119789-1
ISSN	1542-7714 ; 1542-3565
ISSN (online)	1542-7714
ISSN	1542-3565
DOI	10.1016/j.cgh.2023.12.032
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Zs.A 5836: Show issues

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Article: Risk of gastric cancer development after eradication of Helicobacter pylori.

Cheung, Ka-Shing / Leung, Wai K

World journal of gastrointestinal oncology

2018 Volume 10, Issue 5, Page(s) 115–123

Abstract: Helicobacter ... ...

Abstract	Helicobacter pylori
Language	English
Publishing date	2018-04-11
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2573696-6
ISSN	1948-5204
ISSN	1948-5204
DOI	10.4251/wjgo.v10.i5.115
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Article ; Online: Response to letter to the editor by Moayyedi

Cheung, Ka-Shing / Leung, Wai Keung

Gut

2018 Volume 68, Issue 9, Page(s) 1721–1722

MeSH term(s)	Helicobacter Infections ; Helicobacter pylori ; Humans ; Proton Pump Inhibitors ; Stomach Neoplasms
Chemical Substances	Proton Pump Inhibitors
Language	English
Publishing date	2018-08-18
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	80128-8
ISSN	1468-3288 ; 0017-5749
ISSN (online)	1468-3288
ISSN	0017-5749
DOI	10.1136/gutjnl-2018-317127
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Zs.A 160: Show issues

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Article ; Online: Carvedilol Versus Other Nonselective Beta Blockers for Variceal Bleeding Prophylaxis and Death: A Network Meta-analysis.

Cheung, Ka-Shing / Mok, Chiu-Hang / Lam, Lok-Ka / Mao, Xian-Hua / Mak, Lung-Yi / Seto, Wai-Kay / Yuen, Man-Fung

Journal of clinical and translational hepatology

2023 Volume 11, Issue 5, Page(s) 1143–1149

Abstract: Background and aims: We aimed to perform a network meta-analysis (NWM) to examine comparative effectiveness of non-selective beta blockers (NSBBs) on prophylaxis of gastroesophageal variceal bleeding (GVB) and mortality benefit.: Methods: MEDLINE ( ... ...

Abstract	Background and aims: We aimed to perform a network meta-analysis (NWM) to examine comparative effectiveness of non-selective beta blockers (NSBBs) on prophylaxis of gastroesophageal variceal bleeding (GVB) and mortality benefit. Methods: MEDLINE (OVID) and EMBASE databases were searched for eligible randomized clinical trials (RCTs) from inception to July 3, 2021. Outcomes of interest included primary/secondary prophylaxis of GVB, failure to achieve hepatic venous pressure gradient (HVPG) decremental response, liver-related and all-cause mortality. A Bayesian NWM was performed to derive relative risk (RR) with 95% credible intervals (CrIs). The ranking probability of each NSBB was assessed by surface under cumulative ranking curve (SUCRA). Results: Thirty-three RCTs including 3,188 cirrhosis patients with gastroesophageal varices were included. Compared with placebo, nadolol ranked first for reducing variceal bleeding [RR:0.25, (95% CrI:0.11-0.51); SUCRA:0.898], followed by carvedilol [RR:0.33, (95% CrI: 0.11-0.88); SUCRA:0.692] and propranolol [RR:0.52, (95% CrI:0.37-0.75); SUCRA:0.405]. Carvedilol was more effective than propranolol in achieving HVPG decremental response [RR:0.43, (95% CrI: 0.26-0.69)]. Carvedilol ranked first for reducing all-cause mortality [RR: 0.32, (95% CrI:0.17-0.57); SUCRA:0.963), followed by nadolol [RR:0.48, (95% CI:0.29-0.77); SUCRA:0.688], and propranolol [RR:0.77, (95% CI:0.58-1.02); SUCRA: 0.337]. Similar findings were observed for liver-related mortality. Carvedilol ranked the safest. The RR of adverse events was 4.38, (95% CrI:0.33-161.4); SUCRA:0.530, followed by propranolol [RR: 7.54, (95% CrI:1.90-47.89); SUCRA:0.360], and nadolol [RR: 18.24, (95% CrI:91.51-390.90); SUCRA:0.158]. Conclusions: Carvedilol is the preferred NSBB with better survival benefit and lower occurrence of adverse events among patients with gastroesophageal varices.
Language	English
Publishing date	2023-06-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	3019822-7
ISSN	2310-8819 ; 2225-0719
ISSN (online)	2310-8819
ISSN	2225-0719
DOI	10.14218/JCTH.2022.00130S
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Article ; Online: New strategies for the treatment of chronic hepatitis B.

Mak, Lung-Yi / Cheung, Ka-Shing / Fung, James / Seto, Wai-Kay / Yuen, Man-Fung

Trends in molecular medicine

2022 Volume 28, Issue 9, Page(s) 742–757

Abstract: Functional cure, as defined by seroclearance of hepatitis B surface antigen (HBsAg), is the desired treatment endpoint for chronic hepatitis B (CHB) infection, yet is rarely achieved with the currently approved therapy. Novel treatments currently in the ... ...

Abstract	Functional cure, as defined by seroclearance of hepatitis B surface antigen (HBsAg), is the desired treatment endpoint for chronic hepatitis B (CHB) infection, yet is rarely achieved with the currently approved therapy. Novel treatments currently in the clinical phase of development act by inhibiting viral replication/antigen reduction and/or by restoring host immune control. Although some agents are effective in reducing the viral antigen load, a greater magnitude of suppression is required to achieve functional cure. Compounds that target the covalently closed circular DNA (cccDNA) pool, hepatitis B X (HBx) protein inhibition, and mRNA destabilization are also in the preclinical phase of development. Challenges which remain include the clinical implications, immunological perturbations, and safety of these novel compounds to be used in the real-life setting.
MeSH term(s)	Antiviral Agents ; DNA, Viral ; Hepatitis B Surface Antigens ; Hepatitis B virus ; Hepatitis B, Chronic ; Humans ; Virus Replication
Chemical Substances	Antiviral Agents ; DNA, Viral ; Hepatitis B Surface Antigens
Language	English
Publishing date	2022-06-29
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2036490-8
ISSN	1471-499X ; 1471-4914
ISSN (online)	1471-499X
ISSN	1471-4914
DOI	10.1016/j.molmed.2022.06.002
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