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  1. Article ; Online: Perception of pharmacological equivalence of generics or biosimilars in healthcare professionals in Vienna.

    Binder, Lukas / Zeitlinger, Markus

    European journal of clinical pharmacology

    2023  Volume 80, Issue 3, Page(s) 355–366

    Abstract: Purpose: Due to constantly rising therapy costs, biosimilars and generic drugs have gained tremendous importance through recent decades. Nevertheless, the acceptance among healthcare workers regarding biosimilars and generic drugs in previously ... ...

    Abstract Purpose: Due to constantly rising therapy costs, biosimilars and generic drugs have gained tremendous importance through recent decades. Nevertheless, the acceptance among healthcare workers regarding biosimilars and generic drugs in previously published international studies is considerably lower than the scientific data on equivalent safety and efficacy would suggest. The aim of this questionnaire-based survey was to determine the perception and knowledge regarding generic drugs and biosimilars by medical professionals from different healthcare facilities in Vienna, Austria.
    Methods: The online questionnaire was sent to public and religious hospitals in Vienna, including the university hospital "Vienna General Hospital." In addition, doctors' offices were reached by sending out the questionnaire in the weekly news of the Vienna Medical Association.
    Results: A total of 282 physicians and 311 graduated nurses took part in the study. 63% and 62% of the participants were convinced that generic respective biosimilar drugs were clinically equivalent to the original reference drug. On average, 1.6 out of 4 knowledge questions were answered correctly about generics, while only 0.87 out of 4 questions were answered accurately about biosimilars.
    Conclusion: The results of this study support the outcome from previous surveys demonstrating that a large proportion of healthcare professionals is still skeptical about generics and biosimilars. According to the results of this study, better education of the medical staff might ensure greater acceptance of these types of drugs.
    MeSH term(s) Humans ; Biosimilar Pharmaceuticals/therapeutic use ; Drugs, Generic/therapeutic use ; Health Personnel ; Attitude of Health Personnel ; Perception
    Chemical Substances Biosimilar Pharmaceuticals ; Drugs, Generic
    Language English
    Publishing date 2023-12-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 121960-1
    ISSN 1432-1041 ; 0031-6970
    ISSN (online) 1432-1041
    ISSN 0031-6970
    DOI 10.1007/s00228-023-03603-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Horse or Zebra?

    Gruber, Viktoria / Binder, Barbara / Koch, Lukas

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2022  Volume 20, Issue 8, Page(s) 1143–1145

    Language English
    Publishing date 2022-06-27
    Publishing country Germany
    Document type Case Reports
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.14804
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Needs assessment towards research data management at the Medical Faculty of the University of Freiburg - Data of the BE-KONFORM study.

    Fichtner, Urs A / Horstmeier, Lukas M / Brühmann, Boris A / Binder, Harald / Knaus, Jochen

    Data in brief

    2023  Volume 48, Page(s) 109084

    Abstract: In order to investigate employees' needs of the Medical Faculty of the University of Freiburg regarding research data management, the BE-KONFORM study was performed in a two-step approach. First, guideline-based qualitative video interviews with four ... ...

    Abstract In order to investigate employees' needs of the Medical Faculty of the University of Freiburg regarding research data management, the BE-KONFORM study was performed in a two-step approach. First, guideline-based qualitative video interviews with four researchers were performed to identify key constructs of relevance. Second, a standardized online survey was conducted from 1
    Language English
    Publishing date 2023-03-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2786545-9
    ISSN 2352-3409 ; 2352-3409
    ISSN (online) 2352-3409
    ISSN 2352-3409
    DOI 10.1016/j.dib.2023.109084
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Healthcare resource utilisation and associated costs after low-risk pulmonary embolism: pre-specified analysis of the Home Treatment of Pulmonary Embolism (HoT-PE) study.

    Farmakis, Ioannis T / Kaier, Klaus / Hobohm, Lukas / Mohr, Katharina / Valerio, Luca / Barco, Stefano / Konstantinides, Stavros V / Binder, Harald

    Clinical research in cardiology : official journal of the German Cardiac Society

    2024  

    Abstract: Background: Pulmonary embolism (PE) and its sequelae impact healthcare systems globally. Low-risk PE patients can be managed with early discharge strategies leading to cost savings, but post-discharge costs are undetermined.: Purpose: To define ... ...

    Abstract Background: Pulmonary embolism (PE) and its sequelae impact healthcare systems globally. Low-risk PE patients can be managed with early discharge strategies leading to cost savings, but post-discharge costs are undetermined.
    Purpose: To define healthcare resource utilisation and overall costs during follow-up of low-risk PE.
    Methods: We used an incidence-based, bottom-up approach and calculated direct and indirect costs over 3-month follow-up after low-risk PE, with data from the Home Treatment of Patients with Low-Risk Pulmonary Embolism (HoT-PE) cohort study.
    Results: Average 3-month costs per patient having suffered low-risk PE were 7029.62 €; of this amount, 4872.93 € were associated with PE, accounting to 69.3% of total costs. Specifically, direct costs totalled 3019.33 €, and of those, 862.64 € (28.6%) were associated with PE. Anticoagulation (279.00 €), rehospitalisations (296.83 €), and ambulatory visits (194.95 €) comprised the majority of the 3-month direct costs. The remaining costs amounting to 4010.29 € were indirect costs due to loss of productivity.
    Conclusion: In a patient cohort with acute low-risk PE followed over 3 months, the majority of costs were indirect costs related to productivity loss, whereas direct, PE-specific post-discharge costs were low. Effective interventions are needed to reduce the burden of PE and associated costs, especially those related to productivity loss.
    Language English
    Publishing date 2024-01-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2213295-8
    ISSN 1861-0692 ; 1861-0684
    ISSN (online) 1861-0692
    ISSN 1861-0684
    DOI 10.1007/s00392-023-02355-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Hematopoietic Stem Cell Transplantation in Refractory Crohn's Disease: Should It Be Considered?

    Reider, Simon / Binder, Lukas / Fürst, Stefan / Hatzl, Stefan / Blesl, Andreas

    Cells

    2022  Volume 11, Issue 21

    Abstract: Hematopoietic stem cell transplantation (HSCT) is widely used in benign and malignant hematological diseases. During the last decade, HSCT, mainly autologous, also gained increasing attention in the treatment of refractory autoimmune diseases. Crohn's ... ...

    Abstract Hematopoietic stem cell transplantation (HSCT) is widely used in benign and malignant hematological diseases. During the last decade, HSCT, mainly autologous, also gained increasing attention in the treatment of refractory autoimmune diseases. Crohn's disease (CD) is an inflammatory bowel disease leading to transmural inflammation potentially affecting all parts of the luminal gastrointestinal tract. Despite improving therapeutic options, including various biologics, some patients are refractory to all lines of available conservative therapy, leading to increased morbidity and reduced quality of life. Apart from surgery, HSCT might be a reasonable treatment alternative for refractory CD patients. This review aims to describe the current role of HSCT in CD and discusses the procedure, the correct patient selection, the clinical efficacy from initial remission to following relapse rates, and complications of this treatment.
    MeSH term(s) Humans ; Crohn Disease/therapy ; Quality of Life ; Hematopoietic Stem Cell Transplantation/methods ; Transplantation, Autologous ; Inflammatory Bowel Diseases/etiology ; Chronic Disease
    Language English
    Publishing date 2022-11-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11213463
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Clinical evaluation after matrix-associated autologous chondrocyte transplantation : a comparison of four different graft types.

    Binder, Harald / Hoffman, Lukas / Zak, Lukas / Tiefenboeck, Thomas / Aldrian, Silke / Albrecht, Christian

    Bone & joint research

    2021  Volume 10, Issue 7, Page(s) 370–379

    Abstract: Aims: The aim of this retrospective study was to determine if there are differences in short-term clinical outcomes among four different types of matrix-associated autologous chondrocyte transplantation (MACT).: Methods: A total of 88 patients (mean ... ...

    Abstract Aims: The aim of this retrospective study was to determine if there are differences in short-term clinical outcomes among four different types of matrix-associated autologous chondrocyte transplantation (MACT).
    Methods: A total of 88 patients (mean age 34 years (SD 10.03), mean BMI 25 kg/m
    Results: The mean defect size of the tibiofemoral joint compartment was 4.28 cm
    Conclusion: Two years postoperatively, there were no significant differences in terms of outcomes. Our data demonstrated that MACT, regardless of the implants used, resulted in good clinical improvement two years after transplantation for localized tibiofemoral defects. Cite this article:
    Language English
    Publishing date 2021-06-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2669244-2
    ISSN 2046-3758
    ISSN 2046-3758
    DOI 10.1302/2046-3758.107.BJR-2020-0370.R1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Das geht an die Nieren - Rhabdomyolyse unter der Therapie mit Statinen Nicht neu, trotzdem immer wieder aktuell

    Lange, Lukas / Binder-Laurent, Anja

    Krankenhauspharmazie

    2020  Volume 41, Issue 10, Page(s) 387

    Language German
    Document type Article
    ZDB-ID 138842-3
    ISSN 0173-7597
    Database Current Contents Medicine

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  8. Article ; Online: Hematopoietic Stem Cell Transplantation in Refractory Crohn’s Disease

    Simon Reider / Lukas Binder / Stefan Fürst / Stefan Hatzl / Andreas Blesl

    Cells, Vol 11, Iss 3463, p

    Should It Be Considered?

    2022  Volume 3463

    Abstract: Hematopoietic stem cell transplantation (HSCT) is widely used in benign and malignant hematological diseases. During the last decade, HSCT, mainly autologous, also gained increasing attention in the treatment of refractory autoimmune diseases. Crohn’s ... ...

    Abstract Hematopoietic stem cell transplantation (HSCT) is widely used in benign and malignant hematological diseases. During the last decade, HSCT, mainly autologous, also gained increasing attention in the treatment of refractory autoimmune diseases. Crohn’s disease (CD) is an inflammatory bowel disease leading to transmural inflammation potentially affecting all parts of the luminal gastrointestinal tract. Despite improving therapeutic options, including various biologics, some patients are refractory to all lines of available conservative therapy, leading to increased morbidity and reduced quality of life. Apart from surgery, HSCT might be a reasonable treatment alternative for refractory CD patients. This review aims to describe the current role of HSCT in CD and discusses the procedure, the correct patient selection, the clinical efficacy from initial remission to following relapse rates, and complications of this treatment.
    Keywords Crohn’s disease ; inflammatory bowel disease ; hematopoietic stem cell transplantation ; chemotherapy ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Altered B-Cell Expansion and Maturation in Draining Mesenteric Lymph Nodes of Inflamed Gut in Crohn's Disease.

    Kappel-Latif, Sonja / Kotagiri, Prasanti / Schlager, Lukas / Schuld, Gabor / Walterskirchen, Natalie / Schimek, Vanessa / Sewell, Gavin / Binder, Carina / Jobst, Johanna / Murthy, Supriya / Messner, Barbara / Dabsch, Stefanie / Kaser, Arthur / Lyons, Paul A / Bergmann, Michael / Stift, Anton / Oehler, Rudolf / Unger, Lukas W

    Cellular and molecular gastroenterology and hepatology

    2023  Volume 17, Issue 4, Page(s) 662–666

    MeSH term(s) Humans ; Crohn Disease/pathology ; Lymph Nodes/pathology ; Cell Cycle
    Language English
    Publishing date 2023-12-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2819778-1
    ISSN 2352-345X ; 2352-345X
    ISSN (online) 2352-345X
    ISSN 2352-345X
    DOI 10.1016/j.jcmgh.2023.12.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Needs assessment towards research data management at the Medical Faculty of the University of Freiburg – Data of the BE-KONFORM study

    Urs A. Fichtner / Lukas M. Horstmeier / Boris A. Brühmann / Harald Binder / Jochen Knaus

    Data in Brief, Vol 48, Iss , Pp 109084- (2023)

    2023  

    Abstract: In order to investigate employees’ needs of the Medical Faculty of the University of Freiburg regarding research data management, the BE-KONFORM study was performed in a two-step approach. First, guideline-based qualitative video interviews with four ... ...

    Abstract In order to investigate employees’ needs of the Medical Faculty of the University of Freiburg regarding research data management, the BE-KONFORM study was performed in a two-step approach. First, guideline-based qualitative video interviews with four researchers were performed to identify key constructs of relevance. Second, a standardized online survey was conducted from 1st to 15th of November 2020 based on e-mail invitation by the dean and a faculty newsletter. The questionnaire was provided bilingual (English and German) using a backward-forward translation method, no reminders and incentives were used to increase the response rate. The online survey was programmed in REDCap and was accessible via online link. The target population were members of the Medical Faculty (listed in the newsletter mailing list) regardless of the type of working contract signed. The final dataset contains 236 complete cases (90% German and 10% English). The study includes a randomised module asking for data publication (group A) or not (group B). 113 cases were randomized into group A and 99% of them consented to the publication of the collected research data in anonymized form (n=112). The dataset comprised questions about work-related characteristics (professional status, working experience, scientific field of work), data management-related items (definition of research data management, type of data used, type of storage used for saving data, use of electronic laboratory notebooks), experience and attitudes towards data publication in data repositories, as well as needs and preferences regarding research data management support. The produced data offers the possibility to connect with other data collected in this field in other contexts (faculties or universities).
    Keywords Experimental study ; Survey ; Employee demands ; Digital infrastructure ; User preferences ; Theory of planned behavior ; Computer applications to medicine. Medical informatics ; R858-859.7 ; Science (General) ; Q1-390
    Subject code 310
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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